Education


Biography

Graduate in Medicine Specialist in Clinical Toxicology Specialist in Clinical Nephrology Medical Assistant at Unit of Cinical Pharmacology of Faculty of Medicine, Federico II University of Naples, from 1982 to 1997 Assistant Professor at Unit of Clinical Pharmacology of Faculty of Medicine, “Federico II University” of Naples, from 1998 till today Temporary lecturer of Pharmacodiagnostics at “School of Biomedical Laboratory Technician” of Faculty of Medicine, Federico II University Temporary lecturer of Pharmacology at School of “Medical Radiology Technician” of Faculty of Medicine, Federico II University Temporary lecturer of Pharmacology at “Nursing School” of Faculty of Medicine, Federico II University Temporary lecturer of Pharmacology at “Techniques of Cardiovascular Physiopathology and Cardiovascular Perfusion” of Faculty of Medicine, Federico II University Collaborator with teaching activity and member of Committee of exams of Pharmacology at “School of Medicine” and “School of Odontology” of Faculty of Medicine, Federico II University.


Research Interest

My research interests have been always addressed to the field of clinical pharmacology and toxicology. In fact, I carry out clinical studies with regard to therapeutic monitoring, pharmacokinetics of drugs, in particular immunosuppressive drugs,as cyclosporine, tacrolimus, sirolimus, mycophenolic acid and everolimus.Recently, my scientific activity is also devoted to study the pathophysiologic mechanisms of liver diseases, particularly drug-induced.


Scientific Activities

Member of the following Scientific Societies
  • Italian Society of Pharmacology
  • Section of Clinical Pharmacology of the Italian Society of Pharmacology
  • Italian Group for Studies of Pharmacoeconomics
  • Italian Society of Organ Transplantation

Publications

  1. De Marino V., Pisanti N., Gentile A., Capone D., Pharmacokinetic interaction between betamethasone and theophylline in the rat. Rassegna di Medicina Sperimentale. 1983: 30, 1-5.
  2. Pisanti N., De Marino V., Capone D., Gentile A.: Lack of effects of amiodarone on serum levels of theophylline in rats. Rassegna di Medicina Sperimentale. 1983: 30, 84-88.
  3. De Natale G., Lucisano A., Damiano S., Capone D., Basile G.: lack of substantial neuroendocrine changes in short-term high dose cadmium treated rats. Archives of Toxicology. 1985: Suppl.8, 327-328.
  4. De Michele G., Brescia-Morra V., Pisanti N., Giani U., Filla L., Sinisi L., Capone D., Campanella G.: Carbamazepine serum levels in epileptics. Influence of age, sex, body weight and interaction with phenobarbital. Acta Neurologica: New Series. 1985: 7, 228-234.
  5. De Natale G., Lucisano A., Damiano S., Capone D., Basile G., Ambrosio C.: Lack of substantial neuroendocrine changes in short-term high dose cadmium treated rats. Rivista di Tossicologia Sperimentale e Clinica. 1985: 15, 135-140.
  6. De Marino V., Pisanti N., Capone D.: Effects of trazodone and bicuculline on conditioning-avoidance in the rat. Bollettino della Società Italiana di Biologia Sperimentale. 1986: 62, 871-875.
  7. De Marino V., Pisanti N., Capone D., Annicelli A., Del Donno M., Marsico S.A.: Effects of betamethasone on theophylline disposition in man. Are saliva values predictive of serum theophylline levels? Pharmacological Research Communication. 1986: 18, 909-921.
  8. Delfino M., Acri R., Mangone S., Pisanti N., Capone D.: The role of biogenic amines in the pathogenesis of alopecia areata. Italian General Review of Dermatology. 1987: 24, 239-242.
  9. Capone D., Del Rio A., Campanella G., De Marino V., Pisanti N.: Pharmacokinetics of some antiepileptics. Bollettino della Società Italiana di Biologia Sperimentale. 1988: 64, 17-23.
  10. Ferrara L.A., Moscato T.S., Pisanti N:, Marotta T., Krogh V., Capone D:, Mancini M., : Is the sympathetic nervous system altered in children with familial history of arterial hypertension? Cardiology. 1988: 75, 200-205.
  11. Pisanti N., De Marino V., Capone D., Gentile A., Giani U.: Effects of theophylline on netilmicin and gentamicin disposition in rats. Medical Science Research. 1988: 16, 1305-1306.
  12. Ferrara L.A:, Mancini M., De Simone G., Pisanti N., Capone D., Fasano M.L., Mancini M.: Adrenergic nervous system and left ventricular mass in primari hypertension. European Heart Journal. 1989: 10, 1036-1040.
  13. De Marino V., Pisanti N., Capone D.: Effects of nimodipine on psychological-stress situation in aged rats. Acta Neurologica. New Series. 1991: 13, 410-417.
  14. Memoli B., Libetta C., Sabbatini M., Conte G., Russo D., Giani U., Capone D., Andreucci V.E.: renal function riserve: its significance in normal and salt depletion conditions. Kidney International. 1991: 40, 1134-1140.
  15. Capone D., Stanziale P., Balletta M.M., Imperatore P.,. De Marino V., Pisanti N.: Evaluation of Monoclonal/Polyclonal ratio in kidney transplanted patients treated with cyclosporine. International Journal of Clinical Pharmacology Research. 1992: 12, 123-128.
  16. Capone D., De Marino V., Pisanti N., De Marino V.: A new dry chemistry immunoassay: comparison with a fluorescence polarization system. European Review for Medical and Pharmacological Sciences. 1994: 16, 91-94.
  17. Capone D., Aiello C., Santoro G.A., Gentile A., Stanziale P., D’Alessandro R., Imperatore P., Basile V.: Drug interaction between cyclosporine and two antimicrobial agents, josamycin and rifampicin, in organ transplanted patients. International Journal of Clinical Pharmacology Research. 1996, 16, 73-76.
  18. Capone D., De Marino V., Fontana R., Notaro R., De Marino V., Pisanti N.: Effects of different routes of cyclosporin A administration on blood levels in patients undergoing bone marrow transplantation. Bone Marrow Transplantation. 1997: 19, 369-372.
  19. Pisanti N., Stanziale P., Imperatore P., D’Alessandro R., De Marino V., Capone D., De Marino V.: Lack of effects of gemfibrozil on cyclosporine blood concentrations in kidney transplanted patients. American Journal of Nephrology. 1988: 18, 199-203.
  20. Capone D., Gentile A., Vajro P., Stanziale P., Imperatore P., De SilvaC., Pellegrino T., Basile V.: Therapeutic monitoring of tacrolimus in pediatric and adult transplanted patients. Journal of Chemoterapy. 1998: 10, 176-178.
  21. Capone D., De Marino V., Caso N., Stanziale P., Fontana R., Imperatore P., De Marino V., Pisanti N.: Polyclonal/monoclonal ration in kidney and bone marrow transplanted patients treated with cyclosporine. Clinical Transplantation. 1998: 12, 430-433.
  22. Capone D., Stanziale P., Gentile A., Imperatore P., Pellegrino T., Basile V.: Effects of simvastatin and pravastatin on hyperlipdemia and cyclosporin blood level in renal transplant recipients. American Journal of Nephrology. 1999: 19, 411-415.
  23. Capone D., Gentile A., Imperatore P., Palmiero G., Basile V.: Effects of itraconazole on tacrolimus blood concentrations in a renal transplant recipient. Annals of Pharmacotherapy. 1999: 33, 1124-1125.
  24. Capone D., Gentile A., Morra F., Basile V.: Comparison of three immunoassays for digoxin therapeutic monitoring: TDxII, OPUS and IMx. Journal of Applied Therapeutic Research. 1999: 2, 291-297.
  25. Capone D., Gentile A., Basile V.: Possibile interference of digoxin-like immunoreactive substances using the digoxin fluorescence polarization immunoassay. Journal of Applied Therapeutic Research. 1999: 2, 305-308.
  26. Capone D., Spanò A., Gentile A., Ferrara G., Itto E., Palmiero G., Basile V., Oriente P.: Are there differences in methotrexate kinetics between responding and non responding patients with rheumatoid arthritis?. BioDrugs. 2000: 13, 373-379.
  27. Costagliola C., Mastropasqua L., Capone D., Verdolino M., Ciacaglini M., Pisanti N.: Effect of fluoxetine on intraocular presure in the rabbit. Experimental Eye Research. 2000: 70, 169-175.
  28. Federico S., Carrano R., Capone D., Gentile A., Palmiero G., Basile V.: Pharmacokinetic interaction between levofloxacin and ciclosporin or tacrolimus in kidney transplant recipients. Clinical Pharmacokinetics. 2006: 45, 169-175.
  29. Tarantino G., Conca P., Capone D., Gentile A., Polichetti G., Basile V.: Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients. European Journal of Clinical Pharmacology. 2006: 62, 605-612.
  30. Pieri M., Capone D., Gentile A., Miraglia N., Leo E., Federico S., Basile V., Acampora A.: Immunoassay determination of rapamycin: reliability of the method with respect to liquid chromatography mass spectrometric quantification. Clinical Transplantation. 2007: 21, 633-637.
  31. Tarantino G., Conca P., Basile V., Gentile A., Capone D., Polichetti G., Leo E.: A prospective study of acute drug-induced liver injury in patients suffering from non alcoholic fatty liver disease. Hepatology Research. 2007: 37, 410-415.
  32. Capone D., Palmiero G., Gentile A., Basile V., Federico S., Sabbatini M., Potenza M., Perfetti A., Pieri M., Tarantino G.: A pharmacokinetic interaction between clarithromycin ans sirolimus in kidney transplant recipient. Current Drug Metabolism. 2007:8, 379-381.
  33. Tarantino G., Gentile A., Capone D., Basile V., Tarantino M., Di Minno M.N.D. Cuocolo A., Conca P.: Does protracted antviral therapy impact on the HCV-related liver cirrhosis progression? World Journal of Gastroenterology. 2007, 13, 4903-4908.
  34. Capone D.,Gentile A., Polichetti G., Federico S., Sabbatini M., Acampora A., Basile V., Pieri M. ,Tarantino G.: Stability of sirolimus and everolimus measured by immunoassay techniques in whole blood samples from kidney transplant patients. International Journal of Immunopathology and Pharmacology. 2008: 21, 297-307.
  35. Pieri M., Miraglia N., Gentile A., Polichetti G., Castiglia L., Federico S., Sabbatini M., Basile V., Tarantino G., Acampora A., Capone D.: Quantification of sirolimus and everolimus by immunoassay techniques: test specificity and cross-reactivity evaluation. International Journal of Immunopathology and Pharmacology. 2008: 21, 585-594.
  36. Tarantino G., Basile V., Conca P., Ariello M., Di Minno M.N., Romano A., Gentile A., Capone D.: Could the depression of obese patients suffering from chronic hepatitis C be temporarily improved? Journal of Viral Hepatitis. 2008: 15, 646-650.
  37. Striano S., Striano P., Capone D., Pisani F.: Limited place for plasma monitoring of new antiepileptic drugs in clinical practice. Medical Science Monitor. 2008: 14, RA173-178.
  38. Tarantino G., Conca P., Riccio A., Tarantino M., Di Minno M.N., Chianese D., Pasanisi F., Contaldo F., Scopacasa F., Capone D.: Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign? Journal of Translational Medicine. 2008: 6, 72.
  39. Sabbatini M., Capone D., Gallo R., Pisano A., Polichetti G., Tarantino G., Gentile A., Rotaia E., Federico S.: EC-MPS permits lower gastrointestinal symptom burden despite higher MPA exposure in patients with severe MMF-related gastrointestinal side effects. Fundamental and Clinical Pharmacology. 2009: 23, 617-624.
  40. Tarantino G., Pezzullo.G., di Minno M.N.D., Milone F., Pezzullo L.S., Milone M., Capone D.: Drug-induced liver injury due to herbal extract of Lycopodium serratum and Chelidonium maius mimicking acute cholangitis-cholecistitis: a case report. World Journal of Gastroenterology. 2009: 15, 2414-2417.
  41. Tarantino G., Colicchio P., Conca P., Finelli C., Di Minno D.M.N., Tarantino M., Capone D., Pasanisi F.: Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively? Journal of Inflammation. 2009: 6, 6.
  42. Tarantino G., Di Minno M.N.D., Capone D.: Drug Induced Liver Injury: Is It Somehow Foreseeable? World Journal of Gastroenterology. 2009: 15, 2817-2833.
  43. Tarantino G., Conca P., Tarantino M., Di Minno M.N.D., Grimaldi E., Chianese D., Riccio A., Scopacasa F., Capone D.: Does spleen volume play a role in patients with hcv-related chronic hepatitis? International Journal of Immunopathology and Pharmacology. 22: 1009-1017.
  44. Tarantino G., Citro V., Conca P., Riccio A., Tarantino M., Capone D., Cirillo M., Lobello R., Iaccarino V.: What are the implications of the spontaneous spleno-renal shunts in liver cirrhosis? BMC Gastroenterology. 2009; 9: 89.
  45. Capone D., Tarantino G., Gentile A., Sabbatini M., Polichetti G., Santangelo M., Nappi R., Ciotola A., D’Alessandro V., Renda A., Basile V., Federico S.: Effects of Voriconazole on Tacrolimus Metabolism in a Kidney Transplant Recipient. Journal of Clinical Pharmacy and Therapeutics. 2010; 35: 121-124.
  46. Capone D., Tarantino G., Polichetti G., Kadilli I., Sabbatini M., Basile V., Carrano R., Nappi R., Federico S.: Absence of pharmacokinetic interference of moxifloxacin on cyclosporine and tacrolimus in kidney transplant recipients. Journal of Clinical Pharmacology. 2010: 50, 576-580.
  47. Tarantino G., Palmiero G., Polichetti G., Perfetti A., Sabbatini M., Basile V., Kadilli I., Federico S., Capone D.: Long-term assessment of plasma lipids in transplant recipients treated with tacrolimus in relation to fatty liver. International Journal of Immunopathology and Pharmacology. 2010, 23: 1303-1308.
  48. Capone D., Tarantino G., Kadilli I., Polichetti G., Basile V., Federico S., Sabbatini M.: Evaluation of mycophenolic acid systemic exposure by limited sampling strategy in kidney transplant recipients receiving enteric-coated mycophenolate sodium (EC-MPS) and cyclosporine. Nephrology, Dialysis Transplantation. .2011, 26: 3019-3025.
  49. Pieri M., Miraglia N., Polichetti G., Tarantino G., Acampora A., Capone D.: Analytical and pharmacological aspects of therapeutic drug monitoring of mTOR inhibitors: Current Drug Metabolism. 2011, 3: 253-267.
  50. Tarantino G., Colao A., Capone D., Conca P., Tarantino M., Grimaldi E., Chianese D., Finelli C., Contaldo F., Scopacasa F., Savastano S.: Circulating levels of cytochrome C, gamma-glutamy transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease. Journal of Biological Regulators & Homeostatic Agents. 2011, 25: 47-56.
  51. Pignataro G, Capone D, Polichetti G, Vinciguerra A, Gentile A, Di Renzo G, Annunziato L.: Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options. Current Opinion in Pharmacology. 2011, 11::378-394.
  52. Giovanni Tarantino, Silvia Savastano, Annamaria Colao, Giuliano Polichetti, Domenico Capone: Urinary excretion of 5-hydroxy-3-indoleacetic acid in dystimic/depressed, adult obese women. What correlations to hepatic steatosis? International Journal of Immunopathology and Pharmacology. 2011, 29: 769-779.
  53. Tarantino G, Savastano S, Capone D, Colao A.: Spleen: A new role for an old player? World Journal of Gastroenterology. 2011 17: 3776-84.
  54. Tarantino G, Scopacasa F, Colao A, Capone D, Tarantino M, Grimaldi E, Savastano S.: Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease. World Journal of Gastroenterology. 2011, 17: 5280-5288.
  55. Tarantino G, Finelli C, Colao A, Capone D, Tarantino M, Grimaldi E, Chianese D, Gioia S, Pasanisi F, Contaldo F, Scopacasa F, Savastano S.:Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase? J Transl Med. 2012, 10: 50, 1-9
  56. Polichetti G., Capone D., Grigoropoulos K., Tarantino G., Nunziata A., Gentile A.: Effects of ambient air pollution on birth outcomes: an overview: Critical Reviews in Environmental Science and Technology. 2013, 43: 752-774
  57. Tarantino G., Capone D.: Inhibition of the mTOR pathway: A possible protective role in coronary artery disease. Annals of Medicine. 2013, 45: 348-356.
  58. Tarantino G, Capone D, Finelli C.: Exposure to ambient air particulate matter and non-alcoholic fatty liver disease. World J Gastroenterol. 2013,19: 3951-3956.
  59. Sabbatini M, Garofalo G, Borrelli S, Vitale S, Torino M, Capone D, Russo L, Pisani A, Carrano R, Gallo R, Federico S: Efficacy of a reduced pill burden on therapeutic adherence to calcineurin inhibitors in renal transplant recipients: an observational study. Patient Preference and Adherence 2014, 8:73-81.
  60. Tarantino G., Finelli C., Scopacasa F., Pasanisi F., Contaldo F., Capone D., Savastano S.: Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes. Oxidative Medicine and Cellular Longevity Volume 2014, Article ID 920676, 1-10.
  61. Cataldi M, di Geronimo O, Trio R, Scotti A, Memoli A, Capone D, Guida B. Utilization of antihypertensive drugs in obesity-related hypertension: a retrospective observational study in a cohort of patients from Southern Italy.BMC Pharmacol Toxicol. 2016 Mar 16;17(1):9, 1-8.
  62. Federico S, Carrano R, Sabbatini M, Nappi R, Russo L, Apicella L, Balletta MM, Santangelo M, Mosca T, Tarantino G, Capone D. Sublingual administration improves systemic exposure of tacrolimus in kidney transplant recipients: comparison with oral administration. Eur J Clin Invest. 2016 Jul;46 (7):651-7.
  63. Cataldi M, Vigliotti C, Mosca T, Cammarota M, Capone D. Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes.Int J Mol Sci. 2017 Jun 10;18(6).
  64. Capone D, Cataldi M, Vinciguerra M, Mosca T, Barretta S, Ragosta A, Sorrentino A, Vecchione A, Barretta L, Tarantino G. Reticulocyte Hemoglobin Content Helps Avoid Iron Overload in Hemodialysis Patients: A Retrospective Observational Study.In Vivo. 2017 Jul-Aug;31(4)709-712.
  65. Tarantino G, Capone D, Contaldi P, Gianno A, Mosca T, Tufano A. Phenotyping of CYP 4501A2 activity by total overnight salivary caffeine assessment (TOSCA) in patients on warfain treatment. Clinical and applied thrombosis/hemostasis. 2017. In press

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