gary-s-stein
Gary S. Stein, PhD
Director, Professor and Chairperson
  • Department of Biochemistry
    University of Vermont Larner College of Medicine
    Burlington, Vermont, USA
    Phone:  802-656-4874
    E-mail: gary.stein@uvm.edu

Education

BA, Biology

Hofstra University Hempstead, New York

1965

MS, Biology

Hofstra University, Hempstead, New York

1966

PhD, Biology

University of Vermont, Burlington, VT

1969

Biography

Trained in biology and pathology, Gary Stein has a longstanding dedication to translating mechanistic understanding of cancer biology into clinically relevant investigation with the potential for advancing cancer prevention, early detection and therapy.  Transdisciplinary team research has always been a key approach for Gary Stein – it has been the guiding strategy for his own research group and he actively advocates collaboration in his role as Chair of the University of Vermont Department of Biochemistry and Director of the University of Vermont Cancer Center.

Research Interest

Gene expression, Epigenetic control, Growth and differentiation, Bone biology and Pathology

 

Scientific Activities:

Professional Activities

1975

Chair - Florida Colloquium on Molecular Biology of Gene Expression - 1975.

 

Board of Directors, 1975 - 1987.

1977

Scientific Advisory Committee - The American Cancer Society, Florida Div., 1977 - 1987;

1981

President and Chair of the Board - Southeastern Cancer Research Association, 1981 - 1982.

1982

NIH, Biomedical Sciences Study Section, 1982 - 1984.

1984

NIH, Pathobiochemistry Study Section, 1984 - 1989.

 

Research Committee of the Florida Cancer Control and Research Advisory Board, 1984 - 1987.

1985

Vice Chair, 1984; Chair, 1985 - 1987.

1986

Associate Editor– Cancer Research, 1986-2003.

1988

President - International Cell Cycle Society, 1988.

1989

Vice Chair (1989); Chair (1991) Gordon Conference on "Biological Structure and Gene Expression".

 

Program Committee: American Association for Cancer Research, 1989, 1990, 1997.

 

Scientific Advisory Board - Keystone Symposia, 1989 - 1991.

1990

Program Committee: Vitamin D Workshop, 1990-2006

 

Chairman, Massachusetts Subcommittee of the American Association for Cancer Research Public Education State Committee, 1990 - 2005

1992

Research Advisory Committee, Mayo Clinic, 1990 - 1992.

 

Committee on Interagency Radiation Research and Policy Coordination: Panel on the Health Effects of Low-Frequency Electric and Magnetic Fields, 1992 - 1993.

1993

Co-Chair (1993); Chair (1994) FASEB Research Conference on "Molecular Genetic Basis of Cell and Tissue Structure and Function".

1994

Board of Directors, Advances in Mineral Metabolism, 1994 - 1998.

1995

Consulting Director, Allegheny Research Institute, 1995 - 1998.

 

Co-Chair, Keystone Symposium on "The Nuclear Matrix: Involvement in Replication, Transcription, Gene Splicing and Cellular Regulation", 1995.

 

CoChair, American Society for Bone & Mineral Research Working Group on “Molecular Biology and Pathology of Bone”, 1995-present.

 

Scientific Advisory Board, Cambridge Symposia on Cellular & Molecular Biology, 1995 - present.

1996

Chair, Cambridge Symposium on "Nuclear Structure-Gene Expression Interrelationships", 1996.

 

Chair, Cambridge Symposium on "Cell Cycle Control", 1996.

1997

Co-Chair, Keystone Symposium on "The Nuclear Matrix: Involvement in Gene Organization, Transcription, and Cell Cycle Regulation", 1997.

 

Chair, Grant Research Review Panel, State of Texas Advanced Research Technology Program, 1997-1999.

1998

Advisory Panel for Los Alamos National Laboratory Life Sciences Division, 1998-2008.

1999

Chair, National Research Council Task Group for the Evaluation of the NASA Biotechnology Facility for the International Space Station, 1999 to 2000.

 

Science Advisory Panel: National Space Agency of Japan, 1999.

 

Member, Advisory Board for Mayo Clinic, 1999-2004.

2001

Chair (2001, 2005): FASEB Research Conference on “Nuclear Structure & Cancer”.

 

Advisory Committee, St. Jude Children’s Research Hospital, Memphis, TN, 2001-2011

2002

Member, Advisory Committee, University of Tennessee Cancer Institute, 2002-2010

 

Program Committee: Third International Conference on Osteopontin, 2002.

 

Council of the American Society for Bone & Mineral Research, 2002-2005

 

Chair, Scientific Board of SBARRO Health Research Organization, 2002-present

2005

Consultant: Wyeth Ayerst, Procter & Gamble, Pfizer, Henry Ford Health Care, Loyola Univ. Cancer Ctr.

 

Member, American Association for Cancer Research Grants Committee, 2005-2012

2006

CoChair, National Cancer Institute Workshop on “The Nuclear Microenvironment and Cancer”, February, 2006

2007

Chair, Connecticut Stem Cell Research Peer Review Committee, 2007- 2010

 

Member, Scientific Committee of the Nanoworld Institute, University of Genoa, Italy, 2004-present

 

Member, Scientific Advisory Board: Italian National Cancer Institute, Istituto Nazionale

 

Member, Board of Scientific Advisors, BioRunx Co. Ltd, Korea, 2007 – present

2008

Member, External Advisory Board, UConn NIAMS Core Center for Musculoskeletal Biology and Medicine, 2008

2009

Member, Advisory Committee, American Cancer Society’s Hope Lodge Worcester,Mass, 2009-2012

2010

Member, External Scientific Advisory Board of the Vermont Cancer

 

Member, Scientific Advisory Board, Austrian Science Fund, 2010-present

2011

Chair, Connecticut Stem Cell Research Peer Review Committee, 2011 – present

2012

Member, Advisory Committee, American Cancer Society’s Hope Lodge Burlington, Vermont, 2012-present

2013

Member, External Advisory Board of the Dearmouth Norris Cotton Cancer Center

2014

Scientific Advisory Board, University of Chile, Advanced Centre for Chronic Diseases, Santiago, Chile, 2014 – present

2016

Advisory Committee, GMap Region 1 North, 2016 – present

Professional Honors

1970-1972

Basil O'Connor Faculty Fellow

1992

Elected Fellow, American Association for the Advancement of Science.

 

Featured biography and cover in Cancer Biology and Therapy 6(11)November

1993

Elizabeth Winston Lanier-Kappa Delta Award from the American Academy of

 

OrthopaedicSurgeons and the Orthopaedic Research Society (for defining interrelationships between control of cell growthand tissue specific gene expression).

1997

Brown University Steroid Hormone Research Award.

 

Elected Member: Pakistan Academy of Sciences.

1999

Appointed: The Gerald L. Haidak, M.D. and Zelda S. Haidak Distinguished Professor and Chair of Cell Biology

2007

William F. Neuman Award from the American Society for Bone and Mineral Research (with Jane Lian, fordefining nuclear organization of gene regulatory machinery for biological control and cancer).

2012

Featured biography and cover in International Journal of Oncology 40(3)March 2012

2013

Gideon A. Rodan Excellence In Mentoring Award from American Society of Bone and Mineral Research

2015

Honorary Professorship, Andres Bello University, Santiago, Chile


Publications

2008
  1. Montecino M, Stein GS, Stein JL, Lian JB, van Wijnen AJ, Carvallo L, Marcellini S, Cruzat F, Arriagada G. Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery. Crit Rev Eukaryot Gene Expr. 2008;18(2):163-72.
  2. Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer. J Cell Biochem. 2008 Aug 15;104(6):2016-26.
  3. Luong MX, Smith KP, Stein GS. Human embryonic stem cell registries: value, challenges and opportunities. J Cell Biochem. 2008 Oct 15;105(3):625-32.
  4. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein GS, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention.Expert Rev Anticancer Ther. 2008 June 8(6):967-974.
  5. Stein GS, Davie JR, Knowlton JR, Zaidi SK. Nuclear Microenvironments and Cancer.J Cell Biochem. 2008 Aug 15;104(6):1949-52.
2009
  1. Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. Transcription-factor-mediated epigenetic control of cell fate and lineage commitment. Biochem Cell Biol. 2009 Feb;87(1):1-6.
  2. Smith KP, Luong MX, Stein GS. Pluripotency: toward a gold standard for human ES and iPS cells. J Cell Physiol. 2009 Jul;220(1):21-9.
  3. Altieri DC, Languino LR, Lian JB, Stein JL, Leav I, van Wijnen AJ, Jiang Z, Stein GS. Prostate cancer regulatory networks. J Cell Biochem. 2009 Aug 1;107(5):845-52.
  4. Hassan MQ, Saini S, Gordon J, van Wijnen AJ, Montecino M, Stein JL, Stein GS, Lian JB(2009) Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis.Cells Tissues Organs. 2009;189(1-4):122-125.
  5. Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen A, Montecino M, Young DW, Javed A, Pratap J, Choi J-Y, Ali SA, Pande S, Hassan MQ. Organization, Integration and Assembly of Genetic and Epigenetic Regulatory Machinery in Nuclear Microenvironments:Implications for Biological Control in Cancer. Ann NY Acad Sci. 2009 Feb;1155:4-14.
2010
  1. Stein GS, Stein JL, Van Wijnen AJ, Lian JB, Montecino M, Croce CM, Choi JY, Ali SA, Pande S, Hassan MQ, Zaidi SK, Young DW. Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer. Adv Enzyme Regul. 2010;50(1):160-7.
  2. Borstlap J, Luong MX, Rooke HM, Aran B, Damaschun A, Elstner A, Smith KP, Stein GS, Veiga A. International stem cell registries. In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):242-6.
  3. Zaidi SK, Young DW, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information. Mol Cell Biol. 2010 Oct;30(20):4758-66.
  4. Stein GS, van Wijnen AJ, Imbalzano AN, Montecino M, Zaidi SK, Lian JB, Nickerson JA, Stein JL. Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments. Crit Rev Eukaryot Gene Expr. 2010;20(2):149-55.
  5. Zaidi SK, Young DW, Montecino M, Lian JB, van Wijnen AJ, Stein JL, Stein GS. (2010) Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet.2010 Aug;11(8):583-9.
  6. Zaidi SK, Medina RF, Pockwinse SM, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS.Subnuclear Localization and Intranuclear Trafficking of Transcription Factors.Methods Mol Biol. 2010;647:77-93.
2011
  1. Pratap J, Lian JB, Stein GS. Metastatic bone disease: role of transcription factors and future targets. Bone. 2011 Jan;48(1):30-6.
  2. Stein GS, Stein JL, van Wijnen AJ, Lian JB, Zaidi SK, Nickerson JA, Montecino MA, Young DW. An architectural genetic and epigenetic perspective. Integr Biol (Camb). 2011 Apr;3(4):297-303.
  3. Zaidi SK, Young DW, Montecino M, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Bookmarking the genome: maintenance of epigenetic information. J Biol Chem. 2011 May 27;286(21):18355-61.
2012
  1. Altieri DC, Stein GS, Lian JB, Languino LR. TRAP-1, the mitochondrial Hsp90. Biochim Biophys Acta. 2012 Mar;1823(3):767-73.
  2. Lian JB, Stein GS, van Wijnen AJ, Stein JL, Hassan MQ, Gaur T, Zhang Y. MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol. 2012 Jan 31;8(4):212-27.
  3. Stein GS, Stein JL, van J Wijnen A, Lian JB, Montecino M, Medina R, Kapinas K, Ghule P, Grandy R, Zaidi SK, Becker KA. The architectural organization of human stem cell cycle regulatory machinery. Curr Pharm Des. 2012;18(13):1679-85.
  4. Zaidi SK, Trombly DJ, Dowdy CR, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Epigenetic mechanisms in leukemia. Adv Biol Regul. 2012 Sep;52(3):369-76.
2013
  1. van Wijnen AJ, van de Peppel J, van Leeuwen JP, Lian JB, Stein GS, Westendorf JJ, Oursler MJ, Im HJ, Taipaleenmäki H, Hesse E, Riester S, Kakar S. MicroRNA functions in osteogenesis and dysfunctions in osteoporosis. Curr Osteoporos Rep. 2013 Jun;11(2):72-82.
  2. Zaidi SK, Van Wijnen AJ, Lian JB, Stein JL, Stein GS. Targeting deregulated epigenetic control in cancer. J Cell Physiol. 2013 Nov;228(11):2103-8.
2014
  1. Zaidi SK, Grandy RA, Lopez-Camacho C, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes?Cancer Res. 2014 Jan 15;74(2):420-5.
  2. Browne G, Taipaleenmäki H, Stein GS, Stein JL, Lian JB. MicroRNAs in the control of metastatic bone disease.Trends Endocrinol Metab. 2014 Jun;25(6):320-7.
  3. Tai PW, Zaidi SK, Wu H, Grandy RA, Montecino M, van Wijnen AJ, Lian JB, Stein GS, Stein JL. The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.J Cell Physiol. 2014 Jun;229(6):711-27.
2015
  1. Tye CE, Gordon JA, Martin-Buley LA, Stein JL, Lian JB, Stein GS. Could lncRNAs be the missing links in control of mesenchymal stem cell differentiation? J Cell Physiol. 2015 Mar;230(3):526-34.
  2. Hassan MQ, Tye CE, Stein GS, Lian JB. Non-coding RNAs: Epigenetic regulators of bone development and homeostasis. Bone. 2015 Dec;81:746-56.
2016
  1. Barutcu AR, Fritz AJ, Zaidi SK, van Wijnen AJ, Lian JB, Stein JL, Nickerson JA, Imbalzano AN, Stein GS. C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization. J Cell Physiol. 2016 Jan;231(1):31-5.
  2. Stein GS, Messier TL, Gordon JA, Boyd JR, Tye CE, Lian JB, Stein JL. Oncogenic epigenetic control. Aging (Albany NY). 2016 Apr;8(4):565-6. doi: 10.18632/aging.100940.
  3. VanOudenhove JJ, Grandy RA, Ghule PN, Lian JB, Stein JL, Zaidi SK, Stein GS. Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle. J Cell Physiol. 2016 Aug 17.
Books
  1. "Role of Nonhistone Chromosomal Proteins in the Regulation of Gene Expression"GS Stein, LJ Kleinsmith. Academic Press, New York, 1975.
  2. "Methods in Chromatin and Chromosomal Protein Research"(GS Stein JLL Stein, LJ Kleinsmith, eds.) (Volumes 16-19) in the "Methods in Cell biology Series", Academic Press, New York 1977-1978.
  3. "Recombinant DNA and Cell Proliferation" (GS Stein JLL Stein, eds.)Academic Press, New York, 1984.
  4. "Histone Genes" (GS Stein JLL Stein, WF Marzluff, eds.)John Wiley and Sons, Inc., New York 1984.
  5. "Histones and Other Basic Nuclear Proteins" (L Hnilica, GS Stein JLL Stein, eds.) CRC Press, Boca Raton, 1989.
  6. "Molecular and Cellular Approaches to the Control of Proliferation and Differentiation" (GS Stein JLB Lian, eds.)Academic Press, Orlando, 1992.
  7. "Nuclear Structure and Gene Expression" (R Curtis Bird, GS Stein JLB Lian JL Stein, eds.) Academic Press, 1997.
  8. “Stem Cell Biology & Gene Therapy”, (P Quesenberry, GS Stein, B Forget, S Weissman, eds.) Wiley-Liss, New York, 1998.
  9. “Cell Cycle & Growth Control”, (GS Stein, R Baserga, A Giordano, D Denhardt, eds.) Wiley-Liss, New York, 1998.
  10. “Cell Cycle and Growth Control: Biomolecular Regulation and Cancer”, (GS Stein, AB Pardee, eds.), John Wiley & Sons, Inc., Hoboken NJ, 2004.
  11. “The Biology and Treatment of Cancer: Understanding Cancer” (AB Pardee,GS Stein, eds), John Wiley & Sons, Inc., Hoboken NJ, 2009.
  12. “Human Stem Cell Technology and Biology” (GS Stein, M Borowski, MX Luong, M-J Shi, KP Smith, P Vazquez, eds), Wiley-Blackwell, John Wiley & Sons, Inc., Hoboken, NJ,2011.
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