Publications

  1. Sadhu S. S., Xie J., Zhang H., Perumal O., Guan, X.* Glutathione disulfide liposomes - a research tool for the study of glutathione disulfide associated functions and dysfunctions,2014, submitted.
  2. Sadhu S. S., Averineni R.K., Seefeldt T., Xie J., Tummala H., Guan, X.* Anti-metastatic Effect of Glutathione Disulfide Liposomes, 2014 (manuscript in preparation)
  3. Sadhu S. S., Averineni R.K., Guan, X.*Growth inhibition of malignant melanoma by glutathione disulfide liposomes, 2014, (manuscript in preparation).
  4. Li Y,Zhuang C.,Yang Y., Dwivedi C., Lee J, Miskimins K.,* and Guan X.*A combined inhibition of lactate dehydrogenase and pyruvate dehydrogenase kinase through the use of oxamate and dichloroacetate, and their prodrugs as a novel approach for cancer growth inhibition, 2014, (manuscript in preparation).
  5. Yang Y., Guan, X.* A Rapid and Thiol Specific High Throughput Assay for Simultaneous Relative Quantification of Total Thiols, Protein Thiols and Non-Protein Thiols in Cells, Anal Chem 2014(in revision)
  6. Li YH., Yang Y., Guan, X.* Benzofurazan Sulfides for Thiol Imaging and Quantification in Live Cells through Fluorescence Microscopy, Anal Chem 2012, 84, 6877-6883. (NIHMS394213, Publ.ID: ac301306s)
  7. Chen W., Seefeldt T., Young A., Zhang X., Zhao Y.,  Ruffolo J., Radhey Kaushik R.,Guan X.* Microtubule S-Glutathionylation as a Potential Approach for Antimitotic Agents,BMC Cancer 2012, Jun 15;12:245.
  8. Sadhu S. S., Callegari E., Zhao Y., Guan X.,* and Seefeldt T.*  Evaluation of a Dithiocarbamate Inhibitor of Human Glutaredoxin-1. J Enzyme Inhib Med Chem, 2012, 1-7.
  9. Venuganti V.V., Sahdev P., Hildreth M., Guan X., Perumal O. Structure-Skin Permeability Relationship of Dendrimers. Pharm Res. 2011,28, 2246-2260.
  10. Chen W., Seefeldt T., Young A., Zhang X., Guan X.* Design, Synthesis and Biological Evaluation of N-Acetyl-S-(p-chlorophenylcarbamoyl)cysteine (NACC) and Its Analogs as a Novel Class of Anticancer Agents. Bioorg. Med. Chem. 2011, 19, 287-294.
  11. Chen Z., Lawson S., Sun, Z., Zhou X., Guan X., Christopher-Hennings J., Nelson E. A., Fang Y. Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist. Virology2010,398, 87-97.
  12. Zhao Y., Seefeldt T., Chen W., Carlson L., Stoebner A., Hanson S., Foll R., Matthees D.P., Palakurthi S.,Guan X.* Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to x-ray irradiation. Free Radic. Biol. Med. 2009, 47, 176-183.
  13. Zhao Y., Seefeldt T., Chen W., Wang X., Matthees D., Hu Y., Guan X.* Effects of glutathione reductase inhibition on cellular thiol redox and related systems. Arch Biochem Biophys2009,485, 56-62.
  14. Seefeldt T., Zhao Y., Chen W., Raza A.,Carlson L., Herman J., Stoebner A., Hanson S., Foll R., Guan X.* Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione. J. Biol. Chem. 2009,284, 2729-2737.
  15. Chen W., Zhao Y., Seefeldt T., Guan X.*Determination of thiols and disulfides via HPLC quantification of 5-thio-2-nitrobenzoic acid. J. Pharm. Biomed. Anal.2008, 48, 1375–1380.
  16. Pisal D.S., Yellepeddi V.K., Kumar A., Kaushik R.S., Hildreth M.B., Guan X., Palakurthi S. Permeability of surface-modified polyamidoamine (PAMAM) dendrimers across Caco-2 cell monolayers. Int J Pharm.2008, 350, 113-121.
  17. Dwivedi C., Valluri H.B.,Guan X., Agarwal R. Chemopreventive effects of a-santalol on ultraviolet B radiation-induced skin tumor development in SKH-hairless mice. Carcinogenesis.2006, 27, 1917-1922.
  18. Seefeldt T., Dwivedi C., Peitz G., Carlson L., Herman J., Zhang Z.,Guan X.*2-Acetylamino-3-[4-(2-acetylamino-2-carboxy-ethylsulfanylcarbonylamino)phenylcarbamoyl-sulfanyl]propionic acid and its derivatives as a novel class of glutathione reductase inhibitors. J. Med. Chem.2005, 48, 5224 - 5231.
  19. Dwivedi C., Maydew E.R., Hora J.J., Ramaeker D.M.,Guan X. Chemopreventive effects of various concentrations of alpha-santalol on skin cancer development in CD-1 mice.  Eur. J. Cancer Prev.2005 14, 473-476.
  20. Kaur M., Agarwal C., Singh R. P., Dwivedi C.,Guan X., Agarwal R. Skin cancer chemopreventive agent, alpha-Santalol , induces apoptotic death of human epidermoid carcinoma A431 cells via caspases activation together with dissipation of mitochondrial membrane potential and cytochorme c release. Carcinogenesis2005, 26, 369-380.
  21. Guan X.,*Dwivedi C.,Kim S. Y., Fine T., Ratzsch A.,Seefeldt T., Peitz G., Zhang Z. Mercapturic Acid Biosynthesis of 1-Chloro-2,4-dinitrobenzene in Rat Kidney.  Current Topics in Toxicology.2004, 1, 153-160.
  22. Dwivedi C.,Guan X., Harmsen W.L., Voss A.L., Goetz-Parten D.E., KoopmanE.M., Johnson K.M., Valluri H.B., Matthees D.P.  Chemopreventive Effects of alpha-Santalol on Skin Tumor Development in Cd-1 and Sencar mice. Cancer Epidemiol., Biomarkers Prev.2003, 12, 151-156.
  23. Guan X.,* Hoffman B.,  Dwivedi C., Matthees D.P.A Simultaneous Liquid Chromatography/Mass Spectrometric Assay of Glutathione, Cysteine, Homocysteine and Their Disulfides in Biological Samples.  J. Pharm. Biomed. Anal. 2003, 31, 251-261.
  24. Guan X.,*Hoffman B.N.,McFarland D.C.,Gilkerson K.K., Dwivedi C., Erickson A.K., Bebensee S., Pellegrini J. Glutathione and mercapturic acid conjugates of sulofenur and their activity against a human colon cancer cell line. Drug Metab. Dispos.2002, 30, 331-335.
  25. Dwivedi C., Ingalls E.J.,Guan, X.   Biodistribution of cocaine and cocaethylene during perinatal period after concurrent administration of cocaine and ethanol to rats.  Res. Comm. Alcohol Subst. Abuse2001, 22, 1-12.                   
  26. Guan X*., Davis M. R., Tang C., Jochheim C. M., Jin L., Baillie T. A. Identification of S-(n-Butylcarbamoyl)glutathione, a Reactive Metabolite of Tolbutamide in the Rat, and Evaluation of Its Inhibitory Effects on Glutathione Reductase in vitro. Chem. Res. Toxicol., 1999, 12, 1138-1143.
  27. Guan X*. Diarylsulfonylureas – a new class of antitumor agents.  Invest. Drugs1998,1, 334-338.
  28. Guan X., Fisher M. B., Lang D. H., Zheng Y. M., Koop D. R., Rettie A. E.  Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid.  Chem. Biol. Interact.1998, 110, 103-121.
  29. Shirley M. A.,Guan X., Kaiser D. G.,Halstead G. W., Baillie T. A. Taurine Conjugation of Ibuprofen in Humans and in Rat Liver in vitro.  Relationship to Metabolic Chiral Inversion.  J. Pharmacol. Exp. Ther.1994, 269, 1166-1175.
  30. Guan X., Davis M. R., Jin L.,Baillie T. A.Identification of S-(n-Butylcarbamoyl)-glutathione, a Reactive Carbamoylating Agent as a Bilary Metabolite of Benomyl in the Rat. J. Agric. Food. Chem.1994, 42, 2953-2957.
  31. Guan X., Borchardt R. T. A Convenient Method for the Synthesis of Indole-3-acetic Acids. Tetrahedron Lett. 1994, 35, 3013-3016.
  32. Georg G. I.,Guan X. Asymmetric Synthesis of a-Alkylated a-Amino Acids: Azocane-2-carboxylic Acids. Tetrahedron Lett.1992, 33, 17.
  33. Georg G. I.,Guan X., Kant J. Asymmetric Synthesis of a-Alkylated a-Amino Acids: Azepane-2-carboxylic Acids. Bio-Med. Chem. Lett. 1991, 1, 125.
  34. Georg G. I., Mashava P.,Guan X. An Improved Method for the Stereoselective Synthesis of b-Lactams from Carboxylic Acids and Imines. Tetrahedron Lett. 1991, 32, 581.
  35. Georg G. I.,Guan X., Kant J.Asymmetric Synthesis of a-Alkylated, a-Amino Acids via Schmidt Rearrangement of a,a-Bisalkylated b-Keto Esters. Tetrahedron Lett. 1988, 29, 403.
  36. Lu D., Chao Y.,Guan X. Synthesis of a Long-Acting Androgenic Hormone Testosterone Undecanoate. Zhejiang Yike Daxue Xuebao, 1983, 12, 127. (Chemical Abstracts, 1984, 100, 156863c.)

Oral Presentations

  1. Guan X. Design and development of small molecules of biological interests. Abstracts of papers, 234th National Meeting of the American Chemical Society, Boston, MA; American Chemical Society, Washington, DC, 2007; PROF 003.
  2. Guan, X., Development of novel glutathione reductase inhibitors. Cardiovascular Research Institute, Sioux Falls, SD, May, 2005.
  3. Seefeldt,T. M.; Pietz, G.; Dwivedi, C.; Guan, X.  Development of novel glutathione reductase inhibitors.  6th Annual Pharmacy Student Research Conference Western Region.  Denver, CO, June, 2003.
  4. Hoffman, B.N.; Gilkerson, K.K.; McFarland, D.C.; Dee, C.; Guan, X. Reversal of tumor drug resistance via inhibition of glutathione reductase.  4th Annual Pharmacy Student Research Conference Western Region.  Denver, CO, June, 2001.
  5. Hoffman, B.N.; Dwivedi, C.; Guan, X.  A simultaneous liquid chromatography/mass spectrometry assay of glutathione, cysteine, homocysteine and their disulfides in biological samples.  The Joseph F. Nelson Mentorship Seminar in Chemistry, Biology, Microbiology & Veterinary Science.  SDSU, February, 2001
  6. Guan, X. Development of Liquid Chromatograph Mass Spectrometry (LC/MS) in Characterizing and Quantifying Drug Metabolites in Biological Fluids.  2000 Midwest Section AOAC International Annual Meeting and Exposition.  Sioux Falls, SD, 2000.
  7. Guan, X. Mechanistic Elucidation of Sulfonylurea-Elicited Facial Flushing -Potential Lead to A New Generation of Alcohol Deterrent Agents, Symposium of the Discovery of Lead Compounds for Drugs”, Chungnam National University, Taejon, Korea, 1996.
  8. Guan, X.; Georg, G. I.; Kant, J. Asymmetric Synthesis of a-Alkylated a-Amino Acids: Azepane-2-carboxylic Acids.  Abstracts of papers, 201st National Meeting of the American Chemical Society, Atlanta, Georgia; American Chemical Society, Washington, DC, 1991; ORGN 225.
  9. Guan, X.; Mashava, P.; Georg, G. I. An Improved Method for the Stereoselective Synthesis of b-Lactams.  Abstracts of Papers, 25th Midwest Regional American Chemical Society Meeting, Manhattan, Kansas; American Chemical Society, Washington, DC, 1990; ORGN 151.

Poster Presentations

  1. Yang Y., Guan X.Live cell thiol imaging and quantification with a novel benzofurazan sulfide triphenylphosphonium fluorogenic compound. Abstracts of papers, 248th National Meeting of the American Chemical Society, San Francisco, California; American Chemical Society, Washington, DC, 2014; ANYL 215.
  2. Sadhu S., Averineni R.K., Guan X. Growth inhibition of malignant melanoma by glutathione disulfide liposomes.Abstracts of papers, 248th National Meeting of the American Chemical Society, San Francisco, California; American Chemical Society, Washington, DC, 2014; MEDI 142.
  3. Sadhu S., Averineni R.K., SeefeldtT., Xie J., Tummala H.,Guan X. Anti-metastatic effects of glutathione disulfide. Abstracts of papers, 248th National Meeting of the American Chemical Society, San Francisco, California; American Chemical Society, Washington, DC, 2014; MEDI 143.
  4. Yang Y., Guan X.Mitochondrial thiol imaging through the use of a novel thiol specific fluorogenic agent in live cells. Abstracts of papers, 246th National Meeting of the American Chemical Society, Indianapolis, Indiana; American Chemical Society, Washington, DC, 2013; ANYL 70.
  5. Hou, XL., Yang Y., Li, YH, Guan X. Benzofurazan diacid as a thiol specific agent for imaging cell surface thiols in live cells through fluorescence microscopy.Abstracts of papers, 246th National Meeting of the American Chemical Society, Indianapolis, Indiana; American Chemical Society, Washington, DC, 2013; ANYL 83.
  6. Sadhu S., Seefeldt T.,Guan X. Investigation of antimetastatic effects of glutathione disulfide liposomes. Abstracts of papers, 246th National Meeting of the American Chemical Society, Indianapolis, Indiana; American Chemical Society, Washington, DC, 2013; BIOL 137.
  7. Yang Y., Li, YH, Guan X.Bis(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)sulfane for thiol imaging and semi-quantification in live cells through fluorescence microscopy. Abstracts of papers, 244th National Meeting of the American Chemical Society, Philadelphia, Pennsylvania; American Chemical Society, Washington, DC, 2012; BIOL 145.
  8. Li, YH, Yang Y., Guan X. Benzofurazan Sulfides as a Novel Class of Thiol Specific Fluorogenic Agents. Abstracts of papers, 244th National Meeting of the American Chemical Society, Philadelphia, Pennsylvania; American Chemical Society, Washington, DC, 2012; ANYL 44.
  9. Sadhu S., Xie J., Perumal O., Guan, X.Positively Charged Liposomes for Delivery of Glutathione Disulfide. Abstracts of papers, 244th National Meeting of the American Chemical Society, Denver, Colorado; American Chemical Society, Washington, DC, 2012; BIOL148.
  10. Li YH., Guan X., Development of a novel thiol specific fluorogenic agent. Abstracts of papers, 242nd National Meeting of the American Chemical Society, Denver, Colorado; American Chemical Society, Washington, DC, 2011; ANYL 50.
  11. Chen W., Seefeldt T., Young A., Zhang X., Ruffolo J., Kaushik R., Guan X. 2-AAPA - a Novel Anticancer Agent That Induces Microtubule Depolymerization and Apoptosis. American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April, 2010
  12. Zhao Y., Seefeldt T., Chen W., Wang X., Matthees D., Guan X. Effects of glutathione reductase inhibition on intracellular redox systems. Abstracts of papers, 234th National Meeting of the American Chemical Society, Boston, MA; American Chemical Society, Washington, DC, 2007; BIOL 198.
  13. Chen W., Zhao Y., Seefeldt T., Guan X. Quantification of thiols and disulfides through HPLC determination of 5-thio-2-nitrobenzoic acid. Abstracts of papers, 234th National Meeting of the American Chemical Society, Boston, MA; American Chemical Society, Washington, DC, 2007; BIOL 236.
  14. Zhao Y., Seefeldt T., Chen W., Carlson C., Stoebner A., Hanson S., Foll R., Srinath Palakurthi S., Guan X.Increase in oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to radiation. Abstracts of papers, 234th National Meeting of the American Chemical Society, Boston, MA; American Chemical Society, Washington, DC, 2007; MEDI 342.
  15. Chen W., Seefeldt T., Zhao Y., Zhang Z., Young A., Guan X.N-Acetyl-S-(p-chlorophenylcarbamoyl)cysteine and its analogs as a novel class of anticancer agents. Abstracts of papers, 234th National Meeting of the American Chemical Society, Boston, MA; American Chemical Society, Washington, DC, 2007; MEDI 343.
  16. Hanson S., Seefeldt T., Liang Q., Guan X. Evaluation of the effect of 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoyl-sulfanyl]propionic acid (2-AAPA) on doxorubicin induced cardiotoxicity. Abstracts of papers, 234th National Meeting of the American Chemical Society, Boston, MA; American Chemical Society, Washington, DC, 2007; MEDI 344.
  17. Seefeldt T., Zhao Y., Chen W., Carlson C., Stoebner A., Hanson S., Foll R., Srinath Palakurthi S., Guan X. Increase in oxidative stress via glutathione modulation as a novel approach to enhance cancer sensitivity to doxorubicin. Abstracts of papers, 234th National Meeting of the American Chemical Society, Boston, MA; American Chemical Society, Washington, DC, 2007; MEDI 345.
  18. Chen W., Seefeldt T., Zhao Y., Hanson S., Foll R., Guan X. Determination of the Ratio of Total Thiols and Disulfides – an Index of Intracellular Oxidative Stress. South Dakota Academy of Science 92nd Annual Meeting, Brookings, South Dakota, April, 2007.
  19. Hanson S., Seefeldt T., Guan X. Evaluation of the Effect of G0026, a Novel Glutathione Reductase Inhibitor, on Doxorubicin Induced Cardiotoxicity. South Dakota Student Research Poster Session, Pierre, South Dakota, February 2007.
  20. Seefeldt T., Zhao Y., Chen W., Carlson L., Stoebner A., Hanson S., Foll R., Srinath Palakurthi S., Guan X., Increase in oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to chemotherapy, American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, California, April, 2007.
  21. Stoebner A, Seefeldt T, Carlson L, Herman J, Guan X. Increased Ovarian Cancer Sensitivity to L-PAM by a Combined Inhibition of Glutathione Biosynthesis and Reduction. South Dakota Society of Health-System Pharmacists, Sioux Falls, SD, April, 2006.
  22. Carlson L., Seefeldt T., Herman J., and Guan X.  2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid – a novel irreversible glutathione reductase inhibitor.  Abstracts of papers, 230th National Meeting of the American Chemical Society, Washington, DC; American Chemical Society, Washington, DC, 2005; MEDI 342.
  23. Zhao Y., Seefeldt T., Herman J., Carlson L., and Guan X.  Investigation of 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoyl-sulfanyl]propionic acid’s effect on intracellular glutathione reductase, glutathione, and cell growth with monkey kidney cells.  Abstracts of papers, 230th National Meeting of the American Chemical Society, Washington, DC; American Chemical Society, Washington, DC, 2005; MEDI 371.
  24. Seefeldt T., Dwivedi C., Peitz G., Herman J., Carlson L., Zhang Z., and Guan X.  2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino)phenyl-carbamoylsulfanyl]propionic acid and its derivatives as a novel class of glutathione reductase inhibitors.  Abstracts of papers, 230th National Meeting of the American Chemical Society, Washington, DC; American Chemical Society, Washington, DC, 2005; MEDI 343.
  25. Seefeldt, T; McFarland, D.C.; Gilkerson, K.K.; Zhang, Z.; Carlson, L.; Jocqueline Herman, J.; Palakurthi, S.; Guan, X.2-Acetylamino-3-arylcarbamoylsulfanylpropionic Acids as a Novel Class of Anticancer Agents.South Dakota Student Research Poster Session, Pierre, South Dakota, February 2005.
  26. 26  Jocqueline Herman, J.; Seefeldt, T; Carlson, L.; Guan, X.Development of Novel Glutathione Reductase Inhibitors South Dakota Student Research Poster Session, Pierre, South Dakota, February 2005.
  27. Carlson, L.; Seefeldt, T; Jocqueline Herman, J.; Palakurthi, S.; Guan, X.Investigation of G0026’s Effects on the Intracellular Glutathione Reductase Activity of Ovarian Cancer and the Growth of Ovarian Cancer and Monkey Kidney Cells.South Dakota Student Research Poster Session, Pierre, South Dakota, February 2005.
  28. Jocqueline Herman, J.; Seefeldt, T; Carlson, L.; Guan, X.Development of Novel Glutathione Reductase Inhibitors.South Dakota Society of Health-System Pharmacists, Sioux Falls, SD, April, 2005.
  29. Herman, J.; Seefeldt, T; Carlson, L.; Guan, X.Development of Novel Glutathione Reductase Inhibitors.Annual Pharmacy Student Research Conference - Western Region. Denver, CO, June, 2005.

Book chapters

  1. Guan, X. Metabolic Activation and Drug Targeting.  In Drug Delivery Principles and Applications.  Wang, B., Siahaan, T., Soltero, R., Eds.; John Wiley and Sons: New York, 2005; pp 201-244.
  2. Guan, X. The role of drug metabolism in drug discovery. In Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology. Davis, C., Wang, B., Han, C., Eds; John Wiley and Sons: New York, 2010; pp 109-133.
  3. Guan, X. and Faruk Khan, M. O. The Antineoplastic Agents. In Medicinal Chemistry for Pharmacy Students. M. O. Faruk Khan and Ashok Philip., Eds; Jones & Bartlett Learning, LLC.: Sudbury, MA. 2012(submitted).

 

Xiangming Guan

Assistant Dean & Professor

 

  • : (605) 688-5314
    Fax: (605) 688-5993
    • DEPARTMENT Department of Pharmaceutical Sciences
      College of Pharmacy
      South Dakota State University
    • COUNTRYUSA