Education

• 1985-1990, Department of Pharmacology, Postdoctoral training, University of Texas Southwestern Medical Center, Dallas, Texas
• 1980-1985, Ph.D. in Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas
• 1974-1978, B.S. in Pharmacy (Highest Honor, 1st in class), National Defense Medical Center, Taipei, Taiwan

Profile

Dr. Iok-Hou Pang was born in Macau, China, earned his B.S. in Pharmacy at the National Defense Medical Center in Taipei, Taiwan, and Ph.D. in Pharmacology at the University of Texas Southwestern Medical Center, Dallas, Texas. He has been involved in glaucoma drug discovery at Alcon Laboratories, Fort Worth, Texas, for more than 20 years, and became the Head of Glaucoma Research since 2008.  In 2012, he joined the Health Science Center as professor and chair of Pharmaceutical Sciences in the newly established College of Pharmacy, and is a member of the North Texas Eye Research Institute.  Dr. Pang is also an Adjunct faculty member of the Biomedical Engineering graduate program at the University of Texas at Arlington, a Visiting Professor of the School of Pharmacy, National Defense Medical Center in Taipei, Shenzhen Eye Hospital in Shenzhen, and West China Hospital in Chengdu, China. Dr. Pang has edited one book, published more than 100 peer-reviewed manuscripts and book chapters, and has been issued numerous U.S. and international patents.  He is an academic editor of “Medicine” and reviewers of many ophthalmology and pharmacology journals.

Research Interest

Dr. Pang’s research interests mainly focus on the understanding of glaucoma etiology, pathology, and pharmacology, especially on glaucoma neuroprotection.  His is working to delineate essential molecular and cellular mechanisms, as well as characterize receptors and signal transduction pathways related to the abnormal changes in glaucoma.  His laboratory is using rodents and primary cultures of retinal ganglion cells as study models to clarify biological events leading to glaucomatous retinopathy and its prevention and protection.

Professional Activities:

Honors and Awards

Publications

Edited Book:

1. “Animal Models of Retinal Diseases”. I.-H. Pang & A.F. Clark (editors),  Humana Press, New York, USA (2010) 

Book Chapters:

1. P.C. Sternweis, V. A. Florio and I.-H. Pang.  Hormone signaling via G proteins:  What can be learned from reconstitution?   In "Regulation of Potassium Transport across Biological Membrane". (eds.) L. Reuss, J.M. Russel,G. Szabo, University of Texas Press, Austin (1990), p. 367-380.
2. P.C. Sternweis and I.-H. Pang.  Mechanisms of G protein action: insight from reconstitution.  In "G Proteins and Signal Transduction". (eds.) N.M. Nathanson, T.K. Harden.  The Rockefeller University Press, New York, USA. (1990), p.197-205.
3. P.C. Sternweis, I.-H. Pang.  Preparation of G-proteins and their subunits. In "Receptor-effector coupling, a practical approach." E.C. Hulme (ed.), p.1-30, Oxford University Press, UK (1992).
4. I.-H. Pang, A.F. Clark.  IOP as a target – inflow and outflow pathways.  In “Ocular Therapeutics: an Eye on New Discoveries”.  T. Yorio, A.F. Clark, M.B. Wax (eds.), p. 45-67, Academic Press, New York, USA (2008).
5. I.-H. Pang, A.F. Clark.  Outflow signaling mechanisms and new therapeutic strategies for the control of intraocular pressure. In “The Eye’s Aqueous Humor”. M.M. Civan, D.J. Benos, S.A. Simon (eds.), p.422-464, Academic Press, New York, USA (2008).
6. I.-H. Pang, A.F. Clark. Non-primate models for glaucoma retinopathy and optic neuropathy.  In “Animal Models of Retinal Diseases”. I.-H. Pang, A.F. Clark (eds.) p.139-164,  Humana Press, New York, USA (2010) 
7. 彭玉豪.青光眼药物治疗的新方向.《眼病的细胞和分子生物学基础》主编：刘旭阳、张清炯。p.355-370,  北京科学出版社 (2010) 。

Manuscripts:

1. M.T. Lin, C.F. Chen and I.-H. Pang.  Effect of ketamine on thermoregulation in rats.  Can. J. Physiol. Pharmacol. (1978) 56:963-967.
2. M.T. Lin, I.-H. Pang, S.I. Chern and W.Y. Chia.  Changes in serotonin contents in brain affect metabolic heat production of rabbits in cold.  Am. J. Physiol. (1978) 235:R41-R47.
3. M.T. Lin, I.-H. Pang, Y.F. Chern and S.I. Chern.  Effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine on temperature regulation in rats.  J. Pharm. Pharmacol. (1978) 30:723-725.
4. M.T. Lin, I.-H. Pang, Y.F. Chern, S.I. Chern.  Effects of brain catecholamine alterations on the chlorpromazine-induced hypothermia in rats.  ProcNatl Sci Council, ROC (1979) 3:53-58.
5. M.T. Lin, I.-H. Pang, S.I. Chern and Y.F. Chern.  Effects of increasing serotonergic receptor activity in brain on prostaglandin E1-induced fever in rabbits.  Pharmacology (1979) 18:188-194.
6. W.G. Clark, I.-H. Pang and G.L. Bernardini.  Evidence against involvement of b-endorphin in thermoregulation in the cat.  Pharmacol. Biochem. Behav. (1983) 18:741-745.
7. I.-H. Pang, G.L. Bernardini and W.G. Clark.  Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-ala2-D-leu5-enkephalin.  Brain Res. Bull. (1984) 13:263-268.
8. M.R. Vasko, I.-H. Pang and M. Vogt.  Involvement of 5-hydroxytryptamine-containing neurons in antinociception produced by injection of morphine into nucleus raphe magnus or onto spinal cord.  Brain Res. (1984) 306:341-348.
9. G.B. Weiss, I.-H. Pang, F.R. Goodman.  Relationship between 45Ca movements, different calcium components and responses to acetylcholine and potassium in tracheal smooth muscle.  J. Pharmacol. Exp. Ther. (1985) 233:389-394.
10. I.-H. Pang and M.R. Vasko.  Effect of depletion of spinal cord norepinephrine on morphine-induced antinociception.  Brain Res. (1986) 371:171-176.
11. I.-H. Pang and M.R. Vasko.  Morphine and norepinephrine but not 5-hydroxytryptamine and g-aminobutyric acid inhibit the potassium-stimulated release of substance P from rat spinal cord slices.  Brain Res. (1986) 376:268-279.
12. S. Mumby, I.-H. Pang, A.G. Gilman and P.C. Sternweis.  Chromatographic resolution and immunologic identification of the a40 and a41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain. J. Biol. Chem. (1988) 263:2020-2026.
13. D.A. Ewald, I.-H. Pang, P.C. Sternweis and R.J. Miller.  Differential G protein-mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro.  Neuron (1989) 2:1185-1193.
14. I.-H. Pang and P.C. Sternweis.  Isolation of the a subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized bg subunits.  Proc. Natl. Acad. Sci. (1989) 86:7814-7818.
15. P.C. Sternweis and I.-H. Pang.  The G protein-channel connection.  Trends Neurosci. (1990) 13:122-126.
16. Sternweis PC, Pang IH. Mechanisms of G protein action: insight from reconstitution.Soc Gen Physiol Ser. 1990;45:197-205. Review. PubMed PMID: 2165635.
17. I.-H. Pang and P.C. Sternweis.  Purification of unique a subunits of GTP-binding regulatory proteins (G proteins) by affinity chromatography with immobilized bg subunits.  J. Biol. Chem. (1990) 265:18707-18712.
18. P.J. Casey, I.-H. Pang and A.G. Gilman.  Assay of G protein bg subunit complex by catalytic support of ADP-ribosylation of Goa.  Meth. Enzymol. (1991) 195:315-321.
19. M.E. Linder, I.-H. Pang, R.J. Duronio, J.I. Gordon, P.C. Sternweis and A.G. Gilman.  Lipid modifications of G protein subunits: myristoylation of Goa increases its affinity for bg. J. Biol. Chem. (1991) 266:4654-4659.
20. R. Munshi, I.-H. Pang, P.C. Sternweis, J. Linden.  A1 adenosine receptors of bovine brain couple to a guanine nucleotide binding proteins Gi1, Gi2 and Go.  J. Biol. Chem. (1991) 266:22285-22289.
21. I.-H. Pang, D.L. Shade, E. Tamm, L. DeSantis.  Single cell contraction assay for human ciliary muscle cells: effect of carbachol.  Invest. Ophthalmol. Vis. Sci. (1993) 34:1876-1879.
22. R.S. Danziger, R.A. Star, S. Matsumoto, M. Coca-Prados, L. DeSantis, I.-H. Pang.  Characterization of soluble guanylylcyclase in transformed human non-pigmented epithelial cells.  Biochem. Biophys. Res. Comm. (1993) 195:958-962.
23. I.-H. Pang, D.L. Shade, A.F. Clark, H.T. Steely, L. DeSantis.  Preliminary characterization of a transformed cell strain derived from human trabecular meshwork.  Curr. Eye Res. (1994) 13:51-63.
24. I.-H. Pang, S. Matsumoto, E. Tamm, L. DeSantis.  Characterization of muscarinic receptor involvement in human ciliary muscle cell function.  J. Ocular Pharmacol. (1994) 10:125-136.
25. I.-H. Pang, A.V. Smrcka, P.C. Sternweis.  Synthesis and applications of affinity matrix with immobilized bg subunits of G proteins.  Meth. Enzymol. (1994) 237:164-174.
26. J.R. Keefer, J. Nunnari, I.-H. Pang, L.E. Limbird.  Introduction of purified a2A-adrenergic receptors into uniformly oriented, unilamellar, phospholipid vesicles: productive coupling to G proteins but lack of receptor-dependent ion transport.  Mol. Pharmacol. (1994) 45:1071-1081.
27. S. Matsumoto, T. Yorio, L. DeSantis, I.-H. Pang.  Muscarinic effects on cellular functions in cultured human ciliary muscle cells.  Invest. Ophthalmol. Vis. Sci. (1994) 35:3732-3738.
28. K. Ujiie, L. Hogarth, R. Danziger, J.G. Drewett, P.S.T. Yuen, I.-H. Pang, R.A. Star.  Homologous and heterologous desensitization of a guanylylcyclase linked nitric oxide receptor in cultured rat medullary interstitial cells.  J. Pharmacol. Exp. Ther. (1994) 270:761-767.
29. D.L. Shade, A.F. Clark, I.-H. Pang.  Effects of muscarinic agents on human trabecular meshwork cell functions.  Exp. Eye Res. (1996) 62:201-210. 
30. S. Matsumoto, T. Yorio, P.E. Magnino, L. DeSantis, I.-H. Pang.  Endothelin-induced changes of second messengers in cultured human ciliary muscle cells.  Invest. Ophthalmol. Vis. Sci. (1996) 37:1058-1066.
31. I.-H. Pang, D.L. Shade, S. Matsumoto, H.T. Steely, L. DeSantis.  Presence of functional type B natriuretic peptide receptor in human ocular cells.  Invest. Ophthalmol. Vis. Sci. (1996) 37:1724-1731.
32. K.L. Markwardt, P.E. Magnino, I.-H. Pang.  Effect of histamine on phosphoinositide turnover and intracellular calcium in human ciliary muscle cells.  Exp. Eye Res. (1996) 62:511-520.
33. N.A. Sharif, S.-X. Xu, P.E. Magnino, I.-H. Pang.  Human conjunctival epithelial cells express histamine-1 receptors coupled to phosphoinositide turnover and intracellular calcium mobilization: role in ocular allergic and inflammatory diseases.  Exp. Eye Res.  (1996) 63:169-178.
34. K.L. Markwardt, P.E. Magnino, I.-H. Pang.  Histamine induced contraction of human ciliary muscle cells.  Exp. Eye Res. (1997) 64:713-717.
35. I.-H. Pang, T. Yorio.  Ocular actions of endothelins.  Proc. Soc. Exp. Biol. Med. (1997) 215:21-34.
36. B.W. Griffin, P.E. Magnino, I.-H. Pang.  N.A. Sharif.  Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization.  J. Pharmacol. Exp. Ther. (1998) 286:411-418.
37. M.S.R. Haque, I.-H. Pang, L. DeSantis.  Activation of phospholipase C and guanylylcyclase by endothelins in human trabecular meshwork cells.  Curr. Eye Res. (1998) 17:1110-1117.
38. I.-H. Pang, E.M. Wexler, S. Nawy, L. DeSantis, M.A. Kapin. Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. (1999) 40:1170-1176.
39. I.-H. Pang, B. Li, T. Yorio.  Pharmacological actions of endothelins in the eye.  Chinese J. New Drugs Clin. Remedies  (2000) 19:337-341.
40. I.-H. Pang, M.D. McCartney, H.T. Steely, A.F. Clark.  Human ocular perfusion organ culture: a versatile ex vivo model for glaucoma research.  J. Glaucoma (2000) 9:468-479.
41. R.R. Krishnamoorthy, P. Agarwal, G. Prasanna, K Vopat, W. Lambert, H.J. Sheedlo, I.-H. Pang, D. Shade, A.F Clark, R.J. Wordinger, T. Yorio, N. Agarwal. Characterization of a transformed rat retinal ganglion cell line.  Brain Res. Mol. Brain Res. (2001) 86:1-12.
42. I.-H. Pang, H. Moll, M.A. McLaughlin, P.A. Knepper, D.L. Epstein, L. DeSantis, A.F. Clark. Ocular hypotensive and aqueous outflow-enhancing effects of AL-3037A (sodium ferriethylenediaminetetraacetate).  Exp. Eye Res. (2001) 73:815-825.
43. A.F. Clark, I.-H. Pang.  Advances in Glaucoma Therapeutics.  Expert Opin. Emerging Drugs (2002) 7:141-164.
44. B. Li, I.-H. Pang, G. Barnes, M.A. McLaughlin, W. Holt.  A new method and device to induce retinal ischemia in the rat.  Curr. Eye Res. (2002) 24:458-464.
45. I.-H. Pang, B. Li, A.F. Clark.  New drug development in glaucoma. Chin. J. New Drugs Clin. Remedies  (2003) 22:495-501.
46. I-H. Pang, P.E. Magnino, D.L. Fleenor, N. Jacobson, A.F. Clark.  Expression of matrix metalloproteinase and their inhibitors in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.  (2003) 44:3485-3493.
47. D.L. Fleenor, I.-H. Pang, A.F. Clark. Involvement of AP-1 in interleukin-1a-induced MMP-3 expression in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. (2003) 44:3494-3501.
48. I.-H. Pang, D.L. Fleenor, P.E. Hellberg, K. Stropki, M.D. McCartney, A.F. Clark,.  Aqueous outflow-enhancing effect of t-butylhydroquinone: involvement of AP-1 activation and stromelysin expression. Invest. Ophthalmol. Vis. Sci. (2003) 44:3502-3510.
49. I.-H. Pang.  Regulatory peptides involved in the control of intraocular pressure. Curr. Topics Peptides Proteins Res. (2003) 5:171-186.
50. I.-H. Pang, B. Li, A.F. Clark. The pathogenesis of retinal ganglion cell apoptosis induced by glaucoma. Chin. J. Ophthalmol. (2004) 40:495-499.
51. I.-H. Pang, A.F. Clark.  Drug-induced hydrolysis of extracellular matrix: a novel therapeutic mechanism for primary open angle glaucoma. J. Med. Sci. (2004) 24:173-178.
52. I.-H. Pang, B. Li, A.F. Clark. Strategies for optic nerve protection in glaucoma patients. Chin. J. Ophthalmol. (2004) 40:783-787.
53. A.F. Clark, D. Brotchie, A.T. Read, P.E. Hellberg, S. English-Wright, I.-H. Pang, C.R. Ethier, I. Grierson.  Dexamethasone alters F-actin architecture and promotes corss-linked actin network formation in human trabecular meshwork tissue.  Cell Motil. Cytoskeleton (2005) 60:83-95.
54. I.-H. Pang, W.-H. Wang, A.F. Clark. Acute effects of glaucoma medications on rat intraocular pressure. Exp. Eye Res. (2005) 80:207-214.
55. I.-H. Pang, E.C. Johnson, L. Jia, W.O. Cepurna, A.R. Shepard, M.R. Hellberg, A.F. Clark, J.C. Morrison. Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage. Invest. Ophthalmol. Vis. Sci. (2005) 46:1313-1321.
56. I.-H. Pang, H. Li, Q. Peng. Pharmacological effects of natriuretic peptides on intraocular pressure. Chin. J. New Drugs Clin. Remedies  (2005) 24:322-326.
57. I.-H. Pang, W.-H. Wang, J.C. Millar, A.F. Clark. Measurement of mouse intraocular pressure with the Tono-Pen. Exp. Eye Res. (2005) 81:359-360.
58. R.T. Libby, M.G. Anderson, I.-H. Pang, Z.H. Robinson, O.V. Savinova, I.M. Cosma, A. Snow, L.A. Wilson, R.S. Smith, A.F. Clark, S.W.M. John. Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration. Vis. Neurosci. (2005) 22: 637-648
59. W.-H. Wang, J.C. Millar, I.-H. Pang, M.B. Wax, A.F. Clark. Noninvasive measurement of rodent intraocular pressure with a rebound tonometer. Invest. Ophthalmol. Vis. Sci. (2005) 46:4617-4621.
60. D.L. Fleenor, P.E. Hellberg, A.R. Shepard, N. Jacobson, I.-H. Pang, A.F. Clark.TGFβ2-induced changes in trabecular meshwork gene expression: implications for intraocular pressure. Invest. Ophthalmol. Vis. Sci. (2006) 47: 226-234.
61. B.C. Chauhan, T.L. LeVatte, K.L. Garnier, F. Tremblay, I.-H. Pang, A.F. Clark, M.L. Archibald.  Semi-quantitative optic nerve grading scheme for determining axon loss in experimental optic neuropathy. Invest. Ophthalmol. Vis. Sci. (2006) 47: 634-640.
62. I.-H. Pang.  Hydrolysis of extracellular matrix: a new treatment mechanism for glaucoma. Chin..J. New Drugs Clin. Remedies  (2006) 25: 445-448.
63. I.-H. Pang, H. Zeng, D.L. Fleenor, A.F. Clark. Protective effect of pigment epithelium-derived factor on retinal ganglion cell survival. BMC Neurosci. (2007) 8:11.
64. R. Wordinger, D.L. Fleenor, I.-H. Pang, T. Tovar, G. Zode, J. Fuller, A.F. Clark.  Gremlin inhibits Bone Morphogenetic Protein-4 (BMP-4) antagonism of TGFβ2 function in cultured human trabecular cells and in the perfused anterior eye organ culture model.  Invest. Ophthalmol. Vis. Sci. (2007) 48:1191-1200.
65. A.R. Shepard,N. Jacobson,J.C. Millar,I.-H. Pang, H.T. Steely, C.C. Searby, V.C. Sheffield, E.M. Stone, A.F. Clark.Glaucoma-causing myocilin mutants require the Peroxisomal Targeting Signal-1 Receptor (PTS1R) to elevate intraocular pressure. Human Mol. Genetics (2007) 16:609-617.
66. N. Agarwal, R. Agarwal, D.M. Kumar, A. Ondricek, R.J. Wordinger, A.F. Clark, I.-H. Pang.  Comparison of expression profile of neurotrophins and their receptors in primary and transformed rat retinal ganglion cells. Mol. Vis. (2007) 13:1311-1318.
67. I.-H. Pang, A.F. Clark.  Rodent models for glaucoma retinopathy and optic neuropathy. J. Glaucoma (2007) 16:483-505.
68. R.T. Libby, G.R. Howell, I.-H. Pang, O.V. Savinova, A.K. Mehalow, J.W. Barter, R.S. Smith, A.F. Clark, S.W.M. John.  Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model.  BMC Neurosci. (2007) 8:108
69. J.C. Millar, Y. Wang, I.-H. Pang, W.-H. Wang, A.F. Clark. Effect of immunosuppression with anti-CD40L antibody on adenoviral-mediated transgene expression in mouse anterior segment.  Mol. Vis. (2008) 14:10-19.
70. W.-H. Wang, L.G. McNatt, I.-H. Pang­, J.C. Millar, P.E. Hellberg, M.H. Hellberg, H.T. Steely, J.S. Rubin, J.H. Fingert, V.C. Sheffield, E.M. Stone, A.F. Clark. Increased expression of the Wnt antagonist sFRP1 in glaucoma and its regulation of intraocular pressure.  J. Clin. Invest. (2008) 118:1056-1064.
71. W.-H. Wang, L.G. McNatt, I.-H. Pang, P.E. Hellberg, J.H. Fingert, M.D. McCartney, A.F. Clark.  Increased expression of Serum Amyloid A in glaucoma and its effect on intraocular pressure.  Invest. Ophthalmol. Vis. Sci. (2008) 49:1916-1923.
72. I.-H. Pang, W.-H. Wang, J.C. Millar, A.F. Clark.  Intraocular pressure measurement in rodents.  Chin. J. Ophthalmol. (2008) 44:465-468.
73. N.A. Sharif, S. Xu, P.E. Hellberg, I.-H. Pang, D.A. Gamache, J.M. Yanni.  Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. Mol. Vis. (2009) 15:1153-1161.
74. W. Yu, X. Liu,G. Cao, J. Qiu, J. Ma, N. Li,M. Yu, N. Yan, L. Chen, I.-H. Pang. Evaluation of monkey intraocular pressure by rebound tonometer. Mol. Vis. (2009) 15:2196-2201.
75. A.R. Shepard, J.C. Millar, I.-H. Pang, N. Jacobson, W.-H. Wang, A.F. Clark.Adenoviral gene transfer of active human transforming growth factor-b2 elevates intraocular pressure and reduces outflow facility in rodent eyes.  Invest. Ophthalmol. Vis. Sci. (2010) 51:2067-2076.
76. J. Ma, W. Yu, Y. Wang, G. Cao, S. Cai, X. Chen, N. Yan, Y. Yuan, H. Zeng, D.L. Fleenor, X. Liu, I.-H. Pang. Neuroprotective effects of C-type natriuretic peptide on rat retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. (2010) 51:3544-3553.
77. J.C. Millar, A.F. Clark, I.-H. Pang.  Assessment of aqueous humor dynamics in the mouse by a novel method of constant flow infusion. Invest. Ophthalmol. Vis. Sci. (2011) 52: 685-694.
78. H. Sun, Y. Wang, I.-H. Pang, J. Shen, X. Tang, Y. Li, C. Liu, B. Li.  Protective effect of a JNK inhibitor against retinal ganglion cell loss induced by acute moderate ocular hypertension.  Mol. Vis. (2011) 17: 864-875.
79. G. Liu, T. Zeng, W. Yu, N. Yan, H. Wang, S. Cai, I.-H. Pang, X. Liu.  Characterization of Intraocular Pressure Responses of the Tibetan Monkey (Macacathibetana). Mol. Vis. (2011) 17:1405-1413.
80. G. Prasanna, I.-H. Pang.  Key paper evaluation: Myelination transition zone astrocytes - a novel cell type in the optic nerve with a putative role in glaucoma.  Exp. Rev. Ophthalmol. (2011) 6: 291-294.
81. K.A. Fernandes, J.M. Harder, L.B. Fornarola, R.S. Freeman, A.F. Clark, I.-H. Pang, S.W.M. John, R.T. Libby. JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.  Neurobiol. Dis. (2012) 46:393-401.
82. C.M. McDowell, T. Luan, Z. Zhang, T. Putliwala, R.J. Wordinger, J.C. Millar, S.W.M. John, I.-H. Pang, A.F. Clark.  Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice.  Exp. Eye Res. (2012) 100:65-72.
83. Q. Yang, K.-S. Cho, H. Chen,D. Yu,W.-H. Wang, G. Luo,I.-H. Pang, W. Guo,D.F. Chen.  Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma.  Invest. Ophthalmol. Vis. Sci. (2012) 53:3733-3741.
84. W. Mao, J.C. Millar, W.-H. Wang, S.M. Silverman, Y. Liu, R.J. Wordinger, J.S. Rubin, I.-H. Pang, A.F. Clark.  Existence of the canonical Wnt signaling pathway in the human trabecular meshwork.  Invest. Ophthalmol. Vis. Sci. (2012) 53:7043-7051.
85. A.R. Shepard, R.E. Conrow, I.-H. Pang, N. Jacobson, M. Rezwan, K. Rutschmann, D. Auerbach, R. SriRamaratnam, V.W. Cornish.  Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen.  Chem. Biol. (2013) 8:549-558.
86. A.H. Wagner, N. Anand, W.-H. Wang, J.E. Chatterton, D.  Sun, A.R Shepard, N. Jacboson,  I.-H. Pang, A. DeLuca, T.L. Casavant, T.E. Scheetz, R.F. Mullins, T.A. Braun, A.F. Clark. Exon-level Expression Profiling of Ocular Tissues. Exp. Eye Res. (2013) 111:105-111.
87. Y. Liu, I.-H. Pang.  Challenges in the development of glaucoma neuroprotection therapy.  Cell Tissue Res. (2013) 353:253-260.
88. J.D. Dapper, S.D. Crish, I.-H. Pang, D.J. Calkins.  Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy. Neurobiol. Dis. (2013) 59:26-37.
89. M. Giovingo, M. Nolan, R. McCarty, I.-H. Pang, A.F. Clark, R.M. Beverley, S. Schwartz, W.D. Stamer, L. Walker, A. Grybauskas, K. Skuran, P. Kuprys, B.Y.J.T. Yue, P.A. Knepper. sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. Mol. Vis. (2013) 19:2151-2164.
90. X.-Y. Liu, L. Tang, I.-H. Pang, X.-M. Chen, N.-L. Wang.  Research progress of side effect of prostaglandin drugs.  Chin. J. Ophthalmol. (2013) 49:1045-1048.
91. H.-H. Chen, A. Namil, B. Severns, J. Ward, C. Kelly, C. Drace, M.A. McLanghlin, S. Yacoub, B. Li, R. Patil, N. Sharif, M.R. Hellberg, A. Rusinko, I.-H. Pang, K.D. Combrink. IN vivo optimization of 2,3-diaminopyrazine Rho kinase inhibitors for the treatment of glaucoma. Bioorg. Med. Chem. Lett. (2014) 24:1875-1879.
92.  S.S. Swaminathan, D.-J. Oh, M.H. Kang, A.R. Shepard, I.-H. Pang, D.J. Rhee. TGF2-mediated ocular hypertension is attenuated in SPARC-null mice.  Invest. Ophthalmol. Vis. Res. (2014) 55:4084-4097.
93. S. Nashine, B.-J. Kim, A.F. Clark, I.-H. Pang. Role of C/EBP homologous protein in retinal ganglion cell death after ischemis/reperfusion injury. Invest. Ophthalmol. Vis. Sci. (2014) 56:221-231.
94. T.P. Sharma, Y. Liu, R.J. Wordinger, I.-H. Pang, A.F. Clark. Neuritin1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush. Mol. Neurodegen. (2015) 6:e1661. doi: 10.1038/cddis.2015.22.
95. S. Choudhury, Y. Liu, A.F. Clark, I.-H. Pang. Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death. Mol. Neurodeg. (2015) 10:40.
96. J.C. Millar, T.N. Phan, I.-H. Pang, A.F. Clark. Strain and age effects on aqueous humor dynamics in the mouse. Invest. Ophthalmol. Vis. Res. (2015) 56:5764-5776.
97. W. Mao, Y. Liu, R.J. Wordinger, A.F. Clark, I.-H. Pang. Novel therapeutic targets for primary open angle glaucoma. Chin. J. Ophthalmol. (2015)(in press).
98. I.-H. Pang, J.C. Millar, A.F. Clark. Elevation of intraocular pressure in rodents using viral vectors targeting the trabecular meshwork. Exp. Eye Res. (2015) (in press)
99. J.C. Millar, I.-H. Pang. Non-continuous measurement of intraocular pressure in laboratory animals. Exp. Eye Res. (2015) (in press).
100. N. Pollock, I. Grierson, L. Currie, I.-H. Pang, R.L. Williams, A.F. Clark, L. Paraoa. Are cross-linked actin networks (CLANs) indicative of protection in ageing ocular trabecular meshwork cells and tissue? J. Cell Sci. (2015)(submitted).