Education

Biography

Aladin M. Boriek, PhD is a Professor of Medicine and Physiology at Baylor College of Medicine. Dr. Boriek has been a regular member of the Respiratory Integrative Biology and Translational Research Study Section (2005-2009).  Dr. Boriek has served on other NIH study sections including The Respiratory and Applied Physiology, and The Skeletal Muscle Biology and Exercise Physiology, and The Bioengineering and Physiology. He has also served as an external reviewer for the Surgery Review Board of the Department of Veteran Affairs, the Canadian Institutes of Health Research, the Canadian Lung Association /Canadian Thoracic Society, the Research Grant Council of Hong Kong. He has also served on numerous review panels for the National Science Foundation. He served as a member of the editorial Board of the Journal of Applied Physiology (2000-2008).

Research Interest

• Respiratory muscle mechanics
• Mechanical signal transduction
• Muscular dystrophy

Scientific Activities:

• 2008-present Professor of Medicine, Baylor College of Medicine
• 2008-present Professor of Molecular Physiology & Biophysics, Baylor College of Medicine
• 2003-present Associate Professor of Medicine (tenured), Baylor College of Medicine
• 2003-present Associate Professor of Molecular Physiology and Biophysics (tenured), Baylor College of Medicine
• 2003-present Adjunct Associate Professor of Computational & Applied Mathematics, Department of Computational & Applied Mathematics, Rice University, Houston, TX
• 2003-present Adjunct Associate Professor of Mechanical Engineering and Materials Science, Department of Medical Engineering and Materials Science, Rice University
• 2003-present Adjunct Associate Professor of Biomedical Engineering, Department of Medical Engineering and Materials Science, Rice University
• 2003-present Associate Professor of Computational Biology, The W.M. Keck Center for Computational Biology, Rice University and Baylor College of Medicine
• 2002-present Visiting Scientist, Pulmonary and Critical Care, Thoracic Diseases Research Unit, Mayo Clinic and Foundation, Rochester, MN. July 2002-present.
• 1999-present Faculty Member, Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine
• 1998-2003 Adjunct Assistant Professor of Mechanical Engineering and Materials Science, Department of Medical Engineering and Materials Science, Rice University
• 1997-2003 Assistant Professor of Computational Biology, The W.M. Keck Center for Computational Biology, Rice University and Baylor College of Medicine
• 1995-2003 Assistant Professor of Molecular Physiology and Biophysics, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas
• 1994-2003 Assistant Professor of Medicine, Depart. of Medicine, Baylor College of Medicine, Houston, Texas
• 1997-present Appointed to Faculty, W.M. Keck Center for Computational Biology, Rice University and Baylor College of Medicine, Houston, TX
• 1997-2003 Adjunct Assistant Professor of Computational & Applied Mathematics, Department of Computational & Applied Mathematics, Rice University, Houston, TX
• 1992-1994 Research Instructor, Department of Medicine, Baylor College of Medicine, Houston, Texas
• 1990-1992 Research Associate, Department of Medicine, Baylor College of Medicine, Houston, Texas
• 1985-1990 Research Assistant, Department of Mechanical Engineering and Materials Science, Rice University, Houston, Texas
• 1985-1991 Teaching Assistant, Department of Mechanical Engineering and Applied Mechanics, University of Michigan, Ann Arbor, Michigan

Publications

1. Armeniades CD, Boriek AM, Moorhead LC, and Knol GE: Effect of incision length, location and shape on the local corneoscleral deformation during cataract surgery. J Cataract and Refractive Surgery; 1990; 16(1): 83-87.
2. Boriek AM, Liu S, and Rodarte JR: Costal diaphragm curvature in dog. J Appl. Physiol; 1993; 75(2):527 533.
3. Boriek AM, Wilson TA, and Rodarte JR: Displacement and strains in the costal diaphragm of the dog. J Applied Physiol; 1994; 76(1): 223-229.
4. Boriek AM, JR Rodarte JR: Inferences on passive diaphragm mechanics from gross anatomy. J Applied Physiol; 1994; 77(5) 2065-2070.
5. Boriek AM, Rodarte JR, and Margulies SS: The zone of apposition in the passive diaphragm of the dog. J Applied Physiol; 1996; 81(5): 1929-1937.
6. Boriek AM, Cox SJ, Cummings D: Recovering Elastic Moduli of Nonlinear Anisotropic Annular Membranes from Interior Measurements of Deformation and Pressure, Rice University, Computational and Applied Mathematics; 2000; Technical Report #TR-96-35.
7. Boriek AM, Rodarte JR: Effects of transverse fiber stiffness and central tendon on displacement and shape of a simple diaphragm model. J Applied Physiology; 1997; 82(5): 1626-1636.
8. Boriek AM, Rodarte JR, Wilson TA: Kinematics and mechanics of midcostal diaphragm of dog; J Applied Physiology, 1997; 83(4): 1068-1075.
9. Angelillo M, Boriek AM, Rodarte JR, Wilson TA: Theory of diaphragm structure and shape, J Applied Physiology, 1997; 83(5): 1486-1491.
10. Boriek AM, Miller C, and Rodarte JR: Fiber architecture in the diaphragmatic muscle of dog; J Applied Physiology; 1998; 84(1): 318-326.
11. Wilson TA, Boriek AM, and Rodarte JR: Mechanical advantage of the canine diaphragm; J Applied Physiology; 1998; 85(6), 2284-2290.
12. Boriek AM, Rodarte JR and Wilson TA: Ratio of active to passive muscle shortening in the canine diaphragm; J Applied Physiology; 1999; 87(2): 561-566.
13. Angelillo M, Boriek AM, Rodarte JR and Wilson TA: Shape of the canine diaphragm; J Applied Physiology; 2000; 89(7): 15-20.
14. Foster P, Feiverson AH, and Boriek AM: Prediction of time to decompression illness during exercise at altitude based on formation and growth of tissue bubbles. American J Physiol. Regulatory, Integrative and Comparative Physiol. 279: 2317-2328, 2000.
15. Foster P, Feiverson AH, and Boriek AM: A model for influence of exercise on formation and growth of tissue bubbles during altitude decompression. American J Physiol. Regulatory, Integrative and Comparative Physiol. 279: 2304-2316, 2000.
16. Boriek AM, Kelly NG, Rodarte JR, Wilson TA: Biaxial constitutive relations for the passive canine diaphragm. J Applied Physiology. 89(6): 2187-90; 2001.
17. Boriek AM, Rodarte JR, and Reid MB: Shape and tension distribution of the passive rat diaphragm. American J Physiol: Regulatory, Integrative and Comparative Physiol. 280 (1): R33-41; 2001.
18. Boriek AM, Capetanaki Y, Hwang W, Officer T, Badshah M, Rodarte JR, and Tidball JG: Desmin integrates the three-dimensional mechanical properties of muscles. American J Physiol Cell Physiol. 280(1): C46-52.
19. Boriek AM, Zhu D, Zeller M, and Rodarte JR: Inference on force transmission based on fiber architecture of the canine diaphragm, American J Physiol: Regulatory, Integrative and Comparative Physiol. 280: R156-65, 2000.
20. Foster P, Feiverson AH, and Boriek AM. A model for influence of exercise on formation and growth of tissue bubbles during altitude decompression.Am J Physiol. Regul Integr Comp Physiol. 2000, 279(6): 2304-2316, 2001.
21. Boriek AM, Kelly NG, Rodarte JR, Wilson TA. Biaxial constitutive relations for the passive canine diaphragm. J App Physiol. 89(6). 2187-90, 2001.
22. Boriek AM, Rodarte JR, and Reid MB. Shape and tension distribution of the passive rat diaphragm. Am J Physiol Regul Integr Comp Physiol. 280 (1): R33-41, 2001.
23. Boriek AM, Capetanaki Y, Hwang W, Officer T, Badshah M, Rodarte JR, and Tidball JG. Desmin integrates the three-dimensional mechanical properties of muscles. Am J Physiol Cell Physiol. 280(1): C46-52, 2001.
24. Amancharla M, Rodarte JR, and Boriek AM. Modeling the kinematics of the canine midcostal diaphragm. Am J Physiol. Regulatory, Integr and Comp Physiol. 280: R588-R597, 2001.
25. Shardonofsky F, Officer T, Boriek AM, and Rodarte JR. Effects of airway smooth muscle activation on axial mechanical properties of excised canine bronchi. J Appl Physiol. 90. 1258-1266, 2001.
26. Boriek AM, H. Ortiz and Zhu D. Fiber architecture of canine abdominal muscles. J Appl Physiol. 92:725-35, 2002.
27. Kumar A, Imran Chaudhry, Michael B Reid, and Boriek AM. Distinct signaling pathways are activated in response to mechanical stress applied axially and transversely to skeletal muscle fibers. J Biol Chem 2002 Nov 27; 277(48): 46493-503.
28. Kyckelhahn B, Nason P, JG Tidball, and Boriek AM. Modeling of kinematics of single muscle fiber during diaphragm shortening. Journal of Biomechanics. 36(3): 457-461, 2003.
29. Kumar A and Boriek AM. Mechanical stress activates the nuclear factor-kappa pathway in skeletal muscle fibers: A possible role in Duchenne Muscular Dystrophy. The FASEB Journal. 2003; 17: 386-396.
30. Patel N, Jannapureddy SR, Willy Hwang, Imran Chauhdry, and Boriek AM. Altered muscle force and stiffness of skeletal muscles of the -sarcoglycan deficient mice. Am J Physiol Cell Physiol. 2003; 284(4): C962-8.
31. Jannapureddy SR, Nisha Patel, and Boriek AM. Merosin deficiency leads to alterations in the passive and active diaphragm mechanics. J. Appl. Physiol. 94: 2524-2533, 2003.
32. Foster PP, Boriek AM, Butler BD, Gernhardt ML and Bové AA. Patent Foramen Ovale and Paradoxical Systemic Embolism: A bibliographic review. Vol. 74 (6), Section II, Supplement, June 2003.
33. Kumar A, Knox A, and Boriek AM. CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch. J Biol Chem. 2003 May 23; 278(21):18868-76.
34. Kumar A, Lnu S, Malya R, Barron D, Moore J, Corry DB, Boriek AM. Mechanical stress activates nuclear factor-kappa B and activator protein-1 in lung parenchyma: Implication in Asthma. FASEB J. 2003, 17:1800-11.
35. Kumar A, N. Khandelwal, R Malya, Reid MB, and Boriek AM. Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers. FASEB J. 2004, 18(1):102-13.
36. Kumar, A., Takada, Y., Boriek AM. and Aggarwal, BB. Nuclear Factor-kappaB: Its role in health and diseases. Journal of Molecular Medicine: J Mol Med. 2004, 82(7):434-48.
37. A Sharafkhaneh, TM. Office, S Goodnight-White, JR Rodarte, and Boriek AM. A novel method for measuring effects of gas compression on expiratory flow. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology. Am J Physiol Regul Integr Comp Physiol. 2004, 287(2):R479-84.
38. Kumar A, Murphy R, Lei Wei, Boriek AM. Cyclic Mechanical Strain Inhibits Skeletal Myogenesis through the activation of Rho Gtapases and NF-kappa B transcription factor. FASEB J. 2004, 18(13):1524-35.
39. Lopez MA, Mayer U, Jannapureddy S, Tayler T, Hwang W, Boriek AM. Force transmission, compliance, and viscoelasticity are altered in skeletal muscle of the 7 integrin null mice. American Journal of Physiology: Cell Physiology. Am J Physiol Cell Physiol. Muscle Cell Biology and Cell Motility. 2005; 288(2):C282-9.
40. A. Sharafkhaneh, S. Goodnight-White, T.M. Officer, J.R. Rodarte, and Boriek AM. Altered thoracic gas compression contributes to spirometry improvement with lung volume reduction surgery. Thorax. 2005;60:288-92.
41. Hwang W, Kelly NG, Boriek AM. Passive mechanics of the muscle tendinous junction of the canine diaphragm. J Appl Physiol. 2005; 98(4):1328-33.
42. Hwang W, Carvalho JC, Tarlovsky I, Boriek AM. Passive mechanics of canine internal abdominal muscle. Journal of Applied Physiology. J Appl Physiol. 2005; 98(5):1829-35.
43. Boriek AM, Hwang W, Trinh L, Rodarte JR. Shape and tension distribution of the active canine diaphragm. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology. Am J Physiol Regul Integr Comp Physiol. 2005, 288(4): R1021-7.
44. F. R. Shardonofsky, Y. Capetanaki, and Boriek AM. Desmin contributes to lung elastic recoil and airway contractile responses to cholinergic stimulation. Am J Physiol Lung Cell Mol Physiol. 2006; 290(5):L890-6.
45. Length and curvature of the dog diaphragm. Boriek AM, Ben Black, Rolf Hubmayr and Theodore A. Wilson. Journal of Applied Physiology. 2006;101:794-8.
46. A Sharafkhaneh, Babb, T, Hanania, N and Boriek AM. The Confounding Effect of Thoracic Gas Compression on Measurements of Acute Bronchodilator Response. Am J Respir Crit Care Med. 2007; 175(4):330-5.
47. Jizhong Cheng, Jiqiang Zhang, Aksam Merched, Liping Zhang, Ping Zhang, Luan, Truong, Boriek AM and Jie Du. Mechanical Stretch Prevents Ox-LDL-induced Apoptosis via upregulation of αvβ3 Integrin and Stabilization of Cytoskeleton in Vascular Smooth Muscle Cells. Journal of Biological Chemistry 2007. 23; 282(47):34268-75.
48. Pardo, PS, Lopez, MA, and Boriek, AM. FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump. Am J Physl Cell. 294(4): C1056 – C1066, 2008.
49. Lopez MA, Pardo PS, Cox GA, and Boriek AM. Early mechanical dysfunction of the diaphragm in the muscular dystrophy with myositis (Ttnmdm) model. Am J Physiol Cell. 295(5): C1092 – C1102, 2008.
50. Moulik M, Vatta M, Witt SH, Arola AM, Murphy RT, McKenna WJ, Boriek AM, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, and Towbin JA. ANKRD1, the gene encoding ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. 54(4): 325 – 333, 2009.
51. JS Mohamed and AM Boriek. Stretch-activated RhoA/ROCK Signaling Regulates TGF-1 Expression and its Promoter Activity via Protein-Tyrosine Kinase and Phosphatidylinositol 3-Kinase dependent pathway in Human Airway Smooth Muscle Cells. Am J Physiol Lung Cell Mol Physiol.; 299(3): L413-24, 2010.
52. Mohamed, JS, Lopez, MA, and Boriek, AM. Mechanical Stretch Upregulates MicroRNA-26a and Induces Human Airway Smooth Muscle Hypertrophy by Suppressing Glycogen Synthase Kinase-3β. Journal of Biological Chemistry. J Biol Chem.; 285(38): 29336-47, 2010.
53. JS Mohamed, MA. Lopez, GA. Cox and Boriek, AM Anisotropic regulation of Ankrd2 gene Expression in skeletal muscle by mechanical stretch. FASEB J.; 24(9): 3330-40, 2010.
54. Iris Chu, Christina Fernandez, Kathleen Allen, Michael A Lopez, Raymond Lu, Rolf D Hubmayr, Aladin M Boriek. Diaphragm muscle shortening alters kinematics, surface area and volume displacement of lower rib cage in dogs. The American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. Am J Physiol Regul Integr Comp Physiol. 2010; 299(6): R1456-62.
55. Enkhsaikhan Purevjav, Jacquelin Varela, Debra L. Kearney, Michael D. Taylor, Gilberto DeFreitas, William McKenna, Ross T. Murphy, Siefried Labeit, Neil E. Bowles, Matteo Vatta, AM Boriek, and Jeffrey A. Towbin, M.D. Mutations in Nebulette Have Different Effects on Protein Function. Journal of American College of Cardiology. J Am Coll Cardiol. 56(18):1493-502, 2010.
56. Pardo PS, Mohamed JS, Lopez MA, Boriek AM. Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor Egr1 triggers an antioxidative response. J Biol Chem. 286, 2559-2566, 2011.
57. Pardo PS and Boriek AM. Physiologic role of Sirt1 in skeletal muscles. Aging. 2011; 3(4):430-7
58. Brad Greybeck, Casey P. McNamara, Matthew Wettergreen, Rolf D Hubmayr, AMBoriek. Muscle shortening, mode of ventilation and posture are determinants of volume displacement of the diaphragm. The Am J Physiol Regul Integr Comp Physiol. 2011; 301(1): R76-82.
59. Junaith S. Mohamed, Ameena Hajira, Zhenlin Li, Denise Paulin and AM Boriek. Early growth responsive protein-1 induces desmin null airway smooth muscle hypertrophy through MicroRNA-26a. J. Biol. Chem. J Biol Chem. 2011 Dec 16;286(50):43394-404
60. Junaith S. Mohamed and AM Boriek. Loss of desmin intermediate filaments triggers mechanosensitivity and up-regulation of Ankrd1 expression through Akt-NF-kappaB signaling pathway in smooth muscle cells. FASEB J. 2012; 26(2):757-65.
61. Shardonofsky FR, Moore J, Schwartz RJ, Boriek AM. Airways in smooth muscle α-actin null mice experience a compensatory mechanism that modulates their contractile response. J Appl Physiol. 2012; 112(5):898-903.
62. Pardo PS, Boriek AM. An autoregulatory loop reverts the mechanosensitive Sirt1 induction by EGR1 in skeletal muscle cells. Aging (Albany NY). 2012