Publications

A. Publications:

  1. Villa TG, Notario V, Villanueva JR.  Beta-glucanases in the yeast Pichia polymorpha. Arch Mikrobiol 104: 210-216, 1975.
  2. Villa TG, Notario V, Benítez T, Villanueva JR.  Synthesis of b-glucanases and other extracellular proteins by cells and protoplasts of the yeast Pichia polymorpha. Effect of 2-deoxy-D-glucose. Arch Mikrobiol 105: 335-337, 1976.
  3. Notario V, Villa TG, Benítez T, Villanueva JR.  b-Glucanases in the yeast Cryptococcus albidus var. aerius. Production and separation of b-glucanases in asynchronous cultures. Can J Microbiol 22: 261-268, 1976.
  4. Notario V, Villa TG, Villanueva JR. b-Xylosidases in the yeast Cryptococcus albidus var. aerius.  Can J Microbiol 22: 312-315, 1976.
  5. Notario V, Villanueva JR, Villa TG.  Research on yeast hydrolases. Yeast News Letter 24: 70-72, 1976.
  6. Villa TG, Notario V, Benítez T, Villanueva JR. On the effect of glucono-d-lactone on the yeast Pichia polymorpha.  Arch Microbiol 109: 157-161, 1976.
  7. Villa TG, Notario V, Benítez T, Villanueva JR.  Method of purifying b-glucanases from Candida utilis.  Appl Environ Microbiol 32: 185-187, 1976. [PMCID: PMC170026]
  8. Villa TG, Notario V, Benítez T, Villanueva JR. Purification of an exo-1,3-b-glucanase from Candida utilis.  Can J Biochem 54, 927-934, 1976.
  9. Benítez T, Villa TG, Notario V, García-Acha I.  Studies of the walls of Trichoderma viride using fluorescent brighteners.  Trans Br Mycol Soc 67: 485-489, 1976.
  10. Notario V, Villa TG, Villanueva JR.  Purification of an exo-b-D-glucanase from cell-free extracts of Candida utilis.  Biochem J 159: 555-562, 1976. [PMCID: PMC1164153]
  11. Villanueva JR, Notario V, Santos T, Villa TG. b-Glucanases in nature: biochemistry and function of b-glucanases in yeasts.  In: Peberdy JF, Rose AH, Rogers HJ, and Cocking EC (Eds.):  Microbial and Plant Protoplasts. Academic Press, London/New York, pp. 323-355, 1976.
  12. Villa TG, Notario V, Villanueva JR.  Direct chemical proof of different glycosylation patterns for yeast exo- and endo-1,3-b-D-glucanases. J Gen Microbiol 109: 371-374, 1978.
  13. Villa TG, Notario V, Villanueva JR.  Occurrence of an endo-1,3-b-glucanase in culture fluids of the yeast Candida utilis: purification and characterization of the enzyme activity.  Biochem J 177: 107-114, 1979. [PMCID: PMC1186344]
  14. Notario V, Villa TG, Villanueva JR.  Cell wall-associated 1,4-b-D-xylanase in Cryptococcus albidus var. aerius: in situ characterization of the activity.  J Gen Microbiol 114: 415-422, 1979.
  15. Villa TG, Notario V, Villanueva JR.  Beta-glucosidases in the yeast Pichia polymorpha.  FEMS Microbiol Lett 6: 91-94, 1979.
  16. Villa TG, Phaff HJ, Notario V:  A method for preparing laminaribiose using yeast endo-(1-3)-b-glucanase. Carbohyd Res 74, 369-370, 1979.
  17. Notario V (Ed.).  Growth and morphogenesis in yeasts.  Studies on b-glucanases and other related enzymes in Cryptococcus albidus var. aerius, University of Salamanca, Salamanca, Spain, 32 pp, 1979.
  18. Villa TG, Notario V, Villanueva JR.  Chemical and enzymic analyses of Pichia polymorpha cell walls. Can J Microbiol 26: 169-174, 1980.
  19. Gale EF, Ingram J, Kerridge D, Notario V, Wayman F. Reduction of amphotericin B resistance in stationary phase cultures of Candida albicans by treatment with enzymes.  J Gen Microbiol 117: 383-391, 1980.
  20. Notario V, Gale EF, Kerridge D, Wayman F.  Phenotypic resistance to amphotericin B in Candida albicans: relationship to glucan metabolism.  J Gen Microbiol 128: 761-777, 1982.
  21. Notario V.  Purification and characterization of b-glucanases in Candida albicans. Nature of their attachment to cell-wall components on amphotericin B-resistant organisms.  J Gen Microbiol 128: 747-759, 1982.
  22. Notario V, Kawai H, Cabib E. Interaction between b(1,3)glucan synthetase and activating phosphorylating compounds. A kinetic study. J Biol Chem 257:1902-1905, 1982.
  23. Sukumar S, Notario V, Martín-Zanca D, Barbacid M.  Induction of mammary carcinomas in rats by nitroso-methylurea involves the malignant activation of the H-ras-1 locus by single point mutation. Nature 306: 658-661, 1983.
  24. Lacal JC, Santos E, Notario V, Barbacid M, Yamazaki S, Kung H, Seamans C, McAndrew S, Crowl R.  Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins. Proc Natl Acad Sci USA 81: 5305-5309, 1984. [PMCID: PMC391692]
  25. Notario V, Sukumar S, Santos E, Barbacid M.  A common mechanism for the malignant activation of ras oncogenes in human neoplasia and in chemically-induced animal tumors. In Vande Woude GF, Levine AJ, Topp WD, Watson JD (Eds.): Cancer Cells 2: Oncogenes and Viral Genes. Cold Spring Harbor Laboratory, New York, pp. 425-432, 1984.
  26. Notario V, Santos E, Sukumar S, Martín-Zanca D, Barbacid M. The role of oncogenes in human carcinogenesis. In: Genética Molecular.  Instituto de Ciencias del Hombre, Madrid, Spain, pp. 217-236, 1985.
  27. Notario V. Retroviruses, growth factors and oncogenesis. In: El Cáncer. Barcelona, Spain.  Scientific American and Prensa Científica, pp. 98-103, 1985.
  28. Kang MS, Szaniszlo PJ, Notario V, Cabib E. The effect of papulacandin B on b(1-3)glucan synthetases. A possible relationship between inhibition and enzyme conformation. Carbohyd Res 149: 13-21, 1986.
  29. Leal F, Igarashi H, Gazit A, Williams LT, Notario V, Tronick SR, Robbins KC, Aaronson SA.  Mechanism of transformation by an oncogene coding for a normal growth factor.  In: Harris CC (Ed.): Biochemical and Molecular Epidemiology of Cancer. UCLA Symposia on Molecular and Cellular Biology. New York, Alan R. Liss, Inc., pp. 155-165, 1986.
  30. Notario V. Retroviruses and Cancer. In: Villanueva JR (ed.): Biological Perspectives:  The Future of Microbiology. Ramón Areces Foundation, Madrid, pp. 159-175, 1986.
  31. Alkhatib H, Chen D, Cherney B, Bhatia K, Notario V, Giri C, Stein G, Slattery E, Roeder RG, Smulson ME.  Cloning and expression of cDNA for human poly(ADP-ribose)polymerase. Proc Natl Acad Sci USA 84: 1224-1228, 1987. [PMCID: PMC304399]
  32. Doniger J, Notario V, DiPaolo JA.  Carcinogens with diverse mutagenic activities initiate neoplastic guinea pig cells that acquire the same N-ras point mutation.  J Biol Chem 262: 3813-3819, 1987.
  33. Cobianchi F, Karpel RL, Williams KR, Notario V, Wilson SH.  Mammalian hnRNP complex protein A1:  Large-scale overproduction in E.coli and cooperative binding to single-stranded nucleic acids. J Biol Chem 263: 1063-1071, 1988.
  34. Katamine S, Notario V, Rao CR, Miki T, Cheah MSC, Tronick SR, Robbins KC.  Primary structure of the human fgr proto-oncogene product p55c-fgr. Mol Cell Biol 8: 259-266, 1988. [PMCID: PMC363113]
  35. Abbots J, Sen-Gupta DN, Smudzka B, Widen S, Notario V, Wilson SH. Expression of human DNA polymerase b in E. coli and characterization of the recombinant enzyme. Biochemistry 27: 901-909, 1988.
  36. Di Paolo JA, Woodworth CD, Popescu NC, Notario V, Doniger J. Induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 DNA and viral Harvey ras.  Oncogene 4: 395-399, 1989.
  37. Castro R, Brito B, Notario V. Chronic prenatal administration of haloperidol induces postnatal changes on genetic expression in brain regions.  I.S.C.U. Short Reports 9: 149, 1989.
  38. Notario V, Gutkind ES, Imaizumi M, Katamine S, Robbins KC. Expression of the fgr proto-oncogene product as a function of myelomonocytic cell maturation. J Cell Biol 109: 3129-3136, 1989. [PMCID: PMC2115966]
  39. Notario V, Latre JA, Villa TG.  Oncogenic Protein Tyrosine Kinases and Signal Transduction Pathways.  Life Sci Adv (Oncol) 8: 27-42, 1989.
  40. Smulson ME, Alkhatib H, Bhatia K, Chen D, Cherney B, Notario V, Tahourdin C, Dritschilo A, Hensley P, Breitman T, Stein G, Pommier Y, McBride O, Bustin M, Giri C. The cloning of cDNA and Gene for Human Poly(ADP-Ribose) Polymerase: Status on the Biological Function(s) Using Recombinant Probes. In: Jacobson M, Jacobson E (Eds.) Niacin, Nutrition, ADP Ribosylation and Cancer. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, pp. 463-477, 1989.
  41. Castro R, Brito B, Notario V.  Prenatal haloperidol alters the expression of DNA polymerases in brain regions of neonate rats. Cell Mol Neurobiol 10: 281-289, 1990.
  42. Bhatia K, Kang VH, Stein GS, Bustin M, Cherney BW, Notario V, Haque SJ, Huppi K, Smulson ME.  Cell cycle regulation of an exogenous human poly (ADP-ribose) polymerase cDNA introduced in murine cells.  J Cell Physiol 144: 345-353, 1990.
  43. Notario V, Castro R, Flessate DM, Doniger J, DiPaolo JA. Frequent activation of non-ras transforming sequences in neoplastic Syrian hamster cells initiated with chemical carcinogens. Oncogene 5: 1425-1430, 1990.
  44. Woodworth CD, Notario V, DiPaolo JA.  Transforming growth factors b1 and 2 transcriptionally regulate human papillomavirus (HPV) 16 early gene expression in HPV-immortalized human genital epithelial cells.  J Virol 64: 4767-4775, 1990. [PMCID: PMC247964]
  45. Segovia J, Castro R, Notario V, Gale K.  Transplants of fetal substantia nigra regulate glutamic acid decarboxylase gene expression in host striatal neurons.  Mol Brain Res 10: 359-362, 1991.
  46. Alberch J, Brito B, Notario V, Castro R.  Prenatal haloperidol treatment decreases nerve growth factor receptor and mRNA in neonate rat forebrain.  Neurosci Lett 131: 228-232, 1991.
  47. Notario V, Rubio B, Flessate DM, Castro R.  Transforming sequences in neoplastic hamster cells initiated with chemical carcinogens.  In: Molecular Basis of Cancer: Clinical Applications and Technological Developments. Barbacid M, Lacal JC (Eds.) Farmaindustria, Madrid, Spain, pp. 133-145, 1991.
  48. Jung M, Notario V, Dritschilo A. Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells. Cancer Res 52: 6390-6393, 1992.
  49. Leighton T, Ginther C, Fluss L, Harter WK, Cansado J, Notario V.  Molecular characterization of quercetin and quercetin glycosides in Allium vegetables, and their effects on malignant cell transformation.  In: "Phenolic Compounds in Foods and Health", Ho CH, Huang MT (Eds.) American Chemical Society Symposium Series, vol. 507, pp. 220-238, 1992.
  50. Notario V, Popescu N, DiPaolo JA.  Analysis of transforming sequences in neoplastic Syrian hamster fetal cells induced by diverse chemical carcinogens. In: "Environmental Hygiene", Seemayer NH, Hadnagy W. (Eds.) Springer Verlag, pp. 91-94, 1992.
  51. Laborda J, Sausville EA, Hoffman T, Notario V. dlk, a putative mammalian homeotic gene differentially expressed in Small Cell Lung Carcinoma and neuroendocrine tumor cell lines. J Biol Chem 268: 3817-3820, 1993.
  52. Woodworth CD, Wang H, Simpson S, Alvarez-Salas L, Notario V. Overexpression of wild type p53 alters growth and differentiation of normal human keratinocytes but not human papillomavirus expressing cell lines. Cell Growth & Differ 4: 367-376, 1993.
  53. Avila MA, Otero G, Cansado J, Dritschilo A, Velasco JA, Notario V. Activation of phospholipase D: Alternative signal transduction pathway responsive to γ-radiation. Cancer Res 53: 4474-4476, 1993.
  54. Becerra SP, Palmer I, Kumar A, Steele F, Shiloach J, Notario V, Chader, GJ. Overexpression of fetal human pigment epithelium derived factor in Escherichia coli: A functionally active neurotrophic factor. J Biol Chem 268: 23148-23156, 1993.
  55. Velasco JA, Cansado J, Peña MC, Kawakami T, Laborda J, Notario V. Cloning of the dihydroxyacid dehydratase-encoding gene (ILV3) from Saccharomyces cerevisiae. Gene 137: 179-185, 1993.
  56. Jorgensen TJ, Notario V, Thraves PJ, Dritschilo A. Radiation response of NIH/3T3 mouse fibroblasts overexpressing human poly(ADP-ribose) polymerase. Radiat Oncol Invest 1: 189-197, 1993.
  57. Avila MA, Velasco JA, Cansado J, Notario V. Quercetin mediates the downregulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res 54: 2424-2428, 1994.
  58. Velasco JA, Castro R, Avila MA, Laborda J, DiPaolo JA, Cansado J, Notario V. cph, a novel oncogene which cooperates with H-ras in the transformation of NIH/3T3 fibroblasts. Oncogene 9: 2065-2069, 1994.
  59. Albor A, Flessate DM, Soussi T, Notario V. 3-Methylcholanthrene inactivates the p53 gene in Syrian hamster embryo fibroblasts by inducing a specific intronic point mutation. Cancer Res 54: 4502-4507, 1994.
  60. Avila MA, Velasco JA, Smulson ME, Dritschilo A, Castro R, Notario V. Functional expression of poly(ADP-ribose) polymerase in Schizosaccharomyces pombe results in mitotic delay at G1, increased mutation rate, and sensitization to radiation. Yeast 10: 1003-1017, 1994.
  61. Castro R, Brito B, Segovia J, Martín-Trujillo JM, Notario V. Prenatal haloperidol induces a selective reduction in the expression of plasticity-related genes in neonate forebrain. Mol Brain Res 26: 74-80, 1994.
  62. Popescu NC, Zimonjic DB, Albor A, Notario V. Localization of the Tp53 gene on Syrian hamster chromosome 9 by fluorescence in situ hybridization. Cytogenet Cell Genet 68: 71-74, 1994.
  63. Prasad S, Notario V, Sharareh S, Dritschilo A. Poly(ADP-ribose) polymerase in HeLa cells - A high resolution two-dimensional gel analysis. Appl Theor Electrophoresis 4: 3-10, 1994.
  64. Albor A, Laborda J, Notario V. Cloning of the Syrian hamster p53 gene: structural and functional characterization of the upstream promoter region. Mol Carcinog 11: 176-183, 1994.
  65. Notario V, Velasco JA, Avila MA. "Initiation, Promotion, and Progression in Tumor Development". In: "Cell Proliferation and Cancer", Villanueva JR, Cascales M (eds.). Spanish Academy of Pharmacy, Madrid, Spain, pp. 257-292, 1994.
  66. Avila MA, Velasco JA, Cho C, Lupu R, Wen D, Notario V. Hyperactive autocrine loop mediated by a NDF-related factor in neoplastic hamster embryo fibroblasts expressing an activated cph oncogene. Oncogene 10: 963-971, 1995.
  67. Stevens CW, Velasco JA, DiPaolo JA, Dritschilo A, Notario V. Radiation response of human cervical carcinoma cells transfected with sense and antisense p53 retroviral constructs. Radiat Oncol Invest 2: 212-218, 1995.
  68. Albor A, Notario V. The Gnb5 gene is a novel b-transducin homologue transcribed from a divergent promoter located immediately upstream of the Syrian hamster p53 P1 promoter. Mammalian Genome 6: 236-241, 1995.
  69. Velasco JA, Ramsamooj P, Thraves PJ, Eva A, Dritschilo A, Notario V: Co-regulated expression of dbl and poly(ADP-ribose) polymerase in Ewing's sarcoma cells and dbl-transformed fibroblasts. Oncogene 10: 2253-2258, 1995.
  70. Ramsamooj P, Notario V, Dritschilo A. Enhanced expression of Calreticulin in the nucleus of radioresistant squamous carcinoma cells in response to ionizing radiation. Cancer Res 55: 3016-3021, 1995.
  71. Ramsamooj P, Notario V, Dritschilo A. Ionizing radiation alters the expression of nucleolar protein B23. Radiat Res 143: 158-164, 1995.
  72. Wu Y-Q, Notario V, Chader GJ, Becerra SP. Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of adult bovine eyes: a neurotrophic protein with serpin stuctural characteristics. Protein Express Purif 6: 447-456, 1995.
  73. Soldatenkov VA, Velasco JA, Avila MA, Dritschilo A, Notario V. Cloning and characterization of TRKsp, a gene coding for a putative potassium transporter from Schizosaccharomyces pombe. Gene 161: 97-101, 1995.
  74. Soldatenkov VA, Prasad S, Notario V, Dritschilo A.  Radiation-induced apoptosis of Ewing’s sarcoma cells: DNA fragmentation and proteolysis of poly(ADP-ribose) polymerase. Cancer Res 55: 4240-4242, 1995.
  75. Velasco JA, Stevens CW, Esteban JM, Ruthsatz MKJ, Ramsamooj P, Dritschilo A, Notario V. Modulation of proliferation and tumorigenic potential of cervical carcinoma cells by the expression of sense and antisense p53. Int J Oncol 7: 883-888, 1995.
  76. Becerra SP, Sagasti A, Spinella P, Notario V. Pigment epithelium-derived factor (PEDF) behaves like a non-inhibitory serpin: neurotrophic activity does not require the serpin reactive loop. J Biol Chem 270: 25992-25999, 1995.
  77. Ramsamooj P, Prasad A, Dritschilo A, Notario V. Cell cycle-specific patterns of ADP-ribosylation and the effect of ionizing radiation: cyclins A, B1 and D1, cdc2, and PCNA are not modified. Int J Oncol 8: 803-808, 1996.
  78. Velasco JA, Avila M, Cansado J, Notario V. Cloning and sequencing of the cDNA for the cph oncogene from neoplastic hamster fibroblasts reveal partial homology with the dbl exchange factor. Radiat Oncol Invest 3: 262-267, 1996.
  79. Avila MA, Cansado J, Harter KW, Velasco JA, Notario V. Quercetin as a modulator of the cellular neoplastic phenotype: effects on the expression of mutated H-ras and p53 in rodent and human cells. Adv Exptl Med Biol 401: 101-110, 1996.
  80. Soldatenkov VA, Dritschilo A, Notario V. Identification of a rearrangement in the 5' upstream region of the poly(ADP-ribose) polymerase pseudogene on chromosome 13 in Ewing’s sarcoma cells, Oncol Reports 3: 651-654, 1996.
  81. Velasco JA, Zimonjic DB, Popescu NC, Cansado J, DiPaolo JA, Albor A, Notario V. Tissue-specific expression, evolutionary conservation and localization of the cph proto-oncogene on Syrian hamster chromosome X. Oncogene 12: 2713-2717, 1996. 
  82. Soldatenkov VA, Notario V, Dritschilo AD. Expression of the human Bcl-2 increases resistance of Ewing’s sarcoma cells to apoptosis and inhibits poly(ADP-ribose) polymerase cleavage induced by radiation. Int J Oncol 9: 547-551, 1996.
  83. Albor A, Thraves PJ, Dritschilo A, Notario V. Oncogenic activation of the tyrosine kinase domain of the human trk proto-oncogene by fusion to a cell adhesion molecule. Oncogene 13: 1755-1763, 1996.
  84. Otero G, Avila MA, Emfietzoglou D, Clerch LB, Massaro D, Notario V. Increased manganese superoxide dismutase activity, protein and mRNA and concurrent induction of tumor necrosis factor a in radiation initiated Syrian hamster cells. Mol Carcinog 17: 175-180, 1996.
  85. Siwarski D, Müller U, Andersson J, Notario V, Melchers F, Rolink A, Huppi K. Structure and expression of the c-myc/Pvt-1 megagene locus. Curr Top Microbiol Immunol 224: 67-72, 1997.
  86. Otero G, Berkovich A, Clerch LB, Massaro D, Notario V. Radiation-initiated immortal Syrian hamster fibroblasts release elevated levels of H2O2 and show divergent MnSOD and catalase activities. Int J Oncol 10: 1031-1034, 1997.
  87. Otero G, Avila MA, De La Peña L, Emfietzoglou D, Cansado J, Popescu GF, Notario V. Altered processing of precursor transcripts and increased levels of the subunit I of mitochondrial cytochrome c oxidase in neoplastic Syrian hamster fetal cells initiated with ionizing radiation. Carcinogenesis 18: 1569-1575, 1997.
  88. Velasco JA, Feijoó E, Avila MA, Notario V. Secretion of NFD-like polypeptides by cph-transformed fibroblasts: cloning and characterization of Syrian hamster neuregulin cDNAs. Mol Carcinog 21: 156-161, 1998.
  89. Perez-Mediavilla LA, Chew C, Campochiaro P, Chang J, Notario V, Zach DJ, Becerra SP. Sequence and expression analysis of bovine pigment epithelium-derived factor (PEDF). Biochim Biophys Acta 1398: 203-214, 1998.
  90. Notario V. Advances and perspectives of cancer gene therapy. An Sist Sanit Navar, 21: 137-148, 1998.
  91. Notario V, DiPaolo JA. Molecular aspects of neoplasia of Syrian hamster cells transformed in vitro by chemical carcinogens. Toxicol Lett 96-97: 221-230, 1998.
  92. Velasco JA, Avila MA, Notario V. The product of the cph oncogene is a truncated, nucleotide binding protein that enhances cellular survival to stress. Oncogene 18: 689-701, 1999.
  93. Prasad SC, Soldatenkov VA, Notario V, Smulson M, Dritschilo A. Detection of poly(ADP-ribose) polymerase fragments during ionizing radiation-induced apoptosis of MDA-MB-468 breast cancer cells: epitope specific antibody blotting of two dimensional gels. Electrophoresis 20: 618-625, 1999.
  94. Soldatenkov VA, Albor A, Patel BKR, Dreszer R, Dritschilo A, Notario V. Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor. Oncogene 18: 3954-3962, 1999.
  95. Recio JA, Zambrano N, de la Peña L, Powers C, Siwarski D, Huppi K, Notario V. cDNA isolation, expression and chromosomal localization of the mouse Pcph proto-oncogene. Mol Carcinog 26: 130-136, 1999.
  96. Recio JA, Zambrano N, de la Peña L, Reig JA, Rhoads A, Rouzaut A, Notario V. The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping and expression of in normal and tumor cells. Mol Carcinog 27: 229-236, 2000.
  97. Recio JA, Páez JG, Maskeri B, Loveland M, Velasco JA, Notario V. Both normal and transforming PCPH proteins have guanosine diphosphatase activity, but only the oncoprotein co-operates with Ras in activating extracellular signal-regulated kinase ERK1. Cancer Res 60: 1720-1728, 2000.
  98. Rouzaut A, Recio A, Notario V. Expression of the protein product of the PCPH proto-oncogene in human tumor cell lines. Radiat Res 155: 181-187, 2001.
  99. Notario V, Solanas M, Escrich E, Rouzaut A. Frequent alterations in the expression of the PCPH oncogene in experimental models of breast cancer. Rev Senología Patol Mam 14: 3-7, 2001.
  100. Páez JG, Recio JA, Rouzaut A, Notario V. Identity between the PCPH proto-oncogene and the CD39L4 (ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene. Int J Oncol 19: 1249-1254, 2001.                                  
  101. Baladrón V, Ruíz-Hidalgo MJ, Bonvini E, Gubina E, Notario V, Laborda J. The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system. Biochem Biophys Res Commun 291: 193-204, 2002.
  102. Solanas M, Escrich E, Rouzaut A, Costa I, Martínez A, Notario V. Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz(a) anthracene. Mol Carcinog 33: 219-227, 2002.
  103. Newman R, Soldatenkov VA, Dritschilo A, Notario V. Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing’s sarcoma cells. Oncol Reports 9: 529-532, 2002.
  104. Soldatenkov VA, Trofimova I, Rouzaut A, McDermott F, Dritschilo A, Notario V. Differential regulation of the response to DNA damage in Ewing’s sarcoma cells by ETS1 and EWS/FLI-1. Oncogene 21: 2890-2895, 2002.
  105. Recio JA, Páez JG, Sanders S, Kawakami T, Notario V. Partial depletion of intracellular ATP mediates the stress-survival function of the PCPH oncoprotein. Cancer Res 62: 2690-2694, 2002.
  106. Hernandez EM, Johnson A, Notario V, Chen A, Richert JR. AUA as a translation initiation site in vitro the human transcription factor Sp3. J Biochem Mol Biol 35: 273-282, 2002.
  107. Blánquez MJ, Regadera J, Mariño J, Newman RE, Notario V. Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia. Mol Carcinog 35: 186-195, 2002.
  108. Tirado OM, Mateo-Lozano S, Sanders S, Dettin LE, Notario V. The PCPH oncoprotein antagonizes the pro-apoptotic role of mTOR in the response of normal fibroblasts to ionizing radiation. Cancer Res 63: 6290-6298, 2003.
  109. Mateo-Lozano S, Tirado OM, Notario V. Rapamycin induces the fusion-type independent down-regulation of the EWS/FLI-1 proteins and inhibits Ewing’s sarcoma cell proliferation. Oncogene 22: 9281-9286, 2003.
  110. Sanchez R, Franco A, Gacto M, Notario V, Cansado J. Characterization of gdp1(+) as encoding a GDPase in the fission yeast Schizosaccharomyces pombe. FEMS Microbiol Lett 228: 33-38, 2003.
  111. Hernandez EM, Chan CH, Xu B, Notario V, Richert JR. Role of an Internal Ribosome Entry Site in the Translational Control of the Human Transcription Factor Sp3. Int J Oncol 24: 719-724, 2004.
  112. Blánquez MJ, Arenas MI, Conde I, Tirado OM, Paniagua R, Notario V. Deregulated expression of the PCPH proto-oncogene in human breast cancers. Int J Oncol 25: 821-830, 2004.
  113. Tirado OM, Mateo-Lozano S, Notario V. Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax:Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR-inhibitory activity. Oncogene 24: 3348-3357, 2005.
  114. Tirado OM, Mateo-Lozano S, Notario V. Roscovitine is an effective inducer of apoptosis of Ewing’s sarcoma family tumor cells in vitro and in vivo. Cancer Res 65: 9320-9327, 2005.
  115. Regadera J, Blánquez MJ, González-Peramato P, Nistal M, Miller JC, Tirado O, Notario V. PCPH expression is an early event in the development of testicular germ cell tumors. Int J Oncol 28: 595-604, 2006.
  116. Tian S,  Mewani RR, Kumar D, Li B, Danner MT, Ahmad I, Rahman A, Notario V, Dritschilo A, Kasid UN, Gokhale PC. Phosphorylation and stabilization of X-linked inhibitor of apoptosis (XIAP) by Raf-1 kinase. Int J Oncol 29: 861-867, 2006.
  117. Tirado OM, Mateo-Lozano S, Villar J, Dettin LE, Llort A, Gallego S, Ban J, Kovar H, Notario V. Caveolin-1 (CAV1) is an EWS/FLI-1 target and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing’s sarcoma cells. Cancer Res 66: 9937-9947, 2006.
  118. Mateo-Lozano S, Gokhale P, Soldatenkov VA, Dritschilo A, Tirado OM, Notario V. Simultaneous transcriptional and translational targeting of EWS/FLI-1 induces apoptosis in Ewing’s sarcoma cells in vitro and tumor growth inhibition in vivo. Clin Cancer Res 12: 6781-6790, 2006.
  119. Bettayeb K, Tirado OM, Marionneau-Lambot L, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drückes P, Schächtele C, Kubbutat M, Liger F, Marquet B, Joseph B,  Echalier A, Endicott JA, Notario V, Meijer L. Meriolins, a new class of cell death-inducing, cyclin-dependent kinase inhibitors with enhanced selectivity for CDK9. Cancer Res 67: 8325-8334, 2007.
  120. Villar J, Arenas MI, MacCarthy CM, Blánquez MJ, Tirado OM, Notario V. PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a PKC-δ dependent mechanism. Cancer Res 67: 10859-10868, 2007.
  121. Kasid U, Notario V, Haimovitz-Friedman A, Bar-Eli, M. (Eds.) Reviews in Cancer Biology & Therapeutics. Research Signpost, Trivandrum, India. 2007.               
  122. Becerra SP, Pérez-Mediavilla LA, Weldon JE, Locatelli-Hoops S, Senanayake P, Notari L, Notario V, Hollyfield JG. Pigment epithelium-derived factor (PEDF) binds to hyaluronan. Mapping of a hyaluronan binding site. J Biol Chem 283: 33310-33320, 2008. [PMCID: PMC2586245]
  123. Notario V, Tirado OM, Villar J. Molecular Basis of Radiation Therapy - Role of Chemotherapy in Combination with Radiation - New Targeted Therapies and Radiation. In: Molecular Biology in Cancer: Toward New Therapies, García-Foncillas J. (Ed.), Barcelona, Spain: Prous Science, pp. 765-780, 2009.
    • Notario V, Mateo-Lozano S, Villar J, Tirado OM. Targeting EWS/FLI1 Driven Signaling Pathways for Therapy of Tumors of the Ewing’s Sarcoma Family. In: Bradshaw RA, Dennis EA (Eds.): Handbook of Cell Signaling 2nd edition, Oxford: Academic Press, pp. 2859-2872, 2009.
    • Villar J, Quadri HS, Song I, Tomita Y, Tirado OM, Notario V. PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through PKCα-mediated Bcl-2 stabilization. Cancer Res 69: 102-110, 2009. [PMCID: PMC2614304]
    • Popowycz F, Fournet G, Schneider C, Bettayeb K, Ferandin Y, Lamigeon C, Tirado OM, Mateo-Lozano S, Notario V, Colas P, Bernard P, Meijer L, Joseph B. Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: Access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue. J Med Chem 52: 655-663, 2009. [PMCID: PMC3744883]          
    • Tirado OM, MacCarthy CM, Fatima N, Villar J, Mateo-Lozano S, Notario V. Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing’s sarcoma cells by modulating PKCα phosphorylation. Int J Cancer [Epub ahead of print, July 16, 2009] 126: 426-436, 2010. [PMCID: PMC2794946]
    • Liu Y, Yan S, Wondimu A, Bob D, Weiss M, Sliwinski K, Villar J, Notario V, Sutherland M, Colberg-Poley AM, Ladisch S. Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth. Oncogene [Epub ahead of print, March 22, 2010] 29: 3297–3306, 2010. [PMCID: PMC2880627]
    • Sainz-Jaspeado M, Lagares-Tena L, Lasheras J, Navid F, Rodriguez-Galindo C,  Mateo-Lozano S,  Notario V, Sanjuan X, Garcia del Muro X, Fabra A, Tirado OM. Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize. [Selected for the Highlights of the November issue] Mol Cancer Res 8: 1489-1500, 2010. [PMCID: PMC3679656]
    • Sengupta A, Mateo-Lozano S, Tirado OM, Notario V. Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing’s sarcoma cells. Int J Oncol [Epub ahead of print, March 3, 2011] 38: 1259-1265, 2011. [PMCID: PMC3335731]
    • Rotinen M, Villar J, Celay J, Serrano I, Notario V, Encío I. Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells. Mol Cell Endocrinol [Epub ahead of print, April 28, 2011] 339: 45-53, 2011. [PMCID: PMC3119890]
    • Deshpande M, Notari L, Subramanian P, Notario V, Becerra SP. Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: Implications for antitumor activity. Int J Oncol [Epub ahead of print, April 10, 2012] 41: 219-227, 2012. [PMCID: PMC3546833]
    • Subramanian P, Deshpande M, Locatelli-Hoops S,  Moghaddam-Taaheri S, Guerrier S, Rapp M, Notario V, Becerra SP. Identification of Pigment Epithelium-derived Factor (PEDF) Protein Forms with Distinct Activities on Tumor Cells Lines. J Biomed Biotechnol 2012: 425907, doi:10.1155/2012/425907, 2012. [PMCID: PMC3373277]
    • Becerra SP, Notario V. The effects of PEDF on cancer biology: Mechanisms of action and therapeutic potential. Nat Rev Cancer 13: 258-271, 2013. [PMCID: PMC3707632]
    • Sengupta A, Rahman M, Mateo-Lozano S, Tirado OM, Notario V. The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing’s sarcoma. Int J Oncol 43: 803-812, 2013. [PMCID: PMC3787886]
    • MacCarthy CM, Notario V. The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family. Int J Oncol 43: 1244-1252, 2013. [PMCID: PMC3829800]
    • Eldhose B, Notario V, Latha MS. Evaluation of phytochemical constituents and in vitro antioxidant activities of Plumbago indica root extracts. J Pharmacognosy Phytochem 2: 157-161, 2013.
    • Eldhose B, Gunawan M, Rahman M, Latha MS, Notario V. Plumbagin reduces human colon cancer cell survival by inducing cell cycle arrest and mitochondria-mediated apoptosis. Int J Oncol 45: 1913-1920, 2014. [PMCID: Pending – requested by Journal]
    • MacCarthy CM, Hoover DM, Becerra SP, Dakshanamurthy S, Brenner C, Notario, V. Binding to Adenine Nucleotide Translocase (ANT2) mediates the cellular phenotypes associated with transformation by the ENTPD5/mt-PCPH oncoprotein. (Submitted).
    • Sengupta A, Mateo-Lozano S, Villar J, MacCarthy CM, Tirado OM, Notario V. Forkhead box M1 is an EWS/FLI1 target that regulates adhesion, invasion and tumorigenicity in Ewing’s sarcoma cells. (Submitted).
    • Tirado OM, Mateo-Lozano S, Sanders S, Saxena V, Notario V. The PCPH oncoprotein mediates resistance to cisplatin through activation of PKCα and stabilization of the Bcl-2 protein in mouse fibroblasts. Mol Carcinog (Conditionally Accepted)
    • Schwechter A, Grekova M, Ressom H, Notario V, Richert JR. siRNA-mediated knockdown of transcription factor Sp3 induces a pro-inflammatory pattern of cytokine production: relevance to multiple sclerosis. (Submitted)
    • Newman RE, Laborda J, Notario V. DLK1 regulates integrin activation and the invasive phenotype of small cell lung carcinoma cells. (Submitted)

B. Abstracts:

  1. Villa TG, Notario V, Villanueva JR. De novo synthesis of b-glucanases, invertase and acid phosphatase by intact cells of Pichia polymorpha. Effect of 2-deoxy-D-glucose. 6th Congress of the Spanish Biochemical Society, Sevilla (Spain), March/April, 1975.
  2. Notario V, Villa TG, Villanueva JR.  Variation of the b-glucanase activities during growth of Cryptococcus albidus var. aerius. 6th Congress of the Spanish Society for Biochemistry, Sevilla (Spain), March/April, 1975.
  3. Villa TG, Notario V, Benítez T, Villanueva JR. Enzymatic abilities of Pichia polymorpha protoplasts. 4th International Congress on Yeast and Other Protoplats, Nottingham (England), September, 1975.
  4. Notario V, Villa TG, Villanueva JR.  Studies on the susceptibility or resistance of Cryptococcus albidus var. aerius to enzymatic lysis. 5th Congress of the Spanish Society for Microbiology, Salamanca (Spain), October, 1975.
  5. Notario V, Villa TG, Villanueva JR.  Effect of diverse antimicrobial agents on Cryptococcus albidus var. aerius. 32nd Meeting of the Northwest Section of the Spanish Society for Microbiology, Oviedo, Asturias (Spain), June, 1976.
  6. Notario V, Villanueva JR.  Ultrastructural alterations of the yeast Cryptococcus albidus var. aerius induced by changes in the culture conditions. 7th Meeting of the Spanish Society for Electron Microscopy, Córdoba (Spain), September 1976.
  7. Villa TG, Notario V, Villanueva JR. Induction of b-glucosidase activity in the yeast Pichia polymorpha. 1st Meeting of the Federation of European Societies for Experimental Biology, Madrid (Spain), October, 1976.
  8. Notario V, Villanueva JR.  Production of b-(1,4)-xylanase by the yeast Cryptococcus albidus var. aerius. 1st Meeting of the Federation of European Societies for Experimental Biology, Madrid (Spain), October, 1976.
  9. Notario V, Villanueva JR.  Actions of diverse plant hormones on the yeast Cryptococcus albidus var. aerius. 6th Congress of the Spanish Society for Microbiology, Santiago de Compostela, July, 1977.
  10. Notario V, Villanueva JR.  Use of protease inhibitors to control the b-(1,3)glucanase activity of Cryptococcus albidus var. aerius.  7th Meeting of the Spanish Biochemical Society, Pamplona, Navarra (Spain), September, 1977.
  11. Notario V, Martín-Zanca D, Villanueva JR. Isolation of a factor which autoregulates the growth of Cryptococcus albidus var. aerius at non-permissive temperatures. 16th Meeting of the Spanish Society for Physiology, Barcelona (Spain), December, 1977.
  12. Martín-Zanca D, Notario V, Villanueva JR.  New evidence in support for a morphogenetic funcion of yeast b-glucanases. 16th Meeting of the Spanish Society for Physiology, Barcelona (Spain), December, 1977.
  13. Notario V, Villanueva JR.  Abnormal cell wall growth in Cryptococcus induced by xylose: an ultrastructural and enzymatic approach. Symposium on "Wall and Hyphal Growth" of the British Mycological Society. London, April, 1978.
  14. Notario V.  Effect of amphotericin B and other polyene antibiotics on the synthesis, secretion and activity of extracellular lytic enzymes in Candida albicans. 4th Scientific Reunion of the Northwest Section of the Spanish Society for Microbiology, Salamanca (Spain), September, 1978.
  15. Notario V, Villanueva JR. Cooperative action of polysaccharases in morphogenetic processes in the yeast Cryptococcus albidus. 83rd Ordinary Meeting, British Society for General Microbiology, Aberdeen, Scotland (U.K.), September, 1978.
  16. Villa TG, Notario V, Larriba G. Effect of 2-deoxy-D-glucose on the yeast Candida utilis. 79th Annual Meeting of the American Society for Microbiology, Los Angeles/Honolulu (USA), May, 1979.
  17. Notario V.  Effect of amphotericin B on synthesis and secretion of cell wall lytic enzymes and regeneration of Candida albicans protoplasts. 5th International Protoplasts Symposium, Szeged (Hungary), July, 1979.
  18. Notario V.  Production of multiple extracellular forms of 1,3-b-glucanases by the yeast Candida albicans. 86th Ordinary Meeting, British Society for General Microbiology, Dublin (Ireland), September, 1979.
  19. Notario V.  Phenotypic resistance of Candida albicans to amphotericin B: function of the endogenous lytic systems. 7th Congress of the Spanish Society for Microbiology, Cádiz (Spain), September, 1979.
  20. Notario V. Control mechanisms for the cell wall-associated b-1,3-glucanase activity in Candida albicans. 7th Meeting of the Spanish Biochemical Society, Murcia (Spain), September, 1979.
  21. Barbacid M, Santos E, Sukumar S, Pulciani S, Notario V, Reddy EP.  ras transforming genes in human and experimentally induced tumors. Cold Spring Harbor Conference on "Cell Proliferation and Cancer", Cold Spring Harbor, New York (USA), September, 1983.
  22. Barbacid M, Santos E, Sukumar S, Notario V, Lacal JC, Martín-Zanca D.  Transforming genes in human tumors and in tumors induced experimentally.  Symposium on Molecular Genetics, Barcelona (Spain), November, 1983.
  23. Barbacid M, Santos E, Sukumar S, Notario V, Lacal JC, Martín-Zanca D. Transforming genes in human and experimentally induced tumors. 13th Annual UCLA Symposium on "Genes and Cancer", Keystone, Colorado (USA), February, 1984.
  24. Barbacid M, Santos E, Sukumar S, Notario V, Lacal JC, Martín-Zanca D:  Transforming genes in human tumors and in animal tumors induced by chemical carcinogens. 3rd Duran Reynals International Symposium on "Viruses, Oncogenes and Cancer", Barcelona (Spain), May, 1984.
  25. Notario V.  Yeasts as a model for studying the mechanisms of oncogenic transformation. 10th Congress of the Spanish Society for Microbiology, Valencia (Spain), September/October, 1985.
  26. Doniger J, Notario V, DiPaolo JA. Structure of an activated guinea pig N-ras associated with acquisition of tumorigenicity. 77th Annual Meeting of the American Association for Cancer Research, Los Angeles, California (USA), March, 1986.
  27. Cobianchi F, Notario V, Wilson SH.  High-level expression of a rat helix destabilizing protein in E. coli. 76th Annual Meeting of the American Society of Biological Chemists, Washington, DC (USA), June, 1986.
  28. Doniger J, Notario V, DiPaolo JA.  The same N-ras point mutation is acquired in neoplastic guinea pig cells initiated by carcinogens with diverse mutagenic activities. 2nd Annual Meeting on Oncogenes, Frederick, Maryland (USA), July, 1986.
  29. Katamine S, Notario V, Rao CD, Miki T, Cheah MSC, Tronick SR, Robbins KC.  Nucleotide sequence of human c-fgr cDNA and in vivo identification of its encoded product. 3rd Annual Meeting on Oncogenes, Frederick, Maryland (USA), July, 1987.
  30. Notario V.  Experimental Carcinogenesis, Oncogenes and Human Cancer. 6th Meeting of the Health Research Fund (F.I.S.), Santiago de Compostela (Spain), October, 1987.
  31. Smulson M, Bhatia K, Notario V, Kang V, Huppi K, Haque S, Dritschilo A, Cherney B. Changes in the regulation and structure of the poly(ADP-ribose)polymerase gene during cellular proliferation and tumorigenesis. Joint Meeting of the American Society for Cell Biology and the American Society for Biochemistry and Molecular Biology, San Francisco, California (USA), 29 Jan - 2 Feb, 1989.
  32. Castro R, Brito B, Notario V.  Chronic prenatal administration of haloperidol induces postnatal changes on genetic expression in brain regions. Miami Bio/Technology Winter Symposium on Advances in Gene Technology:  Molecular Neurobiology and Neuropharmacology. Miami, Florida (USA), February, 1989.
  33. Segovia J, Castro R, Notario V, Gale K.  Dopamine-containing fetal neural transplants reverse lesion-induced changes in striatal mRNA levels for glutamic-acid decarboxylase (GAD) in adult rat hosts. Third International Symposium on Neural Regeneration. The Asilomar Conference Center, Pacific Grove, California (USA), December, 1989.
  34. Notario V, Thraves PJ, Smulson ME, Dritschilo A. Studies on the role of poly-ADP-ribosylation in the cellular response to ionizing radiation using antisense oligonucleotides as modulators of gene expression. Eighty-First Annual Meeting of the American Association for Cancer Research. Washington, DC (USA), May, 23-26, 1990.
  35. Rubio B, Castro R, DiPaolo JA, Notario V.  Isolation and preliminary characterization of novel transforming sequences from neoplastic Syrian hamster fetal cells initiated with 3-methylcholanthrene.  Sixth Annual Meeting on Oncogenes. Frederick, Maryland (USA), June 26-30, 1990.
  36. Notario V. Transforming sequences in hamster neplastic cells initiated with chemical carcinogens.  II Meeting on Oncogenes.  Madrid, Spain, September 3-5, 1990.
  37. Castro R, Brito B, Martín-Trujillo JM, Lancha A, Notario V. Molecular and cellular approaches reveal a dopamine receptors control of target cells development in forebrain.  3rd European Congress on Cell Biology.  Florence, Italy, September 2-7, 1990.
  38. Castro R, Brito B, Segovia J, Martín-Trujillo JM, Notario V. Reduced mRNA levels of plasticity related genes in neonate rat forebrain after prenatal haloperidol.  ENA/EBBS Congress, Stockholm, Sweden, September 8-12, 1990.
  39. Notario V. Oncogenes and tumor suppressor genes:  A molecular biologist's perspective.  32nd Annual Scientific Meeting of A.S.T.R.O., Miami Beach, Florida (USA), October 15-19, 1990.
  40. Cansado J, Harter KW, Leighton T, Notario V. Quercetin inhibits oncogenic transformation of normal cells and proliferation of tumor cells in vitro.  82nd Annual Meeting of the American Association for Cancer Research.  Houston, Texas (USA), May 15-18, 1991.
  41. Thierry AR, Rahman A, Vige D, Notario V, Dritschilo A. Modulation of multidrug resistance by antisense oligodeoxynucleotides encapsulated in liposomes.  82nd Annual Meeting of the American Association for Cancer Research, Houston, Texas (USA), May 15-18, 1991.
  42. DiPaolo JA, Notario V, Popescu N.  Analysis of Transforming Sequences in Neoplastic Syrian Hamster Fetal Cells Induced by Diverse Chemical Carcinogens.  Third European Meeting of Environmental Hygiene. Dusseldorf, Germany, June 25-27, 1991.
  43. Notario V, Thierry AR, Rahman A, Smulson ME, Dritschilo A.  Use of antisense oligonucleotides to poly (ADP-ribose) polymerase to modulate the cellular radiation response.  9th International Congress of Radiation Research, Toronto, Canada, July 7-12, 1991.
  44. Leighton T, Ginther C, Notario V, Harter KW.  Quercetin and quercetin glycosides: genetic regulation, metabolic processing, and in vitro effects on oncogenic transformation.  National Meeting of the American Chemical Society, New York (USA), August, 1991.
  45. Brito B, Notario V, Segovia J, Santana C, Castro R. Diferente control dopaminérgico de la función gabaérgica durante el desarrollo y madurez del sistema nervioso.  4th Meeting of the Spanish Association for Neurobiology, Alicante, Spain, September, 30 - October, 3, 1991.
  46. Jung M, Notario V, Kern F, Dritschilo A. Mutations in p53 in radio-sensitive and -resistant human squamous carcinoma cell lines. 40th Annual Meeting, Radiation Research Society, Salt Lake City, Utah (USA), March 14-18, 1992.
  47. Prasad S, Notario V, Sharareh S, Dritschilo A.  Analysis of the native forms and endogenous proteolytic products of poly(ADP-ribose) polymerase in HeLa and Ewing's sarcoma cells:  high resolution 2D gel analysis and immunological identification.  40th Annual Meeting, Radiation Research Society, Salt Lake City, Utah (USA), March 14-18, 1992.
  48. Thraves P, Notario V, Reynolds S, Rhim JS, Dritschilo A. Cloning of transforming sequences from radiation transformed human epidermal keratinocytes. 40th Annual Meeting, Radiation Research Society, Salt Lake City, Utah (USA), March 14-18, 1992.
  49. Flessate DM, Albor A, DiPaolo JA, Notario V. Expression of p53 and Rb tumor suppressor genes in chemically initiated neoplastic Syrian hamster fetal cells.  83rd Annual Meeting, American Association for Cancer Research, San Diego, California (USA), May 20-23, 1992.
  50. Woodworth CD, Hong W, Simpson S, Notario V, DiPaolo JA. Growth and differentiation of genital keratinocytes infected with retrovirus vectors encoding wild type p53. 11th International Papillomavirus Workshop, Edinburgh, U.K., 5-11 September, 1992.
  51. Becerra SP, Palmer I, Notario V, Shiloach J, Chader GJ. A novel retinal neurotrophic factor, PEDF: a serine-protease inhibitor? N.I.H. Research Festival, Bethesda, Maryland (USA), 21-25 September, 1992.
  52. Jung M, Notario V, Dritschilo A. Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells. AACR Special Conference on "Genetics of Cancer", Hilton Head, South Carolina (USA), November 4-8, 1992.
  53. Stevens CW, Velasco JA, DiPaolo JA, Dritschilo A, Notario V. Modulation of p53 expression in human cervical tumor cell lines using sense and antisense retroviral constructs. 34th Annual Scientific Meeting, American Society for Therapeutic Radiology and Oncology, San Diego, California (USA), November 9-13, 1992.
  54. Velasco JA, Avila MA, Smulson ME, Dritschilo A, Notario V. Modulation of the cellular radiation response in the yeast Schizosaccharomyces pombe by human poly(ADP-ribose) polymerase. 41st Annual Meeting of the Radiation Research Society, Dallas, Texas (USA), March 19-25, 1993.
  55. Ramsamooj P, Notario V, Dritschilo A. Cell cycle-dependent ADP-ribosylation and the changes induced with radiation. 41st Annual Meeting of the Radiation Research Society, Dallas, Texas (USA), March 19-25, 1993.
  56. Notario V, Loome JF, DiPaolo JA, Dritschilo A, Velasco J. Induction of cellular senescence in human cervical tumor cell lines by p53. Symposium on "Molecular Biology of Aging", Keystone Symposia on Molecular and Cellular Biology, Lake Tahoe, California (USA), March 19-25, 1993.
  57. Becerra SP, Notario V, Chader GJ. Structure-function studies of pigment epithelium derived factor (PEDF). Joint Meeting (FASEB) of the American Society for Biochemistry and molecular Biology and the Division of Biological Chemistry of the American Chemical Society, San Diego, California (USA), May 30-June 3, 1993.
  58. Castro R, Notario V. Phenotypic differentiation induced in PC-12 cells by transfection with the rat GAP-43 gene. 16th Annual Meeting of the European Neuroscience Association, Madrid, Spain, 18-21 September, 1993.
  59. Avila MA, Velasco JA, Dritschilo A, Notario V. Gamma radiation stimulates phosphatidylcholine breakdown in human squamous carcinoma cells: Activation of a phospholipase D. AACR/EOARTC(PAM)/BARC Special Conference on "Cell Signaling and Cancer Treatment", San Juan, Puerto Rico, December 5-9, 1993.
  60. Otero G, Velasco JA, Ramsamooj P, Avila MA, Notario V. Molecular mechanisms of immortalization and oncogenic transformation of primary Syrian hamster embryo cells by ionizing radiation. 42nd Annual Meeting of the Radiation Research Society, Nashville, Tennessee (USA), April 29-May 4, 1994.
  61. Albor A, Thraves PJ, Dritschilo A, Notario V. Activation of the tyrosine kinase domain of the human trk oncogene by fusion to a cell adhesion molecule. 85th Annual Meeting of the American Association for Cancer Research, San Francisco, California (USA), April 10-13, 1994.
  62. Soldatenkov VA, Notario V, Dritschilo A. Ewing's sarcoma poly (ADP-ribose) polymerase: Cloning of the 5'-pseudogene region. 85th Annual Meeting of the American Association for Cancer Research, San Francisco, California (USA), April 10-13, 1994.
  63. Becerra SP, Wu Y-Q, Notario V, Chader GJ.  Pigment epithelium-derived factor: characterization using a highly specific polyclonal antibody. Meeting of the American Society for Biochemistry and Molecular Biology, Washington, DC (USA), May 21-25, 1994.
  64. Notario V, Avila MA, Cansado J, Velasco JA. Cloning and sequencing of cph cDNA reveal homology with GDP-exchange factors.  Keystone Symposium on "Oncogenes: 20 years later", Keystone, Colorado (USA), January 5-11, 1995.
  65. Soldatenkov VA, Patel BKR, Notario V, Dritschilo A. Cloning of the promoter region of the poly(ADP-ribose) polymerase gene from Ewing's sarcoma cells. 86th Annual Meeting of the American Association for Cancer Research, Toronto, Ontario, Canada, March 18-22, 1995.
  66. Ramsamooj P, Notario V, Dritschilo A. Radiation-induced alteration in the expression of nucleolar protein B23 in radioresistant squamous carcinoma cells. 43rd Annual Meeting of the Radiation Research Society, San Jose, California (USA), April 1-6, 1995.
  67. Notario V. Quercetin as a Modulator of the Cellular Neoplastic Phenotype. AICR Annual Research Conference on “Dietary Phytochemicals in Cancer Prevention and Treatment”, Washington, DC (USA), August 31-September 1, 1995.
  68. Notario V, Velasco JA. Chemically initiated neoplastic Syrian hamster embryo cells as a model for human carcinogenesis: isolation and characterization of the cph oncogene, a novel putative guanine nucleotide-exchange factor. Workshop on “Neoplastic Transformation in Human Cell Systems in Culture: Mechanisms of Carcinogenesis”, Chicago, Illinois (USA), September 7-9, 1995.
  69. Becerra SP, Notario V, Alberdi E. Binding of the neurotrophic factor PEDF to retinoblastoma cell membrane receptors is facilitated by extracellular components. Keystone Symposium on “Signaling in Neuronal Development, Differentiation and Degeneration”, Taos, New Mexico (USA), March 27 - April 2, 1996.
  70. Soldatenkov VA, Prasad S, Notario V, Dritschilo A. Radiation-induced apoptosis of Ewing’s sarcoma cells is accompanied by proteolysis of poly(ADP-ribose) polymerase. 44th Annual Meeting of the Radiation Research Society, Chicago, Illinois (USA), April 14-17, 1996.
  71. Otero G, Avila MA, Clerch LB, Massaro D, Notario V. Increased manganese superoxide dismutase activity, protein, and mRNA in radiation-transformed Syrian hamster cells showing production of tumor necrosis factor alpha. 44th Annual Meeting of the Radiation Research Society, Chicago, Illinois (USA), April 14-17, 1996.
  72. Soldatenkov VA, Notario V, Dritschilo A. The effect of BCL-2 protein expression on apoptosis, cell cycle kinetics, and proteolysis of poly(ADP-ribose) polymerase. 9th International Conference of the International Society of Differentiation (ISD) on “Development, Cell Differentiation and Cancer”. Pisa (Italy), September 28- October 2, 1996.
  73. Otero G, Berkovich A, Clerch LB, Massaro D, Notario V. Elevated H2O2 release by immortal Syrian hamster embryo cells initiated with ionizing radiation and showing divergent manganese superoxide dismutase and catalase activities. VIII Biennial Meeting of the International Society for Free Radical Research, Barcelona (Spain), October 1-5, 1996.
  74. Notario V. Cloning and structural and functional characterization of the cph oncogene. 5th Symposium on Oncogenes. San Sebastián, Guipuzcoa (Spain), October 2-5, 1996.
  75. Notario V, DiPaolo JA. Molecular aspects of Neoplasia of Syrian hamster cells transformed in vitro by chemical carcinogens. 6th European Meeting on Environmental Hygiene, Graz (Austria), June 3-5, 1997.
  76. Feijoó E, Notario V. Altered radiation response in neoplastic Syrian hamster embryo fibroblasts expressing antisense RNA to the cph oncogene.  AACR/EACR Conference on “Molecular Genetics of Cancer”, Oxford, England, 1997.
  77. Alberdi E, Notario V, Becerra SP. PEDF-binding to retinal cells: characterization of a candidate receptor for the neurotrophic factor PEDF.  Keystone Symposium on “Specificity in Signal Transduction”, Lake Tahoe, Nevada (USA), March 1-7, 1998.
  78. Notario V. Structural and functional characterization of the cph oncogene. 6th Symposium on Oncogenes. Madrid (Spain), October 4-6, 1998.
  79. Notario V. National Cancer Institute Workshop on “Molecular Radiation Biology and Oncology”, Rockville, Maryland (USA), March 8-9, 1999.
  80. Notario V. Present state and perspectives for the gene therapy of cancer. XIX General Assembly of A.L.D.E.E.U., Santander (Spain), June 1-4, 1999.
  81. Soldatenkov, VA, Dreszer R, Dritschilo A, Notario V. Antisense ETS1 down-regulates poly(ADP-ribose) polymerase gene expression and sensitizes tumor cells to radiation. 11th International Congress of Radiation Research, Dublin (Ireland), 18-23, July, 1999.
  82. Notario V. Studies on the role of the PCPH oncogene in mammalian carcinogenesis: possible involvement in human neoplasia. 11th ICRR Satellite Meeting on “In vitro transformation”, Cork (Ireland), July 24-25, 1999.
  83. Notario V. Structural and functional characterization of the PCPH oncogene: Cooperation with ras and role in cell survival. 4th World Congress on Advances in Oncology, and 2nd International Symposium on Molecular Medicine, Athens (Greece), October 7-8, 1999.
  84. Rouzaut A, Páez JG, Recio JA, Notario V. Characterization of the genomic structure, promoter regions and expression in human tumor cell lines of the PCPH proto-oncogene. 91st Annual meeting of the American Association for Cancer Research, San Francisco, California (USA), April 1-5, 2000.
  85. McDermott F, Notario V, Soldatenkov VA. Regulation of radiation response and apoptosis by ETS1 transcription factor. 47th Annual Meeting of the Radiation Research Society. Albuquerque, New Mexico (USA), April 29-May 3, 2000.
  86. Solanas M, Escrich E, Rouzaut A, Notario V. Analysis of the expression of the PCPH oncogene in experimentally induced tumors and other rat tissues. Effect of dietary lipids. XIX Meeting of the Spanish Society of “Senología y Patología Mamaria”, Madrid, Spain, October 18-20, 2000.
  87. Notario V, Solanas M, Escrich E, Rouzaut A. “Basic Aspects of Breast Cancer: Studies on the Involvement of the PCPH Oncogene”. XIX National Meeting of the Spanish Society for Breast Physiology and Pathology, Madrid, Spain, October 18-20, 2000.
  88. Notario V, Recio JA, De la Peña L, Rouzaut A. Participation of the PCPH oncogene in the neoplastic progression of human cancer cells. 5th World Congress on Advances in Oncology, and 3rd International Symposium on Molecular Medicine, Hersonissos, Crete, Greece, October 19-21, 2000.
  89. Trofimova I, McDermott F, Dritschilo A, Notario V, Soldatenkov VA. Down-regulation of ETS1 transcription factor inhibits apoptosis of Ewing’s tumor cells. 92nd Annual Meeting of the American Association for Cancer Research, New Orleans, Louisiana (USA), March 24-28, 2001.
  90. Rouzaut A, Notario V. Alternative promoter usage and mRNA splicing in the regulation of the expression of the PCPH gene. 92nd Annual Meeting of the American Association for Cancer Research, New Orleans, Louisiana (USA), March 24-28, 2001.
  91. Rouzaut A, Notario V. Regulation of the PCPH proto-oncogene expression in normal vs. transformed cell lines. International Workshop on Cellular and Molecular Carcinogenesis, Pamplona (Spain), June 21-23, 2001.
  92. Notario V. Oncogenes and Carcinogenesis. Joint Meeting of the European Tissue Culture Society, the Scandinavian Society for Cell Toxicology, and the British Prostate Group, Oxford, England, September 22-24, 2002.
  93. Tirado OM, Mateo-Lozano S, Notario V. mTOR activation mediates the apoptotic response of normal fibroblasts to ionizing radiation: Inhibition by the PCPH oncoprotein. 8th World Congress on Advances in Oncology, Crete (Greece), October 16-18, 2003.
  94. Mateo-Lozano S, Tirado OM, Notario V. Induction of apoptosis in Ewing’s Sarcoma (EWS) cells by simultaneous treatment with antisense oligodeoxynucleotides (AS-ODNs) to the EWS/FLI-1 gene and Rapamycin. 95th Annual Meeting of the American Association for Cancer Research, Orlando, Florida (USA), March 27-31, 2004.
  95. Tirado OM, Mateo-Lozano S, Sanders S, Saxena V, Notario V. The PCPH oncoprotein mediates cisplatin resistance through activation of PKCα and stabilization of the Bcl-2 protein in mouse fibroblasts. 95th Annual Meeting of the American Association for Cancer Research, Orlando, Florida (USA), March 27-31, 2004.
  96. Notario V. The PCPH oncoprotein as a versatile effector of cellular anti-apoptotic programs. Frontiers in Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain, October 6, 2004.
  97. Arenas MI, Blánquez MJ, Paniagua R, Conde I, Notario V. Deregulation of PCPH in human prostate. A new marker for neoplastic development. First International Congress of Histology and Tissue Engineering. University of Alcalá, Alcalá de Henares, Madrid, Spain, September 14-17, 2005.
  98. Notario V.Nanotechnology and Cancer Therapy. International Symposium on “Biotechnology: Newer Tools for a New Era”, Santiago de Compostela, Spain, November 29-30, 2005.
  99. Villar J, Arenas MI, Blánquez MJ, Paniagua R, Tirado OM, Notario V. PCPH is differentially expressed in samples of benign and neoplastic human prostate, and contributes to maintaining the malignant phenotype of human prostate cancer cells. 97th Annual Meeting of the American Association for Cancer Research, Washington, DC (USA), April 1-5, 2006.
  100. Mateo-Lozano S, Gokhale PC, Tirado OM, Notario V. Combination therapy targeting the EWS/FLI-1 oncogene with antisense oligonucleotides and rapamycin induces apoptosis of Ewing’s sarcoma cells in vitro and inhibits tumor growth in vivo. 97th Annual Meeting of the American Association for Cancer Research, Washington, DC (USA), April 1-5, 2006.
  101. Tirado OM, Mateo-Lozano S, Villar J, Dettin LE, Llort A, Gallego S, Notario V. Caveolin-1 is a target of EWS/FLI-1 and a key determinant of tumorigenicity and resistance to chemotherapy-induced apoptosis of Ewing's sarcoma cells. 97th Annual Meeting of the American Association for Cancer Research, Washington, DC (USA), April 1-5, 2006.
  102. Schwechter A, Grekova M, Ressom H, Notario V, Richert J. Immune regulation in T-cells by transcription factor Sp3: Implications for multiple sclerosis. Annual Meeting of the American Association of Immunologists, Boston, Massachusetts (USA), May 12-16, 2006.
  103. Quadri H, Tirado OM, Notario V. Proteasome inhibition sensitizes clear cell sarcoma cells to ionizing radiation-induced apoptosis by abrogating their G2 cell cycle arrest. 53rd Annual Meeting of the Radiation Research Society, Philadelphia, Pennsylvania (USA), November 6-9, 2006.
  104. Villar J, MacCarthy CM, Arenas MI, Blánquez MJ, Tirado OM, Notario V. Expression of the PCPH oncogene enhances the invasiveness of prostate cancer cells by a PKCδ- dependent mechanism. 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, California (USA), April 14-18, 2007.
  105. Villar J, Song I, Tomita Y, Tirado OM, Notario V. PCPH expression in human prostate carcinoma cells confers resistance to cisplatin-induced apoptosis through a mechanism that involves PKCα and Bcl-2. AACR-NCI-EORTC International Conference on “Molecular Targets and Cancer Therapeutics. Discovery, Biology, and Clinical Applications”, San Francisco, California (USA), October 22-26, 2007.
  106. MacCarthy CM, Villar J, Notario V. The contribution of PCPH to colon carcinoma cell motility. 47th Annual Meeting of the American Society for Cell Biology, Washington, DC (USA), December 1-5, 2007.
  107. Notario V. Targeting EWS/FLI1-driven pathways for radiation sensitization of Ewing’s sarcoma. Rett Nearburg International Ewing’s Sarcoma Symposium IV, Dartmouth College, Hanover, New Hampshire (USA), April 9-11, 2008.
  108. Notario V. Nanoparticle-based strategies for early detection and treatment of cancer. 2nd International Symposium on “Biotechnology. Newer Tools for a New Era”, Santiago de Compostela, Spain, November 27-28, 2008.
  109. Notario V. Targeting Ewing’s sarcoma for radiosensitization with nanoparticulate drug delivery systems. 2nd International Symposium on “Biotechnology. Newer Tools for a New Era”, Santiago de Compostela, Spain, November 27-28, 2008.
  110. Liu Y, Yan S, Weiss M, Sutherland M, Villar J, Notario V, Colberg-Poley AM, Ladisch S. Characterization of oncogene c-Myc/H-Ras transformed GM3S/GM2S double knockout fibroblasts. Annual Meeting of the Society for Glycobiology, Fort Worth, Texas (USA), November 12-15, 2008.
  111. Liu Y, Yan S, Weiss M, Sutherland M, Villar J, Notario V, Colberg-Poley AM, Ladisch S. GM2 synthase/GM3 synthase knockout transformed fibroblasts: a tumor model of complete ganglioside depletion. 100th Annual Meeting of the American Association for Cancer Research. Denver, Colorado (USA), April 18-22, 2009.
  112. Deshpande M, Notario V, Becerra SP. PEDF-mediated inhibition of tumor cell viability: implications of F1/F0 ATP synthase. ARVO-ISOCB Conference. Ericeira, Portugal, September 9-12, 2009.
  113. Deshpande M, Notario V, Becerra SP. Pigment Epithelium-derived Factor (PEDF)-mediated inhibition of prostate tumor cell viability: implications of F1/F0 ATP synthase. NIH Research Festival, NIH, Bethesda, Maryland (USA), October 6-9, 2009.
  114. Sainz-Jaspeado M, Lagares-Tena L, Lasheras J, Navid F, Rodriguez-Galindo C, Mateo-Lozano S, Notario V, Sanjuan X, Garcia del Muro X, Fabra A, Tirado OM. Caveolin-1 modulates the metastatic ability of Ewing’s sarcoma. 101st Annual Meeting of the American Association for Cancer Research. Washington, DC (USA), April 17-21, 2010.
  115. Sainz-Jaspeado M, Lagares-Tena L, Lasheras J, Navid F, Rodriguez-Galindo C, Mateo-Lozano S, Notario V, Sanjuan X, Garcia del Muro X, Fabra A, Tirado OM. Caveolin-1 modulates the metastatic ability of Ewing’s sarcoma. 16th Annual Meeting of the Connective Tissue Oncology Society, Paris, France, November 11-13, 2010.
  116. Notario V. Tumor markers of early invasion in colon carcinoma. XXXIV Meeting of the A.C.A.D., Ciudad Real, Spain, October 14-15, 2011.
  117. Becerra SP, Deshpande MM, Locatelli-Hoops S, Moghaddam-Taaheri S, Guerrier S, Balko N, Fitzgerald D, Steeg PS, Notario V, Subramanian, P. Identification of pigment epithelium-derived factor (PEDF) protein forms with distinct activities on tumor cells lines. 6th International Symposium on the Chemistry and Biology of Serpins (“Back to the Future”, 1996-2011). The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (USA), October 23-26, 2011.
  118. Sengupta A, Mateo-Lozano S, Villar J, MacCarthy CM, Tirado OM, Notario V. Forkhead box M1 (FoxM1) is a direct transcriptional target of EWS/FLI1 and a regulator of Ewing’s sarcoma cell morphology, adhesiveness  and tumorigenicity. 103st Annual Meeting of the American Association for Cancer Research. Chicago, Illinois (USA), March 31-April 4, 2012.
  119. Riddles C, Subramanian P, Becerra SP, Notario V. Effects of the expression of PCPH or mt-PCPH in colon cancer cells on the expression of PEDF and its receptors PEDF-R and ATP synthase. Twelfth Tri-annual M.S. Internship Program, Spring 2013 Presentations, Washington, DC (USA), April 25, 2013.
  120. Notario V. Round Table on “Effects of science globalization on the scientific community”. 34th International Meeting of the Society of Spanish Professionals in America (A.L.D.E.E.U.). Washington, DC (USA), March 27-28, 2014.
  121. Bokhari BT, Notario V. Differential expression of glycolytic enzymes induced by the mt-PCPH oncoprotein in colon cancer cells: Functional interaction with PTEN. Thirteenth Tri-annual M.S. Internship Program, Biochemistry and Molecular Biology Program. Spring 2014 Presentations, Washington, DC (USA), April 24, 2014.

 

 

Vicente Notario

Professor

Phone: 202-687-2102

  • DEPARTMENTExperimental Carcinogenesis Laboratory Departments of Radiation Medicine Georgetown University Medical Center
  • COUNTRY USA