Yanyuan Wu
Editor in Chief
Jack Ronald Wall, PhD
Professor of Medicine

University of Sydney (Nepean Clinical School)
Penrith, NSW, Australia
Phone: (02) 4734 2613
E-mail: jack.wall@sydney.edu.au

Education

Degree University Year
MB, BS University of Adelaide 1967
MD University of Adelaide 1971
PhD London, UK 1977


Post-Graduate Training:
Research

1968-1970            Department of Medicine, University of Adelaide, Adelaide, Australia
Position: MD graduate student
Thesis title: “Immunological aspects of thyrotoxicosis”.
Supervisor: Prof. BS Hetzel

1972-1974            Department of Medicine, Guy’s Hospital (University of London) London, UK
Position: post-doctoral fellow and PhD. graduate student
Thesis title: “Studies of immunological aspects of male infertility and leprous orchitis”.
Supervisor: Prof. MD. Lessof

1974-1975            Harvard Medical School and Tuft’s University Medical School, Boston, Mass., USA
Position: post-doctoral research fellow
Supervisors: Drs. L. Braverman, SO. Ingbar

Biography

Professor Wall heads our Discipline of Medicine and Department of Endocrinology.Before working here he spent 24 years in academic positions in Canada and the US. He became a full professor at McGill University in 1988. During all of this period he has carried out basic and clinical research into Graves’ disease, the associated ophthalmopathy, and related thyroid and orbital autoimmune disorders. His main area of research interest has been the eye muscle component of thyroid-associated ophthalmopathy for which he is known internationally. He was the first to focus on the autoimmune basis of ophthalmopathy and identify serum autoantibodies and to recognize the importance of the serum eye muscle antibodies as markers of eye muscle damage. He is the founding Medical Director of The International Thyroid Centre, and will develop new collaborative research studies with investigators in Fiji, PNG, the Philippines and Malaysia.

Jack has been invited as keynote speaker or contributor to many national and international symposia and congresses, including an International Symposium on Thyroid Eye Disease in Greece (1998), the Japan Thyroid Association annual meeting and 2nd. Japan, Korea, China Thyroid Conference in Tokyo, International Symposium on Thyroid-Associated Ophthalmopathy in Kyoto (2000), and to Witwatersrand University Medical school, Johannesburg (2001). Recent research funding includes grants from the Canadian Institutes of Health Research (1979-1993 and 2000-2003) and the National Eye Institute of the NIH (1984-1994). Just before leaving Halifax (in 2002) he was awarded a grant from Cy-pres Canada of $204,000 to study an animal model for ophthalmopathy. 

He is a board member of the National Graves’ disease Foundation and foundation scientific advisor, board member and co-founder of The Thyroid Foundation of Canada, the world’s first lay organization for diseases of the Thyroid. In 2004 he was given an “award of excellence” for his work with the Foundation, one of only 3 doctors in Canada so honoured. He has published approximately 200 papers.

 

Research Interest

  • “Thyroidology” (including use of real-time US, US-guided FNA, eye muscle Abs testing)
  • Bone disease, metabolic syndrome
  • Pituitary medicine
  • General endocrinology, diabetes & metabolism
  • Clinical immunology
  • Internal Medicine

Professional Activities:

Honours and Awards:

Year

Name

Awarded by

Type

1962-1966

Commonwealth Scholarship

Australian Government

Undergraduate Studies (Course Fees)

1968-1970

Research Fellowship

National Health & Medical Research Council (Australia)

Graduate Studies Salary

1972-1974

Guy’s Hospital Governors Fellowship

Guy’s Hospital Board of Governors
(London, UK)

Post-Doctoral Research Fellowship (Salary)

1973

Travelling Fellowship

British Council

Living costs, travel expenses, to visit European Research Laboratories

1974

UK-USA Travelling Fellowship

Hays-Fullbright Foundation (USA)

For travel expenses to work in the USA

1974-1975

Research Fellowship

NIH

Post-Doctoral Research (Salary)

1982

Basmajian Award

Faculty of Medicine Queen’s University
Kingston, Ontario

For research achievements 1978-1982

1984

Bourse d’échange ISERM-FRSQ

FRSQ/INSERM

Travel expenses, salary, to work in Marseille, France

2004

“Award of Excellence”

Thyroid Foundation of Canada

Plaque, silver medallion

2005

Nominated as “Teacher of year – first year”

The University of Sydney (Nepean Clinical School)

 

Clinical Interests:
 a)  “Thyroidology” (including use of real-time US, US-guided FNA, eye muscle Abs testing)

  •  Bone disease, metabolic syndrome
  •  Pituitary medicine
  •  General endocrinology, diabetes & metabolism
  •  Clinical immunology
  • Internal Medicine

Clinical Activities:
Internal Medicine
Co-Physician-in-Chief for hospital in-patients (for 6 months of the year), 1975-78
Diabetes in-patient management 1998-present

Endocrinology
Clinical practice at hospital outpatient clinics/ambulatory care, 1975-present
Public [”charity”] thyroid and general endocrinology clinic, 1993-1997
In-hospital consultations, various hospitals, 1975-present
General endocrinology/diabetes “private practice”, Pittsburgh, PA (2 days/wk, April-July 1998
Thyroid and endocrinology Clinics (private practice; Penrith, Katoomba and St Leonards, (N Sydney), 2004- present
Osteoporosis Clinic Nepean Hospital, 2004-present
Diabetes clinics, DRC, two half days/wk, The Geelong Hospital, 7/2002-2004, Monthly diabetic clinic, Lithgow NSW, October 2011-present
Endocrinology consultation service, 1/99-present

Hospital admitting Privileges
Various, 1975-present

Recent CME Courses Taken
Endocrinology refresher course, Harvard University, April 1997
Topics in Internal Medicine, Johns Hopkins University, Baltimore, December 1997.
“Diabetes in the Nineties”: What’s new? University of Pittsburgh, March 14, 1998
Numerous half-day and full-day courses in various topics, 1992-present

 

Publications

Bibliography:
Peer Reviewed Papers:

  1. Hetzel BS, Wall JR  1969.  Pretibial Myxoedema, Aust. J. Dermatology 10:18.
  2. Wall JR, Good BF, Hetzel BS.  1969 Long acting thyroid stimulator in euthyroid relatives of thyrotoxic patients.  Lancet 11:1024-1027.
  3. Wall JR.  1971 Immunological aspects of thyrotoxicosis.  MD. Thesis, Adelaide University.
  4. Wall JR.  Odgers R, Hetzel BS.  1973 Immunological studies of the eye changes of thyrotoxicosis.  Aust NZ J Med 3:162.
  5. Wall JR, Pyke DA, Oakley WG.  1973 Effect of carbohydrate restriction in obese diabetics: relationship of control to weight loss.  Brit Med J 1:577.
  6. Wall JR, Zimmet PZ, Jarret JR, Bailes M, Ramage CM.  1973 Fall in plasma testosterone levels in normal male subjects in response to an oral glucose load.  Lancet 1:967.
  7. Wall JR, Good BF, Forbes IJ, Hetzel BS.  1973 Demonstration of the production of the long-acting thyroid stimulator (LATS) by peripheral lymphocytes cultures in vitro. Clin Exp Immunol 14:555.
  8. Wall JR, Good BF, Hetzel BS.  1973 Failure to produce experimental autoimmune thyrotoxicosis in rabbits immunised with thyroidal microsomes.  Aust J Exp Bio Med Sci 51:703.
  9. Vidor GI, Stewart JS, Wall JR, Wangle A, Hetzel BS.  1973 Pathogenesis of iodine induced thyrotoxicosis: studies in Northern Tasmania.  J. Clin Endocrinol Metab 37:901.
  10. Zimmet PS, Wall JR, Rome R, Stimmler L, Jarrett RJ.  1974 Diurnal variation in glucose tolerance: associated changes in plasma insulin growth hormone and non-esterified fatty acids.  Brit Med J 1:485.
  11. Wall JR, Wright DJM.  1974 Antibodies against testicular germinal cells in lepromatous leprosy.  Clin Exp Immunol 17:51
  12. Wall JR, Stedronska J, Lessof MH.  1974 Antibodies against Sertoli cells in human infertility.  Clin Endocrinol 3:187.
  13. Wall JR.  1974 The Guy’s Hospital Physical Society (1771-1852).  Guy’s Hospital Reports.  123:159.
  14. Wall JR, Harrison RF, Stedronska J, Lessof MH.  1974 Serum spermatozoal antibodies in infertile women with dead or agglutinated spermatozoa on post-coital tests.  Amer J Obstetrics & Gynaecology 121:198.
  15. Wall JR, David R, Stedronska J, Harrison RF, Goriup D, Lessof MH.  1974 Immunological studies of male infertility.  Fertil Steril 26:1035.
  16. Harrison RF, Wall JR, Stedronska J. Lessof MH.  1974 Antibodies against spermatozoa in serum, seminal plasma and cervical mucous from sterile couples with poorly invading spermatozoa on post coital tests.  Irish J Med Sci 69:536.
  17. Wall JR, Fang SL, Braverman LE, Ingbar SO 1976 Studies of cell-mediated immunity in patients with subacute thyroiditis.  J Clin Endocrinol Metab 43: 587.
  18. Walters BAJ, Rutherford JC, Wall JR.  1976 Abnormal “activated” rosette formation in patients with gastrointestinal cancer.  Aust NZ J Med 6:536-539.
  19. Wall JR, Lee Manwar S, Greenwood DM, Walter BA.  1976 The in vitro suppression of lectin induced 3H-thymidine incorporation into DNA of peripheral blood lymphocytes after the addition of Propylthiouracil.  J Clin Endocrinol Metab 43:1406.
  20. Harrison RF, Wall JR, Stedronska J. Wynn-Williams G 1976.  Infertile patients with positive immunofluorescent serum spermatozoal antibodies treated by condom coitus.  Irish J Med Sci 69:539-542.
  21. Wall JR, Gray B, Greenwood DM. 1977 Total and “activated” peripheral blood T lymphocytes in patients with thyroid disorders.  Acta Endocrinologica (KbH).  85:753-759.
  22. Wall JR. 1977 Immunological studies of the testicular disease of lepromatous leprosy and other conditions associated with oligo- and azoospermia.  Ph.D. Thesis.  University of London (UK).
  23. Strakosch CR, Joyner D, Wall JR.  1978 Thyroid stimulating antibodies in patients with autoimmune disease.  J Clin Endocrinol Metab 47:361-365.
  24. Wall JR, Trewin A, Fang SL, Ingbar SO, Braverman LE. 1978 Studies of immunoreactivity to human lachrymal gland fractions in patients with ophthalmic Graves’ disease.  J Endocrinol Invest 1:253-258.
  25. Wall JR, Fang SL, Strakosch C, Ingbar SO, Braverman LE.  1978 Multi-system Immunologically mediated disease - T-lymphocyte deficiency and thyroid immunological disease-A report of four cases.  Aust NZ J Med 8:290-294.
  26. Strakosch CR, Joyner D, Wall JR. 1978 Thyroid stimulating antibodies in patients with subacute thyroiditis.  J Clin Endocrinol Metab 46:345-347.
  27. Walters BAJ, Rutherford JC, Wall JR.  1978 Increased active rosette formation in patients with gastrointestinal cancer after enzyme treatment of lymphocytes in vitro. Aust NZ J Med 8:610-614.
  28. Wall JR, Walters BAJ, Grant C.  1979 Leukocyte adherence, inhibition response to human orbital and lachrymal extracts in patients with Graves’ ophthalmopathy.  J Endocrinol Invest 2:375-378.
  29. Wall JR, Strakosch CR, Trewin A, Joyner DM.  1979 In vitro production of thyroid-binding antibodies by peripheral blood lymphocytes from patients with Graves’ disease: Non-specific responses associated with culture supernatant proteins.  J. Endocrinol Invest 2:261-266.
  30. Wall, JR, Strakosch CR, Fang SL, Ingbar SO, Braverman LE.  1979 Thyroid-binding antibodies and other immunological abnormalities in Graves’ ophthalmopathy: effect of treatment with cyclophosphamide.  Clin Endocrinol (Oxf).  10:79-91.
  31. Wall JR, Trewin A, Joyner DM.  1980 Peripheral blood lymphocyte transformation in response to human thyroid fractions in patients with Graves’ hyperthyroidism and ophthalmopathy.  Acta Endocrinologica 93:419-423.
  32. Wall JR, Ryan EA.  1980 Production of migration inhibitory factor in response to bacterial and fungal antigens in patients with Graves’ hyperthyroidism.  Can Med Assoc J 22:1264-1268.
  33. Chartier B, Bandy P, Wall JR.  1980 Fc receptor-bearing blood mononuclear cells in thyroid disorders - increased levels in patients with subacute thyroiditis.  J Clin Endocrinol Metab 51:1014-1018.
  34. Wall JR, Henderson J, Strakosch CR, Joyner DM.  1981 Graves’ ophthalmopathy:  a review.  Can Med Assoc J.  124:855-866.
  35. Henderson J, Wall JR.  1981.  Failure of hemagglutination and immunofluorescence methods to detect serum orbital antibodies in patients with Graves’ ophthalmopathy.  Clin. Endocrinol 1:153-158.
  36. Wall JR, Walters BAJ.  1981 Immunoreactivity in vitro to human testis in patients with lepromatous leprosy.  Aust NZ J Med 11:375-379.
  37. Easton PA, Wall JR.  1981 Graves’ hyperthyroidism and ophthalmopathy following treatment of spontaneous hypothyroidism with levothyroxine.  Can MEd Assoc J 125:65-67.
  38. Wall JR, Twohig P, Chartier B, 1981.  Effect of experimental hyper-and hypothyroidism on numbers of blood mononuclear cells and immune function in rats and guinea pigs.  J Endocrinol 91:61-67.
  39. Wall JR, Chartier, 1981.  Blood mononuclear cells with suppressor activity in patients with thyroid disorders: increased levels of T cells in subacute thyroiditis.  J Clin Lab Immunol 6(2): 115-119.
  40. Seybold D, Ryan Ea, Wall JR 1981.  Preliminary Report - Natural cytotoxicity of blood mononuclear cells from normal subjects and patients with Hashimoto’s thyroiditis against normal thyroid cells.  J Clin Lab Immunol 6:241-244.
  41. Strakosch CR, Wall JR, 1982.  Pathogenesis of autoimmune thyroid disease: some facts and some speculation.  Can Med Assoc J 126:10-11.
  42. Strakosch CR, Joyner DM, Manley SWS, Wall JR, 1982.  The species specificity of TSH receptor binding antibodies as measured by radio receptor assay.  Clin Endocrinol 17(2): 173-179.
  43. Wall JR, Strakosch CR, Bandy P, Bayly R, 1982.  Nature of thyrotropin displacement activity in subacute thyroiditis.  J Clin Endocrinol Metab 54(2): 349-353.
  44. Wall JR, Strakosch CR, Wellby ML, Gooden J, Joyner D, Bayly R, 1982.  Thyroid-stimulating hormone (TSH) receptor antibodies and antibodies stimulating adenyl cyclase in relatives from two families with a high prevalence of Graves’ hyperthyroidism.  A ten-year follow-up study.  J Clin Immunol 2:15-19.
  45. Kodama K, Sikorska H, Bandy-Dafoe P, Bayly R, Wall JR, 1982.  Demonstration of circulating autoantibody against a soluble eye muscle antigen in Graves’ ophthalmopathy.  Lancet 2:1353-1356.
  46. Chow A, Baur R, Schleusener H, Wall JR, 1983.  Natural and antibody dependent cytotoxicity of peripheral blood leukocytes against human adult and fetal thyroid cells.  Life Sciences 32:67-75.
  47. Baur R, Wall JR, Schleusener H, 1983.  Isolation and characterization of mononuclear cells from various thyroid tissue specimens.  Life Sciences 32:55-66.
  48. Wall JR, Baur R, Schleusener H, Bandy-Dafoe P, 1983.  Peripheral blood and intra thyroidal mononuclear cells populations in patients with autoimmune thyroid disorders enumerated using monoclonal antibodies.  J Clin Endocrinol Metab 56:164-169.
  49. Kodama K, Sikorska H, Bayly R, Bandy-Dafoe P, Wall JR, 1984.  Use of monoclonal antibodies to investigate a possible role of thyroglobulin in the pathogenesis of Graves’ ophthalmopathy.  J Clin Endocrinol Metab 59:67-73.
  50. Wall JR, Fang SL, Kuroki T, Ingbar SO, Braverman LE, 1984.  In vitro immunoreactivity to Propylthiouracil, methimazole and carbimazole in patients with Graves’ disease: a possible cause of anti-thyroid drug-induced agranulocytosis.  J Clin Endocrinol Metab 58:868-872.
  51. Bogner U, Schleusener H, Wall JR, 1984.  Antibody-dependent cell-mediated cytotoxicity against human thyroid cells in Hashimoto’s thyroiditis but not Graves’ disease.  J Clin Endocrinol Metab 59:734-738.
  52. Kuroki T, Ruf T, Whelan L, Miller A, Wall JR, 1985.  Antithyroglobulin monoclonal and autoantibodies cross-reactivity on orbital connective tissue antigen.  A possible mechanism for the association of ophthalmopathy with autoimmune thyroid disorders.  Clin Exp Immunol 69:931-936.
  53. Kuroki T, Kodama K, Carayon P, Ruf J, Miller A, Wall JR, 1986.  Use of mouse and human monoclonal antibodies to investigate the immunologic basis of Graves’ ophthalmopathy.  The Mount Sinai J of Medicine 53:60-69.
  54. Mengistu M, Laryea E, Miller A, Wall JR, 1986.  Clinical significance of a new autoantibody against a human eye muscle soluble antigen detected by immunofluorescence.  Clin Exp Immunol 65:19-27.
  55. Wang PW, Hiromatsu Y, Laryea E, Wosu L, How J, Wall JR, 1986.  Immunologically mediated cytotoxicity against human eye muscle cells in Graves’ ophthalmopathy.  J Clin Endocrinol Metab 63:316-322.
  56. Miller A, Sikorska H, Salvi M, Wall JR, 1986.  Evaluations of an enzyme-linked immunosorbent assay for the measurement of autoantibodies against eye muscle membrane antigens in Graves’ ophthalmopathy.  Acta Endocrinol 113:514-522.
  57. Hiromatsu Y, Wang PW, Wosu L, How J, Wall JR, 1987.  Mechanisms of immune damage in Graves’ ophthalmopathy.  Hor Res 26:198-207.
  58. Bogner U, Wall JR, Schleusener H, 1987.  Cellular and antibody mediated cytotoxicity in autoimmune thyroid disease.  Acta Endocrinol (Suppl) 281:133-138.
  59. Hiromatsu Y, Fukazawa H, How J, Wall JR, 1987.  Antibody-dependent cell-mediated cytotoxicity against human eye muscle cells and orbital fibroblasts in Graves’ ophthalmopathy - roles of Class II MHC antigen expression and gamma-interferon actions on effector cells.  Clin Exp Immunol 70:593-603.
  60. Salvi M, Bingoye F, Chung F, Wall JR, 1988.  Affinity purification of orbital membrane antigens for the study of the pathogenesis of Graves’ ophthalmopathy.  J Clin Endocrinol Metab 66:939-945.
  61. Salvi M, Miller A, Wall JR, 1988.  Human orbital tissue and thyroid membranes express a 64-kDa protein, which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy.  FEBS Letters 232:135-139
  62. Salvi M, Fukazawa H, Hiromatsu Y, Triller H, Bernard N, How J, Wall JR, 1988.  Role of autoantibodies in the pathogenesis of endocrine autoimmune disorders and in their association.  Endocrine Reviews.  9:450-466.
  63. Hiromatsu Y, How J, Miller A, Guinard F, Salvi M, Wall JR, 1988.  A new thyroid cytotoxic antibody that cross-reacts with an eye muscle cell surface antigen may be the cause of thyroid-associated ophthalmopathy.  J Clin Endocrinol Metab 67:565-570.
  64. Dillon J, Zhang ZG, Hiromatsu Y, Bernard N, Salvi M, Wall JR, 1989.  Failure to detect complement mediated antibody dependent cytotoxicity against human orbital tissue cells as the serum of patients with thyroid-associated ophthalmopathy.  Autoimmunity 5:125-132.
  65. Salvi M, Zhang ZG, Haegert D, Woo M, Liberman A, Cadarso L, Wall JR, 1990.  Patients with endocrine ophthalmopathy not associated with overt thyroid disease have multiple thyroid immunological abnormalities.   J Clin Endocrinol Metab 70:89-94.
  66. Hiromatsu Y, Cadarso L, Salvi M, Wall JR, 1990.  Significance of cytotoxic eye muscle antibodies patients with thyroid associated ophthalmopathy.  Autoimmunity 5:205-213.
  67. Pratt C, Wall JR, 1990.  Spontaneous thyroglobulin in autoantibody production by peripheral blood lymphocytes is regulated by T cells and is augmented by soluble T cell factors.  Autoimmunity 3:189-199.
  68. Kapusta M, Salvi M, Triller H, Gardini E, Bernard N, Wall JR, 1990.  Eye muscle membrane reactive antibodies are not detected in the serum or immunoglobulin fraction of patients with thyroid-associated ophthalmopathy using an ELISA and crude membranes.  Autoimmunity 7:33-40.
  69. Bernard N, Boucher A, Zhang ZG, Salvi M, Wall JR, 1991.  Nature of a 64-kDa eye muscle membrane autoantigen as determined from immunoprecipitation and immunoblotting.  Exp Clin Endocrinol 97:191-196.
  70. Fukazawa H, Hiromatsu Y, Salvi M, Wall JR, 1991.  Binding of T cells to thyroid monolayers - a possible role of homing reaction.  Autoimmunity 10:181-188.
  71. Teboul N, Triller H, Chung F, Bernard N, Zhang ZG, Wall JR, 1991.  Muscle and species reactivity of mouse monoclonal antibodies to human eye muscle membrane antigens.  Clin Immunol Immunopath 59:104-116.
  72. Wall JR, Salvi M, Bernard NF, Boucher A, Haegert D, 1991.  Thyroid-associated ophthalmopathy - a model for the association of organ-specific autoimmune disorders.  Immunology Today 12:150-153.
  73. Bernard NF, Ertug F, Teboul N, Zhang ZG, Salvi MS, Wall JR, 1991.  Isotype and immunoglobulin subclass distribution of eye muscle membrane reactive antibodies in the serum of patients with thyroid-associated ophthalmopathy as detected in Western blotting.  Autoimmunity 10:57-63.
  74. Salvi M, Bernard N, Miller A, Zhang ZG, Gardini E, Wall JR, 1991.  Prevalence of antibodies reactive with a 64-kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy.  Thyroid 1:207-213.
  75. Medeiros-Neto G, Zhang ZG, Lima N, Iacona A, Liberman A, Salvi M, Wall JR, 1992.  Immunologically mediated cytotoxicity against human eye muscle and thyroid cells or euthyroid and thyrotoxic Graves’ ophthalmopathy.  Autoimmunity 11:225-231.
  76. Cohen M, Salvi M, Miller A, How J, Bernard N, Wall JR, 1992.  Cell-mediated immunity to orbital tissue antigen in thyroid-associated ophthalmopathy determined using the leukocyte procoagulant activity assay.  Autoimmunity 11:225-231.
  77. Miller A, Arthurs B, Boucher A, Liberman A, Bernard N, Salvi M, Wall JR, 1992.  Significance of antibodies reactive with a 64-kDa eye muscle membrane antigen in patients with thyroid autoimmunity.  Thyroid 2:197-202.
  78. Fukazawa H, Baniassadi J, Wall JR, 1992.  Tissue specific binding of lymphocytes to the thyroid gland of BB/W rats may be an early event in the development of thyroiditis.  Autoimmunity 12:89-93.
  79. Zhang ZG, Salvi M, Miller A, Bernard N, Arthurs B, Wall JR, 1992.  Restricted tissue reactivity of autoantibodies to a 64-kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy.  Clin Immunol Immunopath 62:183-189.
  80. Wall JR, Bernard N, Boucher A, Rodien P, Arthurs B, 1992.  Significance of Antibodies reactive with a 64 kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy, McGill Ophthalmology 4:9-13
  81. Boucher A, Bernard NF, Zhang ZG, Salvi M, Rodien P, Triller H, Wall JR, 1992.  Nature and significance of orbital autoantigen and the corresponding autoantibodies in thyroid-associated ophthalmopathy.  Autoimmunity 13:89-93.
  82. Zhang ZG, Rodien P, Dong Q, Bernard NF, Salvi M, Miller A, Vassart G, Ludgate M, Wall JR, 1992.  Autoantibodies in the serum of patients with autoimmune thyroid disorders react with a recombinant 98 amino acid fragment of a 64-kDa eye muscle recombinant protein, which is also expressed in the thyroid.  Autoimmunity 13:151-157.
  83. Fukazawa H, Yoshida K, Ichinohasama R, Sawai T, Kaise N, Mori K, Kikuchi K, Abe K, Wall JR, 1993.  Expression of the Hermes-1 (CD44) and ICAM-1 molecules on the surface of thyroid cells from patients with Graves’ disease.  Thyroid 3:285-288.
  84. Triller H, Chung F, Rodien P, Boucher A, Liberman A, Bernard NF, Ludgate M, Wall JR, 1993.  Antibodies reactive with an intracellular fragment of a recombinant 64-kDa thyroid and eye muscle protein are associated with thyroid autoimmunity and ophthalmopathy. J Endo Invest 16:863-868.
  85. Wall JR, Bernard N, Zhang ZG, Salvi M, Kennerdell J, Tyutyunikov A, Genovese, 1993.  Pathogenesis of thyroid-associated ophthalmopathy; an autoimmune disorder of the eye muscle associated with Graves’ hyperthyroidism and Hashimoto’s thyroiditis.  Clin Immunol Immunopathol 68:1-8.
  86. Crock PA, Salvi MS, Miller A, Wall JR, Guyda H, 1993.  Detection of anti-pituitary autoantibodies by immunoblotting.  J Immunol Meth 162:31-40.
  87. Margolese H, Ertug F, Wall JR, Bernard NF, 1994.  Expression of major histocompatibility complex class II antigen by thyroid epithelial cells in NOD mice.  Autoimmunity 17:1-11.
  88. Boucher A, Bernard N, Miller A, Salvi M, Wall JR, 1994.  Nature of 64 kDa eye muscle and thyroid membrane proteins and their significance in thyroid-associated ophthalmopathy-an hypothesis.  Autoimmunity 16:79-82.
  89. Boucher A, Bernard N, Miller A, Rodien P, Salvi M, Wall JR, 1994.  Two dimensional gel electrophoresis identifies minor differences in immunologically cross-reactive 64 kDa autoantigens in the thyroid and eye muscle.  J Endo Invest 17:7-13.
  90. Triller H, Chung F, Tsao M, Boucher A, Rodien P, Liberman A, Bernard N, Wall JR, 1994.  Cross-reactive antibodies in the serum of balb/c mice immunized with thyroid eye muscle membranes.  J Endo Invest 17:105-112.
  91. Atabay C, Schrooyen M, Zhang ZG, Salvi M, Glinoer D, Wall JR, 1994.  Use of eye muscle antibody measurements to monitor response to plasmapheresis in patients with thyroid-associated ophthalmopathy.  J Endo Invest 16:669-674.
  92. Bernard NF, Salvi M, Tyutyunikov A, Genovese C, Ludgate, M, Wall JR, 1994.  Antibodies against 1D, a recombinant 64 kDa membrane protein, are associated with ophthalmopathy in patients with thyroid autoimmunity.  Clin Immunol Immunopath 70:225-233.
  93. Kiljanski J, Nebes V, Wall JR, 1995.  The ocular muscle is the target of the immune system in endocrine ophthalmopathy-pro Intl Arch Allerg Immunol 106:204-212.
  94. Atabay C, Tyutyunikov A, Scalise D, Stolarski C, Hayes M, Kennerdell JS, Wall JR, 1995.  Serum antibodies reactive with eye muscle membrane antigens are detected in patients with non-specific orbital inflammation.  Ophthalmology 102:145-153.
  95. Hiromatsu Y, Tanaka K, Ishisaka N, Kamachi J, Kuroki T, Hoshino T, Inoue Y, Wall JR, Nonaka K, 1995.  Human histocompatibility leukocyte antigen-Dr and heat shock protein-70 expression in eye muscle tissue in thyroid-associated ophthalmopathy.  J Clin Endocrinol Metab 80:685-691.
  96. Salvi M, Scalise D, Stolarski C, Arthurs B, Lindley S, Kennerdell J, Wall JR, 1995.  Upper eyelid retraction in the absence of other evidence for progressive ophthalmopathy is associated with eye muscle autoantibodies.  Clin Immunol Immunopathol 74:44-50.
  97. Wall JR, Scalise D, Hayes M, Stolarski C, Sata M, Salvi M, Nebes V, 1995.  Native gel electrophoresis and isoelectric focusing of a 64-kDa protein shows that it is an important target for autoantibodies in patients with thyroid-associated ophthalmopathy and not expressed in other skeletal muscle.  J Clin Endocrinol Metab 80:1226-1232.
  98. Barsouk A, Wengrowitz S, Scalise D, Stolarski C, Nebes V, Sato M, Wall JR, 1995.  New assays for the measurement of serum antibodies reactive with eye muscle membrane antigens confirm their importance in thyroid-associated ophthalmopathy.  Thyroid 5:195-200.
  99. Rosen CE, Rizzuto PR, Kennerdell JS, Burde RM, Wall JR.  1994 Interleukin-2 receptor beta and CD57 expression in orbital tissues from patients with thyroid-associated ophthalmopathy.  Alaska Medicine 36:177-182.
  100. Zhang ZG, Wall JR, Bernard NF, 1995.  Identification of antigenic epitopes of 1D antigen recognized by antibodies in the serum of patients with thyroid associated ophthalmopathy.  Clin Immunol Immunopath 77:193-200.
  101. Wall JR, Kiljanski J, Nebes V, Stachura I, Kennerdell JS, 1995. Should Graves’ disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue?  Hor Metab Res 27:528-532.
  102. Wall JR, Kennerdell JS, 1995.  Progress in thyroid-associated ophthalmopathy (review) Autoimmunity 22:191-195.
  103. Wall JR, 1996.  Extra thyroidal manifestations of Graves’ disease.  J Clin Endocrinol Metab 80:3427-3429 (Editorial).
  104. Kiljanski J, Stolarski C, Nebes V, Wall JR, 1996.  Failure to demonstrate cell-mediated immunity to orbital tissue antigens and epitopic fragments of a 64-kDa protein in the majority of patients with thyroid-associated ophthalmopathy.  J Endo Invest 19:284-292.
  105. Barsouk A, Kiljanski J, Stolarski C, Nebes V, Wall JR, 1996.  Antibody-dependent cell-mediated cytotoxicity against orbital target cells in thyroid associated ophthalmopathy and related disorders; close relationship between serum cytotoxic antibodies and parameters of eye muscle dysfunction.  J Endo Invest 19:334-341.
  106. Zhang ZG, Wall JR, Bernard NF, 1996.  Tissue distribution and quantitation of a gene expressing a 64-kDa antigen associated with thyroid-associated orbitopathy.  Clin Immunol Immunopath 80:236-244.
  107. Wall JR, Barsouk A, Stolarski C, Kiljanski J, Stachura I, Nebes V, Peele K, Volpe R, Kennerdell JS, 1996.  Serum eye muscle and TSH receptor antibodies predicted the development of ophthalmopathy in a euthyroid subject with a family history of autoimmunity.  Thyroid 6:353-358.
  108. Kiljanski J, Nebes A, Wall JR, 1996.  Significance of tissue specific and tissue non-specific autoimmune reactions of Graves’ disease.  Clin Exp Rheumatol (suppl 12) 15:S69-76.
  109.  Kiljanski J, Nebes V, Kennerdell JS, Wall JR, 1996.  Graves’ hyperthyroidism, ophthalmopathy and pretibial myxoedema may be components of a multi-system autoimmune disorder.  Orbit 15:(suppl.) 129-136.
  110.  Barsouk A, Fraiture B, Peele KA, Ing E, Dalil M, Nebes V, Stolarski CS, Kennerdell J, Jani B, Wall JR, 1996.  Increased levels of manganese superoxide dismutase activity in tears from patients with thyroid-associated ophthalmopathy; correlation with eye muscle dysfunction.  Orbit 15: (supple.) 205-211.
  111.  Otto E, Ochs C, Hansen C, Wall JR, Kahaly G, 1996.  Orbital tissue-derived T lymphocytes from patients with Graves’ ophthalmopathy recognize autologous orbital antigens.  J Clin Endocrinol Metab 81:3045-50.
  112.  Salvi M, Spaggiari E, Neri F, Macaluso C, Gardini E, Ferrozzi F, Minelli R, Wall JR, Roti E, 1997.  The study of visual evoked potentials in patients with thyroid-associated ophthalmopathy identifies asymptomatic optic nerve involvement.  J Clin Endocrinol Metab 84:1027-30.
  113.  Ringel MD, Taylor T, Barsouk A, Wall JR, Freter CE, Howard RS, Diehl L, Burman KD, 1997.  Hodgkin’s disease is associated with antibody dependent cellular cytotoxicity against human extra ocular muscle cells.  Thyroid 3:425-428.
  114.  Kiljanski JI, Peele K, Stachura I, Pickeral J, Stolarski C, Kennerdell JS, Wall JR, 1997.  Antibodies against striated muscle, connective tissue and nuclear antigens in patients with thyroid-associated ophthalmopathy: should Graves’ disease be considered a collagen disorder?  J Endo Invest 20:585-591.
  115. Kubota S, Gunji K, Ackrell, BAC, Cochran B, Stolarski C, Wengrowicz S, Kennerdell JS, Hiromatsu Y, Wall J. 1998 The 64‑kilodalton eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune‑mediated damage to the eye muscle in patients with Graves' hyperthyroidism. J Clin Endocrinol Metab 83:443‑7.
  116. Bednarczuk T, Kiljanski J. Mrowiec T, Slon M, Ing E, Stolarski C, Kennerdell JS, Gorski I, Nauman J, Wall JR, 1998.  T cell interactions with extra cellular matrix proteins in patients with thyroid-associated ophthalmopathy.  Autoimmunity 27:221-230.
  117. Wenzel BE, Chow A, Baur R, Schleusener H, Wall JR, 1998.  Natural killer cell activity in patients with Graves’ disease and Hashimoto’s thyroiditis.  Thyroid 8:1019-1022.
  118. Gunji K, S, Swanson J, Kiljanski J, Bednarczuk T, Wengrowicz S, Salvi M, Wall JR, 1998.  Role of the eye muscles in thyroid eye disease: identification of the principal autoantigens.  Thyroid 8:553-556.
  119. Gunji K, Skolnick C, Bednarczuk T, Benes S, Ackrell BA, Cochran B, Kennerdell JS, Wall JR. 1998 Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine‑receptor antibody‑negative patients. Clin Immunol Immunopathol 87:276‑81.
  120. Kubota S, Gunji K, Stolarski C, Kennerdell JS, Wall J. 1998 Reevaluation of the prevalences of serum autoantibodies reactive with "64‑kDa eye muscle proteins" in patients with thyroid‑associated ophthalmopathy. Thyroid 8:175‑9
  121. Kubota S, Gunji K, Stolarski C, Kennerdell JS, Wall JR 1998 Role of eye muscle antibody measurement in diagnosis of thyroid-associated ophthalmopathy: a laboratory update. Endocr Pract. 4:127-32.
  122. Wengrowicz S, Puig-Domingo M, Rodriguez-Alvarez F, Juarez E, Fabra JM, Guardia E, Albareda M, Soldevila J, Wall JR, De Leiva A. 1999 Clinical and immunological changes in patients with thyroid-associated ophthalmopathy treated with high dose iv methylprednisolone pulse therapy followed by oral prednisolone. Endocrionologia 46:108-113.
  123.  Gunji K, Kubota S, Stolarski C, Wengrowicz S, Kennerdell JS, Salvi M, Wall JR 1999 A 63 kDa skeletal muscle protein associated with eye muscle inflammation in Graves' disease is identified as the calcium binding protein calsequestrin.  Autoimmunity 29:1-9.
  124. Gunji K, De Bellis A, Kubota S, Swanson J, Wengrowicz S, Ackrell BAC, Thompson C, Kennerdell JS, Bizzarro A, Wall JR, 1999.  Serum antibodies reactive against the flavoprotein subunit of protein subunit of succinate dehydrogenase are sensitive markers of eye muscle autoimmunity in patients with Graves’ hyperthyroidism.  J Clin Endocrinol Metab 84: 16-22.
  125.  Joffe B, Gunji K, Panz V, Zouvanis M, Swanson J, Ackrell BAC, Wall JR, 1998.  Thyroid-associated ophthalmopathy in black South African patients with Graves’ disease: relationship to anti-flavoprotein antibodies.  Thyroid 8:1023-27.
  126. Hosal BM, Swanson J, Thompson C, Kubota S, Punji K, Kennerdell JS, Wall JR, 1999. Significance of serum antibodies reactive with flavoprotein subunit of succinate dehydrogenase in thyroid-associated orbitopathy.  Brit J Ophthalmol 83:605-8.
  127. Burmeister LA, Beatty RL, Wall JR 1999. Malignant ophthalmopathy presenting one week after radioiodine treatment of hyperthyroidism.  Thyroid 9; 189-92.
  128. Bednarczuk T, Stolarski C, Pawlik E, Slon M, Rowinski M, Kubota S, Hiromatsu Y, Bartoszewiczi Z, Wall JR, Nauman J, 1999.  Autoantibodies reactive with extracellular matrix (ECM) proteins in patients with thyroid-associated ophthalmopathy (TAO).  Thyroid 9:289-95.
  129. Gunji K, De Bellis AM, Li AW, Yamada M, Kubota S, Ackrell BAC, Wengrowicz S, Bellastella, Bizzarro A, Sinisi A, Wall JR, 2000 Cloning and characterization of G2s, a novel eye muscle and thyroid shared autoantigen associated with the development of ophthalmopathy in patients with thyroid autoimmunity J Clin Endocrinol Metab 85:1641-7.
  130. Panz V, Raal F, Wall J, Joffe B, 2000. Circulating Endothelium-Related Adhesion Molecules in Black South African Patients with Graves’ disease. Endocrine 12:1, 21-23.
  131. Salvi M, Pedrazzoni M, Girasole G, Giuliani N, Minelli R, Wall JR, Roti E. 2000 Serum concentrations of proinflammatory cytokines in Graves' disease: effect of treatment, thyroid function, ophthalmopathy and cigarette smoking.  Eur J Endocrinol.143: 197‑202.
  132. Yamada M, Li A W, Wall JR. 2000 Thyroid-Associated Ophthalmopathy: clinical features, pathogenesis and management. Crit Rev Clin Lab Sci 37:523-49.
  133. Al-Jameel, Wall JR, Pollack PT, 2000. Perturbations in total T3 homeostasis correlate with serum amiodarone concentrations. Clin Pharmacol Ther 67:122
    Cheng H-S, Yamada M, Li AW, Wall JR. 2002 T lymphocyte reactivity against G2s in patients with thyroid autoimmunity with and without ophthalmopathy Autoimmunity 35:313-17.
  134. Yamada M, Li AW, West KA, Chang C-H, Wall JR. 2002 Experimental model for thyroid‑associated ophthalmopathy in BALB/c and outbred (CD-1) mice genetically immunized with G2s and the Thyrotropin receptor Autoimmunity 35:403-413
  135. Bednarczuk T, Hiromatsu Y, inoue Y, Yamamoto K, Wall JR, Nauman J T cell mediated immunity in thyroid-associated ophthalmopathy. Proc Intl Symp on Thyroid Associated Ophthalmopathy, Kyoto, Japan, October 2000, Thyroid (suppl.) 12:209-15.
  136. Kaspar M, Archibald C, De Bellis AM, Li AW, Yamada M, Chang H-S, Wall J 2002 eye muscle antibodies and subtype of thyroid-associated ophthalmopathy 2002 Thyroid (suppl.) 12: 187-91
  137. Salvi M, Dazzi, D, Pellistri I, Neri F, Wall JR. 2002 Classification and prediction of the progression of thyroid-associated ophthalmopathy by an artificial neural network. Ophthalmology 109:1703-8.
  138. Wall J R. 2002 Graves’ disease is a multi-system autoimmune disorder in which extra ocular muscle damage and connective tissue inflammation are variable features.  “In my view”. Thyroid 12:35-36.
  139. El Kaissi S, Kotowicz MA, Goodear M, Wall JR. 2003 An Unusual Case of Marine-Lenhart Syndrome. Thyroid 13: 993-994
  140. De Bellis AM, Bizzarro A, Conte M, Coronella C, Solimeno S, Perrino S, Sansone D, Guaglione M, Wall JR.  Bellastella                A.  2003 Relationship between longitudinal behaviour of some markers of eye autoimmunity and changes of ocular findings in patients with Graves’ ophthalmopathy undergoing corticosteroid therapy. Clin Endocrinol (Oxf) 59: 388-395
  141. Mizokami T, Salvi M, Wall JR. 2004 Eye muscle antibodies in Graves’ ophthalmopathy: pathogenic or secondary epiphenomenon? J Endo Invest 27: 221-229.
  142. El Kaissi, Frauman A, Wall JR 2004 Thyroid-associated ophthalmopathy – a practical guide to classification, natural history and management. Int Med Journal 34: 482-491.
  143. De Bellis AM, Wall JR, Bellastella A et al 2004 Extra ocular muscle antibodies and the occurrence of ophthalmopathy in Graves’ disease. Clinical Endocrinology 60:694-8.
  144. A De Bellis, C Coronella, D Sansone, M Conte, S Iorio, S Perrino, M Battaglia, G Bellastella, JR Wall, A Bellastella, A Bizzarro 2005 Serum antibodies to collagen XIII: a further good marker of active Graves’ ophthalmopathy. Clinical Endocrinology 62:24-29
  145. Mizokami T, Li AW, Wall JR 2004 Stress and thyroid autoimmunity Thyroid 14: 1047-55.
  146. Kloprogge, S, Kowal, L, Wall JR, Frauman A 2005 The clinicopathological basis of
    Graves' Ophthalmopathy - A review. Eur J Ophthalmol.5: 315-23
  147. El-Kaissi S, Kotowicz M, Berk M, Wall JR 2005  Acute delirium in the setting of primary hypothyroidism: the role of thyroid hormone replacement therapy. Thyroid 15(9):1099-101
  148. Hiromatsu Y, Fukazawa H, Tani J, How J, Wall J 2005 A serum factor, which inhibits natural     cytotoxicity in patients with differentiated thyroid cancer. Intl J Endo Metab 3: 25-32
  149. Chang H-S, Tani J, Li AW, Wall JR 2005 A patient with Graves’ disease in whom presenting eye signs were associated with antibodies to the Thyrotropin receptor and later eye muscle damage with antibodies to G2s and flavoprotein. Intl J Endo Metab 1: 143-148.
    Gopinath B, Musselman R, Beard N, Tani J, Adams C, Wall JR 2006 Antibodies targeting the calcium binding skeletal muscle protein calsequestrin are sensitive and specific markers of ocular myopathy in patients with Graves’ disease. Clin Exp Immunol 145:56-62.
  150. Tani J, Wall JR 2006 Analysis - Can the development of thyroid-associated ophthalmopathy be explained by autoimmunity against eye muscle antigens? Canad Med Assoc J  17: 239-241.
  151. Gopinath B, Musselman R, Adams C, Tani J, Beard N, Wall JR 2006 Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves’ disease with and without ophthalmopathy – correlation with clinical features. Thyroid 16: 967-974.
  152. Wall JR, Kennerdell J, Stachura I 2006 Image; Mitochondrial abnormalities in eye muscle fiber from three cases of thyroid-associated ophthalmopathy. Thyroid 16: 1181-3.
  153. Bednarczuk T, Gopinath B, Ploski R, Wall JR 2006 Susceptibility Genes in Graves’ Ophthalmopathy – Searching for a Needle in a Hay Stack? (review) Clin Endocrinology 67:3-19.
  154. Watters D, Wall JR 2007 Thyroid Surgery in the Tropics. ANZ Journal of Surgery 77 (11), 933–940.
  155. Gopinath B, Adams CL, Musselman R, Tani J, Wall JR 2007 Antibodies against calsequestrin and type XIII collagen are good markers for chronic upper eyelid lag and retraction. Ocular Immunol & Inflammation 15:81-88
  156. Gopinath B, Tani J, Bao N, Wall JR 2007 Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis Thyroid  17: 1-7.
  157. Tani J, Gopinath B, Nuygen B, Wall JR 2007 Immunological mechanisms for the eye muscle and orbital connective tissue reactions of thyroid-associated ophthalmopathy. Expert Reviews in Clin Immunol 3:299-311.
  158. Wall JR 2007 Use of real-time thyroid ultrasonography by endocrinologists – a work in progress. ASUMJ 10: (4) p. 1-
  159. Wall JR 2007 The TSH-Receptor and Thyroid-Associated Ophthalmopathy-a Convenient Hypothesis with too many exceptions to be true. Int J Endocrinol Metab 2: 49-51
  160. Nguyen B, Gopinath B, Tani J, Wescombe L, Wall JR 2008 Peripheral blood T lymphocyte sensitization against calsequestrin and flavoprotein in patients with Graves’ ophthalmopathy. Autoimmunity 41:372-6.
  161. Gopinath B, Nguyen B, Ma G, Wall JR 2008 A case of Hashimoto’s thyroiditis presenting with chronic upper eye lid retraction and positive calsequestrin and collagen XIII antibodies. Int J Endocrinol Metab _;__
  162. Gopinath B, Wang JJ, Kifley A, Wall JR, Empson M, Leeder SR and Mitchell P 2008 Type 2 diabetes is not a predictor of incident thyroid dysfunction in the elderly. Diabetes Res Clin Pract 82: 1-3.
  163. Champion B, Gopinath B, Ma G, El-Kaissi S, Wall JR 2008 Conversion of Hashimoto’s thyroiditis to Graves’ hyperthyroidism observed by real-time thyroid ultrasonography. Thyroid (Letter to Editor) 18:1135-37.
  164. Wall JR. The role of calsequestrin in Graves’ ophthalmopathy 2008 Clin Endocrinol News 1:14
  165. Gopinath B, Wescombe, Nguyen B, Wall JR 2009 Can Autoimmunity against calsequestrin explain the eye and eyelid muscle inflammation of thyroid eye disease? ORBIT 28: 256 – 261
  166. Gopinath B, Wang JJ, Kifley A, Wall JR, Eastman C, Leeder SR, Mitchell PR 2010 .Five-year Incidence and Progression of Thyroid Dysfunction in an Older Population. Intern Med J. 2010 Jan 4 Epub ahead of publication.
  167. Tjiang H, Lahooti H, McCorquodale T, Parmar KR, Wall JR 2010 Eye and eyelid abnormalities are common in patients with Hashimoto’s thyroiditis Thyroid 20:287-290
  168. Wescombe L, Gopinath B, Lahooti H, Wall JR 2010 The cardiac calsequestrin gene (CASQ2) is up-regulated in the thyroid in patients with Graves’ ophthalmopathy - support for a role of autoimmunity against calsequestrin as the triggering event Clin Endocrinol (Oxf).73:522-528.
  169. Lahooti H, Parmar K R, Wall JR 2010 Pathogenesis of Thyroid Eye Disease: important role of autoimmunity against calsequestrin and collagen XIII. Pathogenesis of Thyroid Eye Disease: important role of autoimmunity against calsequestrin and collagen XIII. A review. Clin Ophthalmol. 14:417-25
  170. Wall JR, Lazarus J 2010 “Caleb Parry – stress linked to hyperthyroidism 1803-1825.” Brain Immune. (Published online 2010).
  171. de Haan S, Lahooti H, Morris O, Champion B, Wall JR 2010 Epitopes, immunoglobulin classes and immunoglobulin G subclasses of calsequestrin antibodies in patients with thyroid eye disease. Autoimmunity 43:698-703.
  172. Nanan R, Lahooti H, Wall JR 2010 Remission of Hashimoto’s thyroiditis at puberty in a 12 year old girl documented by changes in thyroid ultrasonography  Thyroid 20:1187-1190.
  173. Wall JR, Lahooti H. Pathogenesis of thyroid eye disease - does autoimmunity against the TSH Receptor explain all cases? Endokrynologia Polska. 2010; 61:222-227.
  174. Vannucchi G, Campi I, Bonomi M, Covelli D, Dazzi D, Curro N, Simonella S, Bobnana P, Persani C, Gusstella C, Wall JR, Beck-Peccz P, Salvi M 2010 Rituximab treatment in patients with active Graves' orbitopathy: effects on proinflammatory and humoral immune reactions .Clin Exp Immunol. 161:436-443
  175. Girgis C, Wall JR Graves’ disease: part I. Medical Observer, June 2011
  176. Girgis C, Wall JR Graves’ disease: part II. Medical Observer, June 2011
  177. Girgis C, Champion B, Wall J 2011 Current concepts of Graves’ disease: a review. Therapeutic Advances in Endocrinology and Metabolism 2 (3) 135-144
  178. El-Kaissi, Bowden J, Henry M, Yeo M, Champion B, Brotchie P, Nicholson G, Wall JR. 2011 Association between radioiodine therapy for Graves’ hyperthyroidism and thyroid-associated ophthalmopathy. Intl Ophthalmol  30 (3): 397-405
  179. Kambo JS, Girgis CM, Champion BL, Wall JR 2011 Delayed-onset hypoparathyroidism in an adolescent with chromosome 22Q11 deletion syndrome Endocr Pract. 1: 17(5) 123-125
  180. De Bellis AM, Conzo G, Cennamo G, Pane E, et al Wall JR, Bizzarro A, Bellastella A 2012. Time course of Graves’ ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a two year longitudinal study. Endocrine (in press)
  181. El-Kaissi, S, Wall JR 2012 Determinants of Extra-Ocular muscle volume in patients with Graves’ Disease J Thyr Res [Epub ahead of print]
  182. McCorquodale T, Lahooti H, Gopinath B, Wall JR 2012 Long term follow-up of seven patients with ophthalmopathy not associated with thyroid autoimmunity – heterogeneity of autoimmune ophthalmopathy. Clin Ophthalmology 6: 1-9
  183. Nguyen B, Gopinath B, Ma G, Wall JR 2012 Cell mediated immunity against three eye muscle antigens and correlation with eye signs in patients with transient and chronic thyroiditis. The Open Autoimmunity Journal 4: 1-6.
  184. Ardley M, Lahooti H, Wall JR 2012 Eye findings and antibody markers in probands and their euthyroid relatives from a single family with multiple cases of thyroid autoimmunity Thyroid Research 5:1-6.
  185. El-Kaissi S, Wall JR 2012 Targeting the thyrotropin receptor in thyroid disease. Expert Opin Therapeutic Targets. 16:719-27.
  186. Brakoulias V, Wall JR. 2012 Graves’ disease in the Ptolemies? Short report. RSM Journals April 2012 (published online)
  187. Champion BS, Wall JR 2012 The role of real-time thyroid ultrasonography in the assessment and management of hypothyroidism In: Hypothyroidism – influences and Treatments Eds. chapter 10, pp 167-180.
  188. Gopinath B, Harris D, Wall JR, Kifley A, Mitchell P 2013 Relationship between thyroid dysfunction and chronic kidney disease in community-dwelling older adults. Maturitas. 03.009. Epub 2013 Mar 29.
  189. Wall JR. El-Kaissi S 2013 Stress, brain and hormones and the development of organ specific autoimmunity – a complex interrelationship that will be difficult to tease out Brain Immune, Published online
  190. Ma DTS, Styles C, Wall JR 2013 Radioiodine treatment of Graves’ hyperthyroidism with and without anti-thyroid medication pretreatment in an Australian teaching hospital research J of Endo & Metab (published).
  191. Lahooti H, Wise B, Tjiang H, Wall JR 2013 Vitamin D deficiency is a risk factor for ophthalmopathy in patients with Graves’ hyperthyroidism but not Hashimoto's thyroiditis Ophthalmology Research (published).
  192. El Kochairi I, Lahooti H, Champion B, Wall JR. 2013 Risk factors for ophthalmopathy in patients with Hashimoto’s thyroiditis. Science domain international (SDI-Endocrinology) (published).
  193. Lahooti H, Cultrone D, Edirimanne S, Walsh J, Delbridge L, Champion B, Wall JR 2014 Association of the CASQ1 gene rs3838216 with Graves’ ophthalmopathy and Hashimoto’s thyroiditis in patients with thyroid autoimmunity Ophthalmology Research: an International Journal 2 (6): 281-29.
  194. Cultrone D, Lahooti H, Edirimanne S, Delbridge L, Champion B C, Wall JR 2014 Calsequestrin is decreased in the thyroid gland of patients with Graves’ disease – further evidence for a role of autoimmunity against this protein in Graves’ ophthalmopathy British J of medicine & medical research 4 (23): 4065-4075.
  195. Lahooti H, Houtz JA, Tran YC, El Kochairi I, Lytton SD, Champion BC, Wall JR 2014 TSH receptor antibodies as measured in a thyroid stimulating immunoglobulin (TSI) reporter bioassay are not detected in patients with euthyroid Graves’ disease  Austin J of Clin Ophthalmol (in press)
  196. Wall JR 2014 Thyroid function: News and Views: Pathogenesis of Graves ophthalmopathy—a role for TSH-R? Nature Rev Endocrinol 37:256
  197. Wall JR, Lahooti H, El Kochairi I, Lytton S, Champion BC 2014 Thyroid stimulating immunoglobulins (TSI) as measured in a reporter bioassay are not detected in patients with Hashimoto’s thyroiditis and ophthalmopathy or isolated upper eyelid retraction Austin J of Clin Ophthalmol (in press)  
  198. Wall JR Graves disease: an update 2014 Medical Observer (in press)
  199. Scott E, Wall JR 2014 Investigation of the thyroid nodule. Endocrinology Today 3(4):41-44.
  200. Xu L, Champion BL, Wall JR  Response to intensive IV methyl prednisolone treatment in a euthyroid patient with severe congestive ophthalmopathy (in preparation)
  201. Hibbert E, El Kochairi I, Lahooti H, Champion B, Wall JR Relationship between thyroid autoimmunity and ophthalmopathy during pregnancy in patients with Graves’ hyperthyroidism and Hashimoto’s thyroiditis (in preparation)
  202. Dravec D, Hibbert EJ, Champion BL, Wall J  Survey on the management of hypothyroidism in pregnancy (in preparation)
  203. El-Kaissi S, Wall JR Thyroid ultrasonography  eBook (in preparation).
  204. Wall JR, Champion BL Serum thyroglobulin is a marker for ophthalmopathy in patients with thyroid autoimmunity (in preparation)
  205. El-Kaisi S, Wall JR.  Special aspects of diabetes management in the Middle East (in preparation)

Proceedings of Meetings and Symposia:

  1. Wall JR, Braverman LE, Vagenakis A, Ingbar SO (1975).  Positive nitro blue Tetrazolium (NBT) tests in thyrotoxicosis and Hashimoto’s disease.  Proc. 7th. Int. Thyroid Congress, Boston, 1975, p. 387.
  2. Wall JR, Walters BA, Lessof MH (1977). Studies of PBL transformation to testis in patients with lepromatous leprosy, in: Immunological Influence on Human Reproduction: Academic Press (Ed. Boetcher B) p. 328.
  3. Wall JR, Joyner DM, Ryan EA, Wren SFG (1979).  Effect of experimental hyper- and hypothyroidism on B and T lymphocyte reactivity to bacterial fungal and tissue antigens.  Proceedings of the Serono Symposium, Autoimmune Aspects of Endocrine Disorders, Pisa, Italy, (Eds. Pinchera A, Doniach D, Fenzi GF, Baschieri L). Academic Press, Volume 33, p 215.
  4. Wall JR, Ryan EA (1979).  Leukocyte migration inhibitory factor (MIF) production in response to bacterial and fungal antigens in patients with Graves’ hyperthyroidism; possible evidence for general suppressor cell deficiency.  Proceedings of the Serono Symposium, Autoimmune Aspects of Endocrine Disorders, Pisa, Italy, (Eds. Pinchera A, Doniach D, Fenzi GF, Baschieri L).  Academic Press, Volume 33, p 235.
  5.       Wall JR, Joyner DM, Twohig P (1980).  Studies of TSH-displacement activity in subacute thyroiditis and familial medullary thyroid carcinoma.  In Proc 8th Intl Thyroid Congr Sydney, Australia. (Eds. Stockigt JR, Nagataki S). Aust. Acad. Of Science, p. 681.
  6. Wall JR, Ryan EA (1980).  Effect of experimental hyper- and hypothyroidism of immune reactivity.  In: Proc 8th. Int. Thyroid Congr. Sydney, Australia. (Eds. Stockigt JR, Nagataki S) Aust. Acad. Of Science, p. 781.
  7.       Chow A, Baur R, Schleusener H, Wall JR (1983).  Natural and antibody dependent cytotoxicity of peripheral blood and thyroidal mononuclear cells against human thyroid cells.  Proceedings of the Second Asia & Oceania Thyroid Association Meeting, Tokyo, Japan, August 1982 p. 67.
  8. Mariotti A, Pisani S, Anelli S, Russova A, Pinchera A, Wall JR (1983).  Binding reaction of radio labelled monoclonal antibody to human thyroglobulin.  Proceedings of an International Symposium on Monoclonal Antibodies, Venice, Italy, June 1982.
  9. Wall JR (1984). Humoral mechanisms in relationship to Graves’ ophthalmopathy.  In: Autoimmunity and the Thyroid (Eds. Walfish P, Volpé R, Wall JR).  Academic Press Inc. p. 135.
  10. Sikorska H, Miller A, Wall JR (1984).  Analysis of non-specific reaction in enzyme-linked immunosorbent assay testing for human eye muscle specific antibodies in Graves’ ophthalmopathy and Hashimoto’s thyroiditis.  In: Autoimmunity and the Thyroid (Eds. Walfish P, Volpé R, Wall JR).  Academic Press Inc., p. 335.
  11. Sikorska H, Miller A, Wall JR. (1984) Analysis of nonspecific reactions in enzyme-linked immunosorbent assay testing for human eye muscle specific antibodies in graves' ophthalmopathy and Hashimoto`s thyroiditis. Journal of Steroid Biochemistry, Volume 20, Issue 6, Part 2, June 1984, Page 1640
  12. Kuroki T, Kodama K, Whelan L, Wall JR (1984).  Tissue cross-reactivity of mouse and human monoclonal and polyclonal antibodies against human orbital antigens.  In: Autoimmunity and the Thyroid (Eds. Walfish P, Volpé R, Wall JR). Academic Press Inc., p. 337.
  13. Kuroki T, Ruf J, Harvey W, De Young P, Moini AR, Wall JR (1986).  Autoimmunity against a thyroglobulin-orbital connective tissue membrane shared antigen in Graves’ ophthalmopathy, Proc. 9th. Intl. Thyroid Congress, Sao Paulo, 1986, p. 1513.     
  14. Bogner U, Wall JR, Schleusener H (1986).  Direct lymphocytotoxicity in Autoimmune Thyroid Disease.  Proc. 9th. Intl. Thyroid Congress, Sao Paulo, 1985, p. 1395.
  15. Mariotti S, Demicco C, Bechi R, Anelli S, Ruf J, Pacini F, Wall JR, Carayon P, Pinchera A (1986). Monoclonal antibodies to thyroglobulin.  Proceedings of an International Conference, Florence, Italy (October, 1985).
  16. How J, Miller A, Laryea E, Wall JR (1986).  Studies of cell-mediated immunity in Graves’ ophthalmopathy using the antigen-induced leukocyte procoagulant activity assay.  Proc. Intl. Symposium “Thyroid and Autoimmunity”, Amsterdam, March 1986, Elsevier, p. 270.
  17. Hiromatsu Y, Wosu L, Dornan J, Wall JR (1986).  Role of HLA Class II antigen expression on normal human eye muscle cells and orbital fibroblasts in Graves’ ophthalmopathy.  Proc. Intl. Symposium “Thyroid and Autoimmunity”, Amsterdam, March 1986, Elsevier, p. 272.
  18. Salvi M, Hiromatsu Y, Wosu L, Laryea E, How J, Wall JR (1986).  Current status of autoantibodies against orbital antigens in the pathogenesis of Graves’ ophthalmopathy. Proc. Intl. Symposium “Thyroid Autoimmunity”, Amsterdam, March 1986, Elsevier, p. 155.
  19. Salvi M, Wall JR (1987).  Affinity purification of orbital antigens using human monoclonal antibodies.  Proc. Intl. Symposium “Thyroid Autoimmunity”, Pisa, 1986, J. Endo. Invest. 9 (Suppl. 3).
  20. How J, Hiromatsu Y, Wang PW, Salvi M, Wall JR (1987).  Cellular mechanisms for autoimmune damage in thyroid-associated ophthalmopathy.  Proc. Intl. Symposium on Thyroid Autoimmunity, Pisa, 1986, J. Endo. Invest. 9 (Suppl. 3).
  21. Zhang ZG, Madeiro-Neto G, Iacona A, Lima N, Hiromatsu Y, Salvi M, Tiller H, Bernard N, Wall JR (1989).  Studies of cytotoxic antibodies against eye muscle antigens in patients with thyroid associated ophthalmopathy.  Proc. Intl. Symposium on “Graves’ ophthalmopathy”.  Helsinki, May 1989, Acta Endocrinologica 2: (Suppl. 121) 23-30.
  22. Wall JR (1989).  Summary of a symposium on Graves’ ophthalmopathy, “basic aspect”, Helsinki, May 1989, Acta Endocrinologica (Suppl 121) (Suppl. 2): 130-131
  23. Wall JR, Salvi M, Bernard N (1989).  Eye disease and autoimmune thyroid disorders: mechanisms for the association.  In: Pathogenesis and management of Graves’ ophthalmopathy (Eds. Wall JR, How J).  Contemporary issues in Endocrinol and Metab, Blackwell Scientific Pubs. Inc. 1:63-77.
  24. How JS, Bernard N, Wall JR (1990).  Cell-mediated immunity in Graves’ ophthalmopathy.  In: Pathogenesis and management of Graves’ ophthalmopathy (Eds. Wall JR, How J).  Current Issues in Endocrinol. And Metab. Blackwell Scientific Pubs. Inc. 1:37-46.
  25. Wall JR, How J (1990).  Graves’ ophthalmopathy: Current issues and future prospects.  In: Pathogenesis and management of Graves’ ophthalmopathy (Eds. Wall JR, How J), Current Issues in Endocrinol Metab, Blackwell Scientific Pubs. Inc. 1:XI-XII.
  26. Salvi M, Hiromatsu Y, Bernard N, How J, Wall JR (1990).  In: International Workshop on Graves’ ophthalmopathy.  Homburg/Saar, 1987 - Developments in diagnostic methods and therapeutic procedures (Eds. Pickardt CR, Boergen KP).  Developments in ophthalmopathy series, Karger, Basel 20:58-67.
  27. Wall JR, Salvi M, Bernard N, 1990.  Eye disease and autoimmune thyroid disorders:  Mechanisms for the association.  In: Graves’ Ophthalmopathy.  (Eds. Wall JR, How J) Blackwell, Boston, 00 63-77.
  28. Fukazawa Y, Yashida K, Sakurada T, Baniassadi J, Bernard NF, Salvi M, Wall JR, 1991.  Tissue specific homing of lymphocytes to the thyroid gland of BB/W rats.  In:  Progress in thyroid research (Eds. Gordon A, Gross J, HennemannG).  Proc. 10th. Intl. Thyroid Conference, The Hague, February 1991, pp. 345-348.
  29. Iacona A, Zhang ZG, Lima N, Salvi M, Bernard NF, Wall JR.  Medeiros-Neto G 1991.  Cytotoxicity against human eye muscle and thyroid cells in euthyroid and thyrotoxic Graves’ ophthalmopathy.  In: Progress in thyroid research (Eds. Gordon A, Gross J, Hennemann G).  Proc. 10th. Intl Thyroid Conference, The Hague, February 1991, 00. 251-253.
  30. Boucher A, Zhang ZG, Bernard NF, Salvi M, Wall JR, 1991.  Immunoprecipitation of eye muscle cell membrane antigens and two-dimensional gel electrophoresis confirm the importance of a 64-kDa eye muscle antigen in thyroid-associated ophthalmopathy.  In: Progress in thyroid research (Eds. Gordon A, Gross J, Hennemann G).  Proc. 10th. Intl. Thyroid Conference, The Hague, February 1991, pp. 357-360.
  31. Wall JR, Bernard N, Scalise D, Strakosch C, Sato M, Tyutyunikov A, Genovese C, 1993.  Ophthalmopathy in patients with Hashimoto’s thyroiditis: A model for the association of ophthalmopathy with autoimmune thyroid disorders.  In Eds. Nagataki S, Mori T, Torizuka K.  Proc. Int. Symp: Hashimoto’s Disease 80th. Anniversary Meeting, Fukuoka, Japan.  Elsevier Science Pubs. Pp. 417-423.
  32. Tanaka K, Hiromatsu Y, Ishisaka N, Nonaka K, Ludgate M, Wall JR, 1993.  T cell reactivity to a recombinant fragment (D1) of a novel 64 kDa protein in thyroid-associated ophthalmopathy.  In Eds. Nagataki S, Mori T, Torizuka K.  Proc. Int. Symp: Hashimoto’s Disease 80th. Anniversary Meeting, Fukuoka, Japan.  Elsevier Science Pubs. Pp 463-469.
  33. Sato M, Scalise D, Tyutyunikov A, Genovese C, Wall JR, 1993.  Antibodies reactive with eye muscle and thyroid membrane antigens in early and late thyroid-associated ophthalmopathy.  Proc Intl Satellite Meet: Thyrotropin Receptor Antibodies, Kyoto, Japan, and pp 649-652.
  34. Wall JR, 1993, Nature and significance of eye muscle autoantigens.  Devel Ophthalmol Series, Proc Intl Symp Graves’ Ophthalmopathy, Mainz, Germany, Kahaly G (Ed). Basel, 25:77-85.
  35. Wall JR. Autoimmunity and pathogenesis of Graves’ ophthalmopathy. First Virtual Meeting of Endocrinology. www.endocrinologia.org.br
  36. Smallman D, Epstein I, Baker S, Salvi M, Lazier K, Wall JR, 2005 Thyroid-Associated ophthalmopathy – principal antigens and significance of corresponding antibodies in; Orbital Disease- Present status and future challenges, Rootman J. ed., Proc The Vancouver orbital Symposium, Vancouver BC, 2002 pp 157-168.

Invited Book Chapters:

  1. Wall JR, Thyroiditis In: Current Therapy (Eds. Conn HF), p 504, 1982.
  2. Bogner U, Wall JR, Schleusener H.  Cytotoxicity in Hashimoto’s thyroiditis.  In: Autoimmunity and the Thyroid (Eds. Walfish P, Volpé R, Wall JR).  Academic Press Inc. p. 347, 1984.
  3. Wall JR.  Autoimmunity and Graves’ ophthalmopathy.  In: The eye and orbit thyroid   disease (Eds. Gorman C, Waller R, Dyer J).  Pp. 103-114.  Raven Press, NY, 1984.
  4. Wall JR.  Graves’ ophthalmopathy.  In: Medicine North America (Eds. Hart I, Volpé R), 14:1690, 1984.
  5. Wall JR, Kuroki T.  Immunological factors in thyroid disease.  In: Medical Clinics of North America (Eds. Kaplan M, Larsen R).  W. B. Saunders Ltd., 69:913-937, 1985.
  6. Hiromatsu Y, Fukazawa H, Wall JR.  Cytotoxic mechanisms in autoimmune thyroid disorders and Graves’ ophthalmopathy.  In: Endocrinology & Metabolism Clinics of North America (Ed. Wall JR), W. B. Saunders Ltd., Vol 16(2): 269-86, 1987.
  7. Wall JR, How J, Salvi M, Hiromatsu Y (1987).  Can Endocrine exophthalmos now be viewed as separate from thyroid autoimmunity?  In: Bailliére’s clinical immunology and allergy clinics.  (Eds. Doniach D, Bottazzo G).  1:141-163, Bailliére, Tindall, London.
  8. Bednarczuk T, Kennerdell JS, Wall JR.  1997 Thyroid associated ophthalmopathy-etiology and pathogenesis.  In: Thyroid Disease.  Endocrinology, Surgery, Nuclear Medicine, and Radiotherapy.  Second edition (Falk SA ed.)  Raven Press, New York, pp 747-793.
  9. Kennerdell JS, Baron EM, Tyutyunikov A, Wall JR, Genovese C.  1995 Dysthyroid orbitopathy In: Ocular infection and immunity.  Eds.  Pepose JS, Holland GN, Wilhelmus KR, Mosby-Year Book Inc. pp 627-641.
  10. Carayon P, Wall JR.  Autoimmune mechanisms of exophthalmos, 1998  (French language textbook of Ophthalmology)
  11. Nebes V, Wall JR.  Membrane receptor linked disease states. 1998 In: (Ed. Conn M), American Physiology Society handbook Vol 1.  Cellular mechanisms.
  12. Yamada M, Wall J. Eye Muscle Antibodies in Graves’ Orbital Disease. 2000 In: (Ed.  Dutton AJT, Hake BJ) Graves’ Associated Orbital Disease - diagnosis and management, Dekker Inc., New York

Other
Abstracts:

  • Approximately 200 abstracts of scientific presentations made to learned or professional societies, special symposia, etc., have been published as proceedings of meetings, or as supplements to medical journals.

Editorships:

  • Proceedings of an International Symposium “Autoimmunity and the Thyroid” (with R. Volpé and P. Walfish) Toronto, 1984.
  • Proceedings of Research Workshop “The Thyroid and Immunology” (with S. Werner and C. Von Westarp) Edmonton, 1982.
  • Clinics in endocrinology and metabolism of North America issue on “Autoimmunity and the Thyroid” (Guest Editor), 1987.
  • Proceedings of the First International Symposium on “Graves’ ophthalmopathy” with (J.S. How), Montreal, 1988.  The first volume of a Current Issue in Endocrinology and Metabolism, Blackwell Scientific Pubs, Inc. Series.  Published, 1990.
  • Proceedings of an International Symposium in Thyroid Autoimmunity (with J. How) held in Montreal, October 1991.  Autoimmunity, 1992.
  • Proceedings of an International Symposium on “Progress in thyroid-associated ophthalmopathy” (with JS Kennerdell) Pittsburgh, PA, 1995.  Orbit, 1996.        


Workshop Reports:

  • Wall JR, How JS.  Report of a symposium on Graves’ ophthalmopathy held in Montreal, September 1988, Autoimmunity, pp. 147-149, 1989.
  • Wall JR. Report of a symposium on “progress in thyroid-associated ophthalmopathy” held in Pittsburgh, September 1996.  Autoimmunity 22:191-195, 1995.

Letters to Medical Journals:

  • Waring GS, Kodama K, Sikorska H, Wall JR.  TSH and orbital antibodies.
    Lancet II: 224-225, 1983.
  • Sikorska H and Wall JR.  Failure to detect eye muscle membrane specific autoantibodies in Graves’ ophthalmopathy.  Brit Med J 291:604, 1985.


Video Teaching Films:

  1. “Autoimmunity”, sponsored by Sandoz Ltd., produced in Montreal 1985.
    Clinical case taking “thyroid disease”, for the Department of Medical Education, McGill University, 1988.
  2. “Thyroid Disease” for the Thyroid Foundation of Canada, Halifax, NS, 1989.
  3. Teach the Teachers, for University of Sydney, Sydney March 2005.

Other:

  1. Wall JR.  An update of the pathogenesis and management of thyroid associated ophthalmopathy.  Thyroid Today, Vol. XIV, 1991.
  2. Wall JR and others, ad hoc committee on the Classification of Eye Changes of Graves’ Disease.  Mary Ann Liebert, Inc., Publishers.  Thyroid 2(3): 1992.
  3. Wall JR, articles for Harrowsmith Magazine, Home Medicine and other “popular” magazines.
  4. Eight patient information pamphlets for the Thyroid Foundation of Canada, 1984. 
  5. Articles for Thyrobulletin (Thyroid Foundation of Canada) 1985, 1986, 1987, 2004, 2005, 2006, 2009
  6. Article for Thyroid Canada, Thyroid-associated ophthalmopathy – an auto immune disorder7of the extra ocular muscle and periorbital connective tissue, Jan 2003
  7. Article for Thyroid Flyer, Thyroid Disease – the problem (2004)
  8. Articles for T4Life thyroid magazine, Canada (April, May, September issues, 2006)
  9. Thyroid nodular disease. Medical Observer 2006

Book Reviews:
Not listed (several)
(Total;n=253)

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