Publications

Peer Reviewed Original Publications (articles with 50 or more citations are indicated):

  • Slotkoff L, Logan A, Jose P, D'Avella J, Eisner G. Microsphere measurement of intrarenal circulation of the dog. Circ Res 28: 158-166, 1971.
  • Jose P, Eisner G, Hollerman C, Calcagno P. Acute renal effects of amphotericin B. Proc Soc Exp Biol Med 137: 224-228, 1971.
  • Jose PA, Logan A, Slotkoff L, Lilienfield L, Calcagno P, Eisner G. Intrarenal blood flow distribution in canine puppies. Pediatr Res 5: 337-344, 1971. (83 citations)
  • Logan A, Jose P, Eisner G, Lilienfield L, Slotkoff L. Intracortical distribution of blood flow in hemorrhagic shock in dogs. Circ Res 29: 257-266, 1971.
  • Quang LS, Jose P, Slotkoff L, Eisner G, Lilienfield L. Intrarenal blood flow distribution in chronic salt depletion and excess salt ingestion. Acta Med Viet 25-26: 69-81, 1972.
  • Quang LS, Jose P, Slotkoff L, Eisner G, Lilienfield L. The possible role of the autonomic nervous system in the redistribution of intrarenal blood flow in hemorrhagic hypotension. Acta Med Viet 25-26: 105-118, 1972.
  • Jose P, Slotkoff L, Lilienfield L, Calcagno P, Eisner G. Sensitivity of the neonatal renal vasculature to epinephrine.  Am J Physiol 226: 796-799, 1974.
  • Jose PA, Slotkoff LM, Montgomery SB, Calcagno PL, Eisner GM. Autoregulation of renal blood flow in the puppy. Am J Physiol 229: 983-988, 1975.
  • Barakat A, D'Albora J, Martin M, Jose P. Familial nephrosis, nerve deafness, and hypoparathyroidism. J Pediatr 91: 61-64, 1977. (50 citations)
  • Bender JW, Davitt MK, Slotkoff LM, Jose P. Angiotensin-I-converting enzyme activity in term and preterm infants. Biol Neonate 34: 19-23, 1978.
  • Harkavy KL, Scanlon JW, Jose P. The effects of theophylline on renal function in the premature newborn. Biol Neonate 35: 126-130, 1979.
  • Montgomery S, Jose P, Spiro P, Slotkoff L, Eisner G. Regional differences in the binding affinities of beta adrenergic receptors in the canine kidney cortex. Proc Exp Biol Med 162: 260-262, 1979.
  • Tavani N, Calcagno P. Zimmet S, Flamenbaum W, Eisner G, Jose P. Ontogeny of single nephron filtration distribution in canine puppies. Pediatr Res 14: 799-802, 1980.
  • Montgomery SB, Jose PA, Slotkoff LM, Lilienfield LS, Eisner GM. The regulation of intrarenal blood flow in the dog during ischemia. Circ Shock 7: 71-82, 1980.
  • Papadopoulou ZL, Tina LU, Sandler P, Jose PA, Calcagno PL. Hyperlipidemia in children with chronic renal insufficiency. Pediatr Res 15: 887-891, 1980.
  • Papadopoulou ZL, Helfrich GB, Turner ME, Shahinfar S, Currier CB, Jose PA, Calcagno PL. Recurrence of focal segmental glomerulosclerosis in children following renal transplantation. Trans Am Soc Artif Intern Organs 27: 325-328, 1981.
  • Tina LU, Jenis EM, Medani CR, Papadopoulou ZL, Jose PA, Calcagno PL. The glomerular basement membrane in benign familial hematuria. Clin Nephrol 17: 1-4, 1982.
  • Montgomery SB, Jose PA, Eisner GM. The role of anesthesia and catecholamines in the renal response to mild hemorrhage. Circ Shock 9: 434-444, 1982.
  • Felder RA, Calcagno PL, Eisner GM, Jose PA. Ontogeny of myocardial adrenoceptors II. Alpha adrenoceptors.. Pediatr Res 16: 340-342, 1982.
  • Grylack L, Medani C, Hultzen C, Sivasubramanian K, Davitt M, Jose P, Scanlon J. Non-oliguric acute renal failure. Am J Dis Child 136: 518-520, 1982.
  • Wargo AA, Slotkoff LM, Jose PA, Pelayo JC, Eisner GM. Cyclic nucleotide response to stimulation in isolated glomeruli from dog kidney. Nephron 32: 165-169, 1982.
  • Papadopoulou ZL, Jenis EH, Novello AC, Tina LU, Jose PA, Calcagno PL. Chronic relapsing minimal change nephrotic syndrome with or without mesangial deposits: long term follow-up. Int J Pediatr Nephrol 3: 179-186, 1982.
  • Pelayo JC, Ziegler MG, Jose PA, Blantz RC. Renal denervation in the rat: analysis of glomerular and proximal tubular function. Am J Physiol 244 (Renal Fluid Electrolyte Physiol 13): F70-F77, 1983. (79 citations)
  • Felder RA, Pelayo JC, Calcagno PL, Eisner GM, Jose PA. Alpha adrenoceptors in the developing kidney. Pediatr Res 17: 177-180, 1983.
  • Fildes R, Solhaug M, Eisner GM, Tavani N, Calcagno PL, Jose PA. Enhancement of sodium excretion by substance P during saline loading in the canine puppy. Pediatr Res 17: 737-741, 1983.
  • Pelayo JC, Fildes RD, Eisner GM, Jose PA. Effects of dopamine blockade on renal sodium excretion. Am J Physiol 245 (Renal Fluid Electrolyte Physiol 14): F247-F253, 1983. (127 citations)
  • Pelayo JC, Andrews PM, Coffey AK, Calcagno PL, Eisner GM, Jose PA. The influence of age on acute renal toxicity of uranyl nitrate in the dog. Pediatr Res 17: 985-992, 1983.
  • Pelayo JC, Fildes RD, Jose PA. Age-dependent renal effects of intrarenal dopamine infusion. Am J Physiol 247 (Regulatory Integrative Comp Physiol 16): R212-R216, 1984.
  • Felder RA, Blecher M, Eisner GM, Jose PA. Cortical tubular and glomerular dopamine receptors in the rat kidney. Am J Physiol 246 (Renal Fluid Electrolyte Physiol 15): F557-F568, 1984. (155 citations)
  • Felder RA, Blecher M, Calcagno PL, Jose PA. Dopamine receptors in the proximal tubule of the rabbit.  Am J Physiol 247 (Renal Fluid Electrolyte Physiol 16): F499-F505, 1984. (121citations)
  • Fildes RD, Eisner GM, Calcagno PL, Jose PA. Renal alpha-adrenoceptors and sodium excretion in the dog. Am J Physiol 248 (Renal Fluid Electrolyte Physiol 17): F128-F133, 1985.
  • Jose PA, Felder RA, Holloway RR, Eisner GM. Dopamine receptors modulate sodium excretion in denervated kidney.  Am J Physiol 250 (Renal Fluid Electrolyte Physiol 19): F1033-F1038, 1985. (52 citations)
  • Fildes RD, Eisner GM, Calcagno PL, Jose PA. Renal alpha-adrenoceptors and excretion. (Letter to the Editor). Am J Physiol 250 (Renal Fluid Electrolyte Physiol 19): F950-F951, 1985.
  • Felder CC, Robillard JE, Roy S, Jose PA. Severe chloride deficiency in the neonate: the canine puppy as an animal model. Pediatr Res 21: 497-501, 1987.
  • Nakamura KT, Felder RA, Jose PA, Robillard JE. Effects of dopamine in the renal vascular bed of fetal, newborn and adult sheep. Am J Physiol (Regulatory Integrative Comp Physiol 21): R490-R497, 1987.
  • Dimartino-Nardi J, Stoner E, Martin K, Balfe JW, Jose PA, New MI. New findings in apparent mineralocorticoid excess. Clin Endocrinol 27: 49-62, 1987. (55 citations)
  • Jose PA, Eisner GM, Robillard JE. Renal hemodynamics and natriuresis induced by dopamine-1 agonist, SKF 82526. Am J Med Sci 294: 181-186, 1987.
  • Nakamura KT, Matherne GP, Jose PA, Alden BM, Robillard JE. Ontogeny of renal b-adrenoceptor-mediated vasodilation in sheep: comparison between endogenous catecholamines. Pediatr Res 22: 465-470, 1987.
  • Jose PA, Holloway RR, Campbell TW, Eisner GM. Dopamine blockade attenuates the natriuresis of saline loading in the adrenalectomized rat. Nephron 48: 54-57, 1988.
  • Nakamura KT, Matherne GP, Jose PA, Alden BM, Robillard JE. Effects of epinephrine on the renal vascular bed of fetal, newborn and adult sheep. Pediatr Res 23: 181-186, 1988.
  • Felder RA, Nakamura KT, Robillard JE, Kanadjian M, Jose PA. Dopamine receptors in the developing sheep kidney. Pediatr Nephrol 2: 156-162, 1988.
  • Felder RA, Jose PA. Dopamine-1 receptors in the rat kidney identified with 125I-Sch 23982. Am J Physiol 255(Renal Fluid Electrolyte Physiol 24): F970-F976, 1988. (56 citations)
  • Nakamura KT, Alden BM, Matherne GP, Jose PA, Robillard JE. Ontogeny of renal hemodynamic response to terbutaline and forskolin in sheep. J Pharmacol Exp Ther 247: 453-459, 1988.
  • Felder CC, Jose PA, Axelrod J. The dopamine-1 agonist, SKF 82526, stimulates phospholipase C activity independent of adenylate cyclase. J Pharmacol Exp Ther 248: 171-175, 1989. (158 citations)
  • Felder CC, Blecher BM, Jose PA. Dopamine-1 mediated stimulation of phospholipase C activity in rat renal cortical membranes.  J Biol Chem 264: 8739-8745, 1989. (135 citations)
  • Felder CC, McKelvey AM, Gitler MS, Eisner GM, Jose PA. Dopamine receptor subtypes in renal brush border and basolateral membranes. Kidney Int 36: 183-193, 1989. (112 citations)
  • Felder RA, Seikaly MG, Cody P, Eisner GM, Jose PA. Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats. Hypertension 15: 560-569, 1990. (95 citations)
  • Felder CC, McKelvey AM, Nakamura KT, Robillard JE, Jose PA. Ontogeny of renal b adrenoceptors. Pediatr Nephrol 4: 635-639, 1990.
  • Felder CC, Campbell T, Albrecht F, Jose PA. Dopamine inhibits Na+/H+ exchanger activity in renal brush border membrane vesicles by stimulation of adenylate cyclase. Am J Physiol 259 (Renal Fluid Electrolyte Physiol 28): F297-F303, 1990. (239 citations)
  • Kaneko S, Eisner GM, Jose PA. Effect of pramipexole, a dopamine-1/dopamine-2 receptor agonist on sodium excretion and blood pressure in spontaneously hypertensive rats. J Auton Pharmacol 10, Suppl 1: s53-s60, 1990.
  • Sekar KC, Harkavy KL, Jose PA. Renal function during the first 72 hours of life in sick infants with birth weights less than 1250 grams. J Perinat 11: 15-18, 1991.
  • Gitler MS, Piccio MM, Robillard JE, Jose PA. Characterization of renal alpha adrenoceptor subtypes in the sheep during development. Am J Physiol 260 (Regulatory Integrative Comp Physiol 29): R407-R412, 1991.
  • Sidhu A, Vachvanichsanong P, Jose PA, Felder RA. Persistent defective coupling of dopamine-1 receptors to G proteins after solubilization from kidney proximal tubules of hypertensive rats. J Clin Invest  89:789-793, 1992.
  • Kaneko S, Albrecht F, Asico LD, Eisner GM, Robillard JE, Jose PA. Ontogeny of DA1 receptor-mediated natriuresis in the rat: in vivo and in vitro correlations. Am J Physiol 263(Regulatory Integrative Comp Physiol 32): R631-R638, 1992.
  • Seikaly MG, Eisner GM, Jose PA. Contrasting effect of substance P on renal function and dopamine excretion in hydropaenic and volume expanded dogs. J Auton Pharmacol 12: 377-387, 1992.
  • Segar JL, Smith FG, Guillery EN, Jose PA, Robillard JE. Ontogeny of the renal response to specific dopamine-1 receptor stimulation in sheep. Am J Physiol 263 (Regulatory Integrative Comp Physiol 32): R868-R873, 1992.
  • Horiuchi A, Albrecht FE, Eisner GM, Jose PA, Felder RA. Renal dopamine receptors and pre- and post-cAMP mediated sodium transport defect in the spontaneously hypertensive rat. Am J Physiol 263 (Renal Fluid Electrolyte Physiol 32): F1105-F1111, 1992.
  • Yamaguchi I, Jose PA, Mouradian MM, Canessa LM, Monsma FJ Jr, Sibley DR, Takeyasu K, Felder RA. Expression of dopamine D1A receptor gene in proximal tubule of rat kidneys. Am J Physiol 264 (Renal Fluid Electrolyte Physiol 33): F280-F285, 1993.(56  citations)
  • Horiuchi A, Takeyasu K, Mouradian MM, Jose PA, Felder RA. D1A dopamine receptor stimulation inhibits Na+-K+ ATPase activity through protein kinase A. Mol Pharmacol 43: 281-285, 1993.
  • Felder RA, Kinoshita S, Ohbu K, Mouradian MM, Sibley DR, Monsma FJ, Minowa T, Minowa MT, Canessa LM, Jose PA. Organ specificity of the dopamine-1 receptor/ adenylyl cyclase coupling defect in the spontaneously hypertensive rat. Am J Physiol 264 (Regulatory Integrative Comp. Physiol. 33): R726-R732, 1993.(66 citations)
  • Felder CC, Albrecht FE, Campbell T, Eisner GM, Jose PA. Cyclic AMP-independent, G protein-linked  inhibition of Na+/H+ exchange in renal brush border by D1 dopamine agonists.  Am J Physiol  264 (Renal Fluid Electrolyte Physiol 33): F1032-F1037, 1993. (61 citations)
  • Guillery EN, Porter CC, Page WV, Jose PA, Felder R, Robillard JE. Developmental regulation of the a1B-adrenoceptor in the sheep kidney. Pediatr Res 34: 124-128, 1993.
  • Shen Y, Monsma FJ Jr, Metcalf MA, Jose PA, Hamblin MW, Sibley DR. Molecular cloning and expression of a 5-HT7 serotonin receptor subtype. J Biol Chem 268: 18200-18204, 1993. (422 citations)
  • Marmon LM, Albrecht F, Canessa LM, Hoy GR, Jose PA. Identification of dopamine1A receptors in the rat small intestine. Surg Res 54:616-620, 1993.
  • Norwood VF, Carey RM, Geary K, Jose PA, Gomez RA, Chevalier RL. Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells. Kidney Int 45: 1333-1339, 1994.
  • Gao D-Q, Canessa LM, Mouradian MM, Jose PA. Expression of the D2 subfamily of dopamine receptor genes in the kidney. Am J Physiol 266 (Renal Fluid Electrolyte Physiol 35): F646-F650, 1994. (51 citations)
  • Guillery EN, Segar JL, Merrill DC, Nakamura KT, Jose PA, Robillard JE. Ontogenic changes in renal response to a1-adrenoceptor stimulation in sheep. Am J Physiol 267 (Regulatory Integrative Comp. Physiol. 36):R990-R998, 1994.
  • Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE, Ooi GT, Grinberg A, Lee EJ, Huang SP, Bartlett PF, Jose PA, Sibley DR, Westphal H. Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci USA 91: 12564-12568, 1994. PMC45479 (264 citations)
  • Eisner GM, Yamaguchi I, Felder RA, Asico LD, Jose PA. Role of renal dopamine D1 receptors in natriuresis induced by calcium channel blockers. Am J Physiol 267 (Renal Fluid Electrolyte Physiol 36):F965-F970, 1994.
  • Yu P-Y, Asico LD, Eisner GM, Jose PA. Differential regulation of renal phospholipase C isoforms by catecholamines. J Clin Invest 95:304-308, 1995. PMC295432
  • Slobodyansky E, Aoki Y, Gaznabi KM, Aviles DH, Fildes RD, Jose PA. Dopamine and protein phosphatase activity in renal proximal tubules. Am J Physiol 268 (Renal Fluid Electrolyte Physiol 37): F279-F284, 1995.
  • Guillery EN, Karniski LP, Mathews MS, Page WV, Orlowski J, Jose PA, Robillard JE. ole of glucocorticoids in the maturation of renal cortical Na+/H+ exchanger activity during fetal life in sheep. Am J Physiol 268 (Renal Fluid Electrolyte Physiol 37): F710-F717, 1995.
  • Canessa LM, Piccio MM, Vachvanichsanong P, Sidhu A, Porter CC, Robillard JE, Felder RA, Jose PA. Alpha 1B-adrenergic receptors in rat renal microvessels. Kidney Int 48: 1412-1419, 1995.
  • Accili D, Drago J, Lee EJ, Johnson MD, Cool MH, Salvatore P, Asico L, Jose PA, Taylor SI, Westphal H. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene.  Nat Genet 12: 106-109, 1996. (328 citations)
  • Yamaguchi I, Walk SF, Jose PA, Felder RA. Dopamine D2L receptors stimulate Na+/K+ ATPase activity in murine LTK- cells. Mol Pharmacol 49: 373-378, 1996.
  • Wang W, Hahn KH, Bishop JF, Gao DQ, Jose PA, Mouradian MM. Up-regulation of D3 receptor expression by neuroleptics. Synapse 23: 232-235, 1996.
  • Albrecht FE, Drago J, Felder RA, Printz MP, Eisner GM, Robillard JE, Sibley DR, Westphal HJ, Jose PA. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. J Clin Invest  97: 2283-2288, 1996. PMC507308 (131 citations)
  • Yu P-Y, Eisner GM, Yamaguchi I, Mouradian MM, Felder RA, Jose PA. Dopamine D1A receptor regulation of phospholipase C isoform expression. J Biol Chem 271: 19503-19508, 1996. "Free Article" (53 citations)
  • Aoki Y, Albrecht FE, Bergman KR, Jose PA. Stimulation of Na+-K+-2Cl cotransport in rat medullary thick ascending limb by dopamine. Am J Physiol 271 (Regulatory Integrative Comp Physiol 40): R1561-R1567, 1996.
  • Sanada H, Yao L, Jose PA, Carey RM, Felder RA. Dopamine D3 receptors in rat juxtaglomerular cells. Clin Exp Hypertens 19: 93-105, 1997.
  • Yamaguchi I, Yao L, Sanada H, Ozono R, Mouradian MM, Carey RM, Jose PA, Felder RA. Dopamine D1A receptors and renin release in rat juxtaglomerular cells. Hypertension 29: 962-968, 1997.
  • Eisner GM, Asico LD, Albrecht FE, Jose PA. Dopamine and diltiazem-induced natriuresis in the spontaneously hypertensive rat. Am J Physiol 273 (Regulatory Integrative Comp Physiol 42): R317-R323, 1997.
  • Clerch LB, Wright A, Slobodyansky E, Mouradian MM, Wang W, Jose PA. Kidney extracts from spontaneously hypertensive rats (SHR) have greater dopamine 1A receptor RNA-binding activity than extracts from normotensive Wistar-Kyoto rats. Clin Exp Hypertens 19:1009-1021, 1997.
  • Lee S-H, Wang W, Yajima S, Jose PA, Mouradian MM. Tissue-specific promoter usage in the D1A dopamine receptor gene in brain and kidney. DNA Cell Biol 16: 1267-1275, 1997.
  • Asico LD, Eisner GM, Jose PA. Renal nerves and D1-dopamine receptor-mediated natriuresis. Clin Exp Hypertens 20: 259-271, 1998.
  • Asico LD, Ladines C, Fuchs S, Accili D,  Carey RM, Semeraro C, Pocchiari F, Felder RA, Eisner GM, Jose PA. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. J Clin Invest 102: 493-498, 1998.  (105 citations) PMC508909
  • Jose PA, Asico LD, Eisner GM, Pocchiari F, Semeraro C, Felder RA. Effects of costimulation of dopamine D1- and D2-like receptors on renal function. Am J Physiol 275 (Regulatory Integrative Comp Physiol 44): R986-R994, 1998.
  • Yao LP, Li XX, Yu PY, Xu J, Asico LD, Jose PA. Dopamine D1 receptor and protein kinase C isoforms in spontaneously hypertensive rats.   Hypertension 32: 1049-1053, 1998.
  • Sanada H, Jose PA, Hazen-Martin D, Yu P-Y, Xu J, Bruns JE, Phipps J, Carey RM, Felder RA. Dopamine-1 receptor defect in renal proximal tubular cells in essential hypertension. Hypertension 33:1036-1042, 1999. (101 citations)
  • Li XX, Albrecht FE, Robillard JE, Eisner GM, Jose PA. Gbeta regulation of Na-H exchanger-3 activity in rat renal proximal tubules during development. Am J Physiol Regulatory Integrative Comp Physiol 278:R931-R936, 2000.
  • Albrecht FE, Xu J, Moe OW, Hopfer U, Simonds WF, Orlowski J, Jose PA. Regulation of NHE3 activity by G protein subunits in renal brush border membranes. Am J Physiol Regulatory Integrative Comp Physiol 278:R1064-R1073, 2000.
  • Aoki, Y, Aviles DH, Jose PA. Biphasic effects of dopamine on 86rubidium uptake in rat renal proximal tubules. Clin Exp Hypertens 22: 289-301, 2000.
  • Williams SM, Addy JA, Phillips JAIII, Dai M, Kpodonu J, Afful J, Jackson H, Joseph K, Eason F, Murray MM, Epperson P, Aduonum A, Wong LJ, Jose PA, Felder RA. Combinations of variations in multiple genes are associated with hypertension. Hypertension 36: 2-6, 2000. (123 citations)
  • Xu J, Li XX, Albrecht FE, Hopfer U, Carey RM, Jose PA. Dopamine1 receptor, GSa, and Na+/H+ exchanger interactions in the kidney in hypertension. Hypertension 36: 395-399, 2000. (75 citations)
  • Yu P-Y, Asico LD, Eisner GM, Hopfer U, Felder RA, Jose PA. Renal protein phosphatase 2A activity and spontaneous hypertension in rats. Hypertension 36:1053-1058, 2000.
  • D'Souza UM, Wang W, Gao D-Q, Kanda S, Lee G, Hwang CK, Jose PA, Mouradian MM. Characterization of the 5' flanking region of the rat D3 dopamine receptor gene. J Neurochem 76:1736-1744, 2001.
  • Kitiyakara C, Chabrashvili T, Jose P, Welch WJ, Wilcox CS. Effects of dietary salt intake on plasma arginine. Am J Physiol Regul Integr Comp Physiol 280:R1069-1075, 2001.                
  • Li XX, Xu J, Zheng S, Albrecht FE, Robillard JE, Eisner GM, Jose PA. D1 dopamine receptor regulation of NHE3 during development in the spontaneously hypertensive rat. Am J Physiol Regul Integr Comp Physiol 280:F1659-R1656, 2001.
  • Li X, Albrecht FE, Xu J, Robillard JE, Eisner GM, Jose PA. Regulation of NHE3 by D1 dopamine receptor during development of spontaneously hypertensive rats. Zhonghua Yi Xue Za Zhi. 81:549-52, 2001.
  • Bek MJ, Zheng S, Xu J, Yamaguchi I, Asico LD, Sun XG, Jose PA. Differential expression of adenylyl cyclases in the rat nephron. Kidney Int 60:890-899, 2001.
  • Ladines CA, Zeng C, Asico LD, Sun X, Pocchiari F, Semeraro C, Pisegna J, Wank S, Yamaguchi I, Eisner GM, Jose PA. Impaired renal D1-like and D2-like dopamine receptor interaction in the spontaneously hypertensive rat. Am J Physiol Regul Integr Comp Physiol 281:R1071-R1078, 2001.
  • Li XX, Bek M, Asico LD, Yang Z, Grandy DK, Goldstein DS, Rubinstein M, Eisner GM, Jose PA. Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice. Hypertension 38:303-308, 2001.
  • Felder RA, Sanada H, Xu J, Yu P-Y, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams S, Gainer J, Brown NJ, Hazen-Martin D, Wong L-J, Robillard JE, Carey RM, Eisner GM, Jose PA. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci USA 99:3872-3877, 2002. PMC122616 (151 citations)
  • Lau YS, Hendley ED, Felder RA, Jose PA. Hyperactivity and elevated renal cortical calmodulin-dependent protein kinase activity. Clin Exp Hypertens. 24:289-300, 2002.
  • Gomes P, Xu J, Serr o P, Dória S, Jose PA, Soares-da-Silva P. Expression and function of sodium transporters in two opossum kidney cell clonal sublines. Am J Physiol Renal Physiol 283:F73-85, 2002.
  • Watanabe H, Xu J, Bengra D, Jose PA, Felder RA. Desensitization of renal D1 dopamine receptors by G protein-coupled receptor. Kidney Int 62:790-798, 2002. (52 citations)
  • Li X, Bek M, Asico LD, Yang Z, Rubinstein M, Grandy DK, Goldstein DS, Eisner GM, Jose PA. Disruption of the D2 dopamine receptor produces adrenergic and endothelin B receptor-dependent hypertension. Zhonghua Yi Xue Za Zhi. 82:703-7, 2002.
  • Bengra C, Mifflin TE, Khripin Y, Manunta P, Williams SM, Jose PA, Felder RA. Genotyping essential hypertension SNPs using a homogenous PCR method with universal energy transfer primers. Clin Chem 48:2131-2140, 2002.  (55 citations)
  • Hollon TR, Bek MJ, Lachowicz JE, Ariano MA, Mezey E, Soares-da-Silva P, Liu ZF, Grinberg A, Drago J, Westphal H, Jose PA, Sibley Dr. Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci 22:10801-10810, 2002. (86 citations).
  • Zheng S, Yu P, Zeng C, Yang Z, Andrews PM, Felder RA, Jose PA. Ga12 and Ga13 protein subunit linkage of D5 dopamine receptors in the nephron. Hypertension 41:604-610, 2003.
  • Zeng C, Asico LD, Wang X, Hopfer U, Eisner GM, Felder RA, Jose PA. Angiotensin II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of spontaneously hypertensive rats. Hypertension 41:724-729, 2003.
  • Zeng C, Luo Y, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats. Hypertension 42:787-792, 2003. (62 citations)
  • Huang X, Ju Z, Song Y, Zhang H, Sun K, Lu H, Yang Z, Jose PA, Zhou G, Feng S, Hui R. Lack of association between the G protein 3 subunit gene variant and essential hypertension in Chinese: A case-control and family-based study.  J Mol Med 81:729-735, 2003.                                                                                                                               
  • Zeng C, Wang D, Asico LD, Welch WJ, Wilcox CS, Hopfer U, Eisner GM, Felder RA, Jose PA. Aberrant D1 and D3 receptor transregulation in hypertension. Hypertension 43:654-660, 2004.                                       
  • Zeng C, Wang D, Yang Z, Wang Z, Asico LD, Wilcox CS, Eisner GM, Welch WJ, Felder RA, Jose PA. Dopamine D1 receptor augmentation of D3 receptor action in vascular smooth muscles. Hypertension. 43:673-679, 2004. "Free Article"  
  • Yang Z, Yu P, Asico LD, Felder RA, Jose PA. Protein phosphatase 2A B56 a during development in the spontaneously hypertensive rat. Clin Exp Hypertens 26:243-254, 2004.
  • Williams SM, Ritchie MD, Phillips JA 3rd, Dawson E, Prince M, Dzhura E, Willis A, Semenya A, Summar M, White BC, Addy JH, Kpodonu J, Wong LJ, Felder RA, Jose PA, Moore JH. Multilocus analysis of hypertension: A hierarchical approach Hum Hered 57:28-38, 2004. (92 citations)
  • Pedrosa R, Jose PA, Soares-da-Silva P. Defective D1-like receptor-mediated inhibition of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells. Am J Physiol Renal Physiol 286:F1120-1126, 2004.        
  • Pinho MJ, Serr o MP, Gomes P, Hopfer U, Jose PA, Soares-da-Silva P. Overexpression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int 66:216-26, 2004.
  • Pedrosa R, Gomes P, Zeng C, Hopfer U, Jose PA, Soares-da-Silva P. Dopamine D3 receptor-mediated inhibition of the Na+/H+ exchanger in spontaneously hypertensive rat proximal tubular epithelial cells. Br J Pharmacol  142:1343-53, 2004.
  • Fraga S, Jose PA, Soares-da-Silva P. Involvement of GRK 4-6 in rapid agonist-induced desensitization of dopamine D1 receptor in the IEC-6 intestinal epithelial cell line. Am J Physiol Regul Integr Comp Physiol 287:R772-9, 2004.
  • Pedrosa R, Gomes P, Hopfer U, Jose PA, Soares-da-Silva P. Gia3 protein coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in immortalized SHR proximal tubular epithelial cells is a PLC-PKC mediated event. Am J Physiol Renal Physiol 287:F1059-66, 2004.
  • Yu P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. D1 Dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int 66:2167-80, 2004.
  • Yang Z, Asico LD, Yu P, Wang Z,  Jones JE, Bai R-K, Sibley DR, Felder RA, Jose PA. D5 dopamine receptor regulation of phospholipase D. Am J Physiol Heart Circ Physiol. 288:H55-61, 2005.
  • Zeng C, Yang Z, Wang Z, Jones JE, Wang X, Altea J, Mangrum AJ, Hopfer U, Sibley DR, Eisner GM, Felder RA, Jose PA. Interaction of angiotensin II type I and D5 dopamine receptors in renal proximal tubule cells.  Hypertension 45:804-10, 2005 (cover picture). "Free Article"
  • Yoneda M, Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Sasaki M, Katoh T, Watanabe T, Jose PA, Felder RA. Differential effects of angiotensin II type-1 receptor antisense oligonucleotide inhibition on renal function in spontaneously hypertensive rats. Hypertension 46:58-65, 2005.
  • Welch WJ, Mendonca M, Blau J, Karber A, Dennehy K, Lao Y, Jose PA, Wilcox CS. Antihypertensive response to the prolonged tempol in the SHR. Kidney Int 68:179-187, 2005. 
  • Zeng C, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. Aberrant ETB receptor regulation of AT1 receptors in renal proximal tubule cells of spontaneously hypertensive rats. Kidney Int 68:623-631, 2005 (cover picture).
  • Zeng C, Wang Z, Hopfer U, Asico D, Eisner GM, Felder RA, Jose PA. Rat strain effects of AT1 receptor activation on D1 dopamine receptors in immortalized renal proximal tubule cells. Hypertension 46:799-805, 2005.
  • Zeng C, Hopfer U, Asico LD, Eisner GM, Felder RA, Jose PA. Altered AT1 receptor regulation of ETB receptors in renal proximal tubule cells of spontaneously hypertensive rats. Hypertension 46:926-31, 2005.
  • Zeng CY, Yang ZW, Wu LJ, Asico LD, Felder RA, Jose PA. Hypertension in D3 dopamine receptor deficient mice. Zhonghua Xin Xue Guan Bing Za Zhi. 33:1132-1136, 2005.
  • Rankin ML, Marinec PS, Cabrera DM, Wang Z, Jose PA, Sibley DR. The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4: evidence for a novel mechanism of regulation. Mol Pharmacol 69:759-69, 2006. (subject of editorial commentary)
  • Yang Z, Asico LD, Yu P, Wang Z, Jones JE, Escano CS, Wang X, Quinn MT, Sibley DR, Romero GG, Felder RA, Jose PA. D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure. Am J Physiol Regul Integr Comp Physiol 290:R96-R104, 2006. (58 citations)
  • Chen S, Crawford M, Day RM, Briones VR, Leader JE, Jose PA, Lechleider RJ. RhoA modulates SMAD signaling during transforming growth factor- b- induced smooth muscle differentiation. J Biol Chem 281:1765-70, 2006. (73 citations)
  • Bek M, Wang X, Asico LD, Zheng S, Jones JE, Li XX, Eisner GM, Grandy DK, Carey RM, Soares-da-Silva P, Jose PA. Angiotensin type I receptor-mediated hypertension in D4 dopamine receptor deficient mice. Hypertension 47:288-95, 2006.
  • Zeng C, Wang Z, Yu P, Zheng S, Wu L, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells. Hypertension 47:573-9, 2006.
  • Lohmueller KE, Wong LJ, Mauney MM, Jiang L, Felder RA, Jose PA, Williams SM. Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structure. Ann Hum Genet 70:27-41, 2006.
  • Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe H, Felder RA, Jose PA.  Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem 52:352-60, 2006. (61 citations)
  • Sanada H, Yatabe J, Midorikawa S, Katoh T, Shigeatsu H, Watanabe T, Xu J, Felder RA, Jose PA. Amelioration of genetic hypertension by post-translational suppression of GRK4 in the kidney. Hypertension 47:1131-1139, 2006.
  • Zeng CY, Wang Z, Yang ZW, He DF, Yang CM, Asico LD, Felder RA, Jose PA.  G protein kinase 4g A142V overexpression induced hypertension by downregulating D1 receptors in transgenic mice. Zhonghua Xin Xue Guan Bing Za Zhi. 34:411-414, 2006.
  • Yu P-Y, Asico LD, Eisner GM, Hopfer U, Felder RA, Jose PA. D1 dopamine receptor hyperphosphorylation in renal proximal tubules in hypertension. Kidney Int 70:1072-1079, 2006.
  • Zeng C, Liu Y, Wang Z, He D, Huang L, Yu P, Zheng S, Jones JE, Asico LD, Hopfer U, Eisner, GM,  Felder RA, Jose PA. Activation of D3 dopamine receptor decreases AT1 angiotensin receptor expression in rat renal proximal tubule cells. Circ Res  99: 494-500, 2006.
  • Welch WJ, Chabrashvili T, Solis G, Chen Y, Gill PS, Aslam S, Wang X, Ji H, Sandberg K, Jose P, Wilcox CS. Role of extracellular superoxide dismutase in the mouse angiotensin slow pressor response. Hypertension 48;934-41, 2006 (subject of editorial commentary) "Free Article"
  • Fraga S, Luo Y, Jose P, Zandi-Nejad K, Mount DB, Soares-da-Silva P. Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6). Cell Physiol Biochem 18:347-60, 2006.
  • Wang D, Jose P, Wilcox CS.  b1 receptors protect the renal afferent arteriole of angiotensin-infused rabbits from norepinephrine-induced oxidative stress. J Am Soc Nephrol 17:3347-54, 2006. "Free Article"
  • Armando I, Wang X, Villar VA, Jones JE, Asico L, Escano C, Jose PA. Reactive oxygen species-dependent hypertension in dopamine D2 receptor deficient mice. Hypertension 49:672-8, 2007. "Free Article"
  • Pedrosa R, Gonçalves N, Hopfer U, Jose PA, Soares-da-Silva P. Activity and regulation of Na+-HCO3- co-transporter in immortalized SHR and WKY proximal tubular epithelial cells. Hypertension 49:1186-1193, 2007.
  • Li F, Luo Z, Huang W, Lu Q, Wilcox CS, Jose PA, Chen S. Response gene to complement 32, a novel regulator for transforming growth factor-b-induced smooth muscle differentiation of neural crest cells. J Biol Chem 282:10133-7, 2007. "Free Article"
  • Wang Z, Ines Armando I, Asico LD, Escano C, Wang X, Lu Q, Felder RA, Schnackenberg CG, Sibley DR, Eisner GM, Jose PA. The elevated blood pressure of human GRK4g A142V transgenic mice is not associated with increased ROS production. Am J Physiol Heart Circ Physiol 292:H2083-92, 2007. “Free Article”
  • Pinho MJ, Pinto V, Serrao MP, Jose PA, Soares-da-Silva P. Underexpression of the Na+-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney. Am J Physiol Regul Integr Comp Physiol 293:R538-47, 2007.      
  • Pinho MJ, Serrao MP, Jose PA, Soares-da-Silva P.  Organ specific underexpression renal of Na+-dependent B0AT1 in the SHR correlates positively with overexpression of NHE3 and salt intake. Mol Cell Biochem 306:9-18, 2007.
  • Pinho MJ, Serrao MP, Jose PA, Soares-da-Silva P. Overexpression of non-functional LAT1/4F2hc in renal proximal tubular epithelial cells from the spontaneous hypertensive rat. Cell Physiol Biochem 20:535-48, 2007.
  • Gildea JJ, Wang X, Jose PA, Felder RA. Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor. Hypertension 51:360-6, 2008.  “Free Article”
  • Han W, Li H, Villar VM, Pascua AM, Dajani MI, Wang X, Natarajan A, Quinn MT, Felder RA, Jose PA, Yu P. Lipid rafts keep NADPH oxidase in the inactive state in human renal proximal tubule cells. Hypertension 51:481-7, 2008. "Free Article"
  • Sim o S, Fraga S, Jose PA, Soares-da-Silva P. Oxidative stress and a1-adrenoceptor-mediated stimulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells. Br J Pharmacol 153:1445-55, 2008. PMC2437919
  • Pinto V, Pinho MJ, Hopfer U, Jose PA, Soares-da-Silva P. Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells. Mol Cell Biochem 310:191-201, 2008.
  • Pedrosa R, Villar VM, Pascua AM, Sim o S, Hopfer U, Jose PA, Soares-da-Silva P. H2O2, stimulation of Cl-/HCO3- exchanger by angiotensin II and AT1 receptor distribution in membrane microdomains. Hypertension 51:1332-8, 2008. PMC2772095.
  • Sim o S, Pedrosa R, Hopfer U, Mount DB, Jose PA, Soares-da-Silva P. Short-term regulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells. Biochem Pharmacol 75:2224-33, 2008. PMC2772100
  • Li Z, Yu C, Han Y, Ren H, Shi W, Fu C, He D, Huang L, Yang C, Wang X, Zhou L, Asico LD, Zeng C, Jose PA. Inhibitory effect of D1-like and D3 dopamine receptors on norepinephrine-induced proliferation in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 294:H2761-8, 2008. PMC2772091
  • Li H, Armando I, Yu P, Escano C, Mueller SC, Asico L, Pascua A, Lu Q, Wang X, Villar VA, Jones JE, Wang Z, Periasamy A, Lau YS, Soares-da-Silva P, Creswell K, Guillemette G, Sibley DR, Eisner G, Felder RA, Jose PA. Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells. J Clin Invest 118:2180-9, 2008. PMC2373421
  • Sim o S, Fraga S, Jose PA, Soares-da-Silva P. Oxidative stress plays a permissive role in a2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells. Mol Cell Biochem 315:31-9, 2008.
  • Zeng C, Asico LD, Yu C, Villar VA, Shi W, Luo Y, Wang Z, He D, Liu Y, Huang L, Yang C, Wang X, Hopfer U, Eisner GM, Jose PA. Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions. Kidney Int 74:750-9, 2008 (cover picture, subject of editorial commentary). PMC4026929
  • Li H, Li HF, Felder R, Periasamy A, Jose PA. Rab4 and Rab11 coordinately regulate the recycling of angiotensin II type I receptor demonstrated by FRET microscopy. J Biomed Opt 13:031206, 2008.   PMC3731076
  • Yatabe Y, Sanada H, Midorikawa S, Hashimoto S, Watanabe T, Andrews PM, Armando I, Wang X, Felder RA, Jose PA. Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin AT1 receptors in rats. Hypertens Res 31:1455-64, 2008. P MC2876328          
  • Yang Z, Huang X, Jiang H, Zhang Y, Liu H, Qin C, Eisner GM, Jose P, Lenhard R, Ju Z. Short telomeres and prognosis of hypertension in a Chinese population. Hypertension 53:639-45, 2009 (subject of editorial commentary). PMC2890281
  • Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY. RGC-32 mediates transforming growth factor  -induced epithelial-mesenchymal transition in human renal proximal tubular cells. J Biol Chem 284:9426-32, 2009. PMC2666595
  • Yatabe J, Sanada H, Yatabe MS, Hashimoto S, Yoneda M, Felder RA, Jose PA, Watanabe T. Angiotensin II receptor blocker attenuates the mechanical strain induced activation of ERK and NADPH oxidase in mesangial cells in the absence of angiotensin II. Am J Physiol Renal Physiol 296: F1052-60, 2009. “Free Article”
  • Zeng C, Han Y, Huang H, Yu C, Ren H, Shi W, He D, Huang L, Yang C, Wang X, Zhou L, Jose PA. D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression. J Hypertens 29:1033-41, 2009.   PMC3724361
  • Li H, Han W, Villar VM, Keever LB, Lu Q, Hopfer U, Quinn MT, Felder RA, Jose PA, Yu P. D1-like receptors regulate NADPH oxidase activity and subunit expression in lipid raft microdomains of renal proximal tubule cells. Hypertension 53:1054-6, 2009. PMC2879618
  • Yang J, Cui Z, He D, Ren H, Yu C, Fu C, Wang Z, Yang C, Wang X, Asico LD, Villar VM, Hopfer U, Mi M, Zeng C, Jose PA. Insulin increases D5 dopamine receptor expression and function in renal proximal tubule cells from Wistar-Kyoto rats. Am J Hypertens 22:770-6, 2009.  PMC3705572                                                            
  • Yu C, Yang Z, Ren H, Zhang Y, Han Y, He D, Lu Q, Wang X, Wang X, Yang C, Asico LD, Hopfer U, Eisner GM, Jose PA, Zeng C. D3 dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs. Am J Hypertens  22:877-83, 2009. PMC3705568                          
  • Luo Z, Chen Y, Chen S, Welch WJ, Andresen BT, Jose PA, Wilcox CS. Comparison of inhibitors of superoxide generation in vascular smooth muscle cells. Br J Pharmacol 157:935-943, 2009. PMC2737652
  • Villar VA, Jones JE,  Armando I, Palmes-Saloma C, Yu P, Pascua AM, Keever L, Arnaldo FB, Wang Z, Luo Y, Felder RA, Jose PA. G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. J Biol Chem 284:21425-34, 2009. PMC2755867
  • Liu Y, Yang J, Ren H, He D, Pascua A, Armando MI, Yang C, Zhou L, Felder RA, Jose PA, Zeng C. Inhibitory effect of ETB receptor on Na+-K+ ATPase activity by extracellular Ca2+ entry and Ca2+ release from the endoplasmic reticulum in renal proximal tubule cells. Hypertens Res 32:846-52, 2009. PMC2879332
  • Escano CS, Armando I, Wang X, Asico L, Pascua A, Yang Y, Wang Z, Lau YS, Jose PA. Renal dopaminergic defect in C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol 297:R1660-9, 2009. PMC2803619
  • Gildea JJ, Israel JA, Johnson AK, Zhang J, Jose PA, Felder RA.  Caveolin-1 and dopamine-mediated internalization of NaKATPase in human renal proximal tubule cells. Hypertension 54:1070-6, 2009. PMC2897144
  • Li  H, Yu P, Felder RA, Periasamy A, Jose PA. Angiotensin II-induced angiotensin II type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy. SPIE Proc, 7183, 71832G (1-12), 2009.
  • Natarajan A, Han G, Chen S, Yu P, White R, Jose P. The D5 dopamine receptor mediates BKCa channel activation in human coronary artery smooth muscle cells. J Pharmacol Exp Ther 332:640-9, 2010. PMC2812120
  • Rex E, Rankin ML, Yang Y, Lu Q, Gerfen CR, Jose PA, Sibley DR. Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) g/d and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation. Mol Pharmacol 78:1-12, 2010 (cover picture). PMC2912060
  • Wang X, Luo Y, Escano CS, Yang Z, Asico L, Li H, Jones JE, Armando I, Lu Q, Sibley DR, Eisner GM, Jose PA. Upregulation of renal sodium transporters in D5 dopamine receptor deficient mice. Hypertension 55:1431-7, 2010. PMC2876328
  • Yatabe MS, Yatabe J, Yoneda M, Watanabe T, Otsuki M, Felder RA, Jose PA, Sanada H. Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension. Am J Clin Nutr 92:77-82, 2010.  PMC2876328
  • Sim o S, Gomes P, Jose PA, Soares-da-Silva P. Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl-/HCO3-  exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR. Biochem Pharmacol 80:913-9, 2010.
  • Pinto V, Pinho MJ, Jose PA, Soares-da-Silva P. Role of H2O2 on the kinetics of low-affinity high-capacity Na+-dependent alanine transport in SHR proximal tubular epithelial cells. Biochem Biophys Res Commun 398;553-558, 2010. 
  • Yokokawa H, Sanada H, Goto A, Watanabe T, Felder RA, Jose PA, Eisner GM, Yasumura S. Characteristics of antihypertensive medication and change of prescription over 1 year of follow up in Japan: Fukushima Research of Hypertension (FRESH). Am J Hypertens. 23:1299-305, 2010.
  • Wang X, Li F, Jose PA, Ecelbarger CM. Reduction of renal dopamine receptor expression in obese Zucker rats: role of sex and angiotensin II. Am J Physiol: Renal Physiol. 299(5):F1164-70, 2010.     PMC2980410  
  • Wang D, Luo Z, Wang X, Jose PA, Falck JR, Welch WJ, Aslam S, Teerlink T, Wilcox CS. Impaired endothelial function and microvascular asymmetrical dimethylarginine in angiotensin II-infused rats. Effects of tempol. Hypertension. 56:950-55, 2010. PMC3064487                         
  • Asico L, Zhang X, Jiang J, Cabrera D, Escano CS, Sibley DR, Wang X, Yang Y, Mannon R, Jones JE, Armando I, Jose PA. Lack of renal dopamine D5 receptors promotes hypertension. J Am Soc Nephrol. 22:82-89, 2011. PMC3014037        
  • Li H, Yu P, Sun Y, Felder RA, Periasamy A, Jose PA. Actin cytoskeleton-dependent Rab GTPase-regulated angiotensin type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy. J Biomed Opt. 15:056003, 2010. PMC2966490
  • Yu P, Han W, Villar VM, Li H, Arnaldo FB, Concepcion GP, Felder RA, Quinn MT, Jose PA. Dopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross-talk. Free Radic Biol Med. 50:832-40, 2011. PMC3066436  
  • Zhang Y, Fu C, Ren H, He D, Wang X, Asico LD, Jose PA, Zeng C. Impaired stimulatory effect of ETB receptor on D3 receptor in immortalized renal proximal tubule cells of spontaneously hypertensive rats. Kidney Blood Press Res. 34:75-82, 2011. PMC3031151
  • Yatabe J, Yoneda M, Yatabe MS, Watanabe T, Felder RA, Jose PA, Sanada H. Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology. 152:1582-8, 2011.
  • Guo X, Jose PA, Chen  S. Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells. Am J Physiol Cell Physiol. 300:C1415-21, 2011.PMC3118632
  • Huang H, Han Y, Wang X, Chen C, Yu C, He D, Wang H, Zhou L, Asico LD, Jose PA, Zeng C. Inhibitory effect of the D3 dopamine receptor on insulin receptor expression and function in vascular smooth muscle cells. Am J Hypertens. 24:654-60, 2011. PMC3154553
  • Yokokawa H, Goto A, Sanada H, Watanabe T, Felder RA, Jose PA, Yasumura S. Achievement status toward goal blood pressure levels and healthy lifestyles among Japanese hypertensive patients; cross-sectional survey results from Fukushima Research of Hypertension (FRESH). Intern Med. 50:1149-56, 2011. “Free Article”  
  • Huang WY, Xie W, Guo X, Li F, Jose PA, Chen S. Smad2 and PEA3 cooperatively regulate transcription of response gene to complement 32 in TGF-ß-induced smooth muscle cell differentiation of neural crest cells. Am J Physiol Cell Physiol. 301:C499-506, 2011. PMC3154553
  • Zhang Y, Fu C, Asico LD, Villar VA, Ren H, He D, Wang Z, Yang J, Jose PA, Zeng C. Role of Ga12- and Ga13-protein subunit linkage of D3 dopamine receptors in the natriuretic effect of D3 dopamine receptor in kidney. Hypertens Res. 34:1011-15, 2011. (subject of editorial commentary) PMC3987779
  • Zhang Y, Wang Y, Wang X, Zhang Y, Eisner GM, Asico LD, Jose PA, Zeng C. Insulin promotes vascular smooth muscle cell proliferation via microRNA-208-mediated down-regulation of p21. J Hypertens. 29:1560-1568, 2011.           
  • Li Z, Xie WB, Escano CS, Asico LD, X Q, Jose PA, Cheng SY. Response gene to complement 32 is essential for fibroblast activation in renal fibrosis. J Biol Chem. 286:41323-30, 2011. PMC3308844
  • Guo Y, Jose PA. C-terminal di-leucine motif of dopamine D1 receptor plays an important role in its plasma membrane trafficking. Plos One. 6:e29204, 2011. PMC3242775
  • Cuevas S, Zhang Y, Yang Y, Escano C, Asico L, Jones JE, Armando I, Jose PA. Role of renal DJ-1 in the pathogenesis of hypertension associated with increased reactive oxygen species production. Hypertension. 59:446-52, 2012.  PMC3395064  
  • Huang H, Ren H, Chen C, Wang X, Yang J, Han Y, He D, Zhou L, Asico LD, Jose PA, Zeng C. D3 dopamine receptor regulation of D5  receptor expression and function in renal proximal tubule cells. Hypertens Res. 35:639-47, 2012. “PMC in process”
  • Lai EY, Luo Z, Onozato ML, Rudolph EH, Solis G, Jose PA, Wellstein A, Aslam S, Quinn MT, Griendling KK, Le TH, Li P, Palm F, Welch WJ, Wilcox CS. Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass. Am J Physiol Renal Physiol. 303:F64-F74, 2012. PMC3431146                  
  • Yang J, Chen C, Ren H, Han Y, He D, Zhou L, Hopfer U, Jose PA, Zeng C. Angiotensin II AT2 receptor decreases AT1 receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats. J Hypertens. 30:1176-84, 2012. PMC3705562       
  • Yatabe J, Yatabe MS, Yoneda M, Felder RA, Jose PA, Sanada H. Hypertension-related gene polymorphisms of G-protein-coupled receptor kinase 4 are associated with NT-proBNP concentration in normotensive healthy adults .Int J Hypertens. 2012:806810, 2012.  PMC3296214
  • Yang Y, Zhang Y, Cuevas S, Escano C, Villar VA, Asico L, Yu P, Grandy DK, Felder RA, Armando I, Jose PA. Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase. Free Radic Biol Med. 53:437-46, 2012. PMC3408834
  • Jiang X, Wang W, Ning B, Liu X, Gong J, Gan F, Gao X, Zhang L, Jose PA, Qin C, Yang Z. Basal and postprandial serum levels of gastrin in normotensive and hypertensive adults. Clin Exp Hypertens. 35:74-8, 2013.
  • Gildea JJ, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, Sasaki M, Yatabe J, Carey RM, Jose PA, Felder RA. Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. Hypertension. 60:396-403, 2012. PMC3406928
  • Zhang Y, Cuevas S, Asico LD, Escano C, Yang Y, Pascua AM, Wang X, Jones JE, Grandy D, Eisner G, Jose PA, Armando I. Deficient dopamine D2 receptor function causes renal inflammation independently of high blood pressure. PLoS One. 7:e38745, 2012. PMC3375266    
  • Sanada H, Yokokawa H, Yoneda M, Yatabe J, Yatabe MS, Williams SM, Felder RA, Jose PA. High body mass index is an important risk factor for the development of type 2 diabetes. Intern Med. 51;1821-1826, 2012. PMC3540801
  • Carey RM, Schoeffel CD, Gildea JJ, Jones JE, McGrath HE, Gordon LN, Park MJ, Sobota RS, Underwood PC, Williams J, Sun B, Raby B, Lasky-Su J, Hopkins PN, Adler GK, Williams SM, Jose PA, Felder RA. Salt Sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter. Hypertension. 60:1359-66, 2012. PMC3495588    
  • Wang Y, Han Y, Yang J, Wang Z, Liu L, Wang W, Zhou L, Wang D, Tan X, Fu C, Jose PA, Zeng C. Relaxant effect of all-trans retinoic acid via NO-sGC-cGMP pathway and calcium-activated potassium channels in rat mesenteric artery.         Am J Physiol Heart Circ Physiol. 304:H51-7, 2013. PMC3537009     
  • Villar VA, Jones JE, Armando I, Asico LD, Escano CS Jr, Lee H, Wang X, Yang Y, Pascua-Crusan AM, Palmes-Saloma CP, Felder RA, Jose PA. Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. J Biol Chem. 288:152-63, 2013.  PMC3537009
  • Villar VA, Armando I, Sanada H, Frazer LC, Russo CM, Notario PM, Lee H, Comisky L, Russell HA, Yang Y, Jurgens JA, Jose PA, Jones JE. Novel role of sorting nexin 5 in renal D1 dopamine receptor trafficking and function: implications for hypertension. FASEB J. 27:1808-19, 2013. PMC3633819
  • Liu T, Jose PA. Gastrin induces sodium-hydrogen exchanger 3 phosphorylation and mTOR activation via a phosphoinositide 3-kinase-/protein kinase C-dependent but AKT-independent pathway in renal proximal tubule cells derived from a normotensive male human. Endocrinology. 154:865-75, 2013. PMC3548178
  • Lu Q, Yang Y, Villar V, Asico L, Jones JE, Yu Y, Li H, Weinman EJ, Eisner GM, Jose PA. D5 dopamine receptor decreases NADPH oxidase, reactive oxygen species and blood pressure via heme oxygenase-1. Hypertens Res. 36:684-90, 2013. PMC4061571
  • Gildea JJ, Lahiff DT, Van Sciver RE, Weiss RS, Shah N, McGrath HE, Schoeffel CD, Jose PA, Carey RM, Felder RA. A linear relationship between the ex-vivo sodium mediated expression of two sodium regulatory pathways as a surrogate marker of salt-sensitivity of blood pressure in exfoliated human renal proximal tubule cells: The virtual renal biopsy. Clin Chim Acta. 421:236-42, 2013. PMC3724455
  • Cai J, Han Y, Ren H, Chen C, He D, Zhou L, Eisner GM, Asico LD, Jose PA, Zeng C. Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells. J Mol Cell Biol. 5:227-38, 2013.  PMC3733418
  • Wang X, Escano CS, Asico L, Jones JE, Barte A, Lau Y-S, Jose PA, Armando I. Upregulation of renal D5 dopamine receptor ameliorates the hypertension in D3 dopamine receptor deficient mice . Hypertension. 62:295-301, 2013. PMC3781579             
  • Xie WB, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY. Smad2 and MRTFB cooperatively regulate vascular smooth muscle differentiation from neural crest cells. Circ Res. 113:e76-86, 2013.      
  • Chen Y, Asico LD, Zheng S, Villar VA, He D, Zhou L, Zeng C, Jose PA. Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis. Hypertension. 62:927-33, 2013. (subject of editorial commentary) PMC3915294
  • Lee H, Abe Y, Lee I, Shrivastav S, Crusan AP, Hüttemann M, Hopfer U, Felder RA, Asico LD, Armando I, Jose PA, Kopp JB. Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats. Kidney Int. 85:561-69, 2014. PMC3943540
  • Chen K, Fu C, Chen C, Liu L, Ren H, Han Y, Yang J, He D, Zhou L, Yang Z, Zhang L, Jose PA, Zeng C. Role of GRK4 in the regulation of arterial AT1 receptor in hypertension. Hypertension. 63:289-96, 2014.  PMC3932160
  • Armando I, Villar VM, Jones JE, Lee H, Wang X, Asico LD, Yu P, Yang J, Escano CS, Pascua-Crusan AM, Felder RA, Jose PA. Dopamine D3 Receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation . FASEB J. 28:1422-43, 2014. PMC3929671     
  • Jiang X, Konkalmatt P, Yang Y, Gildea J, Jones JE, Cuevas S, Felder RA, Jose PA, Armando I. Single nucleotide polymorphisms of the dopamine D2 receptor increase  inflammation and fibrosis in human renal proximal tubule cells. Hypertension. 63:e74-80, 2014. PMC3929206
  • Wang S, Lu X, Yang J, Wang H, Chen C, Han Y, Ren H, Zheng S, He D, Zhou L, Asico LD, Wang, WE, Jose PA. Regulation of renalase expression by D5 dopamine receptors in rat renal proximal tubule cells. Am J Physiol Renal Physiol. 306:F588-96, 2014. PMC3949042
  • Gildea JJ,  Shah IT, Van Sciver R, Israel JA, Enzensperger C, McGrath HE, Jose PA, Felder RA. The cooperative roles of the dopamine receptors, D1R and D5R, on renal sodium transport regulation. Kidney Int. 86:118-26, 2014. PMC4077925
  • Fu J, Han Y, Wang H, Wang Z, Liu Y, Chen X, Cai Y, Guan W, Yang D, Asico LD, Zhou L, Jose PA, Zeng C. Impaired dopamine D1 receptor-mediated vasorelaxation of mesenteric arteries in obese Zucker rats. Cardiovasc Diabetol. 22:13:50, 2014. PMC3938077
  • Yu P, Han W, Villar VM, Yang Y, Lu Q, Lee H, Li F, Quinn MT, Gildea JJ,  Felder RA, Jose PA. Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells. Redox Biol. 2:570-579, 2014. PMC3969603    
  • Yu C, Wang Z, Han Y, Liu Y, Wang WE, Chen C, Wang H, Jose PA, Zeng C. Dopamine D4 receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression. Cardiovasc Diabetol. 2014;13:97.  PMC4078019
  • Yu P, Sun M, Villar, Zhang Y, Edward J. Weinman EJ, Felder RA,  Jose PA. Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule. Cell Signal.  26: 2521-9, 2014.
  • Yokokawa H, Goto A, Sanada H, Watanabe T, Felder RA, Jose PA, Yasumura S. Association between control to target blood pressures and healthy lifestyle factors among Japanese hypertensive patients: Longitudinal data analysis from Fukushima Research of Hypertension (FRESH). Obes Res Clin Pract.;8(4):e364-73.                                     
  • Cai J, Wu G, Tan X, Han Y, Chen C, Li C, Wang N, Zou X, Chen X, Zhou F, He D, Zhou L, Jose PA, Zeng C. Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice. PLoS One. 2014 Aug 18;9(8):e105200.
  • Yang Y, Cuevas S, Yang S, Villar V, Escano C, Asico L,  Yu P, Jiang X, Weinman EJ, Armando I, Jose PA. Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of ROS production . Hypertension.2 014 Jul 14. [Epub ahead of print]

    • Papers in press/accepted for publication:

  • Chen K, Deng K , Wang X, Wang Z, Zheng S, Ren H, He D, Han Y, Asico LD, Jose PA, Zeng Z. Activation of D4 dopamine receptor decreases AT1 angiotensin II receptor expression in rat renal proximal tubule cells. Hypertension          
  • Arnaldo FB, Villar VA, Konkalmatt PR, Owens SA, Asico LD, Jones JE, Yang J, Lovett DL, Armando I, Jose PA, Concepcion GP. D1-like dopamine receptors down-regulate Na+,K+-ATPase activity and increase camp production in the posterior gills of the blue crab Callinectes sapidus.. Am J Physiol Regul Integr Comp Physiol
  • Armando I, Konkalmatt P, Felder RA, Jose PA. The renal dopaminergic system: novel diagnostic and therapeutic approaches in hypertension and kidney disease. Transl Res. 2014J . pii: S1931-5244(14)00269-2.
  • Yang Y, Cuevas S, Yang S, Villar V, Escano C, Asico L,  Yu P, Jiang X, Weinman EJ, Armando I,  Jose PA. Dopamine D2 receptor decreases renal ROS-induced high blood pressure through antioxidant sestrin2. Hypertension

    • Papers submitted for publication:   

  • Ennis RC, Asico LD, Armando I, Jun B. Feranil JB,. Jurgens JA, Escano CS Jr.2, Yu P, Wang X, Sibley DR,. Jose PA, Villar VM. The dopamine D1-like receptors regulate the a1A adrenergic receptor in human renal proximal tubule cells and D1-like dopamine receptor  knockout mice. Am J Physiol
  • Yang S, Yang Y, Yu P, Yang J, Villar VM, Sibley DR, Pedro A. Jose PA, Zeng C.  Dopamine D1 and D5 receptors differentially regulate oxidative stress through paraoxonase 2 in kidney cells.      
  • Zhang Y, Jiang X, Cuevas S, Jose P, Armando I, Qin C. Dopamine D2 receptors effects on renal inflammation are mediated by regulation of PP2A function     
  • Ennis RC, Asico LD, Armando I, Jun B. Feranil JB,. Jurgens JA, Escano CS Jr.2, Yu P, Wang X, Sibley DR,. Jose PA, Villar VM. The dopamine D1-like receptors regulate the a1A adrenergic receptor in human renal proximal tubule cells and D1-like dopamine receptor  knockout mice. Am J Physiol
  • Yang S, Yang Y, Yu P, Yang J, Villar VM, Sibley DR, Pedro A. Jose PA, Zeng C.  Dopamine D1 and D5 receptors differentially regulate oxidative stress through paraoxonase 2 in kidney cells.      
  • Zhang Y, Jiang X, Cuevas S, Jose P, Armando I, Qin C. Dopamine D2 receptors effects on renal inflammation are mediated by regulation of PP2A function             

Pedro A. Jose

Professor

 

  • : 410-706-6015
  • DEPARTMENTDepartment of Medicine and Physiology
    University of Maryland School of Medicine
  • COUNTRY USA