Robert B Petersen, Phd
Robert B Petersen, Phd
Associate Professor of Pathology

Case Western Reserve University
USA

Education

1981 BS, Biochemistry, University of Minnesota, Magna Cum Laude
1985 Ph.D., Cell and Developmental Biology, University of Minnesota
1986 Postdoctoral Research Fellow, University of Minnesota, Human Genetics Institute
1990 Postdoctoral Research Fellow, The University of Chicago, 

 

Profile

Dr. Petersen received his Ph.D. in Cell and Developmental Biology from the University of Minnesota in 1985. After spending one year in the Institute of Human Genetics at the University of Minnesota as a research associate he moved to the University of Chicago as an NIH postdoctoral fellow in the laboratory of Dr. Susan Lindquist. There he studied posttranscriptional regulation of the heat shock response in the fruit fly, Drosophila melanogaster. At the University of Chicago he attained parenthetical rank as an instructor. He became an Assistant Professor at Case Western Reserve University in the Department of Pathology in 1991 and became an Associate Professor in 1998.

 

Research Interest

The prion protein, a normal cellular protein, is suspected to be a major, if not the only component of the agent that causes the spongiform encephalopathies. During the course of these diseases, the prion protein is "converted" to a protease-resistant form. It is this protease-resistant form that has been attributed with pathogenic potential. Two of these diseases, Creutzfeldt-Jakob disease (CJD) and the recently described fatal familial insomnia (FFI), are propagated as inherited or sporadic forms. The inherited form of FFI shares a mutation of codon 178 of the protein gene with one type of inherited CJD. We have shown that the genetic basis for these two diseases arising from a single mutation lies in a common polymorphism in the prion protein gene. The polymorphism apparently affects the topography of the lesions produced in the two diseases. Since the conformation of the prion protein seems to be at the heart of the pathogenic process, our group is trying to characterize the effect of known mutations in the prion protein gene on the synthesis and metabolism of the protein which result in a variety of distinct neurodegenerative conditions in both cell and animal models. We are also investigating the disease process at a cellular level.

 

Professional Activities:

Faculty Appointment:

2/90 -8/91 Instructor, The University of Chicago, Department of Molecular Genetics and Cell Biology
9/91 –6/98 Assistant Professor, Department of Pathology, Case Western Reserve University, Cleveland, Ohio
7/98 – 6/2014 Associate Professor, Department of Pathology, Case Western Reserve University, Cleveland, Ohio
7/2014-present Professor, Department of Pathology, Case Western Reserve University, Cleveland, Ohio
2001-present Associate Professor, Department of Neuroscience, Case Western Reserve University, Cleveland, Ohio
2011-present Associate Professor, Department of Neurology, Case Western Reserve University, Cleveland, Ohio

Teaching Experience:

1992-98 Phase II, Nervous system, lecturer
1993 Path 516 - Experimental Pathology, lecturer
1997- Path 444- Neurological Diseases: Pathological, Cellular, and Molecular Perspectives. Course director and and lecturer
2006-     Block 2 facilitator
2007 Block 3 facilitator
2012       Nurs 615- lecture on biomarkers in neurodegenerative disease
2013-     Block 6 facilitator

Ad hoc Journal reviewer:

  • American Journal of Human Genetics
  • American Journal of Pathology
  • Biochemistry
  • BioTechniques
  • Brain Pathology
  • Journal of Biological Chemistry
  • The Lancet
  • Neurology
  • Journal of Neuroscience
  • Journal of Alzheimer Disease
  • Clinical Genetics
  • EMBO

Editorial Boards

2009-

Open Pathology Journal

2010- Faculty of 1000, Neurological Disorders, Alzheimer Disease’s
2011- TheScientificWorldJOURNAL
2010- Frontiers in Neurology
2010- Frontiers in Psychiatry
2013 Alzheimer’s and Dementia: the Journal of the Alzheimer’s Association (special Society Journal Reviewer)

Professional Societies:

  • American Association for the Advancement of Science, 1981- present
  • American Society for Microbiology, 1984-present
  • American Society for Neuroscience, 1992- present
  • American Chemical Society, 1995-1996
  • American Society for Cell Biology, 1997- present

Invited Seminars/ PlatformPresentations

  1. Petersen RB, McGarry TJ, DeBenedetti A, Golic KG, Lindquist S.  Translational control during the heat shock response in Drosophila.  ASBC Fed Proc 46: 1958, 1987.
  2. Petersen RB, McGarry TJ, Golic KG, Dellavalle RP, Lindquist S.  Translational control during the heat shock response of Drosophila.  Regulation of Gene Expression by RNA Structure and Anti-messengers, NATO/INSERM Workshop, Les Arcs, Savoie, France, February 1988.
  3. Petersen RB and Lindquist S.  Regulation of the Drosophila Hsp 70 gene.  Translation Control, Cold Springs Harbor, September 1989.
  4. Petersen RB, Vogel J, McGarry TJ, Lindquist S.  Post-transcriptional regulation of the heat shock response in Drosophila.  Post-Transcriptional Control of Gene Expression.  NATO/EEC Workshop, Goslar, W. Germany, 1990.
  5. Petersen RB, Goldfarb L, Tabaton M, Brown P, LeBlanc A, Montagna P, Cortelli P, Monari L, Autilio-Gambetti L, Gajdusek DC, Lugaresi E, Gambetti P.  Fatal familial insomnia and one subtype of familial Creutzfeldt-Jakob disease:  Effect of a polymorphism in the prion protein gene on a pathogenic mutation. Neurology, Vol 43, no. 4.   Am Acad Neurol 45th Annual Meeting, April 1993.
  6. Petersen RB, Tabaton M, LeBlanc A, Montagna P, Cortelli P, Monari L, Autilio-Gambetti L, Lugaresi E, Gambetti P.  Fatal familial insomnia and the expanding family of prion diseases.  Transmissible and Non-Transmissible Neurodegeneration Disorders:  Current Update, Ocho Rios, Jamaica, 1993.
  7. Petersen RB, Richardson SL, Chen SG, Parchi P, Urig CB, Gambetti P.  The prion protein 178Asn mutation alters processing in a transfected human cell line.  Society for Neuroscience, Miami Beach, Florida, November 1994.
  8. Petersen RB, Tresser NJ, Richardson SL, Gali M, Goren H, Gambetti P.  A family with oculoleptomeningeal amyloidosis has a mutation in the transthyretin gene.  American Association of Neuropathologists, San Antonio Texas, June 1995.
  9. Petersen RB.  Effect of PrP mutations on PrP metabolism.  Molecular Biology of Prions and Pathology of Prion Diseases.  Banbury Center CSH Laboratory, November 1995.
  10. Petersen RB.  FFI: genetic and molecular biology findings.  International Workshop on Fatal Familial Insomnia (FFI).  Bologna, Italy, May 1996.
  11. Petersen RB.  The inherited prion diseases and the effects of PrP mutations on the metabolism of PrP.  2nd Annual German American Frontiers of Science Symposium sponsored by the German American Academic Council in conjunction with the U.S. National Academy of Sciences, the Alexander Von Humboldt Foundation, the Max Planck Society and the German Academic Exchange, June 1996
  12. Petersen RB, Capellari S, Chen SG, Parchi P, Singh N, Zanusso G, Gambetti P.  Effect of Pathogenic Mutations on Processing of the Prion Protein in Transfected Cells: Implications for Pathogenesis.  Neurodegenerative Disorders: Common Molecular Mechanisms. Ocho Rios, Jamaica, 1997.
  13. Petersen RB, Smith MA. Effect of Chronic Expression of Heme Oxygenase-1 in Neuronal Cells: Relevance to Neurodegenerative Diseases. American Association of Neuropathologists, Pittsburgh, Pennsylvania, June 1997.
  14. Capellari S, Petersen RB.  Studies of the post-translational modifications to the prion protein.  Neurodegenerative Disorders: Common Molecular Mechanisms, Ocho Rios, Jamaica, 1998.
  15. Petersen RB (lecturer).  Workshop on “Prions and Aggregating Proteins.” Atlanta, GA, June 1998.
  16. Petersen RB (lecturer).  Prions: From Protein to Pathogen.  American Society of Clinical Pathologists Teleconference, June 1998.
  17. Curagen Corp, New Haven, CT. August 1998.
  18. Institute of Human Virology, University of Maryland. Baltimore, MD. November 1998.
  19. Animal Resource Center, Case Western Reserve University, Continuing staff training.  November 20, 1998.
  20. Prion Disease: Current Health Issues.  St. Joseph's Hospital, Milwaukee, WI. May 1999.
  21. Prions: From Protein to Pathogen.  Milwaukee Academy of Medicine. Milwaukee, WI. May 1999.
  22. New Generation- New Approach/ Germany and the USA in an Age of Global History.  Sponsored by the German -American Academic Council Foundation.  Chicago, IL.  November 1999.
  23. Prion disease: an Update. Clinical Pathology Conference Series, CWRU, October, 2000.
  24. Prion Disease: From Protein to Pathogen.  Indiana University of Pennsylvania. Indiana, PA February 9, 2001.
  25. Ruminations on the Origins and Impact of Mad Cow Disease.  CWRU Women’s Alumni Association, September 26, 2001.
  26. Ruminations on the Biology of Prion Disease.  Department of Neuroscience, CWRU, Cleveland, OH.  January 16, 2002.
  27. Diagnostics for TSEs: A Case for Simplicity, Keystone Symposium, Breckenridge, CO. April 5, 2003.
  28. Prion Safety Training, Pathology P3 Staff, Institute of Pathology, Cleveland, OH.  April 15, 2003.
  29. Diagnostics for TSEs: A Case for Simplicity, University of Wyoming, Laramie, WY. April 18, 2003.
  30. Cell Models of Inherited Human Prion Disease, Veterinary Laboratory Agency-Weybridge, New Haw, Addlestone, Surrey, United Kingdom.  August 19, 2003.
  31. Ethics of Using Animals in Research, Department of Pathology, CWRU, Sept. 12, 2003.
  32. Study of Human Prion Diseases. Department of Biology, Andrews University, Berrien Springs, MI.  February 3, 2005.

Honors and Awards

Publications

  1. Petersen RB, Hensel CH, Hackett PB.  Identification of a ribosome-binding site for a leader peptide encoded by Rous sarcoma virus RNA.  J Virol 51: 722-729, 1984.
  2. Petersen RB, Hackett PB.  Characterization of ribosome binding on Rous sarcoma virus RNA in vitro.  J Virol 56: 683-690, 1985.
  3. Hackett PB, Petersen RB, Albericio F, Gunderson SI, Hensel CH, Palmenberg AC, Barany G.  Synthesis in vitro of a seven amino peptide encoded in the lead RNA of Rous sarcoma virus.  J Mol Biol 190: 45-57, 1986.
  4. Petersen R, Lindquist S.  The Drosophila hsp70 message is rapidly degraded at normal temperature and stabilized by heat shock.  Gene 72: 161-168, 1988.
  5. Hensel CH, Petersen RB, Hackett PR.  Effects of alterations in the leader sequence of Rous sarcoma virus RNA on initiation of translation.  J Virol 63: 4986-4990, 1989.
  6. Petersen RB, Moustakas A, Hackett PB.  A mutation in the short 5'-proximal open reading frame on Rous sarcoma virus alters virus production.  J Virol 63; 4787-4796, 1989.
  7. Petersen RB, Lindquist S.  Regulation of HSP70 synthesis by messenger RNA degradation.  Cell Regulation 1: 135-149, 1989.
  8. Yost HJ, Petersen RB, Lindquist S.  RNA metabolism: strategies for regulation in the heat shock response.  Trends In Genetics 6: 233-227, 1990.
  9. Lindquist S, Petersen RB.  Selective translation and degradation of heat shock messenger RNAs in Drosophila.  Enzyme 44: 147-166, 1990.
  10. Hackett RB, Dalton MW, Johnson DP, Petersen RB.  Phylogenetic and physical analysis of the 5'leader RNA sequences of Avian retroviruses.  Nuc Acids Res 19: 6929-6934, 1991.
  11. Petersen RB, Tabaton M, Berg L, Schrank B, Torack RM, Julien J, Vital C, Deleplanque B, Pendlebury WW, Drachman D, Smith TW, Davies P, Martin JJ, Oda M, Montagna P, Autilio-Gambetti L, Lugaresi E, Gambetti P. Analysis of the prion gene in thalamic dementia.  Neurology 42: 1859-1863, 1992.
  12. Goldfarb LG*, Petersen RB*, Tabaton M, Brown P, LeBlanc AC, Montagna P, Cortelli P, Julien J, Vital C, Pendlebury WW, Haltia M, Willis PR, Hauw JJ, McKeever PE, Monari L, B Schrank, Swergold GD, Autilio-Gambetti L, Gajdusek C, Lugaresi E, Gambetti P.  Fatal familial insomnia and familial creutzfeldt jakob disease:  disease phenotype determined by a DNA polymorphism.  Science 258: 806-808, 1992.
    *co-first author, my contribution was experimental design and interpretation including the observation that an intragenic polymorphism could modify the disease phenotype.
  13. Grant MP, Cohen M, Petersen R, Halmagyi GM, McDougall A, Tusa RJ, Leigh RJ.  Abnormal eye movements in Creutzfeldt-Jakob disease.  Ann Neurol 34: 192-187, 1993.
  14. Monari L, Chen SG, Brown P, Parchi P, Petersen RB, Mikol J, Gray F, Cortelli P, Montagna P, Ghetti B, Goldfarb LG, Gajdusek DC, Lugaresi E, Gambetti P, Autilio-Gambetti L.  Fatal Familial Insomnia and Familial Creutzfeldt-Jakob disease: Different prion proteins determined by a DNA polymorphism.  Proc Natl Acad Sci USA 91: 2839-2842, 1994.
  15. Smith MA, Kutty RK, Richey PL, Chader GJ, Wiggert B, Petersen RB, Perry G.  Heme Oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer Disease.  Am J Pathol 145: 42-47, 1994.
  16. Yu J, Nagarajan S, Ueda E, Knez JJ, Petersen RB, Medof ME.  Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells.  Brazilian J Med Biol Res 27: 195-201, 1994.
  17. Dellavalle RP, Petersen RB, Lindquist S.  Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophilia melanogaster.  Mol Cel Biol 14: 3646-3659, 1994.
  18. Petersen RB, Tabaton M, Chen SG, Monari L, Richardson SL, Manetto V, Lanska DJ, Markesbery WR, Currier RD, Autilio-Gambetti, L, Gambetti P.  Familial progressive subcortical gliosis: presence of prions and linkage to chromosome 17.  Neurology 45: 1062-1067, 1995.
  19. Parchi P, Castellani R, Cortelli P, Montagna P, Chen SG, Petersen RB, Lugaresi E, Autilio-Gambetti L, Gambetti P.   Regional distribution of protease resistant prion protein in Fatal Familial Insomnia. Ann Neurol 38: 21-29, 1995.
  20. Premkumar DRD, Smith MA, Richey PL, Petersen RB, Castellani R, Kutty RK, Wiggert B, Perry G, Kalaria RN.  Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer’s disease.  J Neurochem 65:1399-1402, 1995.
  21. Tabaton M, Rolleri M, Masturzo P, Cammarata S, Angelini G, Hansen LA, Saitoh T, Petersen RB, Perry G, Richey P, Gambetti P, Bertolini S.  Apolipoprotein E Î4 allele frequency is not increased in progressive supranuclear palsy.  Neurology 45: 1764-1765, 1995.
  22. Petersen RB, Tresser NJ, Richardson SL, Gali M, Goren H, Gambetti P.  A family with oculoleptomeningeal amyloidosis and dementia has a mutation in the transthyretin gene.  J Neuropathol Exp Neurol 54: 413, 1995.
  23. Sforza E, Montagna P, Tinuper P, Cortelli P, Avoni P, Ferrillo F, Petersen R, Gambetti P, Lugaresi E.  Sleep-wake cycle abnormalities in fatal familial insomnia. Evidence of the role of the thalamus in sleep regulation.  Electroencephalogr Clin Neurophysiol 94: 398-405, 1995.
  24. Petersen RB, Parchi P, Richardson SL, Urig CB, Gambetti P.  Effect of the D178N mutation and the codon 129 polymorphism on the metabolism of the prion protein. J Biol Chem 271: 12661-12668, 1996.
  25. Parchi P, Castellani R, Capellari S, Ghetti B, Young K, Chen SG, Farlow M, Dickson DW Sima AAF, Trojanowski JQ, Petersen RB, Gambetti P.  Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease. Ann Neurol  39: 767-778, 1996.
  26. Petersen RB, Goren H, Cohen M, Richardson SL, Tresser N, Lynn A, Gali M, Estes M, Gambetti, P.  Transthyretin amyloidosis: A new mutation associated with dementia.  Ann Neurol 41(3): 307-313, 1997. 
  27. Parchi P, Capellari S, Chen SG, Petersen RB, Gambetti P, Kopp N, Brown P, Kitamoto T, Tateishi J, Giese A, Kretschmar H.  Typing prion isoforms. Nature 386: 232-233, 1997.
  28. Capellari S, Vital C, Parchi P, Petersen RB, Ferrer X, Jarnier D, Pegoraro E, Gambetti P, Julien J.  Familial prion disease with a 144bp insertion in the prion protein gene in a Basque family.  Neurology 49: 131-141, 1997.
  29. Raymond GJ, Hope J, Kocisko DA, Priola SA, Raymond LD, Bossers A, Ironside J, Will RG, Chen S, Petersen RB, Gambetti P, Rubenstein R, Smits MA, Lansbury PT, Caughey B. Molecular Assessment of the transmissibilities of BSE and scrapie to humans.  Nature 388: 285288, 1997.
  30. Golic MM, Rong Y, Petersen R, Lindquist SL, Golic KG.  FLP-mediated DNA mobilization to specific target sites in Drosophilia chromosomes. Nuc Acids Res 25: 3665-3671, 1997.
  31. Singh N, Zanusso G, Chen SG, Fujioka H, Richardson S, Gambetti P, Petersen RB.  A cell model of inherited prion disease: prion protein aggregation reverted by low temperature.  J Cell Biol 272: 28461-28470, 1997.
  32. Swietnicki W, Petersen RB, Gambetti P, Surewicz WK.  pH-dependent stability and conformation of the recombinant human prion protein PrP (90-231).  J Biol Chem 272: 27517-27520, 1997.
  33. Vital C, Gray F, Vital A, Parchi P, Capellari S, Petersen RB, Ferrer X, Jarnier D, Julien J, Gambetti P.  Prion encephalopathy with insertion of octapeptide repeats: determines the type of cerebellar deposits.  Neuropathol Appl Neurobiol 24: 125-130, 1998.
  34. Zanusso G, Liu D, Ferrari S, Hegyi I, Yin X, Aguzzi A, Hornemann S, Liemann S, Glockshuber R, Manson J, Brown P, Petersen RB, Gambetti P, Sy M-S.  Prion protein expression: analysis with a panel of new monoclonal antibodies.  PNAS USA 95: 8812-8816, 1998.
  35. Chapman J, Cervenáková L, Petersen RB, Lee HS, Estupinan J, Richardson S, Vnencak-Jones CL, Gajdusek DC, Korczyn AD, Brown P, Goldfarb L. APOE in non-Alzheimer amyloidoses: transmissible spongiform encephalopathies. Neurology  51: 548-53, 1998.
  36. Swietnicki W, Petersen RB, Gambetti P, Surewicz.  Familial mutations and the thermodynamic stability of the recombinant human prion protein.  J Biol Chem 273: 31048- 31052, 1998.
  37. Siu IM, Robinson DR, Schwartz S, Kung HJ, Pretlow TG, Petersen RB, Pretlow TP.  The identification of monoclonality in human aberrant crypt foci. Cancer Res  59: 63-66, 1999.
  38. Goedert M, Spillantini MG, Crowther RA, Chen SG, Parchi P, Tabaton M, Lanska DJ, Markesbery WR, Wilhelmson KC, Dickson DW, Petersen RB, Gambetti P.  Tau gene mutation in familial progressive subcortical gliosis. NatMed 4:.454-457, 1999.
  39. Zanusso G, Petersen RB, Jin T, Kanoush R, Sharma Y, Ferrari S, Gambetti P, and Singh N.  Proteosomal degradation and N-terminal protease-resistance of the codon 145 mutant prion protein. J Biol Chem 274: 23396-23404, 1999.
  40. Capellari S, Zaidi SIA, Urig CB,  Perry G, Smith MA, and Petersen RB. Prion protein glycosylation: Sensitivity to Redox Change. J Biol Chem 274: 34846-34850, 1999.
  41. Takeda A, Perry G, Abraham NG, Dywer BE, Kutty RK, Laitinen JT, Petersen RB and Smith MA. Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau.   J. Biol. Chem. 275: 5395-5399, 2000.
  42. Capellari S, Zaidi SIA, Long AC, Kwon EE, and Petersen RB.  The Thr183Ala Mutation, Not the Loss of the First Glycosylation Site, Alters the Physical Properties of the Prion Protein. Journal of Alzheimer disease 2: 27-35, 2000.
  43. Gerst JL, Raina AK, Pirim, A McShea, A, Harris PLR, Siedlak SL, Takeda A, Petersen,RB, Smith MA. Altered Cell-Matrix Associated ADAM Proteins in Alzheimer Disease.  J Neurosci Res 59: 680-684, 2000.
  44. Capellari S, Parchi P, Russo CM, Sanford J, Sy M-S, Gambetti P, Petersen RB.  Effect of the E200K mutation on prion protein metabolism: Comparative study of a cell model and human brain. Am. J Pathol 157: 613-622, 2000.
  45. Kim HT, Russell RL, Raina AK, Harris PLR, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, and Perry G.  Protein Disulfide Isomerase in Alzheimer Disease. Antiox. Redox Signal. 2: 485-489, 2000.
  46. Lu K, Wang W, Xie Z, Wong B-S, Li R, Petersen RB, Sy M-S, Chen SG.  Expression and Structural Characterization of the Recombinant Human Doppel Protein.  Biochemistry 39: 13575-13583, 2000.
  47. Wong B-S, Liu T, Li R, Pan T, Petersen RB, Smith MA, Gambetti P, Perry G, Manson JC, Brown DR, Sy M-S. Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein. J. Neurochem. 76: 1-9, 2001.
  48. Li, R., Liu, D., Zanusso, G., Liu, T., Fayen, J. D., Huang, J. H., Petersen, R. B., Gambetti, P., and Sy, M. S. The expression and potential function of cellular prion protein in human lymphocytes. Cell. Immunol. 207(1): 49-58, 2001.
  49. Liu, T., Li, R., Wong, B. S., Liu, D., Tao, P., Petersen, R. B., Gambetti, P., and Sy, M.S.(2001). PrPC is preferentially expressed on subpopulations of murine hematopoietic cells. J. Immunology 166: 3733-3742, 2001.
  50. Liu, T., Zwingman, T., Li, R., Pan. T., Wong, B. S., Petersen. R.B., Herrup, K., Gambetti, P., and Sy, M. S.  Differential expression of cellular prion protein in the mouse brain as detected with multiple anti-prion monoclonal antibodies. Brain Research 896:118-29, 2001.
  51. Wong, B. S., Liu, T., Paisley, D., Li, R., Pan, T., Chen, S. G., Perry, G., Petersen, R. B., Smith, M. A., Melton, D, W., Gambetti, P., Brown, D. R., and Sy, M. S. (2001). Induction of HO-1 and NOS in Doppel-expressing mice devoid of PrP: Implications for Doppel function. Mol. Cell. Neuro. 17: 768-775, 2001.
  52. Keisuke Hirai, Gjumrakch Aliev, Akihiko Nunomura, Hisashi Fujioka, Robert L. Russell, Craig S. Atwood, Anne B. Johnson, Yvonne Kress, Harry V. Vinters, Massimo Tabaton, Shun Shimohama, Adam D. Cash, Sandra L. Siedlak, Peggy L. R. Harris, Paul K. Jones, Robert B. Petersen, George Perry, and Mark A. Smith. Mitochondrial abnormalities in Alzheimer disease. J Neurosci, 21: 3017-3023, 2001.
  53. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA.  Oxidative Damage is the Earliest Event in Alzheimer Disease.   J Neuropathol Exp Neurol, 60: 759-767, 2001.
  54. Tao Pan T,Monica Colucci,Boon-Seng Wong,Ruliang Li,Tong Liu, Robert B.Petersen,Shu Chen,Pierluigi Gambetti,and Man-Sun Sy. (2001).  Novel differences between two human prion “strains ”revealed by two-dimensional gel electrophoresis.  J. Biol. Chem. 276: 37284-37288, 2001.
  55. Dagvadorj, A, Petersen, R.B., Lee, H.S., Cervenakova, L, Shatunov, A, Budka, H, Brown, P, Gambetti, P, and Goldfarb, L.G.  Spontaneous Mutations in the Prion Protein Gene Causing Transmissible Spongiform Encephalopathy.  Ann. Neurol. 52: 355-359, 2002.
  56. Tao Pan,Boon-Seng Wong,Tong Liu, Ruliang Li,Robert B. Petersen and Man-Sun Sy. Cell-surface prion protein interacts with glycosaminoglycans. Biochem.J 368,81-90, 2002.
  57. Capellari S, Parchi P, Wolff BD, Campbell J, Atkinson R, Posey DM, Petersen RB, and Gambetti P.  Creutzfeldt-Jakob deletion Associated with a deletion of two repeats in the prion protein gene. Neurology 59: 1628-1630, 2002.
  58. Perry, George; Nunomura, Akihiko; Raina, Arun K.; Aliev, Gjumrakch; Siedlak, Sandra L.; Harris, Peggy L. R.; Casadesus, Gemma; Petersen, Robert  B.; Bligh-Glover, William; Balraj, Elizabeth; Petot, Grace; Smith, Mark A. A Metabolic Basis for Alzheimer Disease. Neurochemical Research Volume: 28, Issue: 10, October 2003. pp. 1549-1552.
  59. Chao, M, Zhu, X, Raina, A, Aliev, G, Takeda, A, Petersen, R.B., Nunomura, A., Tabaton, M, Perry, G, Smith, M.A.  Sources contributing to the Initiation and Propagation of Oxidative stress in Alzheimer Disease.  Proc Indian natl Sci Acad  2: 251-260, 2003.
  60. Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PLR, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA. Neuroprotective properties of Bcl-w in Alzheimer disease. J Neurochem 89:1233-1240, 2004.
  61. Lee HG, Ogawa O, Zhu X, O’Neill MJ, Petersen RB, Castellani RJ, Ghanbari H, Perry G, Smith MA. Aberrant expression of metabotrophic glutamate receptor 2 (mGluR2) in the vulnerable neurons of Alzheimer’s disease. Acta Neuropathol 107:365-371, 2004.
  62. Aliev G, Castellani RJ, Petersen RB, Burnstock G, Perry G, and Smith MA.  Pathobiology of familial hypercholesterolemic atherosclerosis. J. Submicrosc. Cytol. Pathol. 36: 225-240, 2004.
  63. Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, Perry G. Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathol (Berl). 110: 232-238, 2005.
  64. Qingzhong Kong, Shenghai Huang, Wenquan Zou, Difernando Vanegas, Meiling Wang, Di Wu, Jue Yuan, Mengjie Zheng, Hua Bai, Huayun Deng, Ken Chen, Allen L. Jenny, Katherine O’Rourke, Ermias D. Belay, Lawrence B. Schonberger, Robert B. Petersen, Man-Sun Sy, Shu G. Chen, and Pierluigi Gambetti.  Chronic Wasting Disease of Elk: Transmissibility to Humans Examined by Transgenic Mouse Models.  The Journal of Neuroscience 25:7944 –7949, 2005.
  65. Zhiliang Xie, Katherine I. O’Rourke, Zhiqian Dong, Allen L. Jenny, Julie A. Langenberg, Ermias D. Belay, Lawrence B. Schonberger, Robert B. Petersen, Wenquan Zou, Qingzhong Kong, Pierluigi Gambetti, and Shu G. Chen.  Chronic wasting disease of elk and deer and Creutzfeldt-Jakob disease: Comparative analysis of the scrapie prion protein J. Biol. Chem. 281: 4199-4206, 2005.
  66. Zaidi SI, Richardson SL, Capellari S, Song L, Smith MA, Ghetti B, Sy MS, Gambetti P, Petersen RB. Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding. J Alzheimers Dis. 7:159-71, 2005
  67. LaFauci G, Carp RI, Meeker HC, Ye X, Kim JI, Natelli M, Cedeno M, Petersen RB, Kascsak R, Rubenstein R.Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC. J Gen Virol. 2006 Dec;87(Pt 12):3773-80.
  68. Xie Z, O'Rourke KI, Dong Z, Jenny AL, Langenberg JA, Belay ED, Schonberger LB, Petersen RB, Zou W, Kong Q, Gambetti P, Chen SG. Chronic wasting disease of elk and deer and Creutzfeldt-Jakob disease: comparative analysis of the scrapie prion protein. J Biol Chem. 2006 Feb 17;281(7):4199-206.
  69. Sparks DL, Connor DJ, Sabbagh MN, Petersen RB, Lopez J, Browne P. Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial.  Acta Neurol Scand Suppl. 2006;185:3-7.
  70. McShea A, Lee HG, Petersen RB, Casadesus G, Vincent I, Linford NJ, Funk JO, Shapiro RA, Smith MA.  Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochim Biophys Acta. 2006 Oct 3; [Epub ahead of print]
  71. Guo L, Ganhdi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen S.  The Parkinson’s disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.  Exp Cell Res, 2007, 313: 3658-3670.
  72. J. Yuan, Z. Donga, J.-P. Guo, J. McGeehan, X. Xiao, J. Wang, I. Cali, P. L. McGeer, N. R. Cashman, R. Bessen, W. K. Surewicz f, G. Knealec, R. B. Petersen,, P. Gambetti and W. Q. Zou, Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions. Cell. Mol. Life Sci. 2008.
  73. Na-Hye Myung, Xiongwei Zhu, Inna I. Kruman, Rudy J. Castellani, Robert B. Petersen, Sandra L. Siedlak, George Perry, Mark A. Smith and Hyoung-gon Lee. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.  AGE, online. June 2008.
  74. Gustaw KA, Garrett MR, Lee H-G, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA.  Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis.  J Neurochem, 2008, 106: 1350-1356.
  75. Shuiliang Yu, Shaoman Yin, Nancy Pham, Poki Wong, Shin-Chung Kang, Robert B. Petersen, Chaoyang Li and Man-Sun Sy. Ligand binding promotes prion protein aggregation – role of the octapeptide repeats.  FEBS, 2008, 275: 5564-5575.
  76. Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA.  Cell cycle re-entry mediated neurodegeneration and its role in the pathogenesis of Alzheimer’s disease.  Neurochem Int 2009 54:84-8.
  77. Myung N-H, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee H-G.  Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. AGE 2008, 30: 209-215.
  78. Friedland RP, Petersen RB and Rubenstein R.  Bovine Spongiform Encephalopathy and Aquaculture. JAD 2009, 17: 277-279.
  79. Singh A, Kong Q, Luo X, Petersen RB, Meyerson H, Singh N. Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.  PLoS One. 2009 Jul 1;4(7):e6115.
  80. Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. Am J Pathol. 2009 174:891-7. Epub 2009 Jan 22.
  81. Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, Fernandez-Funez P, Lee HG, Smith MA, Petersen RB, Guo JP. (2011) Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.  J Biol Chem. 286:15095-105.
  82. Zou RS, Fujioka H, Guo J-P, Xiao X, Shimoji M, Kong C, Chen C, Tasnadi M, Voma C, Yuan J, Moudjou M, Laude H, Petersen RB, Zou W-Q.  (2011) Characterization of spontaneously generated prion-like conformers in cultured cells. Aging 3: 968-84.
  83. Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG. (2012) Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. Hum Mol Genet. 21: 1134-44.
  84. Santos RX, Correia SS, Zhu X, Lee HG, Petersen RB, Nunomura A, Perry G, Smith MA, Moreira PI. (2012) Nuclear and Mitochondrial DNA Oxidation in Alzheimer's Disease. Free Radic Res. 46: 565-576.
  85. Reed-Cossairt A, Zhu X, Lee HG, Reed C, Perry G, Petersen RB. Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome. Curr Gerontol Geriatr Res. 2012:929734.
  86. Rubenstein R, Bulgin MS, Chang B, Sorensen-Melson S, Petersen RB, LaFauci G. (2012) PrP(Sc) detection and infectivity in semen from scrapie-infected sheep. J Gen Virol. 93(Pt 6):1375-83.
  87. Wang X, Snape M, Klann E, Stone JG, Singh A, Petersen RB, Castellani RJ, Casadesus G, Smith MA, Zhu X.  (2012)  Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. J Neurochem. 121(4):672-9.
  88. Rodrigues R, Smith MA, Wang X, Perry G, Lee HG, Zhu X, Petersen RB. (2012) Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress.  Future Neurol. 7:287-305.
  89. Perry G, Phelix CF, Nunomura A, Colom LV, Castellani RJ, Petersen RB, Lee HG, Zhu X. Untangling the vascular web from Alzheimer disease and oxidative stress. Can J Neurol Sci. 2012 39:4.
  90. Kudo W, Petersen RB and Lee H-G  (2013) Cellular prion protein and Alzheimer disease: Link to oligomeric amyloid-β and neuronal cell death.  Prion 7:114-116
  91. Xiao X, Yuan J, Haïk S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ. (2013) Glycoform-selective prion formation in sporadic and familial forms of prion disease.  PLoS One. 2013;8(3):e58786
  92. Ding Y, Li J, Liu S, Zhang L, Xiao H, Li J, Chen H, Petersen RB, Huang K, Zheng L. (2013)  DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding. Int J Obes (Lond). 2013 May 27. doi: 10.1038/ijo.2013.98. [Epub ahead of print]
  93. Cheng B, Gong H, Xiao H, Petersen RB, Zheng L, Huang K.  Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases.  Biochim Biophys Acta. 2013 1830:4860-71.
  94. Yuan J, Zhan YA, Abskharon R, Xiao X, Martinez MC, Zhou X, Kneale G, Mikol J, Lehmann S, Surewicz WK, Castilla J, Steyaert J, Zhang S, Kong Q, Petersen RB, Wohlkonig A, Zou WQ. (2013) Recombinant Human Prion Protein Inhibits Prion Propagation in vitro.  Sci Rep. 3:2911.
  95. Zhao L, Guo H, Chen H, Petersen RB, Zheng L, Peng A, Huang K.  (2013) Effect of Liraglutide on endoplasmic reticulum stress in diabetes.  Biochem Biophys Res Commun. Oct 12. doi:pii: S0006-291X(13)01686-0. 10.1016/j.bbrc.2013.10.026. [Epub ahead of print]

Book Chapters and Invited Articles:

  1. Yost HJ, Petersen RB, Lindquist S.  Post-transcriptional regulation of heat shock protein synthesis in Drosophila.  In:  Stress Proteins in Biology and Medicine, Cold Spring Harbor Press, Cold Spring Harbor, New York, pp. 379-409, 1990.
  2. Gambetti P, Petersen R, Monari L, Tabaton M, Cortelli P, Montagna P, Lugaresi E, Autilio-Gambetti L.  Fatal familial insomnia and the widening spectrum of prion diseases.  In:  Spongiform Encephalopathies.  Allen I (ed).  British Medical Bulletin, Vol 49, No. 4, pp. 980-994, 1993.
  3. Gambetti P, Medori R, Manetto, V, Petersen R, LeBlanc A, Tritschler H.J., Monari L, Tabaton M., Autilio-Gambetti L.  Fatal Familial Insomnia: A prion disease with distinctive  histopathological and genotypic features.  In:  Fatal Familial Insomnia:  Inherited Prion Diseases, Sleep and the Thalamus.  Guilleminault C, Lugaresi P, Montagna P and Gambetti P (eds).  Raven Press, 1994.
  4. Petersen RB, Goldfarb L, Tabaton M, Brown P, Cortelli P, Montagna P, Autilio-Gambetti L, Gajdusek DC, Lugaresi E, Gambetti P.  A novel mechanism of phenotypic heterogeneity demonstrated by the effect of a polymorphism on a pathogenic mutation in the PRNP (Prion Protein Gene).  In:  Molecular Neurobiology, Vol 8, pp. 99-103, 1994.
  5. Gambetti P, Petersen R, Tabaton M, Gallassi R, Lugaresi E.  Thalamic Dementia:  Relationship with Fatal Familial Insomnia.  The Primary Degenerative Dementias Other than Alzheimer’s Disease. Clark A.W. (ed.).
  6. Petersen RB, Richardson SL, Urig CB, Gambetti P.  Analysis of the prion protein 178Asn mutation linked to Fatal Familial Insomnia and Creutzfeldt-Jakob Disease in a transfected human cell line.  In:  Research Advance in Alzheimer’s Disease and Related Disorders.  Iqbal K, Mortimer J, Winblad B, Wisniewski H (eds).  John Wiley & Sons, Ltd., Sussex, England, pp. 783-787, 1995.         
  7. Gambetti P, Parchi P, Petersen RB, Chen SG, Lugaresi E.  Fatal Familial Insomnia and Familial Creutzfeldt-Jakob Disease:  Clinical, Pathological and Molecular Features.  Brain Pathol 5: 43-51, 1995.
  8. Parchi P, Petersen RB, Gambetti P.  New Topics in familial prion diseases.  Seminars in Virology 7: 181-187, 1996.
  9. Petersen RB, Parchi P, Capellari S, Gambetti P.  Fatal Familial Insomnia, Creutzfeldt-Jakob disease and the Prion Protein.   In: Protein Dysfunction in Human Genetic Disease.  Swallow D and Edwards Y (eds), BIOS Scientific Publishers, Oxford, England, pp. 243-254, 1997.
  10. Parchi P, Capellari S, Zanusso G, Singh N, Gambetti P, Petersen RB.  Inherited prion disease: Molecular pathology and Cell Models.  In:  Prions: Molecular and Cellular Biology.  Harris DF (ed).  Horizon Scientific Press, Wymondham, UK, pp. 63-81, 1998.
  11. Parchi P, Petersen RB, Chen SG, Autilio-Gambetti L, Capellari S, Monari L, Cortelli P, Montagna P, Lugaresi E, Gambetti P.  Molecular Pathology of Fatal Familial Insomnia. Brain Pathol 8: 539-548, 1998.
  12. Gambetti P, Petersen RB, Parchi P, Chen SG, Capellari S, Goldfarb L, Gabizon R, Montagna P, Lugaresi E, Piccardo P, Ghetti B.  Inherited prion diseases.  Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 509-583, 1999.
  13. Petersen RB.  Antemortem diagnosis of variant Creutzfeldt-Jakob disease.  Lancet  353: 163-164, 1999.
  14. Wong B-S, Pan T, Liu T, Li R, Petersen RB, Jones IM, Gambetti P, Brown DR, Sy M-S. Prion Disease: A loss of Anti-oxidant Function?  BBRC 275: 249-252, 2000.
  15. Takeda, A., Itoyama, Y., Kimpara, T., Kutty, R.K., Abraham, N.G., Dwyer, B.E., Petersen, R.B., Perry, G. and Smith, M.A. (2002) Role of heme catabolism in neurodegenerative diseases. In Heme Oxygenase in Biology and Medicine, Abraham, N.G. (Ed) and Alam, J. and Nath, K. (Assoc Eds). Kluwer Academic/Plenum Publishers, New York, pp 135-143.
  16. Castellani, R.J., Atwood, C.S., Perry, G., Petersen, R.B. and Smith, M.A. (2002) Prion and Alzheimer diseases: the road to pathogenesis is paved with copper. In Prion Diseases and Copper Metabolism: BSE, Scrapie and CJD Research, Brown, D.R. (Ed.), Horwood Publishing, pp 96-101 and 195-250.
  17. Perry, G., Taddeo, M.A., Petersen, R.B., Castellani, R.J., Harris, P.L.R., Siedlak, S.L., Cash, A.D., Liu, Q., Nunomura, A., Atwood, C.S., and Smith, M.A. (2003) Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. Biometals, 16, 77-81.
  18. Zhu X, Raina AK, Lee HG, Chao M, Nunomura A, Tabaton M, Petersen RB, Perry G, Smith MA. Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways. /Antiox Redox Signal/ *5*:571-576, 2003.
  19. Lee HG, Petersen RB, Zagorski MG, Perry G, Smith MA. Amyloids, aggregates and neuronal inclusions: good news for neurons? /Curr Med Chem – Immun Endoc Metab Agents /*3*:293-298, 2003.
  20. Lee HG, Petersen RB, Zhu X, Honda K, Aliev G, Smith MA, Perry G. Will preventing protein aggregates live up to its promise in neurodegenerative diseases? /Brain Pathol /*13*:630-638, 2003.
  21. Casadesus G, Smith MA, Zhu X, Aliev, G., Cash, A.D., Honda K, Petersen RB, Perry G. Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. J Alzheimers Dis 6, 165-169, 2004.
  22. Honda K, Casadesus G, Petersen RB, Perry G, Smith MA. Oxidative stress and redox-active iron in Alzheimer’s disease. Ann NY Acad Sci 1012:179-182, 2004.
  23. Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry, Smith MA, Zhu X.  Oxidative Stress Associated Signal Transduction Cascades in Alzheimer Disease. In Oxidative Neural Injury, SC Veasey editor, Humana Press, pp 121-136, 2009.
  24. Petersen, R.B., Castellani, R.J., Nunomura, A., Zhu, X., Lee, H.G., Perry, G. and Smith, M.A. (2009) Comment: A short circuit to Alzheimer disease. Swan Alzheimer Knowledge Base, http://hypothesis.alzforum.org/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:comment:174e9b94-0c4b-4987-92d3-658eeead58c1&referrerLinkLabel=structuredcommentslist.
  25. Petersen, R.B. and Smith, M.A. (2009) Faculty of 1000 Medicine: evaluations for Laurén J et al Nature 2009 Feb 26 457 (7233): 1128-1132, http://f1000medicine.com/article/id/1165083/evaluation
  26. Mondragon-Rodriguez S, Garcia-Sierra F, Casadesus G, Lee H-G, Petersen RB, Perry G, Zhu X, Smith MA (2011) Oxidative Stress and Alzheimer Disease: Mechanisms and Therapeutic Opportunities. J.Blass (ed) Neurochemical Mechanisms in Disease, Advances in Neurobiology.  Springer Science+Business Media
  27. Rubenstein R and Petersen RB (2013) Modeling the Cell Biology of Prions. W.-Q. Zou and P. Gambetti (eds.), Prions and Diseases: Volume 1, Physiology and Pathophysiology, Springer Science+Business Media New York.

Abstracts:

  1. Hensel CH, Petersen RB, Hackett PB.  Mutations affecting inhibition of translation on Rous sarcoma virus mRNA.   Am Soc Microbiol, Annual Meeting, 1985.
  2. Hackett PB, Petersen RB, Hensel CH.  Synthesis of a heptapeptide encoded in the leader RNA of Rous sarcoma virus may be important in the retrovirus life cycle.  RNA Tumor Viruses, CSH, June, 1985.
  3. Moustakas A, Petersen RB, Hensel CH, Hackett PB.  Inactivation of an open reading frame of the Rous sarcoma virus leader RNA affects transformation of chicken embryo fibroblasts.  RNA Tumor Viruses CSH, June, 1987.
  4. Hackett PB, Hensel CH, Moustakas A, Petersen RB.  Regulation of gene expression by a short open reading frame in the 5' leader sequence of Rous sarcoma virus RNA.  Int Meeting Biochem, Beijing, China, August, 1987.
  5. Hackett PB, Petersen RB, Moustakas A, Hensel CH.  Translation of an open reading frame of the Rous sarcoma virus leader RNA affects transformation of chicken embryo fibroblasts.  Translational Control, CSH, September, 1987.
  6. Lindquist S, Borkovich K, Fortin M, Golic K, Petersen R, Rossi J, Susek R, Yost J.  Studies on the function and regulation of hsps in yeast and fruit flies.  J Cell Biochem Suppl (12 Part D), 251, 1988.
  7. Petersen RB, Tabaton M, Medori R, Tritschler HJ, Berg L, Schrank B, Torack RM, Julien J, Vital C, Pendlebury W, Montagna P, Lugaresi E, Gambetti P.  Familial thalamic dementia and fatal familial insomnia are prion diseases with the same mutation.  Third International Conference on Alzheimer's Disease and Related Disorders, Abano Terme (Padova), Italy, July 12-17, 1992.
  8. Petersen RB, Goldfarb L, Tabaton M, Brown P, LeBlanc A, Montagna P, Cortelli P, Monari L, Autilio-Gambetti L, Gajdusek DC, Lugaresi E, Gambetti P.  Fatal familial insomnia and one subtype of familial Creutzfeldt-Jakob disease:  Effect of a polymorphism on a pathogenic mutation in the prion protein.  FASEB J  7: A627, 1993.
  9. Tabaton M, Petersen RB, Monari L, Chen S, Lanska DJ, Markesbery WR, Currier RD, Manetto V, Autilio-Gambetti L, Gambetti P.  Progressive subcortical gliosis:  A new prion protein disease.  Society for Neuroscience, Washington, D.C., November 7-12, 1993.
  10. Monari L, Chen SG, Petersen R, Tabaton M, Gray F, Gambetti P, Autilio-Gambetti L.  Differences in the protease-resistant prion protein fragments among human prion disease.  Society for Neuroscience, Washington, D.C., November 7-12, 1993.
  11. Petersen RB, Richardson SL, Urig CB, Autilio-Gambetti L, Gambetti P.  Analysis of the prion protein 178Asn mutation linked to Fatal Familial Insomnia and Creutzfeldt-Jakob disease in a transfected human cell line.  Fourth International Conference on Alzheimer's Disease and Related Disorders, Minneapolis, Minnesota, July 29 - August 3, 1994.
  12. Chen SG, Petersen R, Parchi P, Monari L, Wang W, Gambetti P, Gambetti L.  Truncated forms of prion protein in human brain and cell lines.  Fourth International Conference on Alzheimer's Disease and Related Disorders, Minneapolis, Minnesota, July 29 - August 3, 1994.
  13. Chen SG, Monari L, Brown P, Parchi P, Petersen RB, Mikol J, Gray F, Cortelli P, Montagna P, Ghetti B, Goldfarb LG, Gajdusek DC, Lugaresi E, Gambetti P, Gambetti LA.  Fatal familial insomnia and familial Creutzfeldt-Jakob disease: Different prion proteins determined by a DNA polymorphism.  Fourth International Conference on Alzheimer's Disease and Related Disorders, Minneapolis, Minnesota, July 29 - August 3, 1994.
  14. Petersen RB, Richardson SL, Chen SG, Parchi P, Urig CB, Gambetti P.  The prion protein 178Asn mutation alters processing in a transfected human cell line.  Society for Neuroscience, Miami Beach, Florida, November 13-18, 1994.
  15. Chen SG, Parchi P, Petersen R, Monari L, Wang W, Gambetti P, Gambetti L.  Truncated forms of prion protein in normal and pathological human brains. Society for Neuroscience, Miami Beach, Florida, November 13-18, 1994.
  16. Smith, M.A., Richey, P.L., Kutty, R.K., Chader, G.J., Wiggert, B., Petersen, R.B. and Perry, G. (1994) Heme oxygenase-1 in Alzheimer disease pathology. Neurodegenerative Disorders: Common Molecular Mechanisms, 22.
  17. Petersen RB, Richardson SL, Urig CB, Parchi P, Zaidi SIA, Singh N, Chen SG, Gambetti P.  Affect of mutations in the prion protein on processing in transfected human cell lines.  Neurodegenerative Disorders:  Common Molecular Mechanisms, Ocho Rios Jamaica 1995. 
  18. Petersen RB, Tresser NJ, Richardson SL, Gali M, Goren H, Gambetti P.  A family with oculoleptomeningeal amyloidosis has a mutation in the transthyretin gene.  American Association of Neuropathologists, San Antonio Texas, June 1995.
  19. Smith MA, Premkumar DRD, Richey PL, Petersen RB, Castellani R, Kutty RK, Wiggert B, Perry G, Kalaria R.  Induction of heme oxygenase-1 mRNA in neocortex in Alzheimer disease. Neurodegenerative Disease ‘95: Molecular and Cellular Mechanisms and Therapeutic Advances, 1995.
  20. Singh N, Zanusso G, Gambetti P, Petersen RB.  Cell culture models of prion diseases.  The American Society for Cell Biology, 1995.
  21. Petersen RB, Richardson SL, Urig CB, Parchi P, Singh N, Zaidi SIA, Capellari S, Gambetti P.  Mutations in the prion protein alter processing in transfected human cells.  Society for Neuroscience, San Diego, California, November 11-16, 1995.
  22. Parchi P, Castellani R, Capellari S, Chen SG, Petersen RB, Young K, Farlow MR, Trojanowski JQ, Sima A, Ghetti B, Gambetti P.  Molecular pathology of sporadic Creutzfeldt-Jakob disease: correlation with clinicopathological features and prion protein genotype. Society for Neuroscience, San Diego, California, November 11-16, 1995.
  23. Zanusso GL, Singh N, Gambetti P, Petersen RB.  In vitro study of prion protein processing in a subtype of GSS. 32nd Annual Meeting of the Italian Neuropathological Association, Parma, Italy, June 3-5, 1996.
  24. Petersen RB, Capellari S, Chen SG, Parchi P, Singh N, Zanusso G, Gambetti P. Inherited prion disease: a model system for studying protein processing. 6th International Congress on Cell Biology, 36th American Society for Cell Biology Annual Meeting, San Francisco, California, December 7-11, 1996.
  25. Feldman H, Green GJ, McGillivray BC, Berry K, Petersen RB, Gambetti P. Familial Insomnia: A Chinese kindred with the 178 Asparagine Prion protein gene mutation and 129 methionine homozygosity.  Canadian Congress of Neurological Sciences, 31st Annual Meeting, London, Ontario, Canada, June 25-29, 1996.
  26. Capellari S, Parchi P, Landis DD, Julien J, Vital C, Dickson DD, Richardson SL, Petersen RB, Gambetti P.  Prion encephalopathy with octapeptide repeats insertion: a study of three families.  American Association of Neurology, 1997.
  27. Vital C, Gray F, Vital A, Parchi P, Capellari S, Petersen RB, Julien J, Gambetti P.  Cerebellar modifications at immunohistochemical study (IHC) in 3 cases of prion encephalopathy with octapeptide repeat insertion (OPRI). American Association of Neuropathologists, Pittsburgh, Pennsylvania, June 1997.
  28. Petersen RB, Smith MA.  Effect of chronic expression of heme oxygenase-1 in neuronal cells: relevance to neurodegenerative diseases. American Association of Neuropathologists, Pittsburgh, Pennsylvania, June 1997.
  29. Zanusso G, Petersen RB, Kanoush R, Gambetti P, Singh N.  Mutant prion protein in Gerstmann-Sträussler-Scheinker disease Y145amber is degraded by the proteasomal pathway. 37th American Society for Cell Biology, 1997.
  30. Capellari S, Gambetti P, Petersen RB.  Inter-relationship of the post-translational modifications to the prion protein.  37th American Society for Cell Biology, 1997.
  31. Lu, S.-Y., Smith, M.A., Abraham, N.G., Nishimura, R.N., Laitinen, J.T., Petersen, R.B. and Dwyer, B.E. (1997) H2O2 injury in neuroblastoma cells over- and under expressing heme oxygenase-1. Soc. Neurosci. Abst., 23, 2213.
  32. Jin T, Zanusso G, Jing Y, Petersen RB, Gambetti P, Singh N.  An abnormal isoform of the mutant prion protein in GSS Q217R is bound to the chaperone BiP. Society for Neuroscience, Los Angeles, California, November 7-12, 1998.
  33. Perry G, Hirai K, Nunomura A, Petersen RB, Smith M.  Neuronal mitochondrial proliferation in Alzheimer disease: Evidence for a fundamental metabolic abnormality. Mitochondria: Genetics, Health, and Disease.  NIH Bethesda, MD. December 2, 1998.
  34. Smith, M.A., Abraham, N., and Petersen, R.B. (1998) Stable overexpression of heme oxygenase-1 in neuronal cells results in cytoskeletal abnormalities and proliferative changes. J. Neurochem., 70 (Suppl 1), S45.
  35. Perry, G., Nunomura, A., Hirai, K., Petersen, R.B., and Smith, M.A. (1998) Is Alzheimer disease a metabolic disorder? Molecular and Genomic Effects of Tissue Oxygen Deprivation in Sleep Apnea, 6.
  36. Pretlow TP, Siu I-M, Robinson DR, Schwartz S, Kung H-J, Petersen RB, Pretlow TG.  Monoclonality in human aberrant crypt foci (ACF).  AACR Annual Meeting, April 10-14, 1999.
  37. Petersen RB, Capellari S, Zaidi SIA, Singh N, Gambetti P. Processing of the human prion protein.  Keystone symposia April 10-16, 1999.
  38. Takeda A., Petersen, RB, Smith MA.  Effect of chronic expression of heme oxygenase -1 in neuronal cells: Possible interaction with Tau. American Association of Neuropathologists, Portland, Oregon, June 1999.
  39. Jin T, Zanusso G, Jing Y, Petersen RB, Gambetti P, Singh N. Atypical fragments of the mutant prion protein in GSS Q217R, Y145Stop, and P102L are degraded by the proteosomal pathway and accumulate in distinct intracellular compartments. Society for Neuroscience, Miami Beach, Florida, October 1999. 
  40. Lee, H., Ogawa, O., Zhu, X., Castellani, R.J., Ghanbari, H., Petersen, R.B., Perry, G. and Smith, M.A. (2002) Aberrant expression of metabotropic glutamate receptor 2 (mGluR2) in the vulnerable neurons in Alzheimer’s disease. Soc. Neurosci. Abstr., Program No. 785.16.
  41. Zhu, X., Wang, Y., Ogawa, O., Lee, H.G., Raina, A.K., Fujioka, H., Shimohama, S., Atwood, C.S., Petersen, R.B., Perry, G. and Smith, M.A. (2002) Bcl-w plays a key neuroprotective role in Alzheimer’s disease. J. Neurochem., 81 (Suppl 1), 76.
  42. Smith, M.A., Takeda, A., Abraham, N.G., Dwyer, B.E., Kutty, R.K., Laitinen, J.T., Petersen, R.B. and Perry, G. (2002) Heme oxygenase and tau: synergistic antioxidants in neuronal cells. 2nd International Conference on Heme Oxygenase (HO/CO) and Cellular Stress Response, in press.
  43. Lee, H.G., Ogawa, O., Zhu, X., O’Neill, M.J., Ghanbari, H., Petersen, R.B., Perry, G. and Smith, M.A. (2003) Aberrant expression of metabotrophic glutamate receptor 2 in the vulnerable neurons in Alzheimer disease.  Research ShowCASE 2003, 70.
  44. Smith, M.A., Zhu, X., Casadesus, G., Aliev, G., Ogawa, O., Nunomura, A., Takeda, A., Joseph, J.A., Petersen, R.B. and Perry, G. (2003) Alzheimer disease: causes, consequences, and surprises. Biogerontology 4 (Suppl 1), 88-89.
  45. Petersen, R., Smith, M.A., Richardson, S.L., Perry, G. and Lee, H.G. (2006) Oxidative stress and prion protein mutations. Research ShowCASE 2006, 495.
  46. Lee, H.G., Smith, M.A., Richardson, S.L., Perry, G. and Petersen, R.B. (2006) Oxidative stress and prion protein mutations. J. Neurochem., 98 (Suppl. 1), 27.
  47. Lee, H.G., Smith, M.A., Richardson, S.L., Perry, G. and Petersen, R.B. (2006) Oxidative stress and prion protein mutations. Alzheimers Dementia, 2 (Suppl. 1):S485.
  48. Nunomura, A., Lee, H.G., Casadesus, G., Petersen, R.B., Richardson, S.L., Chiba, S., Yamaguchi, H., Perry, G. and Smith, M.A. (2007) Neuronal cell cycle re-entry induces intraneuronal Aβ accumulation in CaMKII-MYC mice. Neuropathology 27, 205.
  49. Lee, H.G., Casadesus, G., Richardson, S.L., Perry, G., Petersen, R.B. and Smith, M.A. (2007) Neurodegenerative phenotypes induced by the expression of MYC in the brain. Research ShowCASE 2007, 356.
  50. Nunomura, A., Lee, H.G., Casadesus, G., Petersen, R.B., Richardson, S.L., Chiba, S., Yamaguchi, H., Perry, G. and Smith, M.A. (2007) Neuronal cell cycle re-entry induces intraneuronal Aβ accumulation in CaMKII-MYC mice. Neuropathology 27 (Suppl.), 166.
  51. Lee, H.G., Casadesus, G., Richardson, S.L., McShea, A., Perry, G., Petersen, R.B. and Smith, M.A. (2007) The development of novel cellular and transgenic models of neuronal cell cycle re-entry: relevance to Alzheimer disease. 36th Annual Meeting of the American Aging Association, 63-64.
  52. Nunomura, A., Lee, H.G., Casadesus, G., Petersen, R.B., Richardson, S.L., Yamaguchi, H., Chiba, S., Perry, G. and Smith, M.A. (2007) Cell cycle re-entry induces intraneuronal amyloid-β accumulation in CaMKII-MYC mice: pathogenic implication for the mitotic abnormality in Alzheimer’s disease. Int. Psychogeriatr., 19 (Suppl. 1), 154-155.
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