Publications

Selected Peer-reviewed Publications

1. Li X, Nadauld L, Ootani A, Corney D, Reetesh K. Pai, Gevaert O, Cantrell M, Rack P, James T. Neal, Carol W-M. Chan,Trevor Yeung, Xue Gong, Jenny Yuan, Julie Wilhelmy, Sylvie Robine, Laura D. Attardi, Sylvia K. Plevritis, Kenneth E. Hung, Chang-Zheng Chen, Hanlee P. Ji, Calvin J. Kuo.   Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nature Medicine 2014, in press
2. Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X,     Tsherniak A, Schinzel  AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, Root DE, Mesirov JP, Beroukhim R, Kuo  CJ,  Goessling  W,  Hahn  WC.  β-Catenin-driven  cancers  require  a  YAP1  transcriptional  complex  for survival and tumorigenesis. Cell. 2012 Dec 21;151(7):1457-73. doi: 10.1016/j.cell.2012.11.026. Epub 2012  Dec 13.
3. Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC,       Amieva MR, Sangiorgi E, Capecchi MR, Kuo CJ. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations.Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):466-71. Epub 2011 Dec 21.
4. Ootani A, Li X, Sangiorgi E, Ho QT, Ueno H, Toda S, Sugihara H, Fujimoto K,     Weissman IL, Capecchi MR, Kuo CJ.   Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med. 2009 Jun;15(6):701-6. Epub 2009 Apr 27.
5. Li X, Deng W, Lobo-Ruppert SM, Ruppert JM. Gli1 acts through Snail and E-cadherin to promote nuclear signaling by β-catenin   Oncogene. 2007 July 5; 26(31): 4489-4498.
6. Li X, Deng W, Nail CD, Bailey SK, Kraus MH, Ruppert JM, Lobo-Ruppert SM. Snail induction is an early response to Gli1 that determines the efficiency of    epithelial transformation.    Oncogene.  2006 Jan 26;25(4):609-21. Epub 2005 Sep 12.
7. Huang CC, Liu Z, Li X, Bailey SK, Nail CD, Foster KW, Frost AR, Ruppert JM,   Lobo-Ruppert SM. KLF4 and PCNA Identify Stages of Tumor Initiation in a Conditional Model of Cutaneous Squamous Epithelial Neoplasia. Cancer Biol Ther. 2005 Dec;4(12):1401-8.Epub 2005 Dec 23.
8. Foster KW, Liu Z, Nail CD, Li X, Fitzgerald TJ, Bailey SK, Frost AR, Louro ID, Townes TM, Paterson AJ, Kudlow  JE,  Lobo-Ruppert  SM,  Ruppert  JM.  Induciton  of  KLF4  in  basal  keratinocytes  blocks  the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 2005 Feb 24; 24(9): 1491-1500
9. Louro ID, Bailey EC, Li X, South LS, Mckie-Bell PR, Yoder BK, Huang CC,   Johnson MR, Hil AE, Johnson RL, Ruppert JM. Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation Cancer Res. 2002 Oct 15;62(20):5867-5873