Eleftherios S Xenos, MD, PhD, RVT, FACS
Professor of Surgery
  • University of Kentucky Medical Center
    Lexington, Kentucky, USA
    Phone: (859) 218-5142
    E-mail: esxeno2@email.uky.edu


  • 8/1977-5/1983 - Undergraduate: Evangelical High School
  • 7/1983-6/1989 - Medical School: University of Athens Medical School, MD, 1989
  • 7/1992–6/1996 - Residency: General Surgery, State University of New York Health Science Center; Syracuse, NY
  • 7/1996-6/1997 - Fellowship: Transplant Surgery, University of Miami Jackson; Miami, FL
  • 7/2002-6/2004 - Fellowship:  Vascular Surgery, University of Tennessee Medical Center; Knoxville, TN
  • 10/2008-8/2012 - Graduate Certificate in Clinical and Translational Sciences, Center for Clinical and Translational Sciences, University of Kentucky, Lexington, KY 
  • 02/2012-10/2012 - UK Healthcare Executive Leadership and Management Program, University of Kentucky Gatton College of Business and Economics and the Executive Education Center, Lexington, KY
  • 6/8/2014-6/14/2014 - Leadership Program For Health Policy and Management, Brandeis University, Waltham, MA
  • 4/18/15-4/21/2015 - Leadership Program For Health and Policy Management, Washington, DC


Research Interest

  • General Surgery
  • Vascular Surgery


Present Positions
09/2006-present Attending Surgeon Lexington Veterans Administration Medical Center, Lexington, KY
10/2008-present Section Chief Vascular Surgery, Lexington Veterans Administration Medical Center
09/2006-06/2012 Assistant Professor of Surgery University of Kentucky, Lexington, KY
06/2011-2016 Medical Director Non Invasive Vascular Laboratory, University of Kentucky Hospital
07/2012-2017 Associate Professor of Surgery University of Kentucky, Lexington, KY
7/1/2017 Professor of Surgery University of Kentucky, Lexington
07/2012-present Medical Director UK Healthcare
05/2014-present Assistant Medical Director Utilization review/ Documentation Integrity
06/2013-present Associate Chief Medical Officer UK Healthcare
Previous Positions
01/1998-06/2002  Attending Surgeon Lincoln County Medical Center Troy, Missouri
08/2004-08/2006 Attending Surgeon Camden Clark Memorial Hospital, Parkersburg, West Virginia
06/2004-08/2006 Attending Surgeon Marietta Memorial Hospital, Marietta, Ohio
  • 1986-1989 - Papadakis Foundation Scholar
  • 1991-1992 - National Scholarship Foundation of Greece Scholar
  • 2000 - American Medical Association Physician Recognition Award
  • 2003 - 1st place, 4th Annual ISES Endovascular Fellows Research Award Competition, Scottsdale, Arizona (Feb. 9-13, 2003)
  • 2003 - Frederick A. Collier Surgical Society Jobst Award, 49th Annual
  • Meeting of the Frederick A. Collier Surgical Society, Asheville, North Carolina (Oct. 9-12, 2003)
  • 2004 - Founder’s Award Paper, 28th Annual Meeting, Southern Association for Vascular Surgery, Puerto Rico (Jan, 14-17, 2004)
  • 2014 - Recipient of the American College of Surgery/Society for Vascular Surgery Health Policy /Management Scholarship for 2014
Professional Memberships
  • 2003-present - Fellow, American College of Surgeons
  • 2004-present - Member, Southern Association for Vascular Surgery
  • 2006-present - Member, Vascular and Endovascular Surgery Society
  • 2006-present - Member, Society for Vascular Surgery
  • 2006-present - American Registry for Diagnostic Medical Sonography
  • 2009-present - Society for Vascular Ultrasound
  • 2009-present - American Association for Physician Leadership
  • 2010-present - International College of Angiology


  1. Xenos ES, Farney AC, Widmer MB, Casanova D, Stevens RB, Blazar BR, Sutherland DE Gores PF. Effect of tumor necrosis factor alpha and of the soluble tumor necrosis factor receptor on insulin secretion of isolated islets of Langerhans. Transplant Proc. 1992 Dec; 24(6); 2863-2864. PMID: 1334599.
  2. Xenos ES, Stevens RB, Gores PF, Casanova D, Farney AC, Sutherland DE, Platt J L. IL-1b induced inhibition of beta-cell function is mediated through nitric oxide. Transplant Proc. 1993 Feb; 25(1 Pt 2):994. PMID: 7680174.
  3. Farney AC, Xenos E, Sutherland DE, Widmer M, Stephanian E, Field MJ, Kaufman DB, Stevens RB, Blazar B, Platt J, et al. Inhibition of pancreatic islet beta cell function by tumor necrosis factor is blocked by a soluble tumor necrosis factor receptor. Transplant Proc. 1993 Feb (1 Pt 2); 25:865-866. PMID: 8382881.
  4. Casanova D, Gruessner R, Brayman K, Jessurun J, Dunn D, Xenos E, Sutherland DE. Retrospective analysis of the role of pancreatic biopsy (open or transcystoscopic technique) in the management of solitary pancreas transplants. Transplant Proc. 1993 Feb; 25(1 Pt 2):1192-1193. PMID: 8442083.
  5. Xenos ES, Casanova D, Sutherland DE, Farney AC, Lloveras JJ, Gores PF. The in vivo and in vitro effect of 15-deoxyspergualin on pancreatic islet function. Transplantation. 1993 Jul; 56(1):144-147. PMID: 8333036.
  6. Casanova D, Field MJ, Heise J, Xenos E, Gores PF, Sutherland DE. In vitro and in vivo assessment of viability of dog islets subject to cold storage preservation for 24 hours. Transplant Proc. 1994 Apr; 26(2):815. PMID: 7513475.
  7. Casanova D, Xenos E, Lloveras JJ, Field MJ, Barrou B, Sutherland DE, Gores PF. Comparison of human islet isolation from the stored and nonstored pancreas with two different protocols using UW solution. Transplant Proc. 1994 Apr; 26(2):588. PMID: 8171570.
  8. Xenos ES, Stevens R B, Sutherland D E, Lokeh A, Ansite J D, Casanova D, Gores PF, Platt J L. The role of nitric oxide in IL-1beta mediated dysfunction of rodent islets of Langerhans. Implications for the function of intrahepatic islet grafts. Transplantation. 1994 Apr 27; 57(8):1208-1212. PMID: 8178348.
  9. Xenos ES. Perfusion storage versus static storage in kidney transplantation: is one method superior to the other? (Editorial) Nephrol Dial Transplant. 1997 Feb; 12(2):253-254. PMID: 9132639.
  10. Meguid M M, McIvor A, Xenos E . Creation of a neoabdominal wall to facilitate emergency placement of a terminal ileostomy in a morbidly obese patient. Am J Surg 1997;173(4):298-300
  11. Xenos ES, Ciancio G, Burke GW, Roth D, Miller J. The use of tacrolimus as induction and maintenance immunosuppression in renal cadaveric transplant recipients over the age of 60. Clin Transplant. 1997; 11(5 Pt 2):497-499. PMID: 9361949.
  12. Carlin RE, McGraw DJ, Xenos ES, Villavicencio JL. Popliteal venous aneurysm leading to massive pulmonary embolus in a child. Vasc Surg. 1997; 31:463-468
  13. Xenos ES, Khan F, Nery J, Romero R, Mocros J, Tzakis A. Cadaveric small bowel/split liver transplantation in a child. Transpl Int. 1999; 12(1):63-67. PMID: 10080408.
  14. Xenos ES, Mogerman D, Partab P, Reinker D. Crossed ectopic kidney infiltrated by tumor presenting as a pelvic mass. Surg Rounds. 1999; 22(9):490-492.
  15. Xenos ES, Halverson JD. Duodenocolic fistula: case report and review of the literature. J Postgrad Med. 1999; Jul-Sep; 45(3):87-89. PMID: 10734343.
  16. Xenos ES.Percutaneous endoscopic gastrostomy in a patient with a large hiatal hernia using laparoscopy. JSLS. 2000 Jul-Sep; 4(3):231-233. PMID: 10987400.
  17. Xenos ES, Reinker D, Mogerman D. Early experience with laparoscopic antireflux surgery on the rural setting. South Med J. 2001 Jan; 94(1):43-46. PMID: 11213941.
  18. Xenos ES, Padilla P, Partap P, Mogerman D. Paraganglioma and adrenal pheochromocytoma presenting simultaneously in an elderly female. Case report and review of the literature. Urol Int. 2001; 66(2):108-109. PMID: 11223754.
  19. Wexner SD, Litwin D, Cohen J, Earle D, Ferzli G, Flaherty J, Graham H, Horgan S, Katz B L, Kavic M, Kilkenny J , Meador J, Price R, Quebbemann B, Reed W, Sillin L, Vitale G, Xenos ES, Eisen G M, Dominitz J, Faigel D Goldstein J, Kalloo A et al; American Society for Gastrointestinal Endoscopy, Society of American Gastrointestinal Endoscopic Surgeons, American Society of Colorectal Surgeons. Principles of privileging and credentialing for endoscopy and colonoscopy.(guideline) Gastrointest Endosc. 2002 Feb; 55(2):145-148. PMID: 11818913.
  20. Xenos ES. The role of esophageal motility and hiatal hernia in esophageal exposure to acid. Surg Endosc. 2002 Jun; 16(6):914-920. PMID: 12163954.
  21. Xenos ES, Ragsdale J, Pacanowski JP, Kirkpatrick S, Stevens SL, Freeman MB, Goldman MH. Histopathologic study of renal transplant artery stenosis: Role of rejection and cold ischemia time in the pathogenesis of intimal hyperplasia in an arterial allograft. Clin Transplant. 2003;17 Suppl 9:27-30. PMID: 12795664.
  22. Xenos ES, Freeman MB, Stevens SL, Cassada DC, Pacanowski JP, Goldman MH. Covered stents for injuries of the subclavian-axillary arteries. J Vasc Surg. 2003 Sep; 38(3):451-454. PMID: 12947252.
  23. Xenos ES, Stevens SL, Freeman MB, Pacanowski JP, Cassada DC, Goldman MH: Erectile function after open or abdominal aortic aneurysm repair. Ann Vasc Surg. 2003 Sep; 17(5):530-538. PMID: 14508665.
  24. Xenos ES, Stevens SL, Freeman MB, Pacanowski JP, Cassada DC, Goldman MH. Distribution of sac pressure in an experimental aneurysm model after endovascular repair: the effect of endoleak types I and II. J EndovascTher. 2003 Jun; 10(3):516-523. PM ID: 12932163.
  25. Xenos ES, Stevens SL, Freeman MB, Goldman MH. Effect of fluvastatin on endothelial cell nitric oxide synthase. Vasc Med. 2003; 8:137-138.
  26. Xenos ES, Stevens SL, Freeman MB, Cassada DC, Goldman MH. Nitric oxide mediates the effect of fluvastatin on ICAM-1 and PECAM-1 expression on human endothelial cells. Ann Vasc Surg. 2005 May; 19(3):386-392. PMID: 15818460.
  27. Xenos ES, Minion DJ, Sorial EE, Endean ED. Endovascular retrieval of an intraaortic Greenfield vena cava filter. VascEndovasc Surg. 2008 Apr-May; 42:165-167. PMID: 18421032.
  28. Minion D J, Xenos ES, Sorial E, Endean ED. The trifurcated endograft: a novel technique for hypogastric preservation during endovascular aneurysm repair. J Vasc Surg. 2008 Mar; 47:658-661. PMID: 18295123.
  29. Xenos ES, Abedi NN, Davenport DL, Minion DJ, Hamdalla O, Sorial EE, Endean ED. Meta-analysis of endovascular versus open repair for traumatic descending thoracic aortic rupture. J Vasc Surg. 2008 Jan; 48:1343-1351. PMID: 18632242.
  30. Davenport DL, Xenos ES, Hosokawa P, Radford J, Henderson WG, Endean ED. The influence of body mass index  obesity status on vascular surgery 30-day morbidity and mortality. J Vasc Surg. 2009 Jan; 49:140-147, 147.e1; discussion 147. PMID: 19028047.
  31. Xenos ES, Minion DJ, Davenport DL, Hamdallah O, Abedi NN, Sorial EE, Endean EE. Endovascular versus open repair for descending thoracic aortic rupture: institutional experience and meta-analysis. Eur J Cardiothorac Surg. 2009 Feb; 35:282-286. PMID: 19081731.
  32. Xenos ES,Bietz G, Minion DJ, Abedi NN, Sorial EE, Karagiorgos N, Endean ED. Endoluminalthermal ablation versus stripping of the saphenous vein: Meta-analysis of recurrence of reflux.  Int J Angiol. 2009; 18:75-78.PMID: 22477498
  33. Abedi NN, Davenport DL, Xenos E, Sorial E, Minion DJ, Endean ED.  Gender and 30-day outcome in patients undergoing endovascular aneurysm repair (EVAR): an analysis using the ACS NSQIP dataset.  J Vasc Surg.  2009 Sep; 50(3):486-491. PMID: 19628363.
  34. Davenport DL, O’Keeffe S, Minion DJ, Sorial EE, Endean ED, Xenos ES. Thirty-day NSQIP    database outcomes of open versus endoluminal repair of ruptured abdominal aortic aneurysms. J Vasc  Surg. 2010 Feb; 51:305-309. PMID: 19939609.
  35. Abedi NN, Davenport DL, Karagiorgos N, Minion DJ, Sorial ES, Endean ED, Xenos ES. Long-term outcome of infrapopliteal catheter-based intervention for critical limb ischemia. Int J Angiol 2009;     18:126-128. PMID: 22477512.
  36. O’Keeffe S, Davenport DL, Minion DJ, Sorial EE. Endean ED, Xenos ES. Blood transfusion is associated with increased morbidity and mortality after lower extremity revascularization. J VascSurg 2010; 51:616-621, 621.e1-3. PMID: 20110154.
  37. Carter RR, Orr NT, Minion DJ, Xenos ES.  Aortic injury from posterior rib fracture after blunt trauma.  Eur J Cardiothorac Surg. 2011 Jan 3; 39(1):138. PMID: 20627607.
  38. Xenos ES, O’Keefe SD, Davenport DL. Blood transfusion during lower extremity revascularization: NSQIP database outcome analysis. Vasc Dis Management. 2010; 7:E152-156.
  39. O'Keeffe SD, Davenport D, Endean ED, Xenos ES, Sorial EE, Minion DJ. Variations in early outcomes of endovascular aneurysm repair with alternate endograft configurations. Ann Vasc Surg.  2010 Jan; 24(1):28-33. PMID: 20122462.
  40. Carter R, O’Keeffe S, Minion D, Sorial E, Endean E, Xenos E. Spontaneous superior mesenteric artery dissection: Report of two patients and Review of management recommendations. Vasc Endovascular Surg. 2011 Apr; 45(3):295-298. PMID: 21278174.
  41. Xenos ES. Traumatic inferior vena cava thrombosis. VascEndovasc Surg. 2011 May; 45(4):359-360.  PMID: 21444350.
  42. Davenport DL, Xenos ES. Early outcomes and risk factors in venous thrombectomy: an analysis of the American College of Surgeons NSQIP dataset. Vasc Endovascular Surg. 2011 May;45(4):325-328. PMID: 21444346.
  43. Xenos ES, Bietz GJ, Davenport DL. Endoluminal versus open repair of descending thoracic aortic rupture: a review of the National Trauma Databank. TherAdvCardiovasc Dis. 2011 Oct.; 5(5):221- 225. PMID: 21844134.
  44. Xenos ES, Vargas HD, Davenport DL. Association of blood transfusion and venous thromboembolism after colorectal cancer resection. Thromb Res. 2011 Aug 26. [Epub ahead of print] PMID: 21872295
  45. Rubinstein C, Endean ED, Minion DJ, Sorial EE, O’Keeffe SD, Xenos ES. Thrombin injection for treatment of mycotic gluteal aneurysm. VascEndovasc Surg. 2011 Sept 2. [Epub ahead of print] 2012 Jan;46(1):77-9.  PMID:  21890561
  46. Davenport DL, Ritchie JD, Xenos ES. Incidence and risk factors for 30-day postdischarge mortality in patients with vascular disease undergoing major lower extremity amputation. Ann Vasc Surg. 2011 Jun 24. [Epub ahead of print] PMID: 21705190.
  47. Davenport DL, Kasten M, Vargas HD, Xenos ES. Timing and risk factors for in hospital and post-discharge venous thromboembolism after colorectal cancer resection. ClinApplThrombHemost 2012 Dec 18(6):568-574 PMID: 22345485
  48. Minion DJ, Xenos ES. The femoral-based endowedge technique to increase juxtarenal seal and correct graft tilt. J Vasc Surg. 2012 May;55(5):1522-5 PubMed PMID: 22169664.
  49. Xenos ES, Orr NT, Valentino J.  Internal Carotid Pseudoaneurysm Associated with Tortuosity after Tonsillectomy: A Case Report.  Int J Angiology. 2012 Sept;21(3):159-161.
  50. Davenport DL, Xenos ES. Deep Venous Thrombosis After Repair of Non-ruptured Aortic Aneurysm.  J Vasc Surg. 2013 Mar;100(3):219-28PubmedPMID: 23343666
  51. Rubinstein, C, Davenport DL, Dunnagan R, Saha SP, Ferraris VA, Xenos ES.  Intraoperative blood transfusion of one or two units of packed red blood cells is associated with a 5-fold risk of stroke in patients undergoing elective carotid endarterectomy. J VascSurg 2013;57:53S-7S PMID 23336856
  52. Lynch JE, Winkler KA, Xenos ES. Post-traumatic versus Mycotic Dorsalis PedisPseudoaneurysmInt J of Angiology .2013 Jun;22:135-136PMID 24436599
  53. Zwischenberger BA, Beasley MM, Davenport DL, Xenos ES.  Meta-Analysis of the Correlation Between Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis. Vascular and Endovascular Surgery. 2013 Sep 4 PMID 24005191
  54. Zwischenberger BA, Xenos ES. Drug-eluting stents in critical limb ischemia: a systematic review of long-term outcomes.  It J VascEndovascSurg2013 September; 20(3):147-50.
  55. Davenport D, Zwischenberger B, Xenos ES.  Analysis of 30-day readmission after aorto-iliac and infrainguinal revascularization using the ACS NSQIP dataset.  J VascSurg 2014 June 25. Pii: S0741-5214(14) PMID 24973287
  56. Xenos ES, Lyden J, Korosec R, Davenport D:Ninety-day readmission risks, rates and costs after common vascular surgeries.Am J Manag Care 2014;20(10):e432-e438. PMID 254149819
  57. Noah T. Scherrer, Roberto Gedaly, Ramakrishna Venkatesh, Michael A. Winkler, Eleftherios S. Xenos. An ex vivo approach to complex renal artery aneurysm repair. Journal of Vascular Surgery  Cases 2015;1(2) 165-167
  58. Orr NT, El-Maraghi S, Korosec RL, Davenport DL, Xenos ES. Cost analysis of vascular readmissions after common vascular procedures. J Vasc Surg. 2015 Nov;62(5):1281-1287PMID 26251167
  59. Henry B, Zhao M, Shang Y, Uhl T, Thomas DT, Xenos ES, Saha SP, Yu G. Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during planta flexion exercises.  J Biomed Opt. 2015 Dec;20(12):125006.doi.10.1117/1.JBO.20.12.125006 PMID 26720871
  60. Davis KL, Gurley JC, Davenport DL, Xenos ES.  The use of HeRo catheter in catheter-dependent dialysis patients with superior vena cava occlusion.  J Vasc Access. 2016 Jan 20:0. Doi: 10.55301/jva.5000493. PMID: 26797902
  61. Orr NT, Winkler MA, Xenos ES.  Type IIIbEndoleak Associated with an Infected ThoracoabdominalEndograft. The International Society for Minimally Invasive Cardiothoracic Surgery.  Innovations.  2016 Sep/Oct; 11(5):367-369. PMID 27819805
  62. Orr NT, Davenport DL, Minion DJ, Xenos ES.  Comparison of Perioperative Outcomes in Endovascular versus Open Repair for Juxtarenal and Pararenal Aortic Aneurysms: a Propensity Matched Analysis.  Vascular. 2016 Nov 30.  PMID: 27903931.


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