Education

Biography

After obtaining a Bachelor and Master’s degrees in pharmacy from the Pune University (India) in 1998, he spent one year working as a synthetic chemist and three years working as Lecturer of Medicinal chemistry with Padmashree Dr D Y Patil College of Pharmacy, before undertaking a PhD at the University of Nottingham under the supervision of Dr S R Chhabra, Prof. Peter Fischer, Prof. David Pritchard and Prof. Barrie Kellam. After gaining PhD he continued to work on for five years as a post-doctoral research fellow working on

1. Cancer Research project funded by BBSRC, UK, focusing on the work involving Computer aided designing and synthesis of small chemical molecules as inhibitors of pRb-E7 interactions.
2. Seeding Drug Discovery project funded by Welcome Trust, UK focusing on the Synthesis of novel chemicals and lead optimization of new highly selective beta-blockers in the management of cardiovascular disorders.
3. Project funded by MRC, UK, focusing on Development of Inhibitors of Human deadnylase enzyme, new treatment for the Osteoporosis.

He subsequently spent one and a half years as a senior research scientist with Prof. Michael Pollastri (Northeastern University USA) and Prof. Harry De Koning (University of Glasgow UK) at the RD Alternative Discovery & Development, GlaxoSmithKline (Madrid Trescantos, Spain) working on a project involving structural optimization of GSK675728A, hPDE4 inhibitor to generate novel pharmacophore(s) as potent TbrPDE1 inhibitors that are selective over hPDEs in the management of African sleeping sickness (CNS disorder).

He joined Creighton University in early 2017 as an Assistant Professor of medicinal chemistry in Clinical and Translational sciences, within the school of Medicine under the leadership of Dr D K Agrawal.

Research Interest

Dr. Gopal Pundlik Jadhav is currently working on design and development of novel inhibitors of triggering receptor expressed on myeloid cells–1 (TREM-1), towards the management of life threatening sepsis. This interdisciplinary research warranted use of computer aided drug design approach to develop and synthesis of small drug like molecules. Recent treatment employ small peptides molecules (LR-17 and LR-12), that have very short half-life and possibly multiple targets.

Molecular docking and HTS assay techniques will be employed to identify from from a library of 80000 diverse chemical molecules. These hits will be tested for TREM-1 inhibition activity to identify new chemical lead(s). Lead(s) will be recruited for extensive chemical modifications (SAR- development) in order to optimise potency, toxicty and druggability. 

Scientific Activities

Honors and Awards

• Junior Research fellowship awarded by Government of India, for the period of 2 years for pursing Master of Pharmacy research. This was awarded by, All India Council for Technical and Education (AICTE) based on the performance in all India level examination.
• Topped in Pune University in Master of Pharmacy examination in the Pharmaceutical chemistry.

Publications

1. Jillian G Baker, Sheila M Gardiner, Jeanette Woolard, Christophe Fromont, Gopal P Jadhav, Shailesh
2. Mistry,  Kevin  SJ  Thompson,  Barrie  Kellam,  Stephen  J  Hill,  Peter  M  Fischer;  Novel  selective  β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease; The FASEB Journal, 31, 2017; Impact factor = 5.3.
3. Gopal  P  Jadhav,  Shailesh  Mistry,  Jillian  G  Baker,  Sheila  M  Gardiner,  Jeanette  Woolard,  Christophe
4. Fromont, Kevin SJ Thompson, Barrie Kellam, Stephen J Hill, Peter M Fischer; Novel Imidazole containing ethanolamine analogues as selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease; Journal of Medicinal chemistry, 2017 (Manuscript ready for submission).
5. Gopal P Jadhav, Shailesh Mistry, Jillian G Baker, Sheila M Gardiner, Jeanette Woolard, Christophe Fromont, Kevin SJ Thompson, Barrie Kellam, Stephen J Hill, Peter M Fischer; Novel Cyclic analogues as selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease; Jan 2017 (Manuscript ready for submission).
6. Gopal P Jadhav, Shailesh Mistry, Jillian G Baker, Sheila M Gardiner, Jeanette Woolard, Christophe Fromont, Kevin SJ Thompson, Barrie Kellam, Stephen J Hill, Peter M Fischer; Novel chiral bicyclic analogues as selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease; 2017 (Manuscript in preparation).
7. Maryati Maryati, Ishwinder Kaur, Gopal P. Jadhav, Loyin Olotu-Umoren, Blessing Oveh, Lubna Hashmi, Peter M. Fischer and G. Sebastiaan Winkler*; A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity; Nucleic Acids Research, 2013, 1–10.
8. Murray Ewan, Crowley Rebecca, Truman Alex, Clarke Simon, Cottam James, Jadhav Gopal, O'Shea Paul, Lindholm Catharina, Cockayne Alan, Chan Weng, Chhabra Siri, Williams Paul; Targeting Staphylococcus aureus Quorum Sensing with Non-Peptidic Small Molecule Inhibitors J Med Chem.; (Manuscript submitted)
9. Gopal P. Jadhav, Siri Ram Chhabra, Gary Telford, Doreen S. W. Hooi, Karima Righetti, Paul Williams, Barrie Kellam, David I. Pritchard, and Peter M. Fischer ; Immunosuppressive but Non-LasR-Inducing Analogues of the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3- Oxododecanoyl)-L-homoserine Lactone ; J. Med. Chem. 2011, 54, 3348– 3359;
10. *Gopal P. Jadhav; H. N. More and  K. R. Mahadik; Simultaneous estimation  of Nalidixic acid and Metronidazole from various multicomponent formulations by using UV spectrophotometer; Indian Journal of Pharmaceutical Sciences; 1998; 246-248
11. *Gopal P. Jadhav; H. N. More, K. R. Mahadik ; Simultaneous estimation of Nalidixic acid and Metronidazole using UV/Visible spectrophotometer; Indian Drugs; 35(8), 1998, 475-480
12. *A. D. Kale, S. J. Kachhwaha, Gopal P. Jadhav and Piyush Trivedi; Spectrophotometric estimation of Dicyclomine hydrochloride from combined dosage forms by ion pair complex; Indian Drugs; 35(11), 1998, 718-720
13. *Gopal P. Jadhav; Tanya Ray H. N. More; K. R. Mahadik and A. D. Deshpande; Estimation of Piroxicam beta cyclodextrin by High Performance Liquid Chromatography from marketed formulations; Indian Drugs; 36(8), 1999, 505-508

Presentations

• Poster entitled, “Simultaneous estimation of Nalidixic acid and Metronidazole from multicomponent formulations by using UV spectrophotometer”; *Gopal P. Jadhav ; H. N. More and K. R. Mahadik; 49th Indian Pharmaceutical Congress, Thirivananthapuram, Dec 1997.
• Poster entitled “Phase transfer catalyst”; *Gopal P. Jadhav, K. S. Jain, T. S. Chitre, Miniyar; 7th APTI convention, Goa.
• Poster entitled “Electrodialysis-a new analytical technique”; *Gopal P. Jadhav, K. S. Jain, T. S. Chitre; 7th APTI convention, Goa.