Publications

Recent Papers Published in Peer Reviewed Journals since 2010

  1. Brushnahan SK., McGuire TR, Jackson JD, Lane JT, Garvin KL, O’Kane BJ, Berger AM, Tuljapukar SR, Kessinger MA, Sharp JG. Human blood and marrow side population stem cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines.  Mechanisms of Ageing and Development 2010 131, 718-22
  2. McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, O’Kane BJ, Tuljapurkar SR, Sharp JG.  Inflammation Associated with Obesity: Relationship with Blood and Bone Marrow Endothelial Cells.  Obesity 2011 Nov;19 (11)
  3. Sonal R Tuljapurkar; Susan K Brusnahan; Kevin L Garvin; John D Jackson; Margaret A Kessinger; James T Lane; Timothy R McGuire; Barbara J O' Kane; John G Sharp. Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging. Journal of Anatomy 2011. 219 (5): 574-81
  4. S Tuljaputkar, J. Jackson, S Brusnahan, B O’Kane & J Sharp. Characterization of a mesenchymal stem cell line that differentiates to bone and provides niches supporting mouse and human hematopoietic cells. Stem Cell Discovery. Jan 2012 Vol 2 No 1: 5-14.
  5. Mukhopadhyay, Partha, Tracy Farrell, Gayatri Sharma, Timothy McGuire, Barbara O’Kane, J Graham Sharp. Heterogeneity of functional properties of Clone 66 murine breast cancer cells expressing various stem cell phenotypes. PLOS ONE. 2013. Volume 8 (11): 1-15.
  6. Tracy L. Farrell, Timothy R. McGuire, Laura D. Bilek, Susan K. Brusnahan, John D. Jackson, Judy T. Lane, Kevin L. Garvin, Barbara J. O’Kane, Ann M. Berger, Sonal R. Tuljapurkara,M. Anne Kessinger, and John Graham Sharp. Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site. Experimental Hematology 2014. 42:146-154.
  7. Barbara J O’Kane, Marcel D DeVetten, John J Jackson, Jordan P Lacy, Tracy L Farrell, John G Sharp. Multipotential mesenchymal stromal cells (MMSC) ameliorate graft versus host disease in a mouse model, but major suppression of GVHD permits leukemic relapse. Stem Cell Discovery 2014. 4:37-43.

Publications in Peer reviewed Journals (Prior to 2010)

  1. Jackson J.D., Mann S.L., Murphy B.O., Perry G.A., Anderson R.W., Crouse D.A. and Sharp J.G. 1983. Modulation of hematopoiesis in recipients of factor producing transformed Iymphohematopoietic stromal cells. Leukemia Review International 1:188-189.
  2. Sharp J.G., Udeaja G.C., Jackson J.D., Mann S.L., Murphy B.O. and Crouse D.A. 1985. Transplantation of adherent cells from murine long term bone marrow cultures. For: Leukemia: Recent Advances in Biology and Treatment, R.P. Gale et al. (Eds.), Alan Liss, New York.
  3. Crouse D.A., Murphy B.O. and Sharp J.G. 1989. Characteristics of submucosal Iymphoid tissue located in the proximal colon of the rat. J. Anat. 162:53‑65.
  4. O'Kane‑Murphy B., Jackson J. and Dicke K. 1991. Analysis of variations in cryomedium and methods of freezing on human bone marrow stem cells. In: "Bone Marrow Purging and Processing". (Worthington‑White, D.A., Gee, A.P., Gross, S. Eds.), Wiley Liss, New York, 361‑366.
  5. Kessinger A., O'Kane‑Murphy B., Jackson J., Ward B., Kloster T. and Dicke K. 1991. A comparison of different cryomedia and methods of freezing human hematopoietic stem cells obtained from bone marrow and peripheral blood for storage. Int. J. Cell Cloning, 10(Suppl. 1 ).
  6. Knoop, F.C., Owens, M., Marcus, J.N. and Murphy, B. 1991. Elevation of calcium in rat enterocytes by Escherichia coli Heat stable (Sta) enterotoxin. Current Microbiol. 23:291 ‑296.
  7. Dicke, K.A., O'Kane Murphy, B.J., Kessinger, A. And Jackson, J. 1991. Influence of short term incubation of hematopoietic cells with growth factors on production of progenitor cells. Int. J. Cell Cloning, 10(suppl. 1):50‑52.
  8. Alter, R., O'Kane Murphy, B., Korth, D., Costas, P., Wang P.N., Welniak, L., Greally, J., Kuszkynski, C., Warkentin, P.l. and Jackson, J. 1994. Characterization of hematopoietic stem cells in human cord blood. In: Bone Marrow Purging and Processing. (Worthington‑White, D.A., Gee, A.P., Gross, S., eds.) Wiley Liss, New York, pp. 393‑398.
  9. Jackson, J.D., Letheby, B., O'Kane Murphy, B., Costas, P., Wang, P.N., Bishop, M.R., Kessinger, A. And Warkentin, P.l. 1994. Kinetics of low and high dose granulocyte/macrophage colony stimulating factor mobilization of peripheral blood stem cells. In: Bone Marrow Purging and Processing. (Worthington‑White, D.A., Gee, A.P. and Gross, S., eds.), Wiley Liss, New York, pp. 643‑647.
  10. O'Kane Murphy, B., Jackson, J., Kuszynski, C., Costas, P., Wang, P.N., Warkentin, P.l., and Kessinger, A. 1994. CD34 analysis in EPO mobilized peripheral blood stem cells. In: Bone Marrow Purging and Processing. (Worthington‑White, D.A., Gee, A.P. and Gross, S., eds.), Wiley Liss, New York, pp. 371‑376.
  11. Kessinger, A., Bishop, M.R., Jackson, J.D., O’Kane Murphy, B., Vose, J.M., Bierman, P.J., Reed, E.C., Warkentin, P.l., Armitage, J.O., and Sharp, J.G. 1995. Erythropoietin for mobilization of circulating progenitor cells in patients with previously‑treated relapsed malignancies. Exp. Hematol., 23:609‑612.
  12. Bishop,MR, Jackson,JD, Tarantolo,SR, O’Kane Murphy B, IversenPL, Bayever E, Joshi SS, Sharp JG, Pierson JL, Warkentin PI, Armitage JO, Kessinger A. 1997. Ex vivo treatment of bone marrow with phosphorothioate oligonucleotide OL(1)p53 for autologous transplantation in acute myelogenous leukemia and myelodysplastic syndrome. J Hemat 6:441-446.
  13. Traystman MD, Cochran GT, Hake SJ, Kuszynski CA, Mann SL, Murphy BJ, Pirruccello SJ, Zuvanich E, Sharp JG. 1997. Comparison of molecular cytokeratin 19 reverse transcriptase polymerase chain reaction (CK19 RT-PCR) and immunocytochemisrty detection of micrometastatic breast cancer cells in hematopoietic harvests. J Hematotherapy 6: 551-561
  14. Sharp JG, Kessinger A, Clause SR, Mann SL, O’Kane Murphy B. 1998. Concurrent partial body irradiation prevents cytokine mobilization of blood progenitor cells: an effect mediated by a circulating factor.  J Hematotherapy 7:343-349 .
  15. Sharp. J.G., Bishop, M.R., Chan, W.C., Joshi, S.S., Kessinger, A., Mann, S., O'Kane Murphy, B., Pirruccello, S., Sanger, W., Traystman, M., Vose, J., Weekes, C. and Wu.,G. 1999. Application of malignant cell detection techniques to improve the outcome of highdose therapy and transplantation for Iymphoma, leukemia and breast cancer. In: Mulhouse Manual, Karger, Basel Press) (in press).
  16. Schneiderman MH, Jackson JD, Joshi SS, Clark-Pierce L, Murphy BJ, Schniederman GS. 1998. Radiation Research 149:147-154.
  17. Mata JE, Joshi SS, Tracewell WG, Pirruccello SJ, Murphy BJ, Bishop MR, Iversen PL. 2000. Pharmacokinetics and in vivo effects of a six base oligodeoxynucleotide with anticancer and hematopoietic activities in swine. J Hematotherapy and Stem Cell Research 9:205-214.
  18. Kessinger A, Mann S, O’Kane Murphy B, Jackson J, Sharp JG. Circulating factors may be responsible for strain-specific responses to mobilizing cytokines. 2001. Experimental Hematology 29(6):775-778.
  19. Sharp JG, McGuire TR, Mann SL, Murphy B, Kessinger A. Plasma from poorly mobilizing subjects inhibits cytokine-induced murine blood stem cell mobilization. 2002. Cytotherapy 4(4):365-73.
  20. O’Kane Murphy B., Joshi S., Kessinger A., Reed E., Sharp JG. A murine model of bone marrow micrometastases in breast cancer. 2002. Clinical and Experimental Metastasis 19(7):561-569.
  21. Reed E, Kessinger A, Murphy B, Tarantolo S, Traystman M, and Sharp JG.  Occult tumor cells detected in autologous blood stem cell harvests have no impact on five year outcomes for 4-9 node positive breast cancer patients treated with adjuvant high dose therapy and stem cell transplantation.  Bone Marrow Transpl, 31:571-574 (2003).
  22. Sharp JG, O’Kane Murphy BJ, Jackson JD, Brusnahan, SK, Kessinger MA, Neff JR.  Promises and pitfalls of stem cell therapy for promotion of bone healing.  2005 Clinical Orthopedics and Related Research, 435:(52-61).
  23. Kessinger,A, B O’Kane Murphy, J Jackson and JG Sharp.  An ex vivo model of hematopoietic stem cell mobilization. 2005. Cytotherapy 7(6):463-469.
  24. Brushnahan SK., McGuire TR, Jackson JD, Lane JT, Garvin KL, O’Kane BJ, Berger AM, Tuljapukar SR, Kessinger MA, Sharp JG. Human blood and marrow side population stem cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines.  Mechanisms of Ageing and Development 2010 131, 718-22
  25. McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, O’Kane BJ, Tuljapurkar SR, Sharp JG.  Inflammation Associated with Obesity: Relationship with Blood and Bone Marrow Endothelial Cells.  Obesity 2011 Nov;19(11)
  26. Sonal R Tuljapurkar; Susan K Brusnahan; Kevin L Garvin; John D Jackson; Margaret A Kessinger; James T Lane; Timothy R McGuire; Barbara J O' Kane; John G Sharp. Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging. Journal of Anatomy 2011. 219 (5): 574-81
  27. S Tuljaputkar, J. Jackson, S Brusnahan, B O’Kane & J Sharp. Characterization of a mesenchymal stem cell line that differentiates to bone and provides niches supporting mouse and human hematopoietic cells. Stem Cell Discovery. Jan 2012 Vol 2 No 1: 5-14.
  28. Mukhopadhyay, Partha, Tracy Farrell, Gayatri Sharma, Timothy McGuire, Barbara O’Kane, J Graham Sharp. Heterogeneity of functional properties of Clone 66 murine breast cancer cells expressing various stem cell phenotypes. PLOS ONE. 2013. Volume 8 (11): 1-15.
  29. Tracy L. Farrell, Timothy R. McGuire, Laura D. Bilek, Susan K. Brusnahan, John D. Jackson, Judy T. Lane, Kevin L. Garvin, Barbara J. O’Kane, Ann M. Berger, Sonal R. Tuljapurkara,M. Anne Kessinger, and John Graham Sharp. Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site. Experimental Hematology 2014. 42:146-154.
  30. Barbara J O’Kane, Marcel D DeVetten, John J Jackson, Jordan P Lacy, Tracy L Farrell, John G Sharp. Multipotential mesenchymal stromal cells (MMSC) ameliorate graft versus host disease in a mouse model, but major suppression of GVHD permits leukemic relapse. Stem Cell Discovery 2014. 4:37-43.

Abstract Presentations

Abstracts presented and published since 2010

  1. Effect of Various Modes of Exercise on the Mobilization of Stem Cells
    Barbara O’Kane 1, Patrick Passarelli2, Molly Lang4, Susan Brusnahan3, Laura Bilek41- Dept of Oral Biology Creighton University, Omaha NE   2-Dept of Internal Medicine, UNMC, Omaha NE  3-Dept of Pharmacology UNMC, Omaha NE. 4- Division of Physical Therapy Education UNMC, Omaha NE. American Association of Anatomists 2011, Washington DC
  2. Leukemic Relapse Following MMSC Rescue In A Murine Model Of GVHD
    Barbara O’Kane1, Marcel DeVetten2, John Jackson3, Jordan Lacy2,  J Graham Sharp2 Creighton University School of Dentistry1, Omaha NE. University of Nebraska Medical Center2, Omaha NE.  Wake Forest School of Medicine, Institute of Regenerative Medicine3, Winston Salem NC. American Association of Anatomists 2013, Boston Massachusetts
  3. Massie H. Jesse and Barbara J O’Kane. Dept. of Oral Biology, Creighton University School of Dentistry. Primary culture of oral mucosa using the direct explant technique. University Research Day/St Albert’s Day  April 2014, Creighton University, Omaha NE  68178
  4. Massie H. Jesse and Barbara J O’Kane. Dept. of Oral Biology, Creighton University School of Dentistry. Primary culture of oral mucosa using the direct explant technique. American Association of Clinical Anatomists. Orlando FL. July 2014
  5. Master of Oral Biology, Anatomic science track: A path to addressing the need for dental educators. Margaret A. Jergenson, Laura C. Barritt, Neil S. Norton, Barbara J. O’Kane and Mark A. Latta. American Association of Anatomists. Orlando FL July 2014.
  6. Kum, Jason M., Laura C. Barritt, William J. Puetz, Sonia M. Sanchez, Shikha Tarang, and Barbara J. O’Kane. Determination of Expression of TREM-1 and TREM-2 in Oral Keratinocytes. Department of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, USA.  AACA Henderson NV.  2015.
  7. PUETZ III, William J., Laura C. Barritt, Jason M. Kum, Sonia M. Sanchez, Shikha Tarang, Barbara J. O’Kane. Department of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, USA. TREM-1 and TREM-2 protein expression in human gingival tissue. AACA Henderson, NV. 2015
  8. PUETZ III, William J., Laura C. Barritt, Jason M. Kum, Sonia M. Sanchez, Shikha Tarang, Barbara J. O’Kane. Department of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, USA. TREM-1 and TREM-2 protein expression in human gingival tissue. University Research Day/St Albert’s Day  April 2015, Creighton University, Omaha NE  68178

Abstracts Presented And Published Prior To 2010

  1. Jackson JD, Mann SL, O'Kane BJ and Sharp JG. 1981. Development of an in vitro technique for the study of cell proliferation in mouse intestine. Nebr. Acad. Sci. Book of Abstracts, p. 18.
  2. Mann SL, O'Kane BJ, Crouse DA and Sharp JG. 1982. A comparison of two in vitro culture systems for maintenance of murine hematopoiesis. Proc. Nebr. Acad. Sci., p. 27.
  3. Jackson JD, Mann SL, O'Kane BJ, Perry GA, Anderson RA, Crouse DA and Sharp JG. 1983. Hematopoietic abnormalities induced bone marrow derived stromal cells. J. Cell Biochem. Suppl.
  4. Jackson JD, Mann SL, Murphy BO, Perry GA, Anderson RA, Crouse DA and Sharp JG. 1983. Modulation of Iymphopoiesis and hematopoiesis in vivo by factor producing transformed Iymphohematopoietic stromal cells. Midwinter Immunology Conference Abstracts, January 1983.
  5. Murphy BO, Mann SL, Jackson JD, Perry GA, Crouse DA and Sharp JG. 1983. Morphological evidence suggesting transfer of hematopoietic microenvironments to ectopic sites by mouse bone marrowfibroblastoid cells. Exp. Hematol. 11(14):126.
  6. Crouse DA, Perry GA, Jackson JD, Mann SL and Murphy BO. 1983. Functional and morphological evaluation of immunodeficient mice grafted with allo  and semi allogenic low temperature organ culture fetal thymic epithelium. 5th Int'l. Congress of Immunology.
  7. Sharp J.G., Jackson J.D., Mann S.L., Murphy B.O., Perry G.A. and Joshi S.S. 1983. Abdominal irradiation prior to administration of dimethylhydrazine increases the subsequent yield of colonic tumors. Rad. Res. Book of Abstracts, p. 102.
  8. Sharp J.G., Crouse D.A., Jackson J.D., Mann S.L. and Murphy B.O. 1985. Abdominal irradiation is a potent promoter of dimethylhydrazine induced colon tumors in rats. Proc. AACR 26:144.
  9. Sharp JG, Udeaja GC, Mann SL, Murphy BO and Crouse DA. 1985. Transplantation of hematopoietic stromal and stem cells in intimate contact influences stem cell primitiveness in the spleen colony assay. Anat. Rec. 211i174a.
  10. Sharp JG, Udeaja GC, Jackson JD, Mann SL, Murphy BO and Crouse DA. 1985. Stem cell regulatory role of hematopoietic stroma revealed by transplantation of adherent cells from long term marrow cultures. Int. Congress Anat. Meeting, London, 1985.
  11. Jackson JD, Mann SL, Murphy BO, Perry GA, Crouse DA and Sharp JG. 1983. The hematological and immunological effects of Dioxin (CDD) in adult mice. NIH Immunotoxicology Workshop, p. 409.
  12. Anderson RW, Murphy BO and Crouse DA. 1983. Preliminary characterization of the specific defect in a patient with congenital neutropenia (Kostmans Syndrome). Blood 63.
  13. Murphy BO, Crouse DA and Anderson RW. 1984. Decreased colony stimulating factor (CSA) from the mononuclear peripheral blood leukocytes and urine from an agranulocytosis patient. Anat. Rec. 208:304.
  14. Perry GA, Murphy BO, Jordan RK and Crouse DA. 1984. Lymphoid development in grafted thymic epithelium. Anat. Rec. 208:306.
  15. Marcus JN, Anderson C, Murphy B, Anderson L and Schultz R. 1987. Selective depletion of the T4+4B4+ ("Helper inducer") subset in the Iymphopenia associated with cardiopulmonary bypass. Histochemical Society Book of Abstracts.
  16. Anderson E, Marcus J, Schultz R, diMarzo L, Anderson C and Murphy B. 1987. Cardiopulmonary bypass associated Iymphopenia: Helper T (CD4) and natural killer (NKH 1 ) subset depletions followed different time courses. Int'l Meeting of the Society of Analytical Cytology Book of Abstracts.
  17. Marcus JN, Anderson EA and O'Kane Murphy B. 1986. Tumor cell quantitative DNA analysis at the Creighton Flow Cytometry laboratory. Second Nebraska Symposium on Cancer and Smoking Related Diseases Book of Abstracts
  18. O'Kane Murphy B, Jackson J, Purtilo D, Coccia P and Dicke K. 1990. Comparison of cryomedia and freezing methods on human bone marrow. Blood 76(10) Suppl 1.
  19. Dicke KA, O'Kane Murphy B, Jackson J. 1991. Short term exposure of hematopoietic stem cells to cytokines enhances the number of colony forming cells. Second International Symposium on Peripheral Blood Stem Cell Autografts Book of Abstracts.
  20. O'Kane Murphy B, Jackson JD, Dicke KA. 1991. Analysis of variations in cryomedium and methods of freezing on human bone marrow stem cells. Third International Symposium on Bone Marrow Purging and Processing.
  21. Jackson JD, O'Kane Murphy BJ, Clausen SR, Sharp JG. 1993. Ex vivo treatment of swine bone marrow with human cytokines increases progenitor cells. J. Cellular Biochemistry. Abstract #E 1 18, 1 7B: 64(suppl) .
  22. Jackson JD, O'Kane Murphy BJ, Clausen SR, Sharp JG. 1993. Ex vivo treatment of swine bone marrow with human cytokines increases progenitor cells. Keystone Symposium Book of Abstracts.
  23. Costas P, Jackson JD, Murphy B, Welniak L, Wang PN, Greally J, Kuszynski C, Kessinger A and Warkentin Pl. 1993. Expression of CD34 antigen in human cord blood: a comparison of two different antibodies (My10 and 8G12) and correlation with in vitro CFU GM. Pro. American Society of Clinical Oncology 12:116 (Abst. #265).
  24. Jackson J, O'Kane Murphy B, Korth D, Kuszynski C, Warkentin P, Wang PN, Costas P and Kessinger A. 1993. CD 34 quantitation of GM CSF mobilized peripheral blood stem cells. Fourth International Symposium on Bone Marrow Purging and Processing.
  25. Jackson JD, Letheby B, O'Kane Murphy B, Costas P, Wang PN, Bishop MR, Kessinger A, Warkentin Pl. 1993. Kinetics of low and high dose granulocyte/macrophage colony stimulating factor mobilization of peripheral blood stem cells. Fourth International Symposium on Bone Marrow Purging and Processing.
  26. O'Kane Murphy B, Jackson JD, Kuszynski C, Costas P, Wang PN, Warkentin P and Kessinger A. 1993. CD34 analysis in EPO mobilized peripheral blood stem cells. Fourth International Symposium on Bone Marrow Purging and Processing.
  27. Costas P, Jackson JD, Murphy B, Kuszynski C, Wang PN, Welniak L, Kessinger A, Letheby B and Warkentin Pl. 1993. Celulas progenitoras de sangre periferica movilizadas con rhGM CSF: Estudio en el producto de aferesis de la distribucion del immunofenotipo CD34+ y su correlacion con la generacion in vitro de colonias. V Congreso Asociacion Espanola de Investigacion Sobre El Cancer. Las Palmas De Gran Canaria.
  28. Alter R, O'Kane Murphy B, Korth D, Costas P, Wang PN, Welniak L, Greally JF, Kuszkynski C, Warkentin Pl, Jackson JD. 1993. Characterization of hematopoietic stem cells in human cord blood. International Society for Hematotherapy and Graft Engineering .
  29. Kessinger A, Bishop M, Jackson J, Anderson J, O'Kane Murphy B, Vose J, Bierman P, Reed E, Warkentin P, Armitage J, Sharp JG. 1993. Erythropoietin (EPO) for mobilization of circulating progenitor cells in patients with previously treated malignancies. Blood 82:10 (supp 1) 227a (Abst. #892).
  30. Welniak LA, O'Kane Murphy B, Warkentin Pl, Kessinger A, Jackson JD. 1993. Day 28cobblestone area forming cells (CAFCDAy28) correlate to CFU GM in leukapheresis products from patients given GM CSF. Blood 82:10 (supp 1) 287a (Abst. #1133)
  31. Kessinger A, Bishop M, Jackson J, Murphy B, Vose J, Bierman P, Reed E, Warkentin P, Armitage J, Sharp JG. 1993. Erythropoietin for mobilization of circulating progenitor cells. Third International Symposium on Peripheral Blood Stem Cell Autografts.
  32. O'Kane Murphy B, Jackson JD, Bociek G, Costas P, Korth D, Kuszynski C, Wang PN,Warkentin Pl, Bishop MR, Kessinger A. 1993. CD34 analysis of GM CSF mobilized peripheral blood stem cells. Blood 82:10 (supp 1) 488a (Abst. #1937).
  33. O'Kane Murphy B, Jackson JD, Bishop MR, Warkentin Pl, Kessinger A (intro by DA Crouse). 1994. PIXY321 mobilization of hematopoietic progenitors for peripheral blood stem cell transplants. Exp. Hematology 22:8 (Abst. #100).
  34. Winterstein B, Clausen S, Reilly P, Vetter A, Crouse D, Murphy B, Welniak L, JacksonJ, Sharp JG. (1994). In vivo effects of erythropoietin on bone marrow and spleenhematopoietic stem and progenitor cells (HSC) in mice. University of Nebraska MedicalCenter Student Research Forum Book of Abstracts.
  35. Martin Algarra S, Verbik DJ, Murphy BO, Welniak LA, Jackson JD, Kessinger A, Joshi SS. 1995. Incubation of non mobilized peripheral blood stem cells (PBSC) with rhGM CSF and rhlL 2 generates LAK cell activity without decreasing clonogenicity. Proceedings of the AACR, 86th Annual Meeting, 36:469 (abstract #2792).
  36. Bishop MR, O'Kane Murphy B, Jackson JD, Vose JM, Bierman PJ, Armitage JO, Garrison L, Kessinger A. 1995. Mobilization of blood stem cells with PIXY321: Results of a Phase I trial. Blood, 86:10 (supp 1) 579a (Abst. #2302).
  37. Traystman MD, Murphy B, Sharp JG, Kessinger A, Kuszynski CA, Pirruccello S, Tarantolo S, Zuvanich E, Reed E. 1995. Detection of minimal residual disease in breast cancer patients by RT PCR and ICC. American Society of Human Genetics 45th Annual Meeting .
  38. Bishop MR, O'Kane Murphy B, Jackson JD, Vose JM, Bierman PJ, Armitage JO, Garrison L, Kessinger A. 1995. Mobilization of blood stem cells with PIXY321: Results of a Phase I trial. Blood, 86:10 (supp 1) 579a (Abst. #2302).
  39. Murphy BO, Traystman M, Reed E, Kessinger A, Klassen L, Thiele G, Jackson J, Joshi SS, Sharp JG. 1996. Characterization of a murine model of occult metastasis of breast cancer to bone marrow: comparison to observations in patients. 18th Annual San Antonio Breast Cancer Symposium.
  40. Traystman MD, Sharp JG, Murphy B, Kuszynski C, Pirruccello S, Zuvanich E, Cochran G. 1996. Sensitivity detection level for minimal residual disease in breast cancer. American Association for Cancer Research.
  41. Sharp JG, Tarantolo S, Traystman M, Murphy B, Mann S, Zuvanich E, Kessinger A, Reed E. 1996. Relevance of tumor contamination of stem cell grafts in breast cancer. ISHAGE 1st International Meeting on Minimal Residual Cancer.
  42. Tarantolo S, Reed EC, Murphy B, Mann S, Traystman M, Kessinger A, Sharp JG. 1996. Administration of GM CSF to breast cancer patients mobilizes low numbers of tumor cells into leukapheresis harvests. International Society of Experimental Hematology, New York, NY.
  43. O'Kane Murphy B, Jackson J, Kitzan M, Joshi SS, Reed E, Traystman M, Kessinger A, Sharp JG. 1996. Characterization of a murine model for bone marrow micro metastases in breast cancer. Models to Study Breast and Prostate Cancer: Proceedings of The Sixth Biennial Sandoz-Keystone Symposium on Bone Marrow Transplantation, (abstract #420).
  44. Sharp JG, Kessinger A, Clausen S, Mann S, Murphy B. 1996. Concurrent radiation therapy prevents cytokine mobilization of blood stem cells: an effect medicated by a circulating factor. Nebraska Symposium on Cancer and Smoking Related Diseases.
  45. Sharp,JG, Kessinger A, Clausen S, Mann S, Murphy B. Concurrent radiation therapy prevents cytokine mobilization of blood stem cells: an effect mediated by a circulating factor.  Presented at the Nebraska Symposium on Cancer and Smoking Related Diseases, November 21-22, 1996.
  46. Kessinger,A, Clausen S, Mann S, Murphy B, Sharp, JG.  Indifference to blood stem cell mobilization attempts: prior stem cell damage is not the only causal factor.  Blood, 88:10 (supp 2) 225b (Abst. # 3628), 1996.
  47. Sharp JG, Crouse DA, Mann SL, Clausen S, Murphy B, Kessinger A. Hematopoietic stem cell mobilization by cytokines is inhibited by a circulating factor activated by radiation therapy.  Program/Proceedings of Keystone Symposia (Abst. #143), 1997.
  48. Sharp JG, Mann S, Kessinger A, Clause S, Murphy B. Partial body radiation inhibits cytokine mobilization of blood stem cells via a circulating factor.  Program/Proceedings Radiation Research Society 46th Annual Meeting, North American Hyperthermia Society 17th Annual Meeting, p200 (Abst #3460) April 25-29, 1998.
  49. Sharp JG, Chan J, Mann S, Murphy B, Reed B, Tarantolo S, Vose J, Weekes C, Wu G.  Issues influencing the application of techniques of detection of minimal residual disease. J Hematotherapy 7: 272, 1998.
  50. Sharp JG, Mann S, Murphy B, Schmit-Pokorny K, Kessinger A.  Impact of radiation therapy on blood stem cell mobilization.  Radiation Research Laboratory 50th Anniversary.  Book of Abstracts #21, 1998.
  51. Kessinger A, Mann S, Lynch J, O’Kane Murphy B, Sharp JG.  Strain specific patterns of hematopoetic stem/progenitor cell mobilization: possible role of a circulating inhibitor of mobilization.  Blood, Suppl 1:135a (Abst #595), 1999.
  52. Kessinger A, Mann S, Lynch J, O’Kane Murphy B, Sharp JG.  Patterns of mobilization.  Presented at Peripheral Blood Stem Cell Transplantations, Mulhouse, France, September 1999.
  53. Kessinger A, Mann S, Murphy B, Lynch J, Petersen K, Sharp JG.  Determinants of hematopoietic stem cell vigor in autologous donors.  Keystone Symposium on Stem Cells, January 2000.
  54. Sharp JG, Lynch JC, Mann SL, Murphy B, Kessinger A.  Circulating factors influence hematopoietic stem and progenitor cell mobilization in breast cancer patients.  DOD: Era of Hope, June 2000 (in press).
  55. Sharp JG, Mann SL, Murphy B, McDonald T, Weber A, Kessinger A.  Transforming growth factor beta (TGF-B`) is a candidate radiation induced inhibitor of blood stem cell mobilization.  Submitted to the Radiation Research Society Meeting in Albuquerque, New Mexico, April 29-May3, 2000. 
  56. Sharp JG, McGuire TR, Mann SL, O’Kane-Murphy B, Kessinger A.  Transforming growth factor beta is implicated as an inhibitor of blood stem cell mobilization. ASH Proceedings Vol 96:552a, (Abstract #2372) December 2000. 
  57. Kessinger A, O’Kane-Murphy B, Sharp JG.  Influence of erythropoietin plus granulocyte colony stimulating factor on in-vitro migration of progenitors from murine bone marrow.  ASH Proceedings Vol 96:301b, (Abstract #5046) December 2000.
  58. O’Kane Murphy BJ, Jackson JD, Joshi S, Kessinger A, Reed EB, Sharp JG.  The Effect of Cytokine Administration on Bone Marrow Micrometastatic Breast Cancer Cells.  ASH Proceedings Vol 98:298a, (Abstract #1257) November 2001.
  59. Kessinger A, O’Kane Murphy BJ, Jackson JD, Sharp JG.   Ex-Vivo Modeling of Hematopoietic Stem/Progenitor Cell Mobilization.  ASH Proceedings Vol 98:318b, (Abstract #5029).  November 2001.
  60. O’Kane Murphy B, Jackson J, Joshi S, Kessinger A, Sharp J. Metastatic tumor cell migration from mammary adenocarcinomas. ISHAGE Proceedings, June, 2001.61. O=Kane Murphy B, Jackson J, Joshi S, Kessinger A, Reed E, Sharp JG. The effect of cytokine administration on bone marrow micrometastatic breast cancer cells. Proceedings American Society of Hematology. 2001.
  61. J.G. Sharp, G. Lauby, C. Kuszynski, L. Manouilova, J.Jackson, and B. O'Kane Murphy.   Transplanted bone marrow cells and side population (SP) cells generate multi-lineage progeny in tissues of irradiated recipients. Proceedings American Society of Hematology, 2001.
  62. G. Lauby, S. Abe, J. Jackson, B. O’Kane Murphy, J. G. Sharp, S. Rennard.  Lymphohematopoietic progeny derived from lung cells transplanted into irradiated recipients. Proceedings, Keystone Symposium 2002.
  63. Lauby G, Abe S, Manouilova L, Sharp J, Murphy B, Jacskon J and Rennard S.  Bone Marrow Transplantation can be used to introduce genetically manipulated inflammatory cells into the lung. Proceedings American Thoracic Society, 2002.
  64. Lauby G, Jackson J,  Murphy B, Manouilova L,  Kuszynski C, Sharp JG and Rennard S.  Lung contains lymphohematopoietic stem cells. Proceedings American Thoracic Society, 2002.
  65. Sharp JG, Badami M, Brusnahan S, Jackson JD, Kuszynski C, Lauby G, Manouvilova L, O'Kane-Murphy B, Polosukhin V, Wilkie LM, Rennard SI.  Isolation and initial characterization of endodermal side population (SP) cells. ISHAGE Proceedings, June 2002.
  66. O’Kane Murphy BJ, Joshi SS, Kessinger A, Sharp G, Gohr JC.  Characterization of a stem cell-like population in breast cancer” Cytotherapy 5:470, 2003
  67. O’Kane Murphy B, Gohr J, Joshi SS, Kessinger A, Sharp JG. Genotypic and phenotypic evidence for a CD44 mediated pathway in bone marrow metastatic breast cancer. AACR, 2003, Abstract #LB-159.
  68. Brusnahan S, Jackson J, Losee M, Murphy BO, Sharp JG, Kessinger A.  Identification of osteoblastic stem/progenitor cells in cytokine mobilized murine blood.  Keystone Symposium on Stem Cells, 2004.  Abstract #123, Abstract Book, p. 72.
  69. Murphy BO, Gohr J, Kessinger A, Kuszynski C, Jackson J, Sharp JG.  Side population (SP) phenotype identified in murine mammary adenocarcinoma cells.  Keystone Symposium on Stem Cells, 2004.  Abstract #340, Abstract Book, p. 104.
  70. Adipocyte accumulation in bone marrow with aging corresponds to a decrease in side population (SP) stem cells and quality. Sharp, JG, Berger A, O’Kane Murphy B, Brusnahan S, Jackson J, Lane J, Garvin K, Kessinger A. Experimental Biology 2006, San Francisco, April 2006. FASEB Journal 20:A873,2006.
  71. Decreased side population (SP) stem cells but unaltered stromal cells in humans with aging. JG Sharp, AM Berger, SK Brusnahan, KL Garvin, JD Jackson, JT Lane, TR McGuire, BJ O’Kane Murphy, A Kessinger.  Keystone Symposia, Keystone CO, March 2007. Abstract # 315
  72. Retinoic acid mitigates emphysema in aged mice.  CW Boyer, S Kawasaki, J Michalski, B O’Kane Murphy, X Liu, K Fucinaro, JG Sharp and SJ Rennard. American Thoracic Society (ATS), San Francisco, CA., May 2007. Abstract # 4762.
  73. S Kawasaki1, CW Boyer2, XD Liu1, Tetu Kobayashi1, B O’Kane2, JG Sharp2, SI Rennard1. 1 Repopulation of blood and lung from aged hematopoietic stem cells.  ISCT .  Miami FL., May  2008.
  74. Sharp JG., et al. “Effects of locoregional radiation therapy on bone and bone marrow in a mouse model” Radiation Research society Poster Presentation, 2009
  75. Tuljapurkar S., et al. “Alcohol Reduced Bone Marrow Multipotential Mesenchymal Stromal Cell Colony Formation in the Elderly and Induces Adipocyte Differentiation” Midwest and International Student Research Forum, 2009
  76. Tuljapurkar S., et al.  “Human multipotential side population stem cells decline, whereas bone marrow fat increases, with age.  Submitted to Regenerative Medicine Symposium.
  77. Hielscher A., et al. “Mouse and human lymphoma side population (SP) cells with stem cell-like characteristics” AACR Meeting, Boston, MA, 2009 Poster Presentation.
  78. Bilek LD., et al. “Relationship between stem cell number and physical activity in older adults”, GSA Abstract, 2009.

 

Barbara J. O’Kane

Associate Professor

 

 

  • :(402) 280-5029
    • DEPARTMENTDepartment of Oral Biology
      Creighton University
      School of Dentistry
      Omaha, Nebraska
    • COUNTRY USA