Dorothea k. Thompson
Thompson Dorothea K, PhD, JD
Associate Professor of Medical Microbiology & Immunology

Campbell University College of Pharmacy & Health Sciences
USA

Education

  • University of Tennessee College of Law (Knoxville, Tn), Juris Doctor, May 2012, Activities: Executive Editor, Tennessee Law Review, 2011-2012; Staff Member, 2010-2011.
  • The Ohio State University, Department of Microbiology (Columbus, Oh) Ph.D., Molecular Microbiology, Dec. 1997 (GPA 3.89/4.00)
  • Pennsylvania State University, Department of English (University Park, Pa), M.A., English, with a specialization in Technical Writing/Scientific Discourse, May 1992
  • Virginia Polytechnic Institute and State University, Department of Anaerobic Microbiology (Blacksburg, Va), M.S., Anaerobic Microbiology, Aug. 1989
  • University of Tennessee (Knoxville, Tn), B.A., Microbiology and English, summa cum laude, June 1986

 

Profile

Currently, I am an Associate Professor in the Department of Pharmaceutical Sciences at Campbell University, where I teach primarily Medical Microbiology and Immunology in the Doctor of Pharmacy program.  I started my appointment at Campbell in January 2015.  My research interests focus on legal, health policy, and regulatory issues challenging pharmacogenomics and nanotechnology applied to the health and pharmaceutical sciences.  While as a law student, I published the article entitled “Small Size, Big Dilemma:  The Challenge of Regulating Nanotechnology” in the Tennessee Law Review.  I am interested in exploring the intersection of pharmaceutical sciences and regulatory affairs in my research here at Campbell.

Prior to Campbell University, I had a productive career as a Ph.D.-level research scientist working at the U.S. Department of Energy’s Oak Ridge National Laboratory (ORNL) in Oak Ridge, TN.  While at ORNL, my research was in the area of microbial functional genomics, specifically the application of high-throughput technologies such as DNA microarray hybridization and two-dimensional high-performance liquid chromatography-tandem mass spectrometry to metal stress regulation in bacteria.  As an Assistant Professor of Microbiology at Purdue University, I collaborated with biospectroscopists to develop and apply a Raman chemical imaging platform using functionalized nanoprobes to chemically map subcellular metal bioreduction sites in bacteria.  I also have advanced educational training and experience in molecular biology, biochemistry, intellectual property law, and administrative law.  I am a member of the State Bar of Tennessee and am registered to practice before the United States Patent and Trademark Office.

 

Research Interest

My research interests focus on legal, health policy, and regulatory issues challenging pharmacogenomics and nanotechnology applied to the health and pharmaceutical sciences.

 

Professional Activities:

January 2015 – present

Associate Professor

Department of Medical Microbiology & Immunology, Department of Pharmaceutical Sciences

Campbell University, College of Pharmacy & Health Sciences (Buies Creek, Nc)

June 11, 2014 – present

Scientific Consultant

 

Microbial Insights, Inc. (Knoxville, Tn)

1/16/2014 - 9/03/2014

E-Discovery Contractor

 

Nelson Mullins Riley & Scarborough, Llp (Nashville, Tn)

Aug. 2011 – May 2013

Technology Advisor

Life Sciences

Luedeka Neely Group, P.C. (Knoxville, Tn)

Aug. 2009 – Feb. 2011

Research Scientist II

 

Center For Environmental Biotechnology, University of Tennessee (Knoxville, Tn)

Oct. 2005 – July 2009

Assistant Professor

Microbiology & Principal Investigator

Purdue University, Department of Biological Sciences (West Lafayette, In)

Oct. 2004 – Sept. 2005

Group Leader and Staff Research Scientist

Microbial Ecology & Functional Genomics

Oak Ridge National Laboratory, Environmental Sciences Division (Oak Ridge, Tn)

Feb. 1998 – Nov. 1999

Oak Ridge Institute for Science and Education (ORISE) Fellow

 

U.S. Food And Drug Administration, Division of Bacterial Parasitic And Allergenic Products, Center For Biologics Evaluation And Research (Bethesda, Md)

 

Honors & Awards

 

Publications

Books

  • Zhou, J., D. K. Thompson, Y. Xu, and J. M. Tiedje. 2004. Microbial Functional Genomics. John Wiley & Sons, Inc., Hoboken, NJ. (Translated in Chinese).

Book Chapters

  1. Wan, X.-F., and D. K. Thompson. 2009. High-throughput technologies and functional genomics, p. 67-113. In Fu, P., and S. Panke (ed.), Systems Biology and Synthetic Biology, John Wiley & Sons, Inc., Hoboken, NJ.
  2. Zhou, J., and D. K. Thompson. 2004. Microarray Technology and Applications in Environmental Microbiology, p. 183-270. In Sparks, D. L. (ed.), Advances in Agronomy, vol. 82. Elsevier Inc., San Diego, CA.
  3. Zhou, J.-Z., and D. K. Thompson. 2002. Microarrays: Applications in Environmental Microbiology, p. 1968-1979. In Britton, G. (ed.), Encyclopedia of Environmental Microbiology, vol. 4. John Wiley & Sons, NY.

Peer-Reviewed Journal Articles

  1. Ravindranath, S., U. S. Kadam, D. K. Thompson, and J. Irudayaraj. 2012. Intracellularly grown gold nanoislands as SERS substrates for monitoring chromate, sulfate and nitrate localization sites in remediating bacteria biofilms by Raman chemical imaging. Anal Chim Acta 745:1-9.
  2. Ravindranath, S., K. Henne, D. Thompson, and J. Irudayaraj. 2011. Raman Chemical Imaging of Chromate Reduction Sites in a Single Bacterium Using Intracellularly Grown Gold Nanoislands. ACS Nano, 5(6):4729-4736.
  3. Henne, K. L., X.-F. Wan, W. Wei, and D. K. Thompson. 2011. SO2426 is a positive regulator of siderophore expression in Shewanella oneidensis MR-1. BMC Microbiology 11:125.
  4. Ravindranath, S. P., K. L. Henne, D. K. Thompson, and J. Irudayaraj. 2011. Surface-enhanced Raman imaging of intracellular bioreduction of chromate in Shewanella oneidensis. PloS One 6(2): e16634.
  5. Thompson, D. K., K. Chourey, G. S. Wickham, S. B. Thieman, N. C. VerBerkmoes, B. Zhang, A. T. McCarthy, M. A. Rudisil, M. Shah, and R. L. Hettich. 2010. Proteomics reveals a core molecular response of Pseudomonas putida F1 to acute chromate challenge. BMC Genomics 11:311.
  6. Henne, K. L., C. H. Nakatsu, D. K. Thompson, and A. E. Konopka. 2009. High-level chromate resistance in Arthrobacter sp. strain FB24 requires previously uncharacterized accessory genes. BMC Microbiology 9:199.
  7. Mugerfeld, I., B. A. Law, G. S. Wickham, and D. K. Thompson. 2009. A putative azoreductase gene is involved in the Shewanella oneidensis response to heavy metal stress. Applied Microbiology and Biotechnology 82:1131-1141.
  8. Henne, K. L., J. E. Turse, C. D. Nicora, M. S. Lipton, S. L. Tollaksen, C. Lindberg, G. Babnigg, C. S. Giometti, C. H. Nakatsu, D. K. Thompson, and A. E. Konopka. 2009. Global proteomic analysis of the chromate response in Arthrobacter sp. strain FB24. Journal of Proteome Research 8:1704-1716.
  9. Chourey, K., M. R. Thompson, M. Shah, B. Zhang, N. C. VerBerkmoes, D. K. Thompson*, and R. L. Hettich*. 2009. Comparative temporal proteomics of a response regulator (SO2426)-deficient strain and wild-type Shewanella oneidensis MR-1 during chromate transformation. Journal of Proteome Research 8:59-71.
  10. Chourey, K., W. Wei, X.-F. Wan, and D. K. Thompson. 2008. Transcriptome analysis reveals response regulator SO2426-mediated gene expression in Shewanella oneidensis MR-1 under chromate challenge. BMC Genomics 9:395.
  11. Wu, L., X. Liu, M. W. Fields, D. K. Thompson, C. E. Bagwell, J. M. Tiedje, T. C. Hazen, and J. Zhou. 2008. Microarray-based whole-genome hybridization as a tool for determining prokaryotic species relatedness. The ISME Journal (Multidisciplinary Journal of Microbial Ecology) 2:642-655.
  12. Thompson, M. R., D. K. Thompson, and R. L. Hettich. 2008. Systematic assessment of the benefits and caveats in mining microbial post-translational modifications from shotgun proteomic data: response of Shewanella oneidensis to chromate exposure. Journal of Proteome Research 7:648-658.
  13. Luo, F., Y. Yang, J. Zhong, H. Gao, L. Khan, D. K. Thompson, and J. Zhou. 2007. Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory. BMC Bioinformatics 8:299.
  14. Thompson, M. R., N. C. VerBerkmoes, K. Chourey, M. Shah, D. K. Thompson, and R. L. Hettich. 2007. Dosage-dependent proteome response of Shewanella oneidensis MR-1 to acute chromate challenge. Journal of Proteome Research 6:1745-1757.
  15. Chourey, K., M. Thompson, J. Morrell-Falvey, N. C. VerBerkmoes, S. D. Brown, M. Shah, J. Zhou, M. Doktycz, R. L. Hettich, and D. K. Thompson. 2006. Global molecular and morphological effects of 24-h chromium(VI) exposure on Shewanella oneidensis MR-1. Applied and Environmental Microbiology 72:6331-6344.
  16. Gao, H., Z. K. Yang, L. Wu, D. K. Thompson, and J. Zhou. 2006. Global transcriptome analysis of the cold shock response of Shewanella oneidensis MR-1 and mutational analysis of its classical cold-shock proteins. Journal of Bacteriology 188:4560-4569.
  17. Brown, S. D., M. R. Thompson, N. C. VerBerkmoes, K. Chourey, M. Shah, J. Zhou, R. L. Hettich, and D. K. Thompson. 2006. Molecular dynamics of the Shewanella oneidensis response to chromate stress. Molecular & Cellular Proteomics 5:1054-1071.
  18. Leaphart, A. B., D. K. Thompson, K. Huang, E. Alm, X. Wan, A. Arkin, S. D. Brown, L. Wu, T. Yan, X. Liu, G. S. Wickham, and J. Zhou. 2006. Transcriptome profiling of Shewanella oneidensis gene expression following exposure to acidic and alkaline pH. Journal of Bacteriology 188:1633-1642.
  19. Brown, S. D., M. Martin, S. Deshpande, S. Seal, K. Huang, E. Alm, Y. Yang, L. Wu, T. Yan, X. Liu, A. Arkin, K. Chourey, J. Zhou, and D. K. Thompson. 2006. Cellular response of Shewanella oneidensis to strontium stress. Applied and Environmental Microbiology 72:890-900.
  20. Liu, Y., W. Gao, Y. Wang, L. Wu, X. Liu, T. Yan, E. Alm, A. Arkin, D. K. Thompson, M. W. Fields, and J. Zhou. 2005. Genomic expression responses of Shewanella oneidensis MR-1 to salt stress. Journal of Bacteriology 187:2501-2507.
  21. Wan, X.-F., N. VerBerkmoes, D. Stanek, L. A. McCue, D. Stanek, H. Connelly, L. J. Hauser, L. Wu, X. Liu, T. Yan, A. Leaphart, R. L. Hettich, J. Zhou, and D. K. Thompson. 2004. Transcriptomic and proteomic characterization of the Fur modulon in the metal-reducing bacterium Shewanella oneidensis. Journal of Bacteriology 186:8385-8400.
  22. Gao, H., S. Wang, X. Liu, T. Yan, L. Wu, E. Alm, A. Arkin, D. K. Thompson, and J. Zhou. 2004. Global transcriptome analysis of the heat shock response of Shewanella oneidensis. Journal of Bacteriology 186:7796-7803.
  23. Wu, L., D. K. Thompson, X. Liu, M. W. Fields, C. E. Bagwell, J. M. Tiedje, and J. Zhou. 2004. Development and evaluation of microarray-based whole-genome hybridization for detection of microorganisms within the context of environmental applications. Environmental Science and Technology 38:6775-6782.
  24. Yost, C., L. Hauser, F. Larimer, D. Thompson, A. Beliaev, J. Zhou, Y. Xu, and D. Xu. 2003. A computational study of Shewanella oneidensis MR-1: Structural prediction and functional inference of hypothetical proteins. OMICS: A Journal of Integrative Biology 7:177-192.
  25. Liu, Y., J. Zhou, M. Omelchenko, A. Beliaev, A. Venkateswaran, J. Stair, L. Wu, D. K. Thompson, D. Xu, I. B. Rogozin, E. K. Gaidamakova, M. Zhai, K. S. Makarova, E. V. Koonin, and M. J. Daly. 2003. Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation. Proceedings of the National Academy of Sciences 100:4191-4196.
  26. Beliaev, A. S., D. K. Thompson, M. Fields, L. Wu, D. P. Lies, K. H. Nealson, and J. Zhou. 2002. Microarray transcription profiling of a Shewanella oneidensis etrA mutant. Journal of Bacteriology 184:4612-4616.
  27. Thompson, D. K., A. S. Beliaev, C. S. Giometti, S. L. Tollaksen, T. Khare, D. P. Lies, K. H. Nealson, H. Lim, J. Yates III, C. C. Brandt, J. M. Tiedje, and J.-Z. Zhou. 2002. Transcriptional and proteomic analysis of a ferric uptake regulator (Fur) mutant of Shewanella oneidensis: Possible involvement of Fur in Energy Metabolism, Transcriptional Regulation and Oxidative Stress. Applied and Environmental Microbiology 68:881-892.
  28. Zhou, J., and D. K. Thompson. 2002. Challenges in applying microarrays to environmental studies. Current Opinion in Biotechnology 13:204-207.
  29. Beliaev, A. S., D. K. Thompson, T. Khare, H. Lim, C. C. Brandt, G. Li, A. E. Murray, J. F. Heidelberg, C. S. Giometti, J. Yates III, K. H. Nealson, J. M. Tiedje, and J. Zhou. 2002. Gene and protein expression profiles of Shewanella oneidensis during anaerobic growth with different electron acceptors. OMICS: A Journal of Integrative Biology 6:39-60.
  30. Wu, L., D. K. Thompson, G. Li, R. A. Hurt, J. M. Tiedje, and J. Zhou. 2001. Development and evaluation of functional gene arrays for detection of selected genes in the environment. Applied and Environmental Microbiology 67:5780-5790.
  31. Thompson, D. K., C. D. Deal, C. Ison, J. Zenilman, and M. C. Bash. 2000. A typing system for Neisseria gonorrhoeae based on biotinylated oligonucleotide probes to PIB gene variable regions. Journal of Infectious Diseases 181:1652-1660.
  32. Thompson, D. K., J. R. Palmer, and C. J. Daniels. 1999. Expression and heat-responsive regulation of a TFIIB homologue from the archaeon Haloferax volcanii. Molecular Microbiology 33:1081-1092.
  33. Thompson, D. K., and C. J. Daniels. 1998. Heat shock inducibility of an archaeal TATA-like promoter is controlled by adjacent sequence elements. Molecular Microbiology 27:541-551.
  34. Kuo, Y.-P.,* D. K. Thompson,* A. St. Jean, R. L. Charlebois, and C. J. Daniels. 1997. Characterization of two heat shock genes from Haloferax volcanii: A model system for transcription regulation in the Archaea. Journal of Bacteriology 179:6318-6324. (*Authors contributed equally to this work.)
  35. Thompson, D. K. 1993. Arguing for experimental facts in science: A study of research article results sections in biochemistry. Written Communication 10:106-128.
  36. Contributor for 1993 Bibliography: Relations of Literature and Science, 1989-1990. In Configurations 2:283-319.
  37. Thompson, D. K., and J.-S. Chen. 1990. Purification and properties of an acetoacetyl coenzyme A-reacting phosphotransbutyrylase from Clostridium beijerinckii (“Clostridium butylicum”) NRRL B593. Applied and Environmental Microbiology 56:607-613.

 

Autoimmune Journal Flyer