Education

• 1986–1993, High School: Samsun Anatolian High School
• 1993-1997, Bachelor of Science Degree: Hacettepe University Faculty of Pharmacy- Pharmacist
• 1998-2003, Research Assistant: Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Chemistry
• 1997-1999 MS Program: Hacettepe University- Institute of Health Sciences-Pharmaceutical Chemistry     
• 1999- 2003 Ph D Program: Hacettepe University- Institute of Health Sciences-Pharmaceutical Chemistry

Profile

Meric Koksal Akkoc, Ph.D. is Professor of Faculty of Pharmacy at Yeditepe University She obtained her B.Sc. in Pharmacy in 1997 from Hacettepe University, Ankara, Turkey.  She then completed a M.Sc. in 1999andPh.D. In 2003 in Pharmaceutical Chemistry from Institute of Health Sciences at Hacettepe University. During her graduate program, she worked as a research assistant. In 2003 she got a position as an Assistant Professor at Yeditepe University where she still has been. As a medicinal chemist, her research interest includes drug discovery and development. Her papers and projects are focused on synthesis, design and structure activity relationships of potential molecules as an analgesic, antiinflammatoryandanticanceragents.

Research Interest

• Medicinal Chemistry
• Drug Discovery
• Synthesis
• Quantitative Structure-Activity Relationships
• Anticancer Activity
• Analgesic/Anti-inflammatory Activity

Professional Activities:

Honors and Awards

Publications

1. Calis, U., Koksal, M.: Synthesis and Evaluation of Anticonvulsant Activities of Some New Arylhexahydropyrimidine-2,4-diones, Arzneim.-Forsch/Drug Res. 51(II), 523-528 (2001).
2. Calis, U., Koksal, M., Özalp, M: Synthesis of Some New Aminoalkylguanidine Derivatives and Their In Vitro Antimicrobial Activities, FABAD J. Pharm. Sci., 26, 119-123 (2001).
3. Koksal, M., Gokhan, N., Erdoğan, H., Özalp, M., Ekizoğlu, M.: Synthesis of 3-(4- Substituted-benzoylmethyl)–2-Benzoxazolinones and Screening Antimicrobial Activities, IL Farmaco 57, 535-538 (2002).
4. Calis, U., Yarım, M., Koksal, M., Özalp, M: Synthesis and Antimicrobial Activity Evaluation of Some New Adamantane Derivatives, Arzneim.-Forsch/Drug Res. 52 (10), 778-781 (2002).
5. Koysal, Y., Isik, S., Koksal, M., Erdoğan, H., Gokhan, N.: 3-[4-(2-Chlorophenyl)piperazino- methyl]-5-methyl-1-benzoxazolin-2(3H)-one, Acta Crystalloographica Section E, E59, o1975-o1976 (2003).
6. Koysal, Y., Isik, S., Koksal, M., Erdoğan, H., Gokhan, N.: 3-[4-(4-Fluorophenyl)piperazin-1-yl-methyl]-5-methyl-1,3-benzoxazol-2(3H)-one and 3-[4-(2-fluorophenyl)piperazin-1-ylmethyl]-5-methyl-1,3-benzoxazol- 2(3H)-one, Acta Crystalloographica Section C, C60, o232-o234 (2004).
7. Isik, S., Koysal, Y., Yavuz M., Koksal, M., Erdoğan, H.: 5-(2-Chlorobenzoyl)-1,3-benzoxazol-2(3H)-one, Acta Crystalloographica Section E, E60, o2321-o2323 (2004).
8. Koksal, M., Gokhan, N., Kupeli, E., Yeşilada, E., Erdoğan, H.: Synthesis, Analgesic and Antiinflammatory Properties of Certain 5-/ 6-Acyl-3-(4-substituted-1-piperazinylmethyl)-2-benzoxazolinone derivatives, Arch. Pharm. Chem. Life Sci., 338, 117-125 (2005).
9. Gokhan, N., Koksal, M., Kupeli, E., Yeşilada, E., Erdoğan, H.: Some New Mannich Bases of 5-Methyl-2-benzoxazolinones with Analgesic and Anti-inflammatory Activities, Turkish J. Chemistry, 29(4), 445-454 (2005).
10. Koksal, M., Gokhan, N., Kupeli, E., Yeşilada, E., Erdoğan, H.: Analgesic and Antiinflammatory Activities of Some New Mannich Bases of 5-nitro-2-benzoxazolinones, Arch. Pharm. Res., 30(4), 419-424 (2007).
11. Koksal, M., Bilge, S. S.: Synthesis and Antidepressant-Like Profile of Novel 1-Aryl-3-[(4-benzyl)piperidine-1-yl]propane Derivatives, Archiv der Pharmazie, 340(6), 299-303 (2007).
12. Koksal, M., Gokhan-Kelekci, N., Mercanoglu G. O., Erdogan, H.: Synthesis and Evaluation of Analgesic, Anti-inflammatory and Antioxidant Activities of New 6-Acyl-3-alkyl-5-methyl-2(3H)-benzoxazolones, ArzneimForsch/DrugRes, 58(8), 398-404 (2008).
13. Koksal, M., Bilge, S. S., Bozkurt, A., Sahin, Z. S., Isik S., Erol D. D.: Synthesis, Characterizatıon and Anti-inflammatory Activity of New 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiaxoles, ArzneimForsch/DrugRes, 58(10), 510-514 (2008).
14. Gokhan-Kelekci, N., Koksal, M., Unuvar, S., Aktay G., Erdoğan, H.: Synthesis and Characterization of Some New 2(3H)-benzoxazolones with Analgesic and Antiinflammatory Activities, Journal of Enzyme Inhibition and Medicinal Chemistry, 24(1), 29-37 (2007).
15. Kanbak, S. A., Koksal, M., Sahin F., Erol D. D.: Synthesis of New 4(1H)-Pyridinone Derivatives and Their Antibacterial Activity, Rev. Chim. (Bucuresti), 60, 888-892 (2009).
16. Yarim, M., Koksal, M., Schepmann, D., Wunch, B.: Synthesis and in vitro evaluation of novel indole based sigma receptors ligands, Chem. Biol. Drug Des., 78, 869-875 (2011).
17. Koksal, M., Ozkan, I., Yarim, M., Bilge, S. S., Erol, D. D.: Studies on Synthesis, and Anti-inflammatory Activities of Novel 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazines, Rev. Chim. (Bucuresti), 62, 1069-1072 (2011).
18. Koksal-Akkoc, M., Yarim-Yuksel, M., I., Durmaz, Çetin-Atalay, R.: Design, synthesis and biological evaluation of indole-based 1,4-disubstitutedpiperazines as cytotoxic agents, Turkish J. Chemistry, 36, 515-525 (2012).
19. Yarim, M., Koksal, M., I., Durmaz, Çetin-Atalay, R.: Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives”, Int. J. Mol. Sci., 13,  8071-8085 (2012).
20. Koksal, M., Yarim, M., I., Durmaz, Çetin-Atalay, R.: Synthesis and cytotoxic activity of novel 3-methyl-1-[(4-substitutedpiperazin-1-yl)methyl]-1H-indole derivatives, ArzneimForsch/DrugRes, 62, 389-394 (2012).
21. Sahin, Z. S.,  Ozkan, I.,  Koksal, M, Işık S.: 5-(3,4-Dichlorophenyl)-3-{[4-(2-pyridyl)piperazine-1-yl]methyl}-1,3,4-oxadiazole-2(3H)-one: Synthesis, characterization, X-ray and DFT structures”, J. Struct. Chem., 53, 938-942 (2012).
22. Ozkan-Dagliyan, I., F.  Sahin, Koksal, M.: Synthesis, characterization and antimicrobial activity of novel 3,5-disubstituted-1,3,4-oxadiazole-2-ones,  Rev. Chim. (Bucuresti), 64, 534-539 (2013).
23. Koksal, M., Yarim, M., Erdal, A.,  Bozkurt,  A.: Synthesis and Anti-inflammatory Activities of Novel 5-(3,4-dichlorophenyl)-3-[(4-substitutedpiperazin-1-yl)methyl]-1,3,4-oxadiaxole-2(3H)-thiones, Drug Res (Stuttg) , eFirst, DOI: 10.1055/s-0033-1353184 (2013).

Book chapters

1. Yarim, M. and Koksal, M.: Organic Anion Transporting Polypeptides (Oatps/OATPs), Transporters as Drug Carriers: Structure, Function, Substrates,Ed.ted by G. Ecker and P. Chiba, WILEY-VCH Verlag GmbH & Co. KgaA, Weinheim (2009).