Hong Xian
Hong Xian

Department of Biostatistics
College for Public Health& Social Justice
Saint Louis University


  • 1989-1994, Ph.D. in Mathematics, Washington University, St. Louis, MO
  • 1988-1989, M.Sc. in Mathematics, Western Illinois University, Macomb, IL
  • 1984-1986, Graduate Studies in Mathematics, Wuhan University, Wuhan, China
  • 1978-1981, Mathematics, Hainan Normal University, Haikou, China
  • 1994-1996, Post-Doctoral Fellowship in Biostatistics, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO



Hong Xian is a Professor of the Department of Biostatistics, Saint Louis University College for Public Health & Social Justice and the Co-director of Clinical Epidemiology Center at the VA St. Louis Health Care System. In his current position, Professor Xian teaches graduate courses in theory of biostatistics, design and analysis in public health and statistical computing. Professor Xian’s primary research areas include longitudinal data analysis, clinical and psychiatric epidemiology, and genetic and environmental risk factors in the etiology of substance abuse and psychiatric disorders. He has authored and co-authored over 115 peer reviewed publications. Professor Xian received postdoctoral training in statistical genetics and psychiatric epidemiology at the Department of Psychiatry, Washington University School of Medicine in St. Louis. Before joining Saint Louis University, Professor Xian was an Associate Professor at Washington University School of Medicine in St. Louis and Health Science Specialist at the VA St. Louis Health Care System.

Research Interest

Professor Xian’s primary research areas of interest include longitudinal data analysis, clinical and psychiatric epidemiology, and genetic and environmental risk factors in the etiology of substance abuse and psychiatric disorders.

Professional Activities:

2014-present Professor Institute for Global Health and Wellbeing College for Public Health & Social Justice, Saint Louis University, MO
2013-present Co-Director Clinical Epidemiology Center St. Louis VA Health Care System, MO
2012-present Professor Department of Biostatistics, College for Public Health & Social Justice Saint Louis University, MO
2010-present Guest Professor   Hainan Normal University School of Mathematics and Statistics, China
2008-2012 Associate Professor Departments of Internal Medicine and Psychiatry Washington University School of Medicine, St. Louis, MO
2008-2012 Member Institute for Public Health Washington University’s George Warren Brown School of Social Work, St. Louis, MO
2007-2008 Assistant Professor Department of Psychiatry Washington University School of Medicine, St. Louis, MO
2007-2012 Adjunct Associate Professor Biostatistics St. Louis University School of PublicHeath, St. Louis, MO
2004-present Research Health Science Specialist   St. Louis Veterans Affairs Medical Center, MO
2001-2007 Assistant Professor Department of Internal Medicine Washington University School of Medicine, St. Louis, MO
1997-2001 Instructor Department of Internal Medicine Washington University School of Medicine, St. Louis, MO
1994-1996 Postdoctoral Fellow Statistical Genetics and Psychiatric Epidemiology WashingtonUniversity School of Medicine, St. Louis, MO
1989-1994 Teaching Assistant/Instructor (part time) Department of Mathematics Washington University, St. Louis, MO
1988-1989 Teaching Assistant (part time) Department of Mathematics Western Illinois University, Macomb, IL
1982-1987 Instructor Department of  Mathematics, Hainan Normal University, Haikou,China



Peer-Reviewed Journals

  1. Neuman, R.J. &Xian, H.  (1997). Testing the utility of mod scores and sibpair analysis to detect presence of disease susceptibility loci. Genetic Epidemiology,14(6):1035-1040
  2. True,W.R., Xian, H.,Scherrer, J.F., Madden, P.A., Bucholz, K.K., Heath, A.C., Eisen, S.A., Lyons, M.J., Goldberg, J. &Tsuang, M.T. (1999). Common vulnerability for nicotine and alcohol dependence. Archives of General Psychiatry,56(7):655-661
  3. True,W.R., Heath, A.C., Scherrer, J.F., Xian, H., Lin, N., Eisen, S.A., Lyons, M.J., Goldberg, J. &Tsuang, M.T. (1999). Interrelationship of genetic and environmental influences on conduct disorder, alcohol and marijuana dependence symptoms. American Journal of Medical Genetics (Neuropsychiatr Genet),88(4):1-7
  4. Tsuang, M.T., Lyons, M.J., Harley, R.M., Xian, H.,Eisen, S., Goldberg, J., True, W.R. &Faraone S.V. (1999). Genetic and environmental influences on transitions in drug use. Behavior Genetics, 29(6):473-479
  5. Scherrer, J.F., True, W.R., Xian, H., Lyons, M.J., Eisen, S.A., Goldberg, J., Lin, N. &Tsuang, M.T. (2000). Evidence for genetic influences common and specific to symptoms of generalized anxiety and panic. Journal of Affective Disorders, 57(1-3):25-35
  6. Xian, H.,Scherrer, J.F., Eisen, S.A., True, W.R., Heath, A.C., Goldberg, J., Lyons, M.J.&Tsuang, M.T. (2000). Self-reported zygosity and the equal-environments assumption for psychiatric disorders in the Vietnam Era Twin Registry. Behavior Genetics, 30(4):303-310
  7. Romeis, J.C., Scherrer, J.F.,Xian, H., Eisen, S.A., Bucholz, K., Heath, A.C., Goldberg, J., Lyons, M.J., Henderson, W.G. & True, W.R. (2000). Heritability of self-reported health. Health Services Research 2000 Dec, 35(5 Pt 1):995-1010. PMCID: PMC1089180
  8. Xian, H.,Chantarujikapong, S.I., Scherrer, J.F., Eisen, S.A., Lyons, M.J., Goldberg, J., Tsuang, M. & True, W.R.  (2000). Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs. Drug and Alcohol Dependence,61(1):91-102
  9. Slutske, W.S., Eisen, S., Xian, H., True, W.R., Lyons, M.J., Goldberg, J. &Tsuang, M. (2001). A twin study of the association between pathological gambling and antisocial personality disorder. Journal of Abnormal Psychology, 110(2):297-308
  10. Eisen, S.A., Slutske, W.S., Lyons, M.J., Lassman, J., Xian, H.,Roomey, R., Chantarujikapong, S. &Tsuang, M.T. (2001). The genetics of pathological gambling. Seminars in Clinical Neuropsychiatry, 6(3):195-204
  11. Chantarujikapong, S.I., Scherrer, J.F., Xian, H.,Eisen, S.A., Lyons, M.J., Goldberg, J., Tsuang, M. & True, W.R.  (2001). A twin study of generalized anxiety disorder symptoms, panic disorder symptoms, and posttraumatic stress disorder in men. Psychiatry Research, 103(2-3):133-145
  12. Eisen, S.A., Chantarujikapong, S., Xian, H., Lyons, M.J., Toomey, R., True, W.R., Scherrer, J.F.,Goldberg, J., Tsuang, M.T. (2002). Does marijuana use have residual adverse effects on self-reported health measures, socio-demographics and quality of life? A monozygotic co-twin control study in men. Addiction, 97(9):1137-1144
  13. Toomey, R. Lyons, M.J., Eisen, S.A., Xian, H.,Chantarujikapong, S., Seidman, L.J., Faraone, S.V.&Tsuang, M.T. (2003). A twin study of the neuropsychological consequences of stimulant abuse. Archives of General Psychiatry, 60(3):303-310
  14. Xian, H.,Scherrer, J.F., Madden, P.A., Lyons, M.J., Tsuang, M., True, W.R.&Eisen, S.A. (2003). The heritability of failed smoking cessation and nicotine withdrawal in twins who smoked and attempted to quit. Nicotine and Tobacco Research, 5(2):245-254
  15. Scherrer, J.F.,Xian, H.,Bucholz, K.K.,Eisen, S.A., Lyons, M.J., Goldberg, J., Tsuang, M. & True, W.R. (2003). A twin study of depression symptoms, hypertension, and heart disease in middle-aged men. Psychosomatic Medicine, 65(4):548-557
  16. Crider, A.,Kremen, W.S., Xian, H., Jacobson, K.C., Waterman, B., Eisen, S.A.,Tsuang, M.T. &Lyons, M.J. (2004). Stability, consistency, and heritability of electrodermal response liability inmiddle-aged male twins. Psychophysiology, 41(4):501-509
  17. Lyons, M.J., Bar, J.L., Panizzon, M.S., Toomey, R., Eisen, S., Xian, H. &Tsuang, M.T. (2004). Neuropsychological consequences of regular marijuana use: a twin study. Psychological Medicine, 34(7):1239-1250
  18. Eisen, S.A., Griffith, K.H., Xian, H.,Scherrer, J.F., Fischer, I.D., Chantarujikapong, S., Hunter, J., True, W.R., Lyons, M.J. &Tsuang, M.T. (2004). Lifetime and 12-month prevalence of psychiatric disorders in 8,169 male Vietnam War veterans. Military Medicine, 169(11):896-902
  19. Xian, H.,Scherrer, J.F., Madden, P.A., Lyons,M.J., Tsuang, M., True, W.R.&Eisen, S.A. (2005). Latent class typology of nicotine withdrawal: genetic contributions and association with failed smoking cessation and psychiatric disorders. Psychological Medicine, 35(3):409-419
  20. Scherrer, J.F., Xian, H., Shah, K.R., Volberg, R., Slutske, W., Eisen, S.A. (2005). Effects of genes, environmental, and lifetime co-occurring disorders on health-related quality of life in problem and pathological gamblers. Arch Gen Psychiatry, 62(6):677-683
  21. Kremen, W.S., Jacobson, K.C., Xian, H., Eisen, S.A., Waterman, B., Toomey, R., Neale, M.C., Tsuang, M.T. & Lyons, M.J. (2005). Heritability of word recognition in middle-aged men varies as a function of parental education. Behavior Genet, 35(4):417-433
  22. Shah, K.R., Eisen, S.A., Xian, H. & Potenza, M.N. (2005). Genetic studies of pathological gambling: a review of methodology and analyses of data from the Vietnam Era Twin Registry. Journal of Gambling Studies, 21(2):179-203
  23. Potenza, M.N., Xian, H., Shah, K., Scherrer, J.F. &Eisen, S.A. (2005). Shared genetic contributions to pathological gambling and major depression in men. Archives of General Psychiatry, 62(9):1015-1021
  24. Romeis, J.C., Heath, A.C., Xian, H., Eisen, S.A., Scherrer, J.F., Pedersen, N.L., Fu, Q., Bucholz, K.K., Goldberg, J., Lyons, M.J., Waterman, B., Tsuang, M.T. & True, W.R. (2005). Heritability of SF-36 among middle age, middle class, male-male twins. Medical Care, 43(11):1147-1154
  25. Kremen, W.S., Lyons, M.J., Boake, C., Xian, H., Jacobsen, K.C., Waterman, B., Eisen, S.A., Goldberg, J., Faraone, S.V. &Tsuang, M.T. (2006). A discordant twin study of premorbid cognitive ability in schizophrenia.  Journal of Clinical and Experimental Neuropsychology, 28(2):208-224
  26. Scherrer, J.F., Xian, H., Krygiel, Kapp, J.M., Waterman, B., Shah, K.R., Volberg, R. & Eisen, S.A. (2007). Association between exposure to childhood and lifetime traumatic events and lifetime pathological gambling. Journal of Nervous and Mental Disease, 195(1):72-78
  27. Xian, H.Scherrer, J.F., Eisen, S.A., Lyons,M.J., Tsuang, M., True, W.R.&Bucholz, K.K. (2007). Nicotine dependence subtypes: association with smoking history, diagnostic criteria and psychiatric disorders in 5,440 regular smokers from the Vietnam Era Twin Registry. Addictive Behaviors, 32(1):137-147
  28. Xian, H., Scherrer, J.F., Slutske, W.S., Shah, K.R., Volberg, R. &Eisen, S.A. (2007). Genetic and environmental contributions to pathological gambling symptoms in a 10-year follow-up. Twin Research & Human Genetics,10(1):174-179
  29. Scherrer, J.F., Slutske, W.S., Xian, H., Waterman, B., Shah, K.R., Volberg, R. &Eisen, S.A. (2007). Factors associated with pathological gambling at 10-year follow-up in a national sample of middle-aged men. Addiction, 102(6):970-978
  30. Sartor, C.E., Scherrer, J.F., Shah, K.R., Xian, H., Volberg, R. &Eisen, S.A. (2007). Course of pathological gambling symptoms and reliability of the Lifetime Gambling History measure. Psychiatry Research, 152(1):55-61
  31. Franz, C.E., Grant, M.D., Jacobson, K.C., Kremen, W.S., Eisen, S.A., Xian, H., Romeis, J., Thompson-Brenner, H. & Lyons, M.J. (2007). Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal study. Twin Research &Human Genetics, 10(4):537-545
  32. Kremen,W.S., Jacobson, K.C., Xian, H., Eisen, S.A., Eaves, L.J., Tsuang, M.T. & Lyons, M.J. (2007). Genetics of verbal working memory processes:  a twin study of middle-aged men. Neuropsychology, 21(5):569-80
  33. Lyons, M., Hitsman, B., Xian, H., Panizzon, M.S., Jerskey, B.A., Santangelo, S., Grant, M.D., Rende, R., Eisen, S., Eaves, L. &Tsuang, M.T. (2008). A twin study of smoking, nicotine dependence, and major depression in men. Nicotine and Tobacco Research, 10(1):97-108
  34. Sartor, C.E., Xian, H., Scherrer, J.F., Lynskey, M.T., Duncan, A.E., Haber, J.R., Grant, J.D., Bucholz, K.K. & Jacob. T. (2008). Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study. Addictive Behaviors, 33(2):235-51
  35. Kremen, W.S., Xian, H., Jacobson, K.C., Eaves, L.J., Franz, C.E., Panizzon, M.S. Eisen, S.A., Crider, A. & Lyons, M.J. (2008). Storage and Executive Components of Working Memory: Integrating Cognitive Psychology and Behavior Genetics in the Study of Aging. J Gerontol B PsycholSciSocSc, 63:84-91
  36. Iizuka, K., Scalzo, A.A., Xian, H. & Yokoyama, W.M. (2008). Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes. Journal of Immunology, 180(5):3260-3267
  37. Scherrer, J.F., Xian, H., Lyons, M.J., Goldberg, J., Eisen, S.A., True, W., Tsuang, M., Bucholz, K.K. &Koenen, K.C. (2008). Posttraumatic stress disorder, combat exposure and nicotine dependence, alcohol dependence, and major depression in male twins. Comprehensive Psychiatry, 49(3):297-304
  38. Schultz, M.R., Lyons, M.J., Franz, C.E., Grant, M.D., Boake, C., Jacobson, K.C., Xian, H., Schellenberg, G.D., Eisen, S.A. &Kremen, W.S. (2008).Apolipoprotein E genotype and memory in the sixth decade of life. Neurology, 70(19 Pt 2):1771-7
  39. Xian, H., Shah, K., Potenza, M., Volberg, R., Chantarujikapong, S., True, W., Lyons, M., Tsuang, M. &Eisen, S. (2008). A latent class analysis of DSM-III-R pathological gambling criteria in middle-aged men: association with psychiatric disorders. Journal of Addiction Medicine, 2:85-95
  40. Xian, H., Scherrer, J.F., Grant, J.D., Eisen, S.A., True, W.R., Jacob, T. &Bucholz, K.K. (2008). Genetic and environmental contributions to nicotine, alcohol and Cannabis dependence in male twins. Addiction, 103:1391-1398
  41. Xian, H., Shah, K.R., Phillips, S.M., Scherrer, J.F., Volberg, R. &Eisen, S.A. (2008). The association of cognitive distortions with problem and pathological gambling in adult male twins. Psychiatry Research, 160(3):300-7
  42. Ilias, N., Xian, H., Inman, C. & Martin, W.H. (2009). Arm exercise testing predicts clinical outcome. American Heart Journal, 157(1):69-76
  43. Kremen, W.S., Jacobson, K.C., Panizzon, M.S., Xian, H., Eaves, L.J., Eisen, S.A., Tsuang, M.T. & Lyons, M.J. (2009). Factor structure of planning and problem-solving: A behavioral genetic analysis of the Tower of London Task in middle-aged twins. Behavior Genetics, 39(2):133-44
  44. McDonald, J.R., Zeringue, A.L., Caplan, L., Ranganathan, P., Xian, H., Burroughs, T.E., Fraser, V.J., Cunningham, F. &Eisen, S.A. (2009). Herpes zoster risk factors in a national cohort of veterans with rheumatoid arthritis. Clin Infect Dis, 48(10):1364-1371
  45. Scherrer, J.F., Virgo, K.S., Zeringue, A., Bucholz, K.K., Jacob, T., Johnson, R.G., True, W.R., Carney, R.M., Freedland, K.E., Xian, H., Caplan, L., McDonald, J. &Eisen, S.A. (2009). Depression increases risk of Incident Myocardial Infarction Among Veterans Administration Patients with Rheumatoid Arthritis. General Hospital Psychiatry, 31(4):353-359
  46. Lyons, M.J., York, T.P., Franz, C.E., Grant, M.D., Eaves, L.J., Jacobson, K.C., Schaie, K.W., Panizzon, M.S., Boake, C., Xian, H., Toomey, R., Eisen, S.A. &Kremen, W.S. (2009). Genes determine stability and the environment determines change in cognitive ability during 35 years of adulthood. PsycholSci, 20(9):1146-1152
  47. Panizzon, M.S., Fennema-Notestine, C., Eyler, L.T., Jernigan, T.L., Prom-Wormley, E., Neale, M., Jacobson, K., Lyons, M.J., Grant, M.D., Franz, C.E., Xian, H., Tsuang, M., Fischl, B., Seidman, L., Anders, D. &Kremen, W.S. (2009). Distinct genetic influences on cortical surface area and cortical thickness. Cerebral Cortex, 19(11):2728-2735
  48. Agrawal, A., Scherre, J.F., Grant, J.D., Sartor, C.E., Pergadia, M.L., Alexis, E., Duncan, A.E., Madden, P.A., Haber, J.R., Jacob, T., Bucholz, K.K. & Xian, H. (2010). Theeffects of maternal smoking during pregnancy on offspring outcomes. Preventive Medicine, 50:13-18
  49. Doane, L.D., Kremen,W.S., Eaves, L.J., Eisen, S.A., Hauger, R., Hellhammer, D., Levine, S., Lupien, S., Lyons, M.J., Mendoza, S., Prom-Wormley, E., Xian, H., York, T.P., Franz, C.E. & Jacobson, K.C. (2010). Associations between jet lag and cortisol diurnal rhythms after domestic travel. Health Psychology, 29(2):117-123
  50. Xian, H.,Scherrer, J.F., Franz, C.E., McCaffery, J., Stein, P.K., Lyons, M.J., Jacobsen, K.C., Eisen, S.A. &Kremen, W.S. (2010). Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam Era Twin Study of Aging. Psychosomatic Medicine, 72:370-375
  51. Koenig, L.B., Jacob, T., Haber, J.R. & Xian, H. (2010). Testing the equal environments assumption in the children of Twins Design. Behavior Genetics, 40:533-541
  52. Grant, M.D., Kremen, W.S., Jacobson, K.C., Franz, C., Xian, H., Eisen, S.A., Toomey, R., Murray, R.E. & Lyons, M.J. Does parental education have a moderating effect on the genetic and environmental influences of general cognitive ability in early adulthood? Behav Genet, 40(4):438-46
  53. Franz,C.E., York, T.P., Eaves,L.J., Mendoza,S., Hauger,R., Hellhammer,D., Jacobson,K.C.,  Levine,S.,Lupien,S., Lyons,M.J., Prom-Wormley,E., Xian,H. &Kremen,W.S. (2010). Genetic and environmental influences on cortisol regulation across days and contexts in middle-aged men. Behavior Genetics, 40(4):467-479
  54. Sartor, C.E., Lessov-Schlagger, C.N., Scherrer, J.F., Bucholz, K.K., Madden, P.A., Pergadia, M.L., Grant, J.D., Jacob, T., & Xian, H. (2010) Initial response to cigarettes predicts rate of progression to regular smoking: Findings from an Offspring-of-Twins Design. Addictive Behaviors35(8):771-778
  55. Xian,H., Scherrer, J.F., Pergadia, M.L., Madden, P.A., Grant, J.D., Sartor, C.E., Haber, J.R., Jacob, T. &Bucholz, K.K. (2010). Contribution of parental psychopathology to offspring smoking and nicotine dependence in a genetically informative design. J StudAlcohol and Drugs, 71(5):664-673
  56. Panizzon, M.S., Hauger, R., Dale, A.M., Eaves, L.J., Eyler, L.T., Fischl, B., Notestine, C.F., Franz, C.E., Grant, M.D., Jak, A., Jacobson, K.C., Lyons, M.J., Mendoza, S.P., Neale, M.C., Prom-Wormley, E.C., Seidman, L.J., Tsuang, M.T., Xian, H., and Kremen, W.S. (2010). Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. Neurology, 75(10):874-880
  57. Al-Aly, Z., Zeringue, A.L., Fu, Q., Rauchman, M., McDonald, J.R., El-Achkar, T., Nurutdinova, D., Xian, H., Stroupe, K., Abbott, K.C., and Eisen, S.A. (2010).Rate of kidney function decline is associated with increased risk of death. Journal of the American Society of Nephrology, 21(11):1961–1969
  58. Christine Fennema-Notestine, Matthew S Panizzon, Wesley R Thompson, Chi-Hua Chen, Lisa T Eyler, Bruce Fischl, Carol E Franz, Michael D Grant, Amy J Jak, Terry L Jernigan, Michael J Lyons, Michael C Neale, Larry J Seidman, Ming T Tsuang, Hong Xian, Anders M Dale, William S Kremen (2011). Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age. Journal of Alzheimer's disease: JAD 01/2011; 26 Suppl 3:49-60
  59. Al-Aly, Z., Pan, H, Zeringue, A.L., Xian, H., McDonald, J.R., El-Achkar, T., and Eisen, S.A. (2011). Tumor necrosis factor-alpha blockade, cardiovascular outcomes, and survival in rheumatoid arthritis. Translational Research. 157(1):10-18
  60. Scherrer, J.F., Xian, H.,Lustman, P.J., Franz, C.E., McCaffery, J., Lyons, M.J., Jacobson, K.C.,Kremen, W.S. (2011). A Test for Common Genetic and Environmental Vulnerability to Depression and Diabetes. Twin Research & Human Genetics, 14(2):169-72
  61. Franz,C.E., Lyons,M.J., O’Brien, R., Panizzon, M.S., Kim, K., Bhat, R., Grant, M.D., Toomey, R., Xian,H., Eisen, S.A. &Kremen,W.S. (2011). A 35-year longitudinal assessment of cognition and midlife depression symptoms: The Vietnam Era Twin Study of Aging. American Journal of Geriatric Psychology.[Epub ahead of print] 19(16):559-70
  62. Kremen WS., MaiTV.,Panizzon MS., Franz, CE., Blankfeld, HM., Xian, H., Seth A Eisen, SA., Tsuang, MT., Lyons, MJ (2011). A Twin Study of Spatial and Non-Spatial Delayed Response Performance in Middle Age. Brain and Cognition, 76(1):43-51
  63. Doane, LD, Franz CE, Prom-Wormley, PC, Eaves, LJ,Mendoza, SP, Hellhammer, DH, Lupien, S, Xian, H, Lyons, MJ, Kremen, WS, Jacobson, KC (2011). Negative Emotionality, Depressive Symptoms and Cortisol Diurnal Rhythms: Analysis of a Community Sample of Middle-Aged Males. Hormones and Behavior, 60(2):202-209
  64. Panizzon, M.S., Lyons, M.J., Jacobson, K.C., Franz, C.E., Grant, M.D., Eisen, S.A., Xian, H., and Kremen, W.S.(2011 Apr 4. Epub ahead of print). Genetic Architecture of Learning and Delayed Recall: A Twin Study of Episodic Memory. Neuropsychology, 25(4):488-498
  65. Franz CE, York TP, Eaves LJ, Prom-Wormley E, Jacobson KC, Lyons MJ, Grant MD, Xian H, Panizzon MS, Jimenez E, Kremen WS (Epub Date 1/07/2011).Adult Romantic Attachment, Negative Emotionality, and Depressive Symptoms in Middle Aged Men: A Multivariate Genetic Analysis.Behav Genet. 41(4):488-98
  66. McCaffery, JM, Franz, CE, Jacobson, KC, Tricia M. Leahey, TM, Xian, H, Wing, RR, Lyons, MJ, and William S. Kremen, WS (2011) Effects of social contact and zygosity on 21-year weight change in male twins. American Journal of Clinical Nutrition. 94(2):404-409
  67. Giddens, JL., Xian, H., Scherrer, JF.,Eisen, SA., Potenza, MN.(2011). Shared Genetic Contributions to Anxiety Disorders and Pathological Gambling in a Male Population. Journal of Affective Disorders. 132(3):406-412
  68. Franz CE, O'Brien RC, Hauger RL, Mendoza SP, Panizzon MS, Prom-Wormley E, Eaves LJ, Jacobson K, Lyons MJ, Lupien S, Hellhammer D, Xian H, Kremen WS. (Epub Date 2/02/2011) Cross-Sectional and 35-Year Longitudinal Assessment of Salivary Cortisol and Cognitive Functioning: the Vietnam Era Twin Study of Aging. Psychoneuroendocrinology. 36(7):1040-52
  69. Agrawal, A., Scherrer, JF., Pergadia, ML., Lynskey, MT.,  Madden, PA., Sartor, CE., Grant, JD., Duncan, AE., Haber, JR., Jacob, T., Bucholz, KK. and Xian, H. (2011). Alatent class analysis of DSM-IV and Fagerstrom (FTND) criteria for nicotine dependence. Nicotine & Tobacco Research. 13(10):972-981
  70. Wang, J, Xian, H, Licis, A, Deych, E, Ding, J, McLeland, J, Toedebusch, C, Li, T, Duntley, S, Shannon, W. (2011). Measuring the Impact of Apnea and Obesity on Circadian Activity Patterns Using Functional Linear Modeling of Actigraphy Data. Journal of Circadian Rhythms, 2011, 9(1):11
  71. Prom-Wormley, PC., York, TP., Jacobson, KC., Eaves, LJ., Mendoza, SP., Hellhammer, D., Maninger, N., Levine, S., Lupien, S., Lyons, MJ., Hauger, R., Xian, H., Franz, CE., Kremen, WS (2011). Genetic and Environmental Effects on Diurnal Dehydroepiandrosterone Sulfate Concentrations in Middle-Aged Men. Psychoneuroendocrinology. 36:1441-1452
  72. Agrawal, A., Scherrer, JF.,Lynskey, MT.,  Sartor, CE., Grant, JD., Haber, JR., Madden, PA., Jacob, T., Bucholz, KK. and Xian, H. (2011). Patterns of use, sequence of onsets and correlates of tobacco and cannabis. Addictive Behaviors. 36(12):1141-1147
  73. Kremen WS., Panizzon MS, Xian H, March DM, Franz CE, Grant MD, Toomey R, Lyons MJ. (Epub Date 8/29/2011). Genetic Architecture of Context Processing in Late Middle Age: More Than One Underlying Mechanism. Psychology and Aging. (2011), 26(4): 852-863
  74. Chan, AK.,Ilias-Khan, NA., Xian, H., Inman, Cindi. andMartin. WH. (Epub Date Aug 2011).Arm Exercise Stress Perfusion Imaging Predicts Clinical Outcome. Journal of Applied Physiology, 111(6):1546-1553
  75. Vasilopoulos, T,  Kremen, WS, Kim, K,  Panizzon, MS, Stein, PK, Xian, H, Grant, MD,Lyons MJ, Toomey, R, Eaves LJ, Franz, CE, Jacobson, KC (2012). (Epub Date 6/19/2011) Untreated Hypertension Decreases Heritability of Cognition in Late Middle Age. Behavior Genetics, 42(1):107-120
  76. Kremen, WS, Panizzon, MS,  Neale, MC, Fennema-Notestine, C, Prom-Wormley, E, Eyler, LT, Stevens, A,  Franz, CE, Lyons, MJ,  Grant, MD, Jak, AJ,  Jernigan, TL, Xian, H, Fischl, B, Thermenos, HW,  Seidman, LJ, Tsuang, MT,  Dale, AM (2012). Heritability of brain ventricle volume: converging evidence from inconsistent results. Neurobiology of aging, 33(1):1-8
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