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Anastrozole is an aromatase inhibitor (AI) used as adjuvant therapy for breast cancer. Anastrozole is subject to direct glucuronidation catalyzed by UDP-glucuronosyltransferase1A4 (UGT1A4). Interindividual variability in anastrozole glucuronidation may be affected by UGT1A4 SNPs.
Authors: Edavana VK, Penney RB, Yao-Borengasser A, Starlard-Davenport A, Dhakal IB and Kadlubar S | Int J Cancer Res Mol Mech
DNA damage is induced in many types of cells by internal and external cell stress. When DNA is damaged, DNA Damage Response (DDR) programs are activated to repair the DNA lesions in order to preserve genomic integrity and suppress subsequent malignant transformation.
Authors: Sancho SC and Ouchi T | Int J Cancer Res Mol Mech
gC1qR is a multifunctional cellular protein that has been linked to inflammation and cancer. gC1qR is highly upregulated in adenocarcinomas as compared to normal tissue counterparts, and soluble gC1qR (sgC1qR) has been detected in vitro in the pericellular milieu of proliferating malignant cells.
Authors: Peerschke EI, Brandwijk RJ, Dembitzer FR, Kinoshita Y and Ghebrehiwet B | Int J Cancer Res Mol Mech
Cis-diamminedichloroplatinum (II) (cisplatin) is the most widely used chemotherapeutic drug for various cancers, but its effectiveness is limited by tumor cell resistance and the severe side effects it causes. Since high level of cisplatin is cytotoxic to both cancer and normal cells..
Authors: Dasari SR, Velma V, Yedjou CG and Tchounwou PB | Int J Cancer Res Mol Mech
Parkinson's disease (PD) is marked by neuronal loss in the substantia nigra that results in decreased dopaminergic input into the basal ganglia (BG) . PD motor symptoms like bradykinesia, rigidity, resting tremor, and gait difficulties often present asymmetrically.
Authors: Tekin I, Vgontzas A, Lewis MM, Kothari S, Kong L, Lu Y, Vrana KE and Huang X | J Neurol Neurobiol
The present study attempted to identify critical symptom domains of individuals with Myalgic Encephalomyelitis (ME) and chronic fatigue syndrome (CFS). Using patient and control samples collected in the United States, Great Britain, and Norway, exploratory factor analysis (EFA) was used to establish the underlying factor structure of ME and CFS symptoms.
Authors: Leonard A. Jason, Madison Sunnquist, Abigail Brown, Jacob Furst, Marjoe Cid, Jillianna Farietta, Bobby Kot, Craig Bloomer, Laura Nicholson, Yolonda Williams, Rachel Jantke, Julia L. Newton and Elin Bolle Strand | J Neurol Neurobiol
HIV induces neuroinflammation. We evaluated the anti-inflammatory effect of an extract from bamboo Phyllostachys edulis in the hippocampus of HIV-1 transgenic (TG) rats. Five (5) one-month-old TG rats and 5 Fisher 344 (F344) rats were fed a control diet, another 5 TG rats were fed the control diet supplemented with bamboo extract..
Authors: Xiaosha Pang, Jun Panee | J HIV AIDS
The purpose of this study was to quantitatively evaluate the tumor response to magnetic hyperthermia treatment (MHT) combined with radiation therapy (RT) in comparison with that to MHT alone using magnetic particle imaging (MPI).
Author: Akiko Ohki | International Journal of Nanomedicine and Nanosurgery ( ISSN 2470-3206 )
A literature review was conducted using pubmed database. English language articles published over the past 25 years in peer reviewed journals were reviewed - search terms used "Nephronophthisis", "Cilia", "Ciliopathy" and "Cystic Kidney disease".
Author: Vimal Master Sankar Raj | Pediatrics and Neonatal Nursing: Open Access ( ISSN 2470-0983 )
A total of 120 local fresh and imported frozen broilers breast, liver, kidney and gizzard were collected from different places in Al-Menofia Governorate, Egypt for estimation of their contents of Oxytetracycline (OTC) and Ampicillin residues by using high performance liquid chromatography (HPLC).
Author: Abdelrahman M Elbagory | Nutrition and Food Technology: Open Access ( ISSN 2470-6086 )
Video-assisted thoracoscopic surgery (VATS) lobectomy is a minimally invasive anatomic lung resection that has been associated with decreased pain and hospital stay compared to open resection.
Author: Daniel G French | Journal of Surgery: Open Access ( ISSN 2470-0991 )
Health care-associated infections (HAIs) are a leading cause of morbidity and mortality in the hemodialysis population. Despite the encouraging trend in the steady decline in the incidence of hepatitis B (HBV) transmission in hemodialysis since the 1980s..
Author: Samuel Mon-Wei Yu | Journal of Clinical Case Studies ( ISSN 2471-4925 )
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