Professional Activities:

Academic Appointments

2012-Current	Adjunct faculty, Anatomy & Cell Biology	Indiana University
2009-current	Associate Research Professor of medicine	Indiana University
2008-2009	Associate Research Professor	University of Virginia
2002-2008	Assistant Research Professor	University of Virginia
2000–2002	Postdoctoral Fellow	University of Texas Health Science Center, san antonio

Other Employment Pertaining to Current Professional Appointments

1. 1995–2000 Research Assistant University of South Dakota School of Medicine
2. 1993–1995 Teaching Assistant Minnesota State University
3. 1989–1991 Orthopedic Surgeon Cairo, Egypt

Honors and Awards

• 2004 ASBMR Young Investigator Award, $1000
• 2001 University of Texas Health Science Center, Medicine Research Day, $250
• 2000 New Scientist Report “Need a hand?” August 2000 pp34-37,
  www.newscientist.com
• 2000 Hamamatsu Scholarship, $1300
• 1999–2000 Research Assistantship, University of South Dakota, School of Medicine, $13,500
• 1998–1999 Research Assistantship, University of South Dakota, School of Medicine, $13,000
• 1998–1999 Wesley W. Parke Research Award Endowment, $1500
• 1997–1998 Research Assistantship, University of South Dakota, School of Medicine,$13,000
• 1997–1998 Wesley W. Parke Research Award Endowment, $1500
• 1996–1997 Research Assistantship, University of South Dakota, School of Medicine,$12,500
• 1995–1996 Research Assistantship, University of South Dakota, School of Medicine,$12,500

Pofessional Affiliations (including offices held)

• 2006–Current Member, International Society of Bone Morphometry (ISBM)
• 2000–Current Member, American Society for Bone & Mineral research (ASBMR)
• 1998–Current Member, International Bone & Mineral Society (IBMS)
• 2008-2009 Member, European Calcified Tissue Society (ECTS)
• 2013-Current American Association for Cancer Research (AACR)

Committee service:

• 2010-2011: Indiana University, Curriculum reform team. Serving as a team leader for Professionalism and Self Awareness group.
• 2013-2014: Indiana University, Curriculum reform team. Serving as a team member for human structure group. The aim is to write learning objectives for the human anatomy, histology and embryology.
• 2014-2016: Indiana University School of Medicine, Academic standard.

Scientific reviewer:

• Nature
• Journal of Clinical
• Investigations (JCI) Clinical
• Orthopedics and related
• Research Breast Cancer
• Research
• Clinical and experimental metastases
• International Journal of Biochemistry Research
• Endocrine Research

Pojects

• VEGFR1/cMet and its role in bone metastases
• Aim of the project:
• To determine the effect of Anti-VEGFR2/cMet in bone metises from breast cancer
• To determine the effect of Anti-VEGFR2/cMet in bone development
• To dissect the mechanism by which Anti-VEGFR2 exert it effect on bone metastases
  
  
• •Cancer cachexia, Role of ryanodine receptor in cancer associated muscle dysfunction
• Aim of the project:
• To determine mechanism of muscle dysfunction in cancer
• Test the effect of ryanodine stabilizing drug in cancer model with muscle dysfuction
  
  
• Differential TGF-β signaling in the bone micro-environment: Impact on tumor growth
• Aim of the project:
• To determine the effect of TGF-β signaling on osteoblasts and osteoclasts and the impact on tumor growth in bone.
  
  
• TGFβ in the bone microenvironment: role in metastases
• Aim of the project include:
• Determining the mechanism by which TGF-β promotes bone metastases in breast and prostate cancer as well as melanoma
• Determine the role of hypoxia in TGF-β -mediated bone metastases
  
  
• Endothelin-1 in normal and pathological bone remodeling
• Aims of this project include:
• Determine the role of ET-1 and endothelin A receptor (ETAR) in normal bone development, growth and remodeling;
• Determine mechanism of ET-1 stimulation of osteoblastic new bone formation;
• Determine the effects of ET-1 on osteoclastic bone resorption;
• Determine the role of ET-1 and ETAR in bone remodeling in sex-steroid deficient states.
  

Teaching Activities

Classroom, Seminar, or Teaching Laboratory:

• Medical histology
  Indiana University School of Medicine           2013-2014
• Medical histology
  Indiana University School of Medicine           2012-2013
• Medical histology
  Indiana University School of Medicine           2011-2012
• Medical histology
  Indiana University School of Medicine           2010-2011
• Bone Biology-Graduate class
  Indiana University School of Medicine           2009-2010
• Human Gross Anatomy - 1st year medical students
  University of Virginia School of Medicine       2007-2008
• Human Gross Anatomy - 1st year medical students
  University of Virginia School of Medicine       2006-2007
• Human Gross Anatomy - 1st year medical students
  University of Virginia School of Medicine       2005-2006
• Human Gross Anatomy - 1st year medical students
  University of Virginia School of Medicine       2004-2005
• Medical Histology - 1st year medical students
  University of Virginia School of Medicine      2003-2004
• Human Gross Anatomy - 1st year medical students          
  University of Virginia School of Medicine     2003-2004 
• Human Gross Anatomy - 1st year medical students
  University of Texas Health Science Center, San Antonio, TX          2000-2001
• Human Gross Anatomy – 1st year medical students
  University of South Dakota School of Medicine         1995-1997
• Medical Histology – 1st year medical students
  University of South Dakota School of Medicine         1995-1996
• Human Anatomy - premedical students
  Minnesota State University    1993-1995

Teaching Activities other than classroom or clinical, including teaching of undergraduate (pre- baccalaureate), graduate, and postdoctoral students and continuing education.

• Conferences, Grand Rounds, Journal Clubs, etc:

• Endocrine Grand Rounds , University of Virginia                                                2004-2008

Trainees & Supervised individuals:

• Students, Postdoctoral & Research Fellows Trained

Antonella Chiechi. Postdoc., fellow Histology and Histomorphometry, X-ray analysis, MicroCT, DXA	2013-current
Ahmed Harhash, Postdoc., Fellow Internal Medicine, IU Histology and Histomorphometry, X-ray analysis, MicroCT, DXA	2012-2013
David Waning. Postdoc., fellow    Tissue processing, histology and Histomorphometry, X-ray analysis	2011-2012
Laura Wright. PhD Student. The University of Arizona. Tissue processing, histology and Histomorphometry, X-ray analysis	2010 & 2012-current
Steven Rhodes. MD, PhD Student. Indiana University School of Medicine Tissue processing, histology and Histomorphometry, X-ray analysis	2010-2013
Sandra Casimiro PhD. Post Doc. Clinical and Translational Oncology Research Unit Instituto de Medicina Molecular, Lisbon, Portugees Tissue processing, histology and Histomorphometry	2009
Xin Lu, Ph.D. student Princeton University Tissue processing, histology and Histomorphometry	2007
Ben Tiede, Ph.D. student Princeton University Tissue processing, histology and Histomorphometry	2007
Pierrick Fournier. Ph.D. Postdoc., fellow X-ray and Histomorphometry analysis	2006-09
Lauren Dunn, MD., PhD. student, University of Virginia Calvarial organ culture and bone assay, histology and Histomorphometry X-ray analysis	2006-09
Vu Duong, M.D., Internal Medicine resident, University of Virginia histology and histomorphometry	2006-07
Richard Ma, M.D., Orthopedic resident, University of Virginia Animal tumor model, histology and histomorphometry	2006-07
Delphine Javelaud, Ph.D., INSERM, France Animal tumor model of metastases; bone metastases imaging and image analysis	2006
Valerie Siclari, Ph.D. student, University of Virginia Histology, Calvarial organ culture and bone assay, histology Histomorphometry and X-ray analysis	2005-09
Luke Choi, MD, Orthopedic resident, University of Virginia Animal tumor model, histology and histomorphometry	2005-06
Michelle Doucet, BS., Johns Hopkins University Animal imaging and histomorphometry	2005
Christa Maes, PhD., Katholieke Universiteit Leuve, Belgium Animal tumor model of metastases; bone metastases imaging,image analysis, histology and histomorphometry.	2005
Dana Gaddy, PhD.Prodessor, University of Arkansas Calvarial organ culture and bone assay	2004
Christopher Hall, PhD., Post Doc. Fellow. University of Michigan Calvarial organ culture and bone assay	2004
Wende Kozlow, MD., Endocrinology fellow, University of Virginia Bone mineral density, bone histology and histomorphometry	2003-05
Gregory A. Clines, MD, PhD., Endocrinology fellow Bone mineral density, calvarial organ culture, bone histology and histomorphometry	2002-04
Peter Abadir, MD. Post Doc. Fellow. University of Virginia Histology imaging, cryosectioning and immunostaining	2002-03
Michelle Wallis, PhD, Post Doc. Fellow. University of Virginia Cryosectioning and use of cryotome	2002

Research Associates and Assistants Trained

Ning Ma, Tissue harvesting, processing and embedding; paraffin sectioning and staining	2012-current
Yun She, Tissue harvesting, X-ray and microCT Imaging, mouse handling	2012-current
Sreemala Murthy Tissue harvesting, processing and embedding; plastic sectioning and staining, IHC	2012-current
Desiree Lane, Animal imaging including x-rays and bone mineral density Measurements, drug administration Tissue harvesting.	2009-2011
Sutha John                                                                                                       Animal imaging including x-rays and bone mineral density measurements; establishments of tumor models including mammary fat bad tumors, intra-osseous tumors and subcutaneous tumors; drug administration and preparations for metastases models	2010-Current
Yu Sheen Wu                                                                                                   Calvarial organ culture and bone assay	2007-2009
Xiang Hong Peng                                                                                             Tissue harvesting, processing and embedding; paraffin sectioning and staining, IHC	2005–2012
Holly Walton                                                                                                   Animal imaging including x-rays and bone mineral density measurements; establishments of tumor models including mammary fat bad tumors, intra-osseous tumors and subcutaneous tumors; drug administration and preparations for metastases models	2005–09
C. Ryan McKenna                                                                                            Animal imaging including x-rays and bone including mammary fat bad tumors, intra-osseous tumors and subcutaneous tumors; drug administration and preparations for metastases models	2003–2009
ngela Mason                                                                                                   Tissue harvesting, processing and embedding; paraffin sectioning and staining	2003-05

Personnel Currently Supervised

1. Antonella Chiechi. Postdoc., fellow, Internal Medicine, IU
2. Laura Wright, Postdoc., Fellow, Internal Medicine, IU
3. Sreemala Murthy, BS, Research associate, Internal Medicine, IU
4. Sutha John, MSc, Research associate, Internal Medicine, IU
5. Ning Ma, Research Associate, Internal Medicine, IU

Journal reviews

• Journal of Clinical Investigation (JCI), Clinical Orthopedics and Related Research (CORR), Clinical and Experimental Metastases.