Publications

• Chen SS and Chiorazzi N. 2014 Genetically-engineered murine and human xenograft models of chronic lymphocytic leukemia. Seminars in hematology, 51(3):188-205.
• Chen SS, Batliwalla F, Holodick N, Yan XJ, Yancopoulos S, Croce, CM, Rothestin TL and Chiorazzi N. 2013 Antigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling. PNAS, 110(16):E1500-7.
• Chen SS*, Ponader S*, Buggy JJ, Balakrishnan K, Gandhi VV, Wierda WG, Keating MJ, O’Brien S, Chiorazzi N, Burger J. 2012 Bruton’s tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 119 (5): 1182-9.
• Chen SS, Claus R, Lucas DM, Yu L, Qian J, Ruppert AS, West DA, Williams KE, Johnson AJ, Sablitzky F, Plass C, Byrd JC. 2011 Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL. Blood 117 (3):862-71.
• Chen SS, Sherman M, Hertlein E, Johnson AJ, Teitell MA, Byrd JC. 2009 Epigenetic alterations in a murine model for chronic lymphocytic leukemia. Cell Cycle 8(22):3663-7.
• Chen SS, Raval A, Johnson AJ, Hertlein E, Liu TH, Jin V, Sherman M, Liu SJ, Dawson D, Williams K, Chaffee B, Lanasa M, Liyanarachchi S, Lin T, Marcucci G, Pekarsky Y, Davuluri R, Croce C, Guttridge D, Teitell M, Byrd JC, Plass C. 2009 Early Genetic and Epigenetic Events in TCL1 driven Chronic Lymphocytic Leukemia.  Proc Natl Acad Sci U S A. 106(32):13433-8.
• Hackanson B, Bennett K, Brena RM, Chen SS, Jiang J, Maharry K, Whitman SP, Schmittgen TM, Lübbert M, Marcucci G, Bloomfield CD, Plass C. 2008 Dual epigenetic control of CCAAT/enhancer binding protein α (C/EBPα) expression in acute myeloid leukemia. Cancer Res. 68(9):3142-51.
• Smiraglia DJ, Kazhiyur-Mannar R, Oakes CC, Wu YZ, Hall J, Liang P, Ansari T, Su J, Rush L, Smith L, Yu L, Liu C, Dai ZY, Chen SS, Wang SH, Costello J, Ioschikhes I, Dawson DW, Hong JS, Teitell MA, Szafranek A, Camoriano M, Song F, Elliot R, Held W, Trasler JM, Plass C, Wenger R. 2007 Restriction Landmark Genomic Scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations. BMC Genomics 30(8):446.
• Raval A, Tanner SM, Byrd JC, Angerman EB, Perko JD, Chen SS, Hackanson B, Grever MR, Lucas DM, Matkovic JJ, Lin TS, Kipps TJ, Murray F, Weisenburger D, Sanger W, Lynch J, Watson P, Jansen M, Yoshinaga Y, Rosenquist R, de Jong PJ, Coggill P, Beck S, Lynch H, de la Chapelle A, Plass C. 2007 Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell 129(5):879-90.
• Dawson DW, Hong JS, Shen RR, French SW, Troke JJ, Wu YZ, Chen SS, Gui D. Regelson M, Marahrens Y, Morse HC, Plass C, Teitell MA. 2007 Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas. Oncogene 26(29):4243-52.
• Liu TH, Raval A, Chen SS, Matkovic JJ, Plass C. 2006 CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia. Cancer Res. 66(2):653-8.
• Juan CC, Kan LS, Huang CC, Chen SS, Ho LT, Au LC. 2003 Production and characterization of bioactive recombinant resistin in Escherichia Coli. J. Biotechnol. 103(2):113-7.