Hongxia Xu
Hongxia Xu, PhD
Professor and Director

Department of Nutrition
Daping Hospital, Third Military Medical University
China

Education

  • 2008-2010 Post-Doctoral Fellow, Department of Pharmacology & Toxicology, Division of Clinical Pharmacology, , University of Alabama School of Medicine, Birmingham, AL, USA
  • 2001-2004 Ph.D., Department of Nutrition & Food Hygiene, Third Military Medical University, Chongqing, China
  • 1996-1999 M.S., School of Preventive Medicine, Third Military Medical University, Chongqing, China
  • 1988-1993 B.S., M.D., Chongqing University of Medical Sciences, Chongqing, China

 

Profile

Dr.Hongxia Xu was born in Chongqing, China, earned her M.D. degree from Chongqing University of Medical Sciences, China in 1993. She received her Ph.D.  in Nutrition and Food Hygiene, from Third Military Medical University, China in 2004, after working with Professor Mantian Mi at Third Military Medical University. She completed a Post-Doctoral Fellow in the Department of Pharmacology & Toxicology, Division of Clinical Pharmacology, University of Alabama School of Medicine, Birmingham from 2008-2010. In 2012, she joined Daping Hospital, Third Military Medical University as Professor and Director of Department of Nutrition in Dapiong Hospital. Dr. Xu’s research has been continuously funded by National Natural Science Foundation of China (NSFC) and other agencies, publishing >50 papers, 3 books, >12 invited book chapters. Dr. Xu is also the Vice Chief Editor for Electronic Journal of Metabolism and Nutrition of Cancer (Chinese) and the reviewer for other 6 SCI journals.

 

Research Interest

  • Clinical Nutrition
  • Nutrition and health
  • Nutritional Oncology
  • Drug discovery and development
  • Molecular cancer biology
  • Molecular, biochemical, and clinical pharmacology and experimental therapeutics
  • Preclinical Pharmacology
  • Biotechnology and biopharmaceuticals
  • Cancer prevention and biomarkers

 

Professional Activities:

1993-1996

Physician Resident

Hospital of Stainless Steel Corporation, Chongqing, China

1996-999

Teaching Assistant & Research Associate

Department of Nutrition & Food Hygiene, Schoolof Preventive Medicine,Third Military Medical University (TMMU), Chongqing, China

1999-2004

Lecturer & Research Associate

Department of Nutrition & Food Hygiene, TMMU, China

2004-2005

Senior Research Associate

Department of Nutrition & Food Hygiene, TMMU, China

2005-2008

Associate Professor

Department of Nutrition & Food Hygiene, TMMU, China

2008-2010

Post-Doctoral Fellow

Department of Pharmacology & Toxicology, Division of Clinical Pharmacology, , University of AlabamaSchool of Medicine, Birmingham, AL, USA

2010-2012

Associate Professor

Department of Nutrition & Food Hygiene, TMMU, China

2012- present

Professor and Director

Department of Nutrition, Daping Hospital, TMMU, China

 

Honors and Awards

Publications

Original Research Articles:

  1. Lu Z, Zhou R, Kong Y, Wang J, Xia W, Guo J, Liu J, Sun H, Liu K, Yang J, Mi M, Xu H*.S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway. Curr Cancer Drug Targets. 2015 Dec 6. [Epub ahead of print] (*Corresponding Author)
  2. Zhou R, Lu Z, Liu K, Guo J, Liu J, Zhou Y, Yang J, Mi M, Xu H*. Platycodin D induces tumor growth arrest by activating FOXO3aexpression in prostate cancer in vitro and in vivo. Curr Cancer Drug Targets. 2014;14: 860-871. (*Corresponding Author)
  3. Yang J, Mao Q, Xu H, Ma X, Zeng C. Tea consumption and risk of type2 Diabetes mellitus: a systematic review and meta-analysis update. BMJ Open. 2014;4(7):1-12.
  4. Lu Z, Wang L, Zhou R, Qiu Y, Zhang C, Mi M, Xu H*. Evaluation of the spermicidal and contraceptive activity of platycodin D, a saponin from platycodon grandiflorum. PLOS ONE. 2013 Nov 26; 8(11): e82068.(*Corresponding Author)
  5. Zhang X**, Xu H**, Zhang X, Voruganti S, Murugesan S, Nadkarni DH, Velu SE, Wang MH, Wang W, Zhang R. Preclinical evaluation of anticancer efficacy and pharmacological properties of FBA-TPQ, a novel synthetic makaluvamine analog. Mar Drugs. 2012 May; 10(5): 1138-55. (**Co-First Author)
  6. Xu H, Zhang Z, Li M, Zhang R. MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change. J Biol Chem. 2010 Jun 11;285(24):18407-18414.
  7. Liu K, Xing A, Chen K, Wang B, Zhou R, Chen S,Xu H, Mi M. Effect of fruit juice on cholesterol and blood pressure in adults: a meta-analysis of 19 randomized controlled trials. PLoS One. 2013 Apr 24; 8(4):e61420.
  8. Zhang T, Wang F, Xu H, Yi L, Qin Y, Hui C, Mantian Mi, QianYong Zhang. Activation of nuclear factor erythroid 2 related factor 2 and PPARγ plays a role in the genistein mediated attenuation of oxidative stress induced endothelial cell injury. Br J Nutr, 2013 Jan 28;109(2):223-235.
  9. Rayburn E, Wang W, Li M, Zhang X, Xu H, Li H, Qin J, Jia L, Covey J, Lee M, Zhang R. Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent.2012 Jun;69(6):1423-1431
  10. Hui C, Yu F, Li Y, Long Y, Xu H, Yong Z, Jundong Z, Qianyong Z, Mantian M. MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea- induced breast carcinogenesis. Breast Cancer Res. 2012 May 22; 14(3):R80.
  11. Wang W, Ao L, Rayburn ER, Xu H, Zhang X, Zhang X, Nag SA, Wu X, Wang MH, Wang H, Van Meir EG, Zhang R. KCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. PLoS One. 2012; 7(9):e44883.
  12. Li H, Ezell SJ, Zhang X, Wang W, Xu H, Zhang R. Development and validation of an HPLC method for quantitation of BA-TPQ, a novel iminoquinone anticancer agent, and an initial pharmacokinetic study in mice.Biomed Chromatogr. 2011 May; 25(5):628-634.
  13. Ezell SJ, Li H, Xu H, Zhang R et al. Preclinical pharmacology of BA-TPQ, a novel synthetic iminoquinone anticancer agent. Mar Drugs. 2010 Jul 13;8(7):2129-2141.
  14. Zeng K, Xu H, Chen K, Zhu J, Zhou Y, Zhang Q, Mantian M. Effects of taurine on glutamate uptake and degradation in Müller cells under diabetic conditions via antioxidant mechanism.Mol Cell Neurosci. 2010 Oct; 45(2):192-199.
  15. Zeng K, Xu H, Mi M, Chen K, Zhu J, Yi L, Zhang T, Zhang Q, Yu X.  Effects of taurine on glial cells apoptosis and taurine transporter expression in retina under diabetic conditions.Neurochem Res. 2010 Oct; 35(10):1566-1574.
  16. Chen F, Mi M, Zhang Q, Wei N, Chen K, Xu H, Yuan J, Zhou Y, Lang H, Yu X, Wang B, Wang J, Tang Y, Chang H. Taurine buffers glutamate homeostasis in retinal cells in vitro under hypoxic conditions.Ophthalmic Res. 2010; 44(2):105-112.
  17. Chen K, Zhang Q, Wang J, Liu F, Mi M, Xu H, Chen F, Zeng K. Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction.Brain Res. 2009 Jul 7;1279:131-138.
  18. Zeng K, Xu H, Mi M, Zhang Q, Zhang Y, Chen K, Chen F, Zhu J, Yu X. Dietary taurine supplementation prevents glial alterations in retina of diabetic rats.Neurochem Res. 2009 Feb;34(2):244-254.
  19. Yu X, Xu Z, Mi M, Xu H. Dietary taurine supplementation ameliorates diabetic retinopathy via anti- excitotoxicity of glutamate in streptozotocin- induced Sprague- Dawley rats. Neurochem Res. 2008; 33: 500-507.
  20. Guo J,Li N,Fan Y,Liu J,Sun H,Jiang B,Yang J,Xu H*. Early enteral nutritional support in patients after laryngeal cancer surgery. Parenteral &Enteral Nutrition.2014;21(3):132-134. (in Chinese)(*Corresponding Author)
  21. Lin X, He X, Liu J, Sun H, Guo J,Lu Z,Yang J, Jiang B,Xu H*. Clinical outcomes of oral nutritional supplements and tube feeding in hospitalized older patients. Parenteral &Enteral Nutrition.2014;21(4):208-210. (in Chinese)(*Corresponding Author)
  22. Zhou R,Lu Z,Liu K,Yang L,Hu  Y,Chang  H,Zhou Y,Mi M,Li Y,Xu H*. Synthetic sodium channel amine ligands suppress growth and invasion in prostate cancer cells in vitro. Journal of Third Military Medical University. 2014;36(5):422-426. (in Chinese)(*Corresponding Author)
  23. Xu H. Carnitine, not just a fatty acid arrier. Election J Metab Nutr Cancer. 2014;1(1):21-25.(in Chinese)
  24. Kong Y,Lu Z,Liu J,Sun H,Guo J, Lin X,Fan Y,Tang R,Zhou R,Jiang B,Xu H*.Nutritional status investigation and analysis of 342 cases of elderly inpatients. Chongqing Medicine. 2014;43(30):4056-4058. (in Chinese)(*Corresponding Author)
  25. Liu J, Xu H*. The protein supplement for the sarcopenia. Election J Metab Nutr Cancer. 2014;1(3):10-13. (in Chinese)(*Corresponding Author)
  26. Li N,Wang J, Xu H*. American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention Reducing the Risk of Cancer With Healthy Food Choices and Physical Activity. Election J Metab Nutr Cancer. 2014,1(2):39-45. (in Chinese)(*Corresponding Author)
  27. Guo J, Kong Y, Tang R, Fang Y, Lu Z, Jiang B, Yang J, Xu H*. Value of early enteral nutritional support in patients after laryngeal cancer surgery. Election J Metab Nutr Cancer. 2014;1(2):39-45.(in Chinese) (*Corresponding Author)
  28. Yang L,Lu Z,Zhou R,Qiu Y,Wang L,Cai M, Zhang  C, Xu H*. Effects of platrcodin D on spermcidal and apoptosis-inducing activities. Clin J Fam Plan.2013;21(6):386-390. (in Chinese)(*Corresponding Author)
  29. Lu Z, Yang L, Zhou R, Xu H*. Natural product and spermicide in vitro. Clin J Fam Plan. 2013; 21(11):782-784,788.(in Chinese) (*Corresponding Author)
  30. Sun H, Zhang L, He X, Lin X, Tang R, Jiang B,Yang J, Xu H*.Value of nutritional intervention in gastronintestinal ployps patients with diabetes after gastroscope argon coagulation. J Mod Med Health. 2014;30(19): 8-10. (in Chinese)(*Corresponding Author)
  31. Zhang Y, Xu H, Zeng KH,Mi MT. The influence of taurine on the expression of GFAP and TAUT in the Müller cells from retina in high glucose culture. Journal of Medical Colleges of PLA. 2007,22(3):147-151.(in Chinese)
  32. Zhou Y, Mi MT, Yang Z, Zhu J, Xu H. Effect of genistein on cell cycle of bone marrow hematopoietic cells in normal and irradiated mice. Chinese Journal of Radiological Medicine and Protection. 2006;26(5):434-437.(in Chinese)
  33. Luo Y, Mi M, Wei N, Xu H, Zhu J. Effects of lovastatin on cells cycle distribution in MCF-7 cells transfected with BRCA1. Chinese Journal of Cancer.2004;23(8): 924-928.(in Chinese)
  34. Luo Y, Mi M, Xu H, Wei N, Zhang Q. Effects of LOV on p21 in BRCA1-overexpressing MCF-7 cells. Acta Academate Medicinae Militaris Tertiae.2004;26(5):386-389. (in Chinese)
  35. Zhang Y, Xu H , Zeng K,Mi M. Influence of taurine on the expression of GFAP and TAUT in the Muller cells from retina in high glucose culture. Progress in Modern Biomedicine. 2007;7(5): 649-652.(in Chinese)
  36. Zhang Y, Xu H, Zeng K,Mi M. Protective effects of taurine on Muller cells apoptosis in diabetic retinopathy. Acta Academate Medicinae Militaris Tertiae, 2007, 29(12): 1193-1196.(in Chinese)
  37. Xu H, Mi M, Huang G, Chen K. Purified retinal ganglion cells cultured in serum-free neurobasal medium. Chinese Journal Ocular fundus disease.2006; 22(3):200-203.(in Chinese)
  38. Xu H, Mi M, Xu Z. Protective effects of taurine against glutamate -induced excitotoxicity in rat retina. Acta Nutritmenta Sinica.2005;27(2):114-118.(in Chinese)
  39. Xu H, Mi M, Huang G, Zhou Y, Lang H, Chen K. Taurine depresses glutamate-induced RGCs apoptosis in rat retina. Chinese Journal of Clinical Rehabilitation.2005;9(14):149-151. (in Chinese)
  40. Xu H, Mi M, Xu Z. The effect of glutamate excitotoxicity on glial fibrillary acid protein and the protective effect of taurine. Acta Academate Medicinae Militaris Tertiae.2005;27(11):1078-1082.(in Chinese)
  41. Xu Z, Mi M, Xu H. Effects of taurine treatment on glutamate transporter mRNA expression in diabetic rat retina. Chinese Journal of Diabetes. 2005;13(5): 340-342,345.(in Chinese)
  42. Xu Z, Mi MT, Xu H. Effects of taurine on retina in diabetic rats. Chinese Journal of Public Health.2005;21(8):950-952.(in Chinese)
  43. Xu Z, Mi M, Xu H. Effect of taurine on retinal ultrastructure of rats with early-stage diabetic retina. Chinese Journal of Public Health.2004;20(5): 554-555.(in Chinese)
  44. Wang J, Mi M, Zhu J, Xu H. Effect of simulated altitude acute hypoxia on appetite and orexin mRNA expression in rats. Parenteral & Enteral Nutrition. 2005;11(5): 265-269.(in Chinese)
  45. Liu J, Mi M, Xu H, Zhang QY. Protective effect of taurine on the damage of retina I rats exposed to 5000m high altitude. Acta Academate Medicinae Militaris Tertiae. 2004;26(21): 1936-1939.(in Chinese)
  46. Tian X, Mi M, Xu H. Effects of different altitudes and acute hypoxia for different time on the expression of NPY mRNA in the rat hypothalamus. Acta Academate Medicinae Militaris Tertiae. 2004;26(11): 943-945.(in Chinese)
  47. Huang G, Mi M, Xu H, Lang H, Zhou D. Effects of taurine on rat retinal glutamate, GABA contents. Chinese Journal of Public Health.2003;19(12): 1436-1437.(in Chinese)
  48. Xu H, Mi M, Lang H, Wei N, Huang G, Yu X. Effects of taurine and micronutrient complex on iNOS mRNA in retina of rat. Acta Academate Medicinae Militaris Tertiae, 2001, 23(10): 1177-1179.(in Chinese)
  49. Xu H, Mi M, Lang H, Yu X, Wei N, Huang G. Effects of taurine and micronutrient complex on metabotropic glutamate receptor mGluR6 mRNA in rat retina. Acta Nutritmenta Sinica, 2000,22(4), 303-307.(in Chinese)
  50. Xu H, Mi M, Wei N, Lang H, Huang G, Yu X. Effects of taurine on expression of transducin αsubunit in retinal rods during light and dark adaptations in rats. Acta Academate Medicinae Militaris Tertiae, 2000, 22(3): 216-219.(in Chinese)
  51. Zhou D, Mi M, Lang H, XU H. Efect of Cholesterol deficiency on the activity of protein tyrosine kinases in Jurkat cells. China Public Health, 2001, 17(4): 297-299.(in Chinese)
  52. Zhou D, Mi M, XU H, Wei N, Zhang Q, Yang Z. Effect of cholesterol deficiency on the proliferation of Jurkat cells and its molecular mechanisms. Immunological Journal, 2000, 16(2): 106-109.(in Chinese)
  53. Zhou D, Mi M, XU H, Lang H, Zhang Q. Effects of cholesterol deficiency on the expression of cell cycle regulatory proteins in Jurkat cells. Immunological Journal, 1999, 15(4): 249-252.(in Chinese) Wei N, Xu H, Mi M, Yu X, Lang H. Effects of taurine on the expression of nitric oxide synthase in the lateral geniculate nucleus in rat. Acta Academate Medicinae Militaris Tertiae, 2000, 22(4):

 

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