isabel-t-de-andres
Isabel T De Andres, PhD
Professor of Anatomy Histology and Neuroscience
  • Autonomous University of Madrid (UAM)
    Arzobispo Morcillo, Madrid, Spain
    Phone: 34-91-397-53-37
    E-mail: isabel.deandres@uam.es

Education

1976-1977 Postdoctoral Fellow Mental Retardation Research Center, UCLA, Medical School, California, USA
1975 PhD Degree Complutense University of Madrid, Madrid, Spain
1964 Bachelor in Sciences Complutense University of Madrid, Madrid, Spain

Biography

Dr. Isabel T. De Andres is a Professor of Anatomy, Histology and Neuroscience, UAM, Medical School, Madrid, Spain. She was a Visiting Research Neurophysiologist in Mental Retardation Research Center, UCLA in 1980 and 1984. She guarded as President to Postgraduate Committee in the Department of Anatomy, Histology and Neuroscience, UAM. She was also a member of Spanish Society of Sleep in the year 1991. Her clinical research includes Neuroanatomical, neurophysiological and neurochemical sleep-wakefulness mechanisms, Acute and Chronic effects of opiates on sleep and EEG.

Research Interests

Neuroanatomical, neurophysiological and neurochemical sleep-wakefulness mechanisms.


Scientific Activities

Teaching Experience
2017-Present Emeritus Professor of Anatomy Histology and Neuroscience, UAM, Medical School, Madrid, Spain
1986-2017 Professor of Anatomy Histology and Neuroscience, UAM, Medical School, Madrid, Spain
1977-1986 Associate Professor of Morphology, UAM, Medical School, Madrid, Spain
Professional Activities

MEMBERSHIP FOR PROFESSIONAL ORGANIZATIONS

1991 Spanish Society of Sleep
1990 Spanish Society of Anatomy
1985 Spanish Society of Neuroscience
1984 International Brain Research Organization
1981 European Neuroscience Association
1980 American Society for Neuroscience
1976 European Sleep Research Society

Publications

  1. De Andrés I. y E. Aguirre. Un molde endocraneano de Praedama (Cérvido) del Pleistoceno medio de Madrid. Quaternaria, l8: 303-330. l974.
  2. De Andrés I., E. Gutiérrez-Rivas and F. Reinoso-Suárez. Modifications of the sleep-wakefulness cycle after lesions at the level of oral pontine tegmentum and superior cerebellar peduncle. In: Sleep l974. Levin and Koella Eds. pp. 235-238. l975.
  3. De Andrés I., B.E. Nava, E. Gutiérrez-Rivas and F. Reinoso-Suárez. Comparative study of sleep- wakefulness cycle between a dog's implanted head and its receptor. In: Sleep Research, vol. 4 Eds: Chase, Stern and Walter Eds. Brain Infor. Serv. UCLA. Los Angeles. pp. 26. l975.
  4. De Andrés I.Efectos en cronicidad de las lesiones en el brachium conjunctivum y otras estructuras cerebelosas en los estados de vigilia y de sueño. An. Anat. 25: 237-265. l976.
  5. De Andrés I., E. Gutiérrez-Rivas, B.E. Nava and F. Reinoso-Suárez. Independence of sleep-wakefulness cycle in an implanted head 'encéphale isolée'. Neurosc. Let. 2: l3-l8. l976.
  6. Reinoso-Suárez F. and I. de Andrés. Brain structures and sleep. Trab. Inst. Cajal. Inv. Biol., 58:39-68. l976.
  7. Gómez-Montoya J. e I. de Andrés. Influencia de las condiciones de registro en el ciclo vigilia-sueño del gato normal. An. Anat., 25 (nº extraord.): l79-l90. l977.
  8. Gómez-Montoya J., I. de Andrés, E. Gutiérrez-Rivas and F. Reinoso-Suárez. Dynamics of sleep- wakefulness cycle of the cat in different environmental conditions. In Sleep l976. Eds: P. Levin and W.P. Koella. Basel, pp. 4l3-416. l977.
  9. De Andrés I., E. Gutiérrez-Rivas y J. Gómez-Montoya. El ciclo vigilia-sueño. En: Bases Fisiológicas de la Psiquiatria. Ed. Reycosa, Madrid. pp.73-89. l977.
  10. Gutiérrez-Rivas E., I. de Andrés, J. Gómez-Montoya and F. Reinoso-Suárez. The function of the rostropontine ventrolateral region on the sleep-wakefulness cycle. Experientia, 34: 61-62. l978.
  11. Villablanca J., Ch. E. Olmstead and I. de Andrés. Effects of caudate nuclei or frontal cortical ablations in kittens. II. Responsiveness to auditory stimuli and comparison with adults operated littermates. Exp. Neurol., 61: 635-649. l978.
  12. Gómez-Montoya J, E. Gutiérrez-Rivas, I. de Andrés and F. Reinoso-Suárez. Alternance of states within the sleep-wakefulness cycle. An approach to its study. Rev. Esp. Fisiol., 34: -394. l978.
  13. De Andrés I. and F. Reinoso-Suárez. Cerebellar participation in the regulation of sleep-wakefulness cycle through the superior cerebellar peduncle. Arch. ital. Biol., ll7: l40-l63. l979.
  14. De Andrés I. y F. Reinoso-Suárez. Influencia del cerebelo en la regulación del ciclo vigilia-sueño. En : Cerebelo, problemas fisiopatológicos y clinicos. Monografias Neuroquirúrgicas de Santander. pp. 22-29. Ed. Banco de Santander.Santander. l979.
  15. García-Uria J., I. de Andrés, J.D. Cunchillos and F. Reinoso-Suárez. Modifications of the sleep- wakefulness cycle after surgical removal of cerebellar cortex. In: Sleep l978. Eds: L. Popoviciu, B. Asgian and G. Badin. Tirgu-Mures. pp. 289-292. l980.
  16. Gutiérrez-Rivas E. e I. de Andrés. El ciclo vigilia-sueño del gato II. Modificaciones tras lesiones rostropontinas. Arch. Neurobiol., 43: 353-376. l980.
  17. Sigüenza J.A., I. de Andrés and F. Reinoso-Suárez.Visual evoked potentials elicited by a light emitting diode chronically implanted in the frontal sinus of the freely moving cat. J. Neurosc. Methods. , 5: l73-l79. l982.
  18. Cunchillos J.D. and I. de Andrés. Participation of the cerebellum in the regulation of the sleep- wakefulness cycle. Results in cerebellectomized cats. Electroenceph. Clin. Neurophysiol., 53: 549-558. l982.
  19. Villablanca J.R., Ch.E. Olmstead and I. de Andrés. Striatal lesions change the behavioral effects of morphine in cats. Brain Res. 248: l59-l67. l982.
  20. Harris C.M., J.R. Villablanca, I. de Andrés and J.W. Burgess. Morphine induces dose dependent increase of stereotyped head and paw movements in cats. The Physiologist. 25: 333 (68.5). l982.
  21. Sigüenza, J.A., I. de Andrés, J.M. Ibarz and F. Reinoso-Suárez. Análisis estadístico de los parámetros que definen a los potenciales evocados visuales corticales durante las fases del ciclo vigilia- sueño, Rev. Esp. Fisiol. 39: 253-258. l983.
  22. Caballero A. and I. de Andrés.Dorsopontine mechanims of the sleep-wakefulness cycle. In: Sleep Research vol l2. Eds: Chase, Weeb and Wilder-Jones. Brain Inform. Serv. UCLA. Los Angeles. pp.42. l983.
  23. Sigüenza J.A., I. de Andrés, J.M. Ibarz and F. Reinoso-Suárez. Cortical visual evoked potentials during the sleep-wakefulness cycle in the freely moving cat. Characterization and statistical comparisons. Electroenceph.. Clin. Neurophysiol. 59: l65-l71. l984.
  24. Caballero A. e I. de Andrés. Variabilidad de los estados de vigilia y de sueño en el gato de laboratorio. Rev. Esp. Fisiol. 40: 249-254. l984.
  25. Villablanca, J.R., C.M. Harris, J.W. Burgess and I. de Andrés. Reassessing morphine effects in cats: I. Specific behavioral responses in intact and unilaterally brain-lesioned animals. Pharmacol. Biochem. and Behav., 2l: 9l3-921. l984.
  26. De Andrés I., J.R. Villablanca and J.W. Burgess. Reassessing morphine effects in cats: II. Protracted effects on sleep-wakefulness and on the EEG. Pharmacol. Biochem. and Behav. 21: 923-928. l984.
  27. Harris C.M., J.R. Villablanca, J.W. Burgess and I. de Andrés. Reassessing morphine effects in cats: III.
  28. Responses of intact, caudate nuclei-lesioned and hemispherectomized animals following chronic administration and precipitated withdrawal. Pharmacol. Biochem. and Behav., 21: 929-936. l984.
  29. De Andrés I., J. Gómez-Montoya, E. Gutiérrez-Rivas and F. Reinoso-Suárez. Differential action upon the sleep-wakefulness cycle of lateral and central areas of pontine tegmental field. Arch. ital. Biol., l23: l-ll. l985.
  30. Sigüenza J.A., I. de Andrés, J.M. Ibarz and F. Reinoso-Suárez. Cortical visual evoked potentials during the sleep-wakefulness cycle in the freely moving cat. A dynamic study. Intern. J. Neuroscience. 27:257-264. l985.
  31. De Andrés I., A. Caballero and J.M. Ibarz. Periodic organization of sleep and wakefulness states in the laboratory cat. In: Sleep l984. Eds: W.P. Koella, E. Rüther and H. Schulz. Gustav Fischer Verlag. Stuttgart. New York. pp. 251-253. l985. (A)
  32. Caballero A. and I. de Andrés. Unilateral lesions in the Locus coeruleus area enhance paradoxical sleep". Electroenceph. Clin. Neurophysiol. 64: 339-346. 1986. (A)
  33. De Andrés I and A. Caballero. Chronic morphine administration in cats: Effects on sleep and EEG. Pharmacol. Biochem. and Behav. 32: 519-526. 1989.
  34. Reinoso-Suárez F., I. de Andrés, E. Martínez-Moreno y L. Santamaria. El Departamento de Morfología de la Facultad de Medicina de la U.A.M. En: Veinte años de la Facultad de Medicina de la UAM. Análisis crítico de una experiencia docente. J. Ortiz Vazquez (Ed.). Farmaindustria. Madrid.
  35. De Andrés, I., M.L. Rodrigo-Angulo y F. Reinoso-Suárez. Implicación del tegmento pontino en los estados de vigilia y de sueño. Rev. Esp. Fisiol. Supl. 45: 158-167. 1989. A.
  36. Navarro J.F., G.Buela-Casal e I. de Andrés. Indicadores del Sueño. En : Avances en investigación del sueño y sus transtornos. Eds: G. Buela-Casal y J. F. Navarro. Siglo XXI. Madrid. 1990 pp. 165- 182.
  37. De Andrés e I. Corpas. Control por el sistema nervioso central de los estados de vigilia y de sueño. En: Avances en investigación del sueño y sus transtornos. Eds: G. Buela -Casal y J. F. Navarro. Siglo XXI. Madrid. 1990 pp. 61-78.
  38. Reinoso-Suárez F., ML. Rodrigo-Angulo, E. Rodriguez-Veiga and I. de Andrés. Thalamic connections of the oral pontine tegmentum sites whose cholinergic stimulation produces enhancement of paradoxical sleep signs. In: The Diencephalon and Sleep. Eds: M. Mancia and G. Marini. Raven Press. New York. 1990 pp. 49-63.
  39. Corpas I. and I. de Andrés. Morphine effects in brainstem transected cats: I. EEG and sleep- wakefulness in the isolated forebrain. Beh. Brain Res. 44: 11-19. 1991.
  40. De Andrés I. and I. Corpas. Morphine effects in brainstem transected cats: II. Sleep and behavior of the decerebrate cat. Beh. Brain Res. 44: 21-26. 1991.
  41. Nuñez A., I. de Andrés and E. García-Austt. Relationships of the nucleus reticularis pontis oralis neuronal activity with sensory and carbachol evoked hippocampal theta rhytm. .Exp.Brain Res. 87: 303-308. 1991.
  42. Rodrigo-Angulo ML., E. Rodriguez-Veiga, I. de Andrés and F. Reinoso-Suárez. Prosencephalic connections of the pontine tegmentum sites related to cholinergic generation of paradoxicacl sleep. In: Sleep Research vol 20 A. Eds: M.H. Chase, P.L.Parmeggiani and C. O´Connor. BIS/BRI. UCLA. Los Angeles. pp. 63. l991.
  43. Arpa J. and I. de Andrés. Re-examination of the effects of raphe lesions on the sleep-wakefulness cycle states in cats. J. Sleep Res. 2:96-102. 1993.
  44. Reinoso-Suárez F., I. de Andrés, M.L. Rodrigo-Angulo and E. Rodriguez-Veiga. Location and anatomical connections of a paradoxical sleep induction site in the brainstem of the cat. Eur. J. Neurosci. 6 : 1829-1836. 1994
  45. Reinoso-Barbero, F. and I. de Andrés. Effects of opioid microinjections in the nucleus of the solitary tract on the sleep-wakefulness cycle states in cats. Anesthesiology 82: 144-152. 1995.
  46. Garzón M., S. Tejero, A.M. Beneitez and I. de Andrés. Microinjections of opiates in the Locus coeruleus area of the cat produce enhancement of slow wave sleep. . Neuropeptides 29: 229- 239.1995.
  47. Garzón, M., I. de Andrés and F. Reinoso-Suárez. Dose-related effects on heart rate during cholinergic- induced paradoxical sleep after carbachol microinjections in the ventral oral pontine tegmentum. In: Sleep Research vol 24 A. Eds. M.H. Chase, T. Roth and C.O'Connor. BIS/BRI. UCLA. Los Angeles. pp. 83. 1995 .
  48. Garzón, M., I. de Andrés, and F. Reinoso-Suárez. Neocortical and hippocampal electrical activities are similar in spontaneous and cholinergic-induced REM sleep. Brain Res. 766: 266-270. 1997.
  49. Garzón, M. e I. de Andrés. Mecanismos neurales generadores de las distintas fases del ciclo vigilia-sueño. Vigilia-Sueño. 9: 95-105. 1997.
  50. Garzón, M., I. de Andrés, I and F. Reinoso-Suárez. Sleep patterns after carbachol delivery in the ventral oral pontine tegmentum of the cat. Neuroscience 83: 1137-1144. 1998.
  51. Manquillo, A., M. Garzón e I. de Andrés. Bases anatomo-fisiológicas del sueño paradójico y de sus distintas manifestaciones poligráficas. Vigilia-Sueño. S5-S13. 1998.
  52. De Andrés, I. El ciclo vigilia-sueño. En: Manual de Neurociencia. Eds: J.M. Delgado, A. Ferrus, F. Mora y F.J. Rubia . Síntesis. Madrid pp: 801-820. 1998.
  53. Arpa, J., C. Padrino, A. Rodriguez-Albariño, and I. de Andrés. Centralis superior raphe, reticularis pontis nuclei, and sleep-wakefulness cycle in cats. J.Sleep Res. 7: 263-275. 1998.
  54. Reinoso-Suárez, F., I. de Andrés, ML. Rodrigo-Angulo, C. de la Roza, A. Nuñez and M. Garzón. The anatomy of dreaming and REM sleep. Eur. J. Anat. 3: 163-175.1999.
  55. Reinoso-Suárez, F., I. de Andrés, ML. Rodrigo-Angulo, and M. Garzón. Brain structures and mechanisms involved in the generation of Rem sleep. Sleep Med. Rev. 5: 63-77. 2001.
  56. Manquillo, AM., Garzón e I. de Andrés. Atonía muscular en el sueño REM: Acciones mediadas por los receptores GABAA y GABAB en el perilocus coeruleus alfa. Vigilia-Sueño. 13: 23-27. 2001.
  57. Villablanca JR., I. de Andrés and Ch E. Olmstead. Sleeping and waking develop independently in the isolated forebrain and decerebrate cat after a mesencephalic transection early postnatally. Neuroscience 106: 717-731. 2001.
  58. Núñez A., M. Rodrigo, I. de Andrés and F. Reinoso- Suárez. Firing activity and postsynaptic propierties of morphologically identified neurons of the ventral oral pontine reticular nucleus. Neuroscience 115: 1165-1175. 2002.
  59. De Andrés I. El Tegmento Pontino y la Generación del Sueño REM. Vigilia-Sueño15: 66-68. 2003.
  60. De Andrés I., M. Garzón and J. Villablanca. The disconnected brain stem does not support rapid eye movement sleep rebound following selective deprivation. Sleep. 26: 419-435; 2003.
  61. Villablanca J, I. de Andrés and M. Garzón. Debating how rapid eye movement sleep is regulated (and by what). J. Sleep Res. 12: 259-262. 2003.
  62. De Andrés I., M. Garzón and J. Villablanca. The brain stem but not the forebrain independently supports basic morphine´s tolerance and withdrawal effects. A study in cats with midbrain transection Beh. Brain Res 148: 133-144. 2004.
  63. Núñez A., ME. Moreno-Balandrán, ML. Rodrigo-Angulo, M.Garzón M, and I. de Andrés. Relationship between the perifornical hypothalamic area and the oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of REM sleep. Eur. J. Neurosci. 24: 2834-2842. 2006.
  64. Moreno-Balandrán ML, M. Garzón, C. Bódalo, F. Reinoso-Suárez and I. de Andrés. Sleep- wakefulness effects after microinjections of hypocretin 1 (orexin A) in cholinoceptive areas of the cat oral pontine tegmentum. Eur. J. Neurosci., Vol. 28, pp. 331-341. 2008.
  65. Núñez A, ML. Rodrigo-Angulo, I. de Andrés and M. Garzón. Hypocretin/orexin neuropeptides Participation in the control of sleep-wakefulness cycle and energy homeostasis. Curr. Neuropharmacol., 7: 50-59 2009.
  66. De Andrés I., M. Garzón. A. Núñez y ML. Rodrigo-Angulo. Fisiología en el Sueño. En: La Medicina del Sueño. Aspectos biológicos, clínico-quirúrgicos y terapéuticos. Ed: J.L. Velayos. Interamericana. Madrid.pp. 19-29. 2009.
  67. Reinoso-Suárez F, C. de la Roza, ML. Rodrigo-Angulo, I. de Andrés, A. Núñez, M. Garzón. Involvement of GABAergic mechanisms in the ventral oral pontine tegmentum -REM sleep induction site- in the modulation of sleep-wake states. In: Gaba and Sleep. Ed. Monti. Springer. Cheanal. India.233-252. 2010.
  68. Reinoso-Suárez F., I. de Andrés, M. Garzón. Functional Anatomy of the Sleep-Wakefulness Cycle: Wakefulness. Adv Anat, Embryol Cell Biol, 208: 1-128. 2011.
  69. Villablanca JR. and I. de Andrés. Understanding REM sleep clues from brain lesion studies.
  70. In: Rapid Eye Movement Sleep: Mechanism of Regulation and Dysregulation. Eds: BN Mallick, SR Pandi-Perumal, R McCarley and A Morisson. Cambrige University Press. UK. 89-98. 2011.
  71. De Andrés I., M. Garzón and F. Reinoso-Suárez. Functional anatomy of NREM sleep. Front Neurol. 2011; 2: 70. Epub 2011 Nov 15.
  72. Carús-Cadavieco M. e I. de Andrés. La adenosina y el control homeostático del sueño. Acciones en estructuras diana de los circuitos de vigilia y sueño. Rev. Neurol., 55: 423-420. 2012.
  73. De Andrés I. Autorregulación cerebral del sueño. En: Series Monografías de la Real Academia Nacional de Medicina 5. Neurociencia. pp. 111-117. Francisco Rubia Vila (Ed).
  74. Fundación Real Academia Nacional de Medicina, 2013.
  75. De Andrés I., M. Garzón y F.Reinoso-Suárez. Mecanismos neurobiológicos de los estados del ciclo vigilia-sueño. En: En:Tratado de Medicina del Sueño. pp. 62-75. Ed: Soc. Española de Sueño. Panamericana. Madrid. 2015.
  76. Garzón M, Villablanca J, e I. de Andrés. Acciones de los opiaceos en el sueño. Diferente participación del prosencéfalo y del tronco del encéfalo. Tratado de Medicina del Sueño. pp. 112-119. Ed: Soc. Española de Sueño. Panamericana. Madrid. 2015.
  77. Bódalo C. and I. de Andrés. Temporal organization of REM sleep ponto-geniculo-occipital activity. Relationships with EEG sensorimotor rhythm. A quantitative study in cats.
  78. Reinoso-Barbero F. and I. de Andrés. Cardiorespiratory changes associated to EEG/behavioral states are enhanced by mu-opioid microinjections in the nucleus of the solitary tract in cats.

     
Journal of Sleep Disorders and Medical Care