Publications

  1. Hara H, Ohdan H, Mizunuma K, Zhou W, Tanaka Y, Fudaba Y, Tashiro H, Asahara T. The role of mouse stroma in rat haematopoiesis in xenogeneic rat/mouse bone marrow transplantation chimeras. Transplant Proc. 2002 ;34:2759.
  2. Zhou W, Ohdan H, Tanaka Y, Hara H, Tokita D, Onoe T, Asahara T. NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant. Transpl Immunol. 2003;12:9-18.
  3. Ohdan H, Mizunuma K, Tashiro H, Tokita D, Hara H, Onoe T, Ishiyama K, Shibata S, Mitsuta H, Ochi M, Nakahara H, Itamoto T, Asahara T. Intraoperative near-infrared spectroscopy for evaluating hepatic venous outflow in living-donor right lobe liver. Transplantation. 2003;76:791-797.
  4. Hara H, Ohdan H, Tokita D, Onoe T, Zhou W, Asahara T. Construction of ectopic xenogeneic bone marrow structure associated with persistent multi-lineage mixed chimerism by engraftment of rat bone marrow plugs into mouse kidney capsules. Xenotransplantation. 2003;10:259-266.
  5. Onoe T, Ohdan H, Ochi M, Tanaka Y, Tokita D, Hara H, Mizunuma K, Zhou W, Tashiro H, Asahara T. Multiparameter flow cytometric mixed lymphocyte reaction assay using fluorescent cytoplasmic dye for assessing phenotypic property of T cells responding to allogeneic stimulation. Transplant Proc. 2003;35:557-558.
  6. Tanaka Y, Ohdan H, Zhou W, Onoe T, Hara H, Tokita D, Mizunuma K, Tashiro H, Asahara T. Enzyme-linked immunospot assay for detecting cells secreting antibodies against human blood group A epitopes. Transplant Proc. 2003;35:555-556.
  7. Hara H, Ohdan H, Zhou W, Tanaka Y, Tokita D, Onoe T, Mizunuma K, Ochi M, Tashiro H, Asahara T. Limited engraftment capacity of bone marrow-derived mesenchymal cells in xenogeneic bone marrow transplantation. Transplant Proc. 2003;35:504-505.
  8. Tashiro H, Itamoto T, Ohdan H, Arihiro K, Tateaki Y, Nakahara H, Ochi M, Hino H, Mizunuma K, Hara H, Tokita D, Onoe T, Ishiyama K, Mitsuta H, Sugino K, Asahara T. Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation. Transpl Int. 2004;17:626-633.
  9. Hara H, Ohdan H, Tashiro H, Itamoto T, Tanaka Y, Mizunuma K, Tokita D, Onoe T, Ito R, Asahara T. Differential diagnosis between graft-versus-host disease and hemophagocytic syndrome after living-related liver transplantation by mixed lymphocyte reaction assay. J Invest Surg. 2004;17:197-202.
  10. Marubayashi SM, Tashiro H, Ohdan H, Tokita D, Hara H, Onoe T, Kitayama T, Hayamizu K, Asahara T, Doi S, Okumoto S, Taniguchi Y, Fukuda Y, Dohi K. Studies on eleven kidney transplants from non-heart-beating donors. Hiroshima J Med Sci. 2004 ;53:7-11.
  11. Ochi M, Ohdan H, Mitsuta H, Onoe T, Tokita D, Hara H, Ishiyama K, Zhou W, Tanaka Y, Asahara T. Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice. Hepatology. 2004;39:1321-1331.
  12. Onoe T, Ohdan H, Tokita D, Shishida M, Tanaka Y, Hara H, Zhou W, Ishiyama K, Mitsuta H, Ide K, Asahara T. Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. J Immunol. 2005;175:139-146.
  13. Tashiro H, Ohdan H, Itamoto T, Ishifuro M, Hara H, Tokita D, Onoe T, Ishiyama K, Mitsuta H, Ide K, Ogawa T, Asahara T. Vascular closure staples for portal vein reconstruction in living-donor liver transplantation. Am J Surg. 2005;190:65-68.
  14. Ide K, Ohdan H, Kobayashi T, Hara H, Ishiyama K, Asahara T. Antibody- and complement-independent phagocytotic and cytolytic activities of human macrophages toward porcine cells. Xenotransplantation. 2005;12:181-188.
  15. Tokita D, Ohdan H, Onoe T, Hara H, Tanaka Y, Asahara T. Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes. Transpl Int. 2005;18:237-245.
  16. Onoe T, Ohdan H, Tokita D, Hara H, Tanaka Y, Ishiyama K, Asahara T. Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers. Transpl Int. 2005;18:206-214.
  17. Rood PP, Hara H, Ezzelarab M, Busch J, Zhu X, Ibrahim Z, Ball S, Ayares D, Awwad M, Cooper DK. Preformed antibodies to alpha1,3-galactosyltransferase gene-knockout (GT-KO) pig cells in humans, baboons, and monkeys: implications for xenotransplantation. Transplant Proc. 2005;37:3514-3515.
  18. Rood PP#, Hara H#, Busch JL#, Ezzelarab M#, Zhu X, Ball S, Ayares D, Awwad M, Cooper DK. Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models. Transpl Int. 2006;19:158-165. (#contributed equally)
  19. Hara H, Ezzelarab M, Rood PP, Lin YJ, Busch J, Ibrahim Z, Zhu X, Ball S, Ayares D, Zeevi A, Awwad M, Cooper DK. Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans. Xenotransplantation. 2006;13(4):357-365.
  20. Ezzelarab M#, Hara H#, Busch J#, Rood PP#, Zhu X, Ibrahim Z, Ball S, Ayares D, Awwad M, Cooper DK. Antibodies directed to pig non-Gal antigens in naive and sensitized baboons. Xenotransplantation. 2006;13:400-407. (#contributed equally)
  21. Rood PPM, Bottino R, Balamarugan A.N, Smentanka C, Exxelarab M, Busch J, Hara H, Trucco M, Cooper DKC. Safe induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: efficacy, side effects, and early responses. Pancreas 2006; 33:287-292.
  22. Tokita D, Shishida M, Ohdan H, Onoe T, Hara H, Tanaka Y, Ishiyama K, Mitsuta H, Ide K, Arihiro K, Asahara T. Liver Sinusoidal Endothelial Cells That Endocytose Allogeneic Cells Suppress T Cells with Indirect Allospecificity. J Immunol. 2006; 177:3615-3624.
  23. Tai, H-C, Ezzelarab, M, Hara H, Ayares, D., Cooper, D.K.C. Progress in xenotransplantation following the introduction of gene-knockout technology. Transpl Int. 2007; 20:107-117.
  24. Tai HC, Zhu X, Hara H, Lin YJ, Ezzelarab M, Long C, Ball S, Ayares D, Cooper DK. The pig-to-primate immune response: relevance for xenotransplantation. Xenotransplantation. 2007;14:227-235.
  25. Rood PP, Tai HC, Hara H, Long C, Ezzelarab M, Lin YJ, van der Windt DJ, Busch J, Ayares D, Ijzermans JN, Wolf RF, Manji R, Bailey L, Cooper DK. Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants. Transpl Int. 2007;20:1050-1058
  26. Cooper DK, Ezzelarab M, Hara H, Ayares D. Recent advances in pig-to-human organ and cell transplantation. Expert Opin Biol Ther. 2008;8:1-4.
  27. Casu A, Bottino R, Balamurugan AN, Hara H, van der Windt DJ, Campanile N, Smetanka C, Cooper DK, Trucco M. Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice. Diabetologia. 2008;51:120-129.
  28. Hara H, Lin YJ, Zhu X, Tai HC, Ezzelarab M, Balamarugan AN, Bottino R, Houser SL, Cooper DK. Safe induction of diabetes by high-dose streptozotocin in pigs. Pancreas. 2008;36:31-38.
  29. Hara H, Gridelli B, Lin YJ, Marcos A, Cooper DK. Liver xenografts for the treatment of acute liver failure: Clinical and experimental experience and remaining immunologic barriers. Liver Transpl. 2008; 14:425-434.
  30. Ezzelarab M, Welchons D, Torres C, Hara H, Long C, Yeh P, Ayares D, Cooper DK. Atorvastatin down-regulates the primate cellular response to porcine aortic endothelial cells in vitro. Transplantation. 2008. 86:733-737.
  31. Hara H*, Long C, Lin YJ, Tai HC, Ezzelarab M, Ayares D, Cooper DK. In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transpl Int. 2008. 21:1163-1174. (* corresponding author)
  32. Lin YJ, Hara H*, Tai H-C, Long C, Tokita D, Yeh P, Ayares D, Morelli AE, Cooper DKC. Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses. Transplantation. 2008. 86:1452-1462. (* corresponding author)
  33. Ezzelarab M, Garcia B, Azimzadeh A, Sun H, Lin CC, Hara H, Kelishadi S, Zhang T, Lin YJ, Tai HC, Wagner R, Thacker J, Murase N, McCurry K, Barth RN, Ayares D, Pierson RN 3rd, Cooper DK. The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation. 2009;87:805-812.
  34. Long C#, Hara H*, #, Pawlikowski Z, Koike N, d’Arville T, Yeh P, Ezzelarab M, Ayares D, Yazer M, Cooper DKC. Genetically-engineered pig red blood cells for clinical transfusion: initial in vitro studies Transfusion. 2009;49:2418-2429. (* corresponding author, #contributed equally)
  35. Daly K, Stewart-Akers A, Hara H, Ezzelarab M, Long C, Cordero K, Johnson S, Ayares D, Cooper D, Badylak SF.Effect of the alphaGal Epitope on the Response to Small Intestinal Submucosa Extracellular Matrix in a Nonhuman Primate Model. Tissue Eng Part A. 2009;15:3877-3888.
  36. Echeverri GJ, McGrath K, Bottino R, Hara H, Dons EM, van der Windt DJ, Ekser B, Casu A, Houser S, Ezzelarab M, Wagner R, Trucco M, Lakkis FG, Cooper DK. Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs. Am J Transplant. 2009;9:2485-2496.
  37. van der Windt DJ, Bottino R, Casu A, Campanile N, Smetanka C, He J, Murase N, Hara H, Ball S, Loveland BE, Ayares D, Lakkis FG, Cooper DK, Trucco M. Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant. 2009;9:2716-2726.
  38. Ekser B, Long C, Echeverri GJ, Hara H, Ezzelarab M, Lin CC, de Vera ME, Wagner R, Klein E, Wolf RF, Ayares D, Cooper DK, Gridelli B. Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: Clinical relevance. Am J Transplant. 2010;10:273-285.
  39. Lin CC, Ezzelarab M, Shapiro R, Ekser B, Long C, Hara H, Echeverri G, Torres C, Watanabe H, Ayares D, Dorling A, Cooper DKC. Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation. Am J Transplant. 2010;10:1556-1568.
  40. Yeh P, Ezzelarab M, Bovin N, Hara H, Long C, Tomiyama K, Sun F, Ayares D, Awwad M, Cooper DKC. Investigation of potential carbohydrate antigen targets for human and baboon antibodies. Xenotransplantation. 2010;17:197-206.
  41. Cooper DKC, Hara H, Yazer M. Genetically-engineered pigs as a source for clinical red blood cell transfusion. Clin Lab Med. 2010;30:365-380.
  42. Lin CC, Ezzelarab M, Hara H, Lin CW, Dorling A, Cooper DKC. Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells. J Thromb Haemost. 2010; 8:2001-2010.
  43. Ekser B, Echeverri GJ, Cortese Hassett A, Yazer MH, Long C, Meyer M, Ezzelarab M,Lin CC, Hara H, van der Windt DJ, Dons EM, Phelps C, Ayares D, Cooper DKC, Gridelli B. Hepatic function after genetically-engineered pig liver transplantation in baboons. Transplantation. 2010; 15:483-493.
  44. Hara H*, Campanile N, Tai H-C, Long C, Ekser B, Yeh P, Ezzelarab M, Ayares D, Yazer M, Cooper DKC. An in vitro model of pig liver transplantation – pig complement is associated with reduced lysis of wild-type and genetically-modified pig cells. Xenotransplantation. 2010;17:370-378. (* corresponding author)
  45. Hara H*, Cooper DKC. The immunology of corneal xenotransplantation: a review of the literature. Xenotransplantation. 2010;17:338-349. (* corresponding author)
  46. Hara H*, Cooper DKC. Xenotransplantation - The future of corneal transplantation? Cornea. 2011;30:371-378. (* corresponding author)
  47. Hara H*, Koike N, Long C, Piluex J, Roh DS, SundarRaj N, Funderburgh JL, Mizuguchi Y, Isse K, Phelps C, Ball S, Ayares D, Cooper DKC. Initial in vitro investigation of the human immune response to corneal cells from genetically-modified pigs. Invest Ophthalmol Vis Sci. 2011;52:5278-5286. (* corresponding author)
  48. Ezzelarab M, Ezzelarab C, Wilhite T, Kumar G, Hara H, Ayares D, Cooper DK. Genetically-modified pig mesenchymal stromal cells: xenoantigenicity and effect on human T-cell xenoresponses. Xenotransplantation. 2011;18:183-195.        
  49. Koshika T, Phelps C, Fang J, Lee SE, Fujita M, Ayares D, Cooper DKC, Hara H*. Relative efficiency of porcine and human CTLA4-Ig in inhibiting human CD4+T cell responses costimulated by porcine and human B7 molecules. Immunology. 2011; 134:386-397. (* corresponding author)
  50. Tai HC, Zhu X, Lin YJ, Hara H, Ezzelarab M, Epperley M, Quader MA, Cooper DKC Attempted depletion of passenger leukocytes by irradiation in pigs. J Transplant. 2011;2011:928759.
  51. Ekser B, Ezzelarab M, Hara H, van der Windt DJ, Wijkstrom M, Bottino R, Trucco M, Cooper DK. Clinical xenotransplantation: the next medical revolution? Lancet. 2012; 379(9816):672-683.
  52. Ekser B, Klein E, He J, Stolz DB, Echeverri GJ, Long C, Lin CC, Ezzelarab M, Hara H, Veroux M, Ayares D, Cooper DK, Gridelli B. Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs. PLoS One. 2012;7:e29720.
  53. Kumar G, Hara H, Long C, Shaikh H, Ayares D, Cooper DKC, Ezzelarab M. Adipose-derived mesenchymal stem cells from genetically-modified pigs - immunogenicity and immune modulatory properties. Cytotherapy. 2012;14:494-504.
  54. Wilhite T, Ezzelarab C, Hara H, Long C, Ayares D, Cooper DK, Ezzelarab M. The effect of Gal expression on pig cells on the human T-cell xenoresponse. Xenotransplantation. 2012;19:56-63.
  55. Dons EM, Montoya C, Long CE, Hara H, Echeverri GJ, Ekser B, Ezzelarab C, Medellin DR, van der Windt DJ, Murase N, Rigatti LH, Wagner R, Wolf RF, Ezzelarab M, West LJ, Ijzermans JN, Cooper DK. T-cell-based immunosuppressive therapy inhibits the development of natural antibodies in infant baboons. Transplantation. 2012;93:769-776.
  56. Ekser B, Lin CC, Long C, Echeverri GJ, Hara H, Ezzelarab M, Bogdanov VY, Stolz DB, Enjyoji K, Robson SC, Ayares D, Dorling A, Cooper DK, Gridelli B. Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation. Transpl Int. 2012 25:882-889.
  57. Cooper DK, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, Tector AJ, Phelps C, Azimzadeh AM, Ayares D, Robson SC, Pierson RN 3rd. Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation. 2012;19:144-158. [Review].
  58. Ezzelarab MB, Ekser B, Echeverri G, Hara H, Ezzelarab C, Long C, Bajona P, Garcia B, Murase N, Ayares D, Cooper DK. Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates. Xenotransplantation. 2012;19:221-232.
  59. Fang J, Walters A, Hara H, Long C, Yeh P, Ayares D, Cooper DK, Bianchi J. Anti-gal antibodies in α1,3-galactosyltransferase gene-knockout pigs. Xenotransplantation. 2012;19:305-310.
  60. van der Windt DJ, Bottino R, Kumar G, Wijkstrom M, Hara H, Ezzelarab M, Ekser B, Phelps C, Murase N, Casu A, Ayares D, Lakkis FG, Trucco M, Cooper DK. Clinical islet xenotransplantation: how close are we? Diabetes. 2012;61:3046-3055.
  61. Fujita M, Mehra R, Lee SE, Roh DS, Long C, Funderburgh JL, Ayares DL, Cooper DK, Hara H*. Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells. Ophthalmic Res. 2012;49:127-138. (* corresponding author)
  62. Fujita M, McGrath K, Dons E, Kumar G, Echeverri GJ, Bottino R, Hata J, Haruma K, Cooper DKC, Hara H*. Technique of endoscopic biopsy of islet allografts transplanted into the gastric submucosal space in pigs. Cell Transplant. 2013;22:2335-2344. (* corresponding author)
  63. Hara H*, Witt W, Crossley T, Long C, Isse K, Fan L, Phelps CJ, Ayares D, Cooper DK, Dai Y, Starzl TE. Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status. Immunology. 2013; 140:39-46. (* corresponding author)
  64. Satyananda V, Hara H, Ezzelarab M, Phelps C, Ayares D, Cooper DKC. New concepts of immune modulation in xenotransplantation. Transplantation; 2013;96:937-945.
  65. Cooper DK, Hara H, Ezzelarab M, Bottino R, Trucco M, Phelps C, Ayares D, Dai Y. The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation. J Biomed Res. 2013;27:249-253.
  66. Kumar G, Satyananda V, Fang J, Zhou H, Fujita M, Ekser B, Long C, Dons E, Sun Q, Ayares D, Hara H, Cooper DKC. Is there a correlation between anti-pig antibody levels in humans and geographic location during childhood? Transplantation. 2013;96:387-393.
  67. Hara H, Bentall A, Long C, Fang J, Andreyev O, Lunz J, Ezzelarab M, Abu-Elmagd KM, Shapiro R, Ayares D, Stegall M, Cooper DKC. Minimal effect of bortezomib in reducing anti-pig antibodies in human leukocyte antigen-sensitized patients: a pilot study. Xenotransplantation. 2013;20:429-437.
  68. Nagaraju S, Bottino R, Wijkstrom M, Hara H, Trucco M, Cooper DK. Islet xenotransplantation from genetically engineered pigs. Curr Opin Organ Transplant. 2013;18:695-702.
  69. Lee SE, Mehra R, Fujita M, Roh DS, Long C, Funderburgh JL, Ayares D, Cooper DKC, Hara H*. Characterization of porcine corneal endothelium for xenotransplantation. Semin Ophthalmol. 2014;29:127-135 (* corresponding author).
  70. Iwase H, Ekser B, Hara H, Phelps C, Ayares D, Cooper DK, Ezzelarab MB. Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition. Xenotransplantation. 2014: 21: 72–83.
  71. Lamm V, Hara H, Mammen A, Dhaliwal D, Cooper DK. Corneal blindness and xenotransplantation. Xenotransplantation. 2014: 21: 99–114.
  72. Cohen D, Miyagawa Y, Mehra R, Lee W, Isse K, Long C, Ayares D, Cooper DKC, Hara H*. Distribution of nonGal antigens in the pig cornea: relevance to corneal xenotransplantation. Cornea. 2014;33:390-397. (* corresponding author)
  73. Zhou H, Iwase H, Wolf RF, Ekser B, Ezzelarab M, Hara H, White G, Cooper DK. Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models? Xenotransplantation. 2014:21:287-290.
  74. Lee W, Miyagawa Y, Long C, Cooper DK, Hara H*. A comparison of three methods of decellularization of pig corneas to reduce immunogenicity. Int J Ophthalmol. 2014:7:587-593. (* corresponding author)
  75. Cooper DK, Satyananda V, Ekser B, van der Windt DJ, Hara H, Ezzelarab MB, Schuurman HJ. Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature. Xenotransplantation. 2014;21:397-419.
  76. Kim MK, Choi HJ, Kwon I, Pierson RN 3rd, Cooper DK, Soulillou JP, O'Connell PJ, Vabres B, Maeda N, Hara H, Scobie L, Gianello P, Takeuchi Y, Yamada K, Hwang ES, Kim SJ, Park CG. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation. Xenotransplantation. 2014;21:420-430.
  77. Bottino R, Wijkstrom M, van der Windt DJ, Hara H, Ezzelarab M, Murase N, Bertera S, He J, Phelps C, Ayares D, Cooper DK, Trucco M. Pig-to-monkey islet xenotransplantation using multi-transgenic pigs. Am J Transplant. 2014;14:2275-2287.
  78. Bottino R, Nagaraju S, Satyananda V, Hara H, Wijkstrom M, Trucco M, Cooper DKC. Potential for clinical pancreatic islet xenotransplantation. Transplant Research and Risk Management. 2014:6 1–8.
  79. Hara H, Lin YJ, Tai HC, Ezzelarab M, Quader MA, Houser SL, Nakao A, Cooper DK. Hematopoietic chimerism following allotransplantation of the spleen, splenocytes or kidney in pigs. Transpl Immunol. 2014;31:125-133.
  80. Ezzelarab MB, Ekser B, Azimzadeh A, Lin CC, Zhao Y, Rodriguez R, Echeverri GJ, Iwase H, Long C, Hara H, Ayares D, Pierson RN, Thomson AW, Cooper DK. Systemic inflammation in xenograft recipients precedes activation of coagulation. Xenotransplantation. 2015;22:32-47.
  81. Wijkstrom M, Bottino R, Iwase H, Hara H, Ekser B, van der Windt D, Long C, Toledo FG, Phelps CJ, Trucco M, Cooper DK, Ayares D. Glucose metabolism in pigs expressing human genes under an insulin promoter. Xenotransplantation. 2015;22:70-79.
  82. Iwase H, Ekser B, Satyananda V, Zhou H, Hara H, Bajona P, Wijkstrom M, Bhama JK, Long C, Veroux M, Wang Y, Dai Y, Phelps C, Ayares D, Ezzelarab MB, Cooper DK. Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs. Transpl Immunol. 2015; 32:99-108.
  83. Lee W, Miyagawa Y, Long C, Zhang M, Cooper DKC, Hara H*. Effect of Rho kinase inhibitor, Y-27632, on porcine corneal endothelial cells culture, and anti-inflammation and immune regulation. Ocul Immunol Inflamm. 2015 (in press) (* corresponding author)
  84. Lee W, Hara H*, Cooper DK, Manji RA. Expression of NeuGc on pig heart valves. Xenotransplantation. 2015;22:153-154. (* corresponding author)
  85. Iwase H, Ekser B, Satyananda V, Bhama J, Hara H, Ezzelarab M, Klein E, Wagner R, Long C, Thacker J, Li J, Zhou H, Jiang M, Nagaraju S, Zhou H, Veroux M, Bajona P, Wijkstrom M, Wang Y, Phelps C, Klymiuk N, Wolf E, Ayares D, Cooper DK. Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens. Xenotransplantation. 2015;22:211-20
  86. Iwase H, Liu H, Wijkstrom M, Zhou H, Singh J, Hara H, Ezzelarab M, Long C, Klein E, Wagner R, Phelps C, Ayares D, Shapiro R, Humar A, Cooper DK. Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date. Xenotransplantation. 2015 ;22:302-9.
  87. Nagaraju S, Bertera S, Tanaka T, Hara H, Rayat GR, Wijkstrom M, Ayares D, Trucco M, Cooper DK, Bottino R. In vitro exposure of pig neonatal isletlike cell clusters to human blood. Xenotransplantation. 2015;22:317-24.
  88. Iwase H, Ekser B, Zhou H, Liu H, Satyananda V, Humar R, Humar P, Hara H, Long C, Bhama JK, Bajona P, Wang Y, Wijkstrom M, Ayares D, Ezzelarab MB, Cooper DK. Further evidence for sustained systemic inflammation in xenograft recipients (SIXR). Xenotransplantation. 2015;22:399-405.
  89. Manji RA, Hara H, Cooper DK. Characterization of the cellular infiltrate in bioprosthetic heart valves explanted from patients with structural valve deterioration. Xenotransplantation. 2015;22:406-7.
  90. Lee W, Miyagawa Y, Long C, Ekser B, Walters E, Ayares D, Tector AJ, Cooper DKC, Hara H*. Expression of NeuGc on pig corneas and its potential significance in pig corneal xenotransplantaion. Cornea. 2015.

 

 

 

 

 

 

 

 

Hidetaka Hara

Research Assistant Professor

 

 

  • : 412-624-6699     
  • : 412-624-1172     
    • DEPARTMENTThomas E. Starzl Transplantation
      Institute University of Pittsburgh
    • COUNTRY USA