Education

Profile

Dr. Taspinar is an Associate Professor in the Department of Medical Biology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.  Dr. Taspinar, obtained his undergraduate degrees from Yuzuncu Yil University (YYU) and his medical and graduate training in PhD program at Ankara University, Faculty of Medicine, Department of Medical Biology, Ankara, Turkey.  Afterwards, he continued his postdoctoral training in molecular genetics of brain tumors at Faculty of Medicine in YYU.
The research focus of our team is to investigate all genes that may play role on the mechanisms of chemotherapeutic resistance in Glioblastoma (GB) and other types of brain tumors in terms of clinical, genetic and epigenetics status. Our current work includes finding novel biomarkers that able to show the results of clinical therapy before chemotherapy treatment in GB patients.  In addition, another focus of investigation is to development of novel therapy model by using natural and synthetic chemicals in primary cells of these patients. With this purpose, He is working at several national and international projects. Dr Taspinar and his team are performing primary culture from fresh tissues of GB patients and other molecular genetics techniques such as DNA damage (comet, tunel), RT-PCR, western Blottting, etc…

Research Interest

• Brain tumors
• Glioblastoma
• Chemotherapeutic resistance
• Novel approach for cancer therapy

Professional Activities:

Honors and Awards

Publications

1. Ilgaz NS, Aydos OS, Karadag A, Taspinar M, Eryılmaz OG, Sunguroğlu A. Impact of follicle-stimulating hormone receptor variants in female infertility. J Assist Reprod Genet. 32(11), 1659-1668., Doi: 10.1007/s10815-015-0572-5.
2. Ugur HC, Taspinar M, Ilgaz S, Sert F, Canpinar H, Rey JA, Castresana JS, Sunguroglu A. (2014).Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination. Mol Biol Rep. 2014 Feb;41(2):697-703. doi: 10.1007/s11033-013-2908-5.
3. Taspinar M, Gerceker D, Cetin N, Karasartova D, Türegün B, Ozturk S, Sahin F (2013).HHV-6 is ubiquitously found microorganism in tonsils and adenoid tissues of healthy peopleusing western blot. New Microbiologica 36(3):251-6.
4. Bucak MN, Ataman MB, Başpınar N, Uysal O, Taşpınar M, Bilgili A, Oztürk C,Güngör S, Inanç ME, Akal E (2015). Lycopene and resveratrol improve post-thaw bull sperm parameters: sperm motility, mitochondrial activity and DNA integrity. Andrologia, 47(5):545-552. doi: 10.1111/and.12301.
5. Aras Z, Taspinar M, Aydın İ. A novel polymerase chain reaction to detect Brucella canis in Dogs. (2015). Kafkas Uni. Vet Fak.Derg, 21 (2):169-172. 
6. Bucak MN, Keskin N, Taşpınar M, Çoyan K, Başpınar N, Cenariu MC, Öztürk C, Kurşunlu AN (2013). Raffinose and hypotaurine improve 1 the post-thawed Merino ram sperm parameters. Cryobiology,  67(1):34-9. doi: 10.1016/j.cryobiol.2013.04.007.
7. Atinkaya C, Taspinar M, Sakiragaoglu O, Oz G, Yazici U, Oztuna D, Tastepe I, Sunguroglu A (2012). The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer: A case control study. Human Experimental Toxicology, 31(10):1074-80, doi:10.1177/0960327111428630.
8. Taspinar M, Ilgaz S,  Ozdemir M, Ozkan T, Oztuna D, Canpinar H, Rey JA, Sunguroglu A, Castresana JS, Ugur HC (2013). Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells. Tumor Biology. 34(3):1935-47. doi: 10.1007/s13277-013-0738-7.
9. Taspinar M, Aydos S, Sakiragaoglu O, Duzen I.V, Yalcinkaya A,  Oztuna D, Bardakci H, Tutar E, Sunguroglu A. (2012). Impact of genetic variations of CYP1A1, GSTT1 and GSTM1 genes on the risk of coronary arter disease. DNA and Cell Biology, 31(2):211-8.doi: 10.1089/dna.2011.1252
10. Coyan K, Bucak MN, Başpınar N, Taspinar M, Aydos S. (2012). Ergothioneine attenuates the DNA damage of post-thawed Merino ram sperm.106; 165-167. doi:10.1016/j.smallrumres.2012.02.002
11. Atinkaya C, Bilgiç E, Yazıcı Ü, Taşpınar M, Öz G, Yürüker S, Özpolat B, Taştepe İ. (2011) Küçük Hücreli Dışı Akciğer Kanserli Hastalarda CD14 ve CD44s Ekspresyonu. Türkiye Klinikleri J Med Sci, Tıp Bilimleri Dergisi, 31(3):518-524. doi:10.5336/medsci.2010-16943.
12. Bucak MN, Tuncer PB, Sarıozkan S, Başpınar N, Taspinar M, Akalın PP, Coyan K, Buyukleblebici S, Aydos S, Ilgaz S.(2010). Effects of antioxidants on post-thawed bovine sperm and oxidative stress parameters: Antioxidants protect DNA integrity against cryodamage. Cryobiology, 61(3):248-53. doi:10.1016/j.cryobiol.2010.09.001.
13. Aydos S, Taspinar M, Sunguroglu A, Aydos K.(2009). Association of CYP1A1 and GST Polymorphisms with Male Infertility. Fertility Sterility, 92(2):541-7. doi:10.1016/j.fertnstert.2008.07.017.Taspinar M, Aydos SE, Comez O, Elhan AH, Karabulut HG, Sunguroğlu A. (2008).
14. CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia. Swiss Med Wkly, 12;138(1-2):12-7. doi: 2008/01/smw-12036.
15. Sahin F, Taspinar M, Sunguroglu A. (2007). Molecular pathogenesis of pancreatic cancer: Review. Türkiye Klinikleri J Med Sci, Tıp Bilimleri Dergisi, 27(4):560-566.
16. G.Öztürk, E.Erdoğan, Ö. Anlar, M. Kösem, M. Taşpınar. (2005). Effect of leukemia inhibitor factor in experimental cisplatin neuropathy in mice. Cytokine, 29(1):31-41. doi:10.1016/j.cyto.2004.09.006.
17. Aydos S, Taspinar M, Sakiragaoğlu O, Ilgaz S, Sunguroglu A, Aydos K. (2009). FSH receptor gene polymorphism in Turkish fertil and infertil men. (Fertil ve İnfertil Türk Erkeklerinde FSH Reseptör Gen Polimorfizmi). Optimal Medical Journal (Optimal Tıp Dergisi), Cilt 22; sayı 1-4; p.9-12. [Turkish-English (Abstract)]
18. Aydos S, Taspinar M, Sakiragaoglu O, Sunguroglu A, Aydos K.(2008). The effect of G197T polymorphism of Protamine 1(PRM1) on to male infertility in Turkish Population. (Türk toplumunda Protamin 1 (PRM1) Geni G197T Tek Nükleotid Polimorfizminin Erkek Fertilitesi Üzerine Etkisi) Klinik Laboratuvar ve Araştırma Dergisi Cilt 12; sayı 1-4; p.9-11. [Turkish-English (Abstract)]
19. Sahin F, Taşpinar M, Karasartova D, Ozkul A, Gerçeker D.(2006). Investigation of the role of Ribonuclease 1 gene in response to against viral infections in tonsil tissue. (Tonsil dokusunun viral enfeksiyonlara karşı yanıtında Ribonükleaz l geninin rolünün araştırılması). Mikrobiyoloji Bülteni, 40(4):307-15. [Turkish-English (Abstract)]