Professor
Department of Biostatistics
College for Public Health& Social Justice
Saint Louis University
USA
Education
- 1989-1994, Ph.D. in Mathematics, Washington University, St. Louis, MO
- 1988-1989, M.Sc. in Mathematics, Western Illinois University, Macomb, IL
- 1984-1986, Graduate Studies in Mathematics, Wuhan University, Wuhan, China
- 1978-1981, Mathematics, Hainan Normal University, Haikou, China
- 1994-1996, Post-Doctoral Fellowship in Biostatistics, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO
Biography
Hong Xian is a Professor of the Department of Biostatistics, Saint Louis University College for Public Health & Social Justice and the Co-director of Clinical Epidemiology Center at the VA St. Louis Health Care System. In his current position, Professor Xian teaches graduate courses in theory of biostatistics, design and analysis in public health and statistical computing. Professor Xian’s primary research areas include longitudinal data analysis, clinical and psychiatric epidemiology, and genetic and environmental risk factors in the etiology of substance abuse and psychiatric disorders. He has authored and co-authored over 115 peer reviewed publications. Professor Xian received postdoctoral training in statistical genetics and psychiatric epidemiology at the Department of Psychiatry, Washington University School of Medicine in St. Louis. Before joining Saint Louis University, Professor Xian was an Associate Professor at Washington University School of Medicine in St. Louis and Health Science Specialist at the VA St. Louis Health Care System.
Research Interest
Professor Xian’s primary research areas of interest include longitudinal data analysis, clinical and psychiatric epidemiology, and genetic and environmental risk factors in the etiology of substance abuse and psychiatric disorders.
Professional Activities:
2014-present | Professor | Institute for Global Health and Wellbeing | College for Public Health & Social Justice, Saint Louis University, MO |
2013-present | Co-Director | Clinical Epidemiology Center | St. Louis VA Health Care System, MO |
2012-present | Professor | Department of Biostatistics, College for Public Health & Social Justice | Saint Louis University, MO |
2010-present | Guest Professor | Hainan Normal University School of Mathematics and Statistics, China | |
2008-2012 | Associate Professor | Departments of Internal Medicine and Psychiatry | Washington University School of Medicine, St. Louis, MO |
2008-2012 | Member | Institute for Public Health | Washington University’s George Warren Brown School of Social Work, St. Louis, MO |
2007-2008 | Assistant Professor | Department of Psychiatry | Washington University School of Medicine, St. Louis, MO |
2007-2012 | Adjunct Associate Professor | Biostatistics | St. Louis University School of PublicHeath, St. Louis, MO |
2004-present | Research Health Science Specialist | St. Louis Veterans Affairs Medical Center, MO | |
2001-2007 | Assistant Professor | Department of Internal Medicine | Washington University School of Medicine, St. Louis, MO |
1997-2001 | Instructor | Department of Internal Medicine | Washington University School of Medicine, St. Louis, MO |
1994-1996 | Postdoctoral Fellow | Statistical Genetics and Psychiatric Epidemiology | WashingtonUniversity School of Medicine, St. Louis, MO |
1989-1994 | Teaching Assistant/Instructor (part time) | Department of Mathematics | Washington University, St. Louis, MO |
1988-1989 | Teaching Assistant (part time) | Department of Mathematics | Western Illinois University, Macomb, IL |
1982-1987 | Instructor | Department of Mathematics, | Hainan Normal University, Haikou,China |
Publications
Peer-Reviewed Journals
- Neuman, R.J. &Xian, H. (1997). Testing the utility of mod scores and sibpair analysis to detect presence of disease susceptibility loci. Genetic Epidemiology,14(6):1035-1040
- True,W.R., Xian, H.,Scherrer, J.F., Madden, P.A., Bucholz, K.K., Heath, A.C., Eisen, S.A., Lyons, M.J., Goldberg, J. &Tsuang, M.T. (1999). Common vulnerability for nicotine and alcohol dependence. Archives of General Psychiatry,56(7):655-661
- True,W.R., Heath, A.C., Scherrer, J.F., Xian, H., Lin, N., Eisen, S.A., Lyons, M.J., Goldberg, J. &Tsuang, M.T. (1999). Interrelationship of genetic and environmental influences on conduct disorder, alcohol and marijuana dependence symptoms. American Journal of Medical Genetics (Neuropsychiatr Genet),88(4):1-7
- Tsuang, M.T., Lyons, M.J., Harley, R.M., Xian, H.,Eisen, S., Goldberg, J., True, W.R. &Faraone S.V. (1999). Genetic and environmental influences on transitions in drug use. Behavior Genetics, 29(6):473-479
- Scherrer, J.F., True, W.R., Xian, H., Lyons, M.J., Eisen, S.A., Goldberg, J., Lin, N. &Tsuang, M.T. (2000). Evidence for genetic influences common and specific to symptoms of generalized anxiety and panic. Journal of Affective Disorders, 57(1-3):25-35
- Xian, H.,Scherrer, J.F., Eisen, S.A., True, W.R., Heath, A.C., Goldberg, J., Lyons, M.J.&Tsuang, M.T. (2000). Self-reported zygosity and the equal-environments assumption for psychiatric disorders in the Vietnam Era Twin Registry. Behavior Genetics, 30(4):303-310
- Romeis, J.C., Scherrer, J.F.,Xian, H., Eisen, S.A., Bucholz, K., Heath, A.C., Goldberg, J., Lyons, M.J., Henderson, W.G. & True, W.R. (2000). Heritability of self-reported health. Health Services Research 2000 Dec, 35(5 Pt 1):995-1010. PMCID: PMC1089180
- Xian, H.,Chantarujikapong, S.I., Scherrer, J.F., Eisen, S.A., Lyons, M.J., Goldberg, J., Tsuang, M. & True, W.R. (2000). Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs. Drug and Alcohol Dependence,61(1):91-102
- Slutske, W.S., Eisen, S., Xian, H., True, W.R., Lyons, M.J., Goldberg, J. &Tsuang, M. (2001). A twin study of the association between pathological gambling and antisocial personality disorder. Journal of Abnormal Psychology, 110(2):297-308
- Eisen, S.A., Slutske, W.S., Lyons, M.J., Lassman, J., Xian, H.,Roomey, R., Chantarujikapong, S. &Tsuang, M.T. (2001). The genetics of pathological gambling. Seminars in Clinical Neuropsychiatry, 6(3):195-204
- Chantarujikapong, S.I., Scherrer, J.F., Xian, H.,Eisen, S.A., Lyons, M.J., Goldberg, J., Tsuang, M. & True, W.R. (2001). A twin study of generalized anxiety disorder symptoms, panic disorder symptoms, and posttraumatic stress disorder in men. Psychiatry Research, 103(2-3):133-145
- Eisen, S.A., Chantarujikapong, S., Xian, H., Lyons, M.J., Toomey, R., True, W.R., Scherrer, J.F.,Goldberg, J., Tsuang, M.T. (2002). Does marijuana use have residual adverse effects on self-reported health measures, socio-demographics and quality of life? A monozygotic co-twin control study in men. Addiction, 97(9):1137-1144
- Toomey, R. Lyons, M.J., Eisen, S.A., Xian, H.,Chantarujikapong, S., Seidman, L.J., Faraone, S.V.&Tsuang, M.T. (2003). A twin study of the neuropsychological consequences of stimulant abuse. Archives of General Psychiatry, 60(3):303-310
- Xian, H.,Scherrer, J.F., Madden, P.A., Lyons, M.J., Tsuang, M., True, W.R.&Eisen, S.A. (2003). The heritability of failed smoking cessation and nicotine withdrawal in twins who smoked and attempted to quit. Nicotine and Tobacco Research, 5(2):245-254
- Scherrer, J.F.,Xian, H.,Bucholz, K.K.,Eisen, S.A., Lyons, M.J., Goldberg, J., Tsuang, M. & True, W.R. (2003). A twin study of depression symptoms, hypertension, and heart disease in middle-aged men. Psychosomatic Medicine, 65(4):548-557
- Crider, A.,Kremen, W.S., Xian, H., Jacobson, K.C., Waterman, B., Eisen, S.A.,Tsuang, M.T. &Lyons, M.J. (2004). Stability, consistency, and heritability of electrodermal response liability inmiddle-aged male twins. Psychophysiology, 41(4):501-509
- Lyons, M.J., Bar, J.L., Panizzon, M.S., Toomey, R., Eisen, S., Xian, H. &Tsuang, M.T. (2004). Neuropsychological consequences of regular marijuana use: a twin study. Psychological Medicine, 34(7):1239-1250
- Eisen, S.A., Griffith, K.H., Xian, H.,Scherrer, J.F., Fischer, I.D., Chantarujikapong, S., Hunter, J., True, W.R., Lyons, M.J. &Tsuang, M.T. (2004). Lifetime and 12-month prevalence of psychiatric disorders in 8,169 male Vietnam War veterans. Military Medicine, 169(11):896-902
- Xian, H.,Scherrer, J.F., Madden, P.A., Lyons,M.J., Tsuang, M., True, W.R.&Eisen, S.A. (2005). Latent class typology of nicotine withdrawal: genetic contributions and association with failed smoking cessation and psychiatric disorders. Psychological Medicine, 35(3):409-419
- Scherrer, J.F., Xian, H., Shah, K.R., Volberg, R., Slutske, W., Eisen, S.A. (2005). Effects of genes, environmental, and lifetime co-occurring disorders on health-related quality of life in problem and pathological gamblers. Arch Gen Psychiatry, 62(6):677-683
- Kremen, W.S., Jacobson, K.C., Xian, H., Eisen, S.A., Waterman, B., Toomey, R., Neale, M.C., Tsuang, M.T. & Lyons, M.J. (2005). Heritability of word recognition in middle-aged men varies as a function of parental education. Behavior Genet, 35(4):417-433
- Shah, K.R., Eisen, S.A., Xian, H. & Potenza, M.N. (2005). Genetic studies of pathological gambling: a review of methodology and analyses of data from the Vietnam Era Twin Registry. Journal of Gambling Studies, 21(2):179-203
- Potenza, M.N., Xian, H., Shah, K., Scherrer, J.F. &Eisen, S.A. (2005). Shared genetic contributions to pathological gambling and major depression in men. Archives of General Psychiatry, 62(9):1015-1021
- Romeis, J.C., Heath, A.C., Xian, H., Eisen, S.A., Scherrer, J.F., Pedersen, N.L., Fu, Q., Bucholz, K.K., Goldberg, J., Lyons, M.J., Waterman, B., Tsuang, M.T. & True, W.R. (2005). Heritability of SF-36 among middle age, middle class, male-male twins. Medical Care, 43(11):1147-1154
- Kremen, W.S., Lyons, M.J., Boake, C., Xian, H., Jacobsen, K.C., Waterman, B., Eisen, S.A., Goldberg, J., Faraone, S.V. &Tsuang, M.T. (2006). A discordant twin study of premorbid cognitive ability in schizophrenia. Journal of Clinical and Experimental Neuropsychology, 28(2):208-224
- Scherrer, J.F., Xian, H., Krygiel, Kapp, J.M., Waterman, B., Shah, K.R., Volberg, R. & Eisen, S.A. (2007). Association between exposure to childhood and lifetime traumatic events and lifetime pathological gambling. Journal of Nervous and Mental Disease, 195(1):72-78
- Xian, H.Scherrer, J.F., Eisen, S.A., Lyons,M.J., Tsuang, M., True, W.R.&Bucholz, K.K. (2007). Nicotine dependence subtypes: association with smoking history, diagnostic criteria and psychiatric disorders in 5,440 regular smokers from the Vietnam Era Twin Registry. Addictive Behaviors, 32(1):137-147
- Xian, H., Scherrer, J.F., Slutske, W.S., Shah, K.R., Volberg, R. &Eisen, S.A. (2007). Genetic and environmental contributions to pathological gambling symptoms in a 10-year follow-up. Twin Research & Human Genetics,10(1):174-179
- Scherrer, J.F., Slutske, W.S., Xian, H., Waterman, B., Shah, K.R., Volberg, R. &Eisen, S.A. (2007). Factors associated with pathological gambling at 10-year follow-up in a national sample of middle-aged men. Addiction, 102(6):970-978
- Sartor, C.E., Scherrer, J.F., Shah, K.R., Xian, H., Volberg, R. &Eisen, S.A. (2007). Course of pathological gambling symptoms and reliability of the Lifetime Gambling History measure. Psychiatry Research, 152(1):55-61
- Franz, C.E., Grant, M.D., Jacobson, K.C., Kremen, W.S., Eisen, S.A., Xian, H., Romeis, J., Thompson-Brenner, H. & Lyons, M.J. (2007). Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal study. Twin Research &Human Genetics, 10(4):537-545
- Kremen,W.S., Jacobson, K.C., Xian, H., Eisen, S.A., Eaves, L.J., Tsuang, M.T. & Lyons, M.J. (2007). Genetics of verbal working memory processes: a twin study of middle-aged men. Neuropsychology, 21(5):569-80
- Lyons, M., Hitsman, B., Xian, H., Panizzon, M.S., Jerskey, B.A., Santangelo, S., Grant, M.D., Rende, R., Eisen, S., Eaves, L. &Tsuang, M.T. (2008). A twin study of smoking, nicotine dependence, and major depression in men. Nicotine and Tobacco Research, 10(1):97-108
- Sartor, C.E., Xian, H., Scherrer, J.F., Lynskey, M.T., Duncan, A.E., Haber, J.R., Grant, J.D., Bucholz, K.K. & Jacob. T. (2008). Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study. Addictive Behaviors, 33(2):235-51
- Kremen, W.S., Xian, H., Jacobson, K.C., Eaves, L.J., Franz, C.E., Panizzon, M.S. Eisen, S.A., Crider, A. & Lyons, M.J. (2008). Storage and Executive Components of Working Memory: Integrating Cognitive Psychology and Behavior Genetics in the Study of Aging. J Gerontol B PsycholSciSocSc, 63:84-91
- Iizuka, K., Scalzo, A.A., Xian, H. & Yokoyama, W.M. (2008). Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes. Journal of Immunology, 180(5):3260-3267
- Scherrer, J.F., Xian, H., Lyons, M.J., Goldberg, J., Eisen, S.A., True, W., Tsuang, M., Bucholz, K.K. &Koenen, K.C. (2008). Posttraumatic stress disorder, combat exposure and nicotine dependence, alcohol dependence, and major depression in male twins. Comprehensive Psychiatry, 49(3):297-304
- Schultz, M.R., Lyons, M.J., Franz, C.E., Grant, M.D., Boake, C., Jacobson, K.C., Xian, H., Schellenberg, G.D., Eisen, S.A. &Kremen, W.S. (2008).Apolipoprotein E genotype and memory in the sixth decade of life. Neurology, 70(19 Pt 2):1771-7
- Xian, H., Shah, K., Potenza, M., Volberg, R., Chantarujikapong, S., True, W., Lyons, M., Tsuang, M. &Eisen, S. (2008). A latent class analysis of DSM-III-R pathological gambling criteria in middle-aged men: association with psychiatric disorders. Journal of Addiction Medicine, 2:85-95
- Xian, H., Scherrer, J.F., Grant, J.D., Eisen, S.A., True, W.R., Jacob, T. &Bucholz, K.K. (2008). Genetic and environmental contributions to nicotine, alcohol and Cannabis dependence in male twins. Addiction, 103:1391-1398
- Xian, H., Shah, K.R., Phillips, S.M., Scherrer, J.F., Volberg, R. &Eisen, S.A. (2008). The association of cognitive distortions with problem and pathological gambling in adult male twins. Psychiatry Research, 160(3):300-7
- Ilias, N., Xian, H., Inman, C. & Martin, W.H. (2009). Arm exercise testing predicts clinical outcome. American Heart Journal, 157(1):69-76
- Kremen, W.S., Jacobson, K.C., Panizzon, M.S., Xian, H., Eaves, L.J., Eisen, S.A., Tsuang, M.T. & Lyons, M.J. (2009). Factor structure of planning and problem-solving: A behavioral genetic analysis of the Tower of London Task in middle-aged twins. Behavior Genetics, 39(2):133-44
- McDonald, J.R., Zeringue, A.L., Caplan, L., Ranganathan, P., Xian, H., Burroughs, T.E., Fraser, V.J., Cunningham, F. &Eisen, S.A. (2009). Herpes zoster risk factors in a national cohort of veterans with rheumatoid arthritis. Clin Infect Dis, 48(10):1364-1371
- Scherrer, J.F., Virgo, K.S., Zeringue, A., Bucholz, K.K., Jacob, T., Johnson, R.G., True, W.R., Carney, R.M., Freedland, K.E., Xian, H., Caplan, L., McDonald, J. &Eisen, S.A. (2009). Depression increases risk of Incident Myocardial Infarction Among Veterans Administration Patients with Rheumatoid Arthritis. General Hospital Psychiatry, 31(4):353-359
- Lyons, M.J., York, T.P., Franz, C.E., Grant, M.D., Eaves, L.J., Jacobson, K.C., Schaie, K.W., Panizzon, M.S., Boake, C., Xian, H., Toomey, R., Eisen, S.A. &Kremen, W.S. (2009). Genes determine stability and the environment determines change in cognitive ability during 35 years of adulthood. PsycholSci, 20(9):1146-1152
- Panizzon, M.S., Fennema-Notestine, C., Eyler, L.T., Jernigan, T.L., Prom-Wormley, E., Neale, M., Jacobson, K., Lyons, M.J., Grant, M.D., Franz, C.E., Xian, H., Tsuang, M., Fischl, B., Seidman, L., Anders, D. &Kremen, W.S. (2009). Distinct genetic influences on cortical surface area and cortical thickness. Cerebral Cortex, 19(11):2728-2735
- Agrawal, A., Scherre, J.F., Grant, J.D., Sartor, C.E., Pergadia, M.L., Alexis, E., Duncan, A.E., Madden, P.A., Haber, J.R., Jacob, T., Bucholz, K.K. & Xian, H. (2010). Theeffects of maternal smoking during pregnancy on offspring outcomes. Preventive Medicine, 50:13-18
- Doane, L.D., Kremen,W.S., Eaves, L.J., Eisen, S.A., Hauger, R., Hellhammer, D., Levine, S., Lupien, S., Lyons, M.J., Mendoza, S., Prom-Wormley, E., Xian, H., York, T.P., Franz, C.E. & Jacobson, K.C. (2010). Associations between jet lag and cortisol diurnal rhythms after domestic travel. Health Psychology, 29(2):117-123
- Xian, H.,Scherrer, J.F., Franz, C.E., McCaffery, J., Stein, P.K., Lyons, M.J., Jacobsen, K.C., Eisen, S.A. &Kremen, W.S. (2010). Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam Era Twin Study of Aging. Psychosomatic Medicine, 72:370-375
- Koenig, L.B., Jacob, T., Haber, J.R. & Xian, H. (2010). Testing the equal environments assumption in the children of Twins Design. Behavior Genetics, 40:533-541
- Grant, M.D., Kremen, W.S., Jacobson, K.C., Franz, C., Xian, H., Eisen, S.A., Toomey, R., Murray, R.E. & Lyons, M.J. Does parental education have a moderating effect on the genetic and environmental influences of general cognitive ability in early adulthood? Behav Genet, 40(4):438-46
- Franz,C.E., York, T.P., Eaves,L.J., Mendoza,S., Hauger,R., Hellhammer,D., Jacobson,K.C., Levine,S.,Lupien,S., Lyons,M.J., Prom-Wormley,E., Xian,H. &Kremen,W.S. (2010). Genetic and environmental influences on cortisol regulation across days and contexts in middle-aged men. Behavior Genetics, 40(4):467-479
- Sartor, C.E., Lessov-Schlagger, C.N., Scherrer, J.F., Bucholz, K.K., Madden, P.A., Pergadia, M.L., Grant, J.D., Jacob, T., & Xian, H. (2010) Initial response to cigarettes predicts rate of progression to regular smoking: Findings from an Offspring-of-Twins Design. Addictive Behaviors35(8):771-778
- Xian,H., Scherrer, J.F., Pergadia, M.L., Madden, P.A., Grant, J.D., Sartor, C.E., Haber, J.R., Jacob, T. &Bucholz, K.K. (2010). Contribution of parental psychopathology to offspring smoking and nicotine dependence in a genetically informative design. J StudAlcohol and Drugs, 71(5):664-673
- Panizzon, M.S., Hauger, R., Dale, A.M., Eaves, L.J., Eyler, L.T., Fischl, B., Notestine, C.F., Franz, C.E., Grant, M.D., Jak, A., Jacobson, K.C., Lyons, M.J., Mendoza, S.P., Neale, M.C., Prom-Wormley, E.C., Seidman, L.J., Tsuang, M.T., Xian, H., and Kremen, W.S. (2010). Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. Neurology, 75(10):874-880
- Al-Aly, Z., Zeringue, A.L., Fu, Q., Rauchman, M., McDonald, J.R., El-Achkar, T., Nurutdinova, D., Xian, H., Stroupe, K., Abbott, K.C., and Eisen, S.A. (2010).Rate of kidney function decline is associated with increased risk of death. Journal of the American Society of Nephrology, 21(11):1961–1969
- Christine Fennema-Notestine, Matthew S Panizzon, Wesley R Thompson, Chi-Hua Chen, Lisa T Eyler, Bruce Fischl, Carol E Franz, Michael D Grant, Amy J Jak, Terry L Jernigan, Michael J Lyons, Michael C Neale, Larry J Seidman, Ming T Tsuang, Hong Xian, Anders M Dale, William S Kremen (2011). Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age. Journal of Alzheimer's disease: JAD 01/2011; 26 Suppl 3:49-60
- Al-Aly, Z., Pan, H, Zeringue, A.L., Xian, H., McDonald, J.R., El-Achkar, T., and Eisen, S.A. (2011). Tumor necrosis factor-alpha blockade, cardiovascular outcomes, and survival in rheumatoid arthritis. Translational Research. 157(1):10-18
- Scherrer, J.F., Xian, H.,Lustman, P.J., Franz, C.E., McCaffery, J., Lyons, M.J., Jacobson, K.C.,Kremen, W.S. (2011). A Test for Common Genetic and Environmental Vulnerability to Depression and Diabetes. Twin Research & Human Genetics, 14(2):169-72
- Franz,C.E., Lyons,M.J., O’Brien, R., Panizzon, M.S., Kim, K., Bhat, R., Grant, M.D., Toomey, R., Xian,H., Eisen, S.A. &Kremen,W.S. (2011). A 35-year longitudinal assessment of cognition and midlife depression symptoms: The Vietnam Era Twin Study of Aging. American Journal of Geriatric Psychology.[Epub ahead of print] 19(16):559-70
- Kremen WS., MaiTV.,Panizzon MS., Franz, CE., Blankfeld, HM., Xian, H., Seth A Eisen, SA., Tsuang, MT., Lyons, MJ (2011). A Twin Study of Spatial and Non-Spatial Delayed Response Performance in Middle Age. Brain and Cognition, 76(1):43-51
- Doane, LD, Franz CE, Prom-Wormley, PC, Eaves, LJ,Mendoza, SP, Hellhammer, DH, Lupien, S, Xian, H, Lyons, MJ, Kremen, WS, Jacobson, KC (2011). Negative Emotionality, Depressive Symptoms and Cortisol Diurnal Rhythms: Analysis of a Community Sample of Middle-Aged Males. Hormones and Behavior, 60(2):202-209
- Panizzon, M.S., Lyons, M.J., Jacobson, K.C., Franz, C.E., Grant, M.D., Eisen, S.A., Xian, H., and Kremen, W.S.(2011 Apr 4. Epub ahead of print). Genetic Architecture of Learning and Delayed Recall: A Twin Study of Episodic Memory. Neuropsychology, 25(4):488-498
- Franz CE, York TP, Eaves LJ, Prom-Wormley E, Jacobson KC, Lyons MJ, Grant MD, Xian H, Panizzon MS, Jimenez E, Kremen WS (Epub Date 1/07/2011).Adult Romantic Attachment, Negative Emotionality, and Depressive Symptoms in Middle Aged Men: A Multivariate Genetic Analysis.Behav Genet. 41(4):488-98
- McCaffery, JM, Franz, CE, Jacobson, KC, Tricia M. Leahey, TM, Xian, H, Wing, RR, Lyons, MJ, and William S. Kremen, WS (2011) Effects of social contact and zygosity on 21-year weight change in male twins. American Journal of Clinical Nutrition. 94(2):404-409
- Giddens, JL., Xian, H., Scherrer, JF.,Eisen, SA., Potenza, MN.(2011). Shared Genetic Contributions to Anxiety Disorders and Pathological Gambling in a Male Population. Journal of Affective Disorders. 132(3):406-412
- Franz CE, O'Brien RC, Hauger RL, Mendoza SP, Panizzon MS, Prom-Wormley E, Eaves LJ, Jacobson K, Lyons MJ, Lupien S, Hellhammer D, Xian H, Kremen WS. (Epub Date 2/02/2011) Cross-Sectional and 35-Year Longitudinal Assessment of Salivary Cortisol and Cognitive Functioning: the Vietnam Era Twin Study of Aging. Psychoneuroendocrinology. 36(7):1040-52
- Agrawal, A., Scherrer, JF., Pergadia, ML., Lynskey, MT., Madden, PA., Sartor, CE., Grant, JD., Duncan, AE., Haber, JR., Jacob, T., Bucholz, KK. and Xian, H. (2011). Alatent class analysis of DSM-IV and Fagerstrom (FTND) criteria for nicotine dependence. Nicotine & Tobacco Research. 13(10):972-981
- Wang, J, Xian, H, Licis, A, Deych, E, Ding, J, McLeland, J, Toedebusch, C, Li, T, Duntley, S, Shannon, W. (2011). Measuring the Impact of Apnea and Obesity on Circadian Activity Patterns Using Functional Linear Modeling of Actigraphy Data. Journal of Circadian Rhythms, 2011, 9(1):11
- Prom-Wormley, PC., York, TP., Jacobson, KC., Eaves, LJ., Mendoza, SP., Hellhammer, D., Maninger, N., Levine, S., Lupien, S., Lyons, MJ., Hauger, R., Xian, H., Franz, CE., Kremen, WS (2011). Genetic and Environmental Effects on Diurnal Dehydroepiandrosterone Sulfate Concentrations in Middle-Aged Men. Psychoneuroendocrinology. 36:1441-1452
- Agrawal, A., Scherrer, JF.,Lynskey, MT., Sartor, CE., Grant, JD., Haber, JR., Madden, PA., Jacob, T., Bucholz, KK. and Xian, H. (2011). Patterns of use, sequence of onsets and correlates of tobacco and cannabis. Addictive Behaviors. 36(12):1141-1147
- Kremen WS., Panizzon MS, Xian H, March DM, Franz CE, Grant MD, Toomey R, Lyons MJ. (Epub Date 8/29/2011). Genetic Architecture of Context Processing in Late Middle Age: More Than One Underlying Mechanism. Psychology and Aging. (2011), 26(4): 852-863
- Chan, AK.,Ilias-Khan, NA., Xian, H., Inman, Cindi. andMartin. WH. (Epub Date Aug 2011).Arm Exercise Stress Perfusion Imaging Predicts Clinical Outcome. Journal of Applied Physiology, 111(6):1546-1553
- Vasilopoulos, T, Kremen, WS, Kim, K, Panizzon, MS, Stein, PK, Xian, H, Grant, MD,Lyons MJ, Toomey, R, Eaves LJ, Franz, CE, Jacobson, KC (2012). (Epub Date 6/19/2011) Untreated Hypertension Decreases Heritability of Cognition in Late Middle Age. Behavior Genetics, 42(1):107-120
- Kremen, WS, Panizzon, MS, Neale, MC, Fennema-Notestine, C, Prom-Wormley, E, Eyler, LT, Stevens, A, Franz, CE, Lyons, MJ, Grant, MD, Jak, AJ, Jernigan, TL, Xian, H, Fischl, B, Thermenos, HW, Seidman, LJ, Tsuang, MT, Dale, AM (2012). Heritability of brain ventricle volume: converging evidence from inconsistent results. Neurobiology of aging, 33(1):1-8
- Panizzon, M.S., Hauger, RL., Eaves, LJ., Chen, CH., Dale, AM., Eyler, LT., Fischl, B., Fennema-Notestine, C., Franz, CE., Grant, MD., Jacobson, KC., Jak, AJ., Lyons, M.J., Mendoza, SP., Neale, MC., Prom-Wormley, E., Seidman, LJ., Tsuang, MT., Xian, H., and Kremen, W.S. (2012). Genetic Influences on Hippocampal Volume Differ as a Function of Testosterone Level in Middle-Aged Men. NeuroImage, 59(2):1123-1131
- Vasilopoulos, T, Franz, CE, Panizzon, MS, Xian, H, Grant, MD,Lyons MJ,Toomey, R, Jacobson, KC, Kremen, WS, Kim, K. (2012). Genetic Architecture of the Delis-Kaplan Executive Function System Trail Making Test: Evidence for Distinct Genetic Influences on Executive Function. Neuropsychology, 26(2):238-250
- Scherrer, JF., Xian, H., Pan, H., Pergadia, ML., Madden, PA., Grant, JD., Sartor, CE., Haber, JR., Jacob, T., Bucholz, KK.(2012). Parent, sibling and peer influences on smoking initiation, regular smoking and nicotine dependence. Results from a genetically informative design. Additive Behaviors, 37(3):240-247
- Scherrer, JF., Grant, JD., Agrawal, A., Madden, PA., Fu, Q., Jacob, T., Bucholz, KK. and Xian, H. (2012). Suicidal Behavior, Smoking and Familial Vulnerability. Nicotine & Tobacco Research, 14(4):415-424
- Panizzon, M., Fennema-Notestine, C., Kubarych, TS., Chen, C., Eyler, LT., Fischl, B., Franz, CE., Grant, MD., Hamza, S., Jak, A., Jernigan, TL., Lyons, MJ., Neale, MC., Prom-Wormley, E., Seidman, L., Tsuang, MT., Wu, H., Xian, H., Dale, AM., Kremen, WS. (2012). Genetic and Environmental Influences of White and Gray Matter Signal Contrast: A New Phenotype for Imaging Genetics? NeuroImage, 60(3):1686-1695
- Chen, LS, Saccone, NL, Culverhouse, RC, Bracci, PM. Chen, CH, Dueker, N, Han, Y, Huang, H, Jin, G, Kohno, T, Ma, JZ, Przybeck, TR, Sanders, AR, JA, Smith, Sung, YJ, Wenzlaff, AS, Wu, C, Yoon, D, Chen, YT, Cheng, YC, Cho, YS, David, SP, Duan, J, Eaton, B, Furberg, H, Goate, AM, Gu, D, Hansen, HM, Hartz, S, Hu, Z, Kim, YJ, Kittner, SJ, Levinson, DF, Mosley, TH, Payne, TJ, Rao, DC, Rice, JP, Rice, TK, Schwantes-An, TH, Shete, SS, Shi, J, Spitz, MR, Sun, YV, Tsai, FJ, Wang, JC, Wrensch, MR, Xian, H, Gejman, PV, He, Jiang, Hunt, SC, Kardia, SL, Li, MD, Lin, D, Mitchell, BD, Park, T, Schwartz, AG, Shen, H, Wiencke27, JK, Wu, JY, Yokota, J, Amos, CI, Bierut, LJ (2012). Smoking and Genetic Risk Variation across Populations of European, Asian, and African-American Ancestry - A Meta-analysis of Chromosome 15q25. Genetic Epidemiology, 36(4):340-351
- Jacobson, KC, Hoffman, CL, Vasilopoulos, T, Kremen, WS, Panizzon, MS, Grant, M, Lyons, MJ, Xian, H, & Franz, CE. (2012). Genetic and Environmental Influences on Individual Differences in Frequency of Play with Pets among Middle-Aged Men: A Behavioral Genetic Analysis. Anthrozoos, 25(4):441-456
- Chen, LS., Xian, H., Grucza, R.A., Saccone, N.L., Wang, J.C., Johnson, E.O., Breslau N., Hatsukami D., Bierut L.J. (2012).Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4nicotinic receptor genes. Drug and Alcohol Dependence, 123(Suppl. 1), S42–51. doi: 10.1016/j.drugalcdep.2012.01.014
- Day, TE, Ravi, N, Xian, H,Brugh, A (2013). An Agent-Based Modeling Template for a Cohort of Veterans with Diabetic Retinopathy. PLOS ONE, 8(6):e66812
- McCutcheon, V.V., Scherrer, J.F., Grant, J.D., Xian, H, Haber, JR, Jacob, T, Bucholz, KK (2013). Parent, Sibling and Peer Associations with Subtypes of Psychiatric and Substance Use Disorder Comorbidity in Offspring. Drug and Alcohol Dependence, 128:20-29
- Vasilopoulos, T, Grant, M.D., Franz, C.E., Panizzon, MS., Xian, H., Toomey, R., Lyons, M.J., Kremen, W.S., and Jacobson, K.C. (2013). Shared and Distinct Genetic Influences among Different Measures of Pulmonary Function. Behavior Genetics, 43:141-150
- Vuoksimaa, E., Panizzon, MS., Chen, C., Eyler, LT., Fennema, NC, Fiecas, M., Fischl, B., Franz, CE., Grant, MD., Jak, A., Lyons, MJ., Neale, MC., Thompson, WK., Tsuang, MT., Xian, H., Dale, AM., and Kremen, WS. (2013). Cognitive Reserve Moderates the Association Between Hippocampal Volume and Episodic Memory in Middle Age. Neuropsychologia, 51:1124-1131
- Panizzon, M., Hauger, R., Jacobson, KC., Eaves, LJ., York, TP., Prom-Wormley, E., Grant, MD., Lyons, MJ., McKenzie, R., Mendoza, SP., Xian, H., Franz, CE., Kremen, WS (2013). Genetic and Environmental Influences of Daily and Intra-individual Variation in Testosterone Levels in Middel-aged Men. Psychoneuroendocriinology (2013), 38(10):2163-2172
- Genderson,MR, Rana BK, Panizzon, MS, Grant, MD, Toomey R, Jacobson, KC, Xian, H, Cronin-Golomb, A, Franz, CE, Kremen, WS, Lyons, MJ (2013). Genetic and Environmental Influences on Sleep Quality in Middle-aged Men: a Twin Study. Journal of Sleep Research, 22:519-526
- Panizzon MS, Vuoksimaa E, Spoon KM, Jacobson KC, Lyons MJ, Franz CE, Xian H, Vasilopoulos T, &Kremen WS. Genetic and Environmental Influences of General Cognitive Ability: Is g a valid latent construct? (2014). Intelligence, 43:65-76
- Pittman, CB, Davis, LA, Zeringue, AL, Caplan, L, Scherrer, JF, Xian, H, Cunningham, FE, Mcdonald, JR, Arnold, A and Eisen S. (2014) Myocardial Infarction Risk Among Fracture Patients Receiving Bisphosphonates. Mayo Clinic Proceedings, 89(1):43-51
- Martin, WH, Xian, H, Wagner, D, Chandiramani, P, Bainter, E, Ilias-Khan, N. (2014) Arm Exercise as an Alternative to Pharmacologic Stress Testing. American Heart Journal, 167 (2):169-177
- Xian, H, Gonzalez, C, Deych, E, Farris, S, Ding, J, Shannon, W and McCall, WV (2014). Age-related Effects on Circadian Phase in the Sleep of Patients with Depression and Insomnia. Behavioral Sleep Medicine, 12:1-9
- Day TE, Ravi N, Xian H, Brugh A. (2014) Sensitivity of Diabetic Retinopathy Associated Vision Loss to Screening Interval in an Agent-Based/Discrete Event Simulation Model. Computers in Biology and Medicine,47:7-12
- Kremen, WS, Jak AJ, Panizzon MS, Spoon KM, Franz, CE, Thompson WK, Jacobson, KC, Vasilopoulos, T, Vuoksimaa, E, Xian, H, Toomey R, Lyons, MJ (2014). Early identification and heritability of mild cognitive impairment. International Journal of Epidemiology, 43(2):600-10. doi: 10.1093/ije/dyt242. Epub 2013 Dec 26
- Xian, H, Giddens, JL, Scherrer, JF, Eisen, SA, Potenza, MN (2014). Environmental Factor Selectively Impact Co-occurrence of Problem/Pathological Gambling with Specific Drug-Use Disorder in Male Twins. Addiction, 109(4):635-44. doi: 10.1111/add.12407. Epub 2014 Jan 12
- Kremen WS, Jak AJ, Panizzon MS, Spoon KM, Franz CE, Thompson WK, Jacobson KC, Vasilopoulos T, Vuoksimaa E, Xian H, Toomey R, Lyons MJ. Authors' response to: commentary by Johnson et al.Int J Epidemiol. 2014 Apr;43(2):612-3. doi: 10.1093/ije/dyu087. PubMed PMID: 24760875; PubMed Central PMCID: PMC3997381
- Kremen WS, Panizzon MS, Franz CE, Vuoksimaa E, Jacobson KC, Vasilopoulos T, Xian H, McCaffery JM, Rana BK, Toomey R, McKenzie R, Lyons MJ. Genetic Complexity of Episodic Memory: A Twin Approach to Studies of Aging(2014). Psychology and Aging, 29(2):404-417
- Rana BK, Dhamija A, Panizzon MS, Spoon KM, Vasilopoulos T, Franz CE, Grant MD, Jacobson KC, Kim K, Lyons MJ, McCaffery JM, Stein PK, Xian H, O’Connor DT, Kremen WS (2014). Imputing Observed Blood Pressure for Antihypertensive Treatment: Impact on Population and Genetic Analyses. American Journal of Hypertension, 27(6):828-837
- Panizzon, MS, Hauger, R, Xian, H, Vuoksimaa, E, Spoon, KM, Mendoza, SP, Jacobson, KC, Vasilopoulos, T, Rana, BK, McKenzie. R, McCaffery, JM, Lyons, MJ, Kremen, WS, and Franz, CE (2014). Interaction of APOE genotype and testosterone on episodic memory in middle-aged men. Neurobiology of Aging, 35(7):1778.e1-8. doi: 10.1016/j.neurobiolaging.2013.12.025. Epub 2013 Dec 27
- Munigala S, Kanwal F, Xian H, Scherrer JF, Agarwal B (2014). Increased Risk of Pancreatic Adenocarcinoma After Acute Pancreatitis. Clinical Gastroenterology and Hepatology, 12(7):1143-1150. Epub Jan. 16, 2014
- Munigala, S, Kanwal, F, Xian, H, and Agarwal, B (2014). New Diagnosis of Chronic Pancreatitis: Risk of Missing an Underlying Pancreatic Cancer. American Journal of Gastroenterology, 109(11):1824-1830
- Vasilopoulos, T, Kremen, WS., Grant, MD, Panizzon, MS., Xian, H, Toomey, R, Lyons, MJ, Jacobson, KC, and Franz, CE. (2015). Individual Differences in Cognitive Ability at Age 20 Predict Pulmonary Function 35 Years Later. Journal of Epidemiology & Community Health, 69(3):261-165
- Jak, A, Panizzon MS, Spoon KM, Fennema-Notestine, C, Franz CE, Thompson, WK, Jacobson KC, Xian, H, Eyler, L, Toomey, R, Lyons MJ, Neale, MC,Fischl, B, Tsuang, MT, Dale, AM, and Kremen WS (2015). Hippocampal Atrophy Varies by Neuropsychologically-Defined MCI among Men in Their 50s. American Journal of Geriatric Psychiatry,23(5):456-465
- Martin, WH, Xian, H, Wagner, D, Chandiramani, P, Bainter, E, Ilias-Khan, N (2015). Arm Exercise Myocardial Perfusion Imaging for Prognostication of Long Term Outcome. Medicine & Science in Sports & Exercise, 46(12): 2216-2223
- Franz CE, Lyons MJ, Spoon K, Hauger RL, Jacobson K, Lohr J, McKenzie R, Panizzon MS, Thompson W, Tsuang M, Vasilopoulos T, Vuoksimaa E, Xian H, Kremen WS (2015). Post-traumatic Stress Symptoms and Adult Attachment: A 24-year Longitudinal Study. American Journal of Geriatric Psychiatry, 22(12): 1603-1612
- Scherrer, JF, Xian, H, Slutske, WS, Eisen, SA, Potenza, MN (2015). Associations between Obsessive-Compulsive Classes and Pathological Gambling in a National Cohort of Male Twins. JAMA Psychiatry, 72(4): 342-349
- Zeng, X, Qian, Z. Vaughn, M, Xian, H, Elder, K, Rodemich, E, Bao, J, Jin, Y, Dong, G (2015). Human serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in Uyghurs from Sinkiang-Uighur Autonomous Region, China: background levels study. Environ SciPollutResInt, 22(6): 4736-4746
- Prom-Wormley E, Maes H, Schmitt JE, Panizzon MS, Xian H, Eyler LT, Franz CE, Lyons MJ, Tsuang MT, Dale AM, Fennema-Notestine C, Kremen WS, Neale MC (2015). Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use. Behav Genet, (online Feb 18, 2015). 45(2): 157-170
- Panizzon MS, Neale MC, Docherty A,Franz, CE, Jacobson KC, Toomey R, Xian H, Vasilopoulos T, Brinda R, McKenzie R, Lyons MJ, Kremen WS (2015). Genetic and Environmental Architecture of Changes in Episodic Memory from Middle to Late Middle Age. Psychology and Aging, 30(2): 286-300
- Yang T, Yu L, Jiang S, Feng X, Xian H, Cottrell RR, Rockett IRH (2015). Household Smoking Restrictions among Urban Residents in China: Individual and Regional Influences. Int J Public Health, DOI 10.1007/s00038-015-0672-2, 60(4):479-486
- Martin, WH, Xian, H, Wagner, D, Chandiramani, P, Bainter, E, Klein, AJP (2015).Cardiovascular mortality prediction in veterans with arm exercise versus pharmacologic myocardial perfusion imaging. American Heart Journal, 170(2):362-370
- Panizzon MS, Sailors M, Hauger RL, Lyons MJ,Jacobson KC, Murray RE, Rana B, Vasilopoulos T, Vuoksiamaa E, Xian H, Kremen WS, Franz, CE (In Press).A New Look at the Genetic and Environmental Coherence of Metabolic Syndrome Components.Obesity
- Xie Y, Bowe B, Xian H, Balasubramanlan S, Al-Aly Z (In Press). Rate of Kidney Function Decline and Risk of Hospitalizations. Clin J. of the American Society of Nephrology