graham-b-jones
Editor in Chief
Graham B Jones, BSc, DipIC, PhD, DSc
Professor of Medicine and Director
  • Clinical and Translational Science Institute
    Tufts University Medical Center
    Boston, MA, USA
    Phone: [001]857-275-7045
    E-mail: graham.jones@tufts.edu

Education

1983-1986 BSc (Chemistry) University of Liverpool, Liverpool
1986-1989 PhD and DipIC (Organic Chemistry) Imperial College of Science Technology and Medicine, London
1989-1991 NATO Fellow Harvard University
2006 D.Sc. University of Liverpool

Biography

Graham B. Jones is Professor of Medicine and Director of Research Partnerships for the Tufts University Medical Center Clinical and Translational Science Institute. Jones received his BSc degree in 1986 from the University of Liverpool, followed by a PhD in 1989 from the Imperial College of Science Technology and Medicine, London. He was then awarded a NATO fellowship where he worked at Harvard University with the 1990 chemistry Nobelist, E. J. Corey. His research program has involved application of bio-organic and medicinal chemistry to drug design, bio-conjugation, drug delivery, and molecular imaging, and has produced more than 150 publications and secured over $30M of external funding. Jones sits on several editorial and advisory boards and is the recipient of numerous research awards. He provided invited testimony at the FDA hearings on biopharmaceuticals and has been a leader in developing institutional industry-academia partnerships within the New England pharmaceutical & biotechnology hub. In 2006 he was awarded the DSc for career contributions to medicinal chemistry.

Research Interest

  • Application of bio-organic and medicinal chemistry
  • Drug design
  • Bio-conjugation
  • Drug delivery
  • Molecular imaging
  • Precision Medicine
  • Digital Biomarkers

Scientific Activities

Employment History
2012- Professor of Medicine and Director of Research Partnerships, NIH (CTSI) Tufts University Medical Center, Boston, MA
1998-2012/5 Full Professor of Chemistry Northeastern University, Boston, MA
2002-03 Pro-Vice Chancellor for Research & Enterprise University of Hull, UK
1991-98 Tenured Associate Professor of Chemistry Clemson University, Clemson, SC
Honors And Awards
  • 1986-1989- Imperial College of Science Technology and Medicine, London: PhD (Organic Chemistry) Awarded Cancer Research Foundation Fellowship
  • 1989-1991- NATO Fellow, Harvard University [with E J Corey, 1990 Chemistry Nobelist]
  • 2006 University of Liverpool D.Sc. (for career contributions to chemistry)

Publications

  1. Flow and Microwave Induced Pellizzari Reactions: Synthesis of Heterocyclic Analogues of the Benzoxazepine Antipsychotic Agents Loxapine and JL-13, Nadeesha Ranasinghe, Enrico Mongeau, Zachary Minden, Scott Waldron, Christopher Patrick Jr, Farid Fouad, Sabiha Ahmed, and Graham B. Jones, Adv. Chem. 2017, in press, #8147421.
  2. Fluorinated adenosine A2A receptor antagonists inspired by Preladenant as potential cancer  immunotherapeutics, Gengyang Yuan, Tanner C. Jankins, Christopher G. Patrick Jr., Phaethon Philbrook, Olivia Sears, Stephen Hatfield, Michail Sitkovsky, Neil Vasdev, Steven H. Liang, Mary Jo Ondrechen, Michael P. Pollastri, Graham B. Jones, Int. J. Med. Chem. 2017 in press, #4852537.
  3. Homology Modeling Inspired Synthesis of 5-HT2A Inhibitors: A Diazepine Analogue of the Atypical Antipsychotic JL13, Enrico Mongeau, Gengyang Yuan, Zachary Minden, Scott Waldron, Raymond Booth, Daniel Felsing,  Mary Jo Ondrechen, and Graham B. Jones, CNS Agents Med. Chem. 2017, in press DOI: 10.2174/1871524917666170426123607.
  4. Optimizing the bioavailability of subcutaneously administered therapeutics through mechanochemical drivers, J. M. Wright, N. R Thyagarajapuram, R. Sirkar, S. Kapur, M. W. Harrison, D. S. Collins, David J. Bryan, and G. B. Jones, Pharm. Res, 2017, 34(10), 2000-2011.
  5. Personalizing Drug Delivery: Exploiting the Subcutaneous Revolution, G. B. Jones, D.S. Collins, M.W. Harrison, N. R. Thayagarjapuram, and J. M. Wright, Science Translational Medicine, 2017, 9(405), eaaf9166.
  6. Radiosynthesis and preliminary PET evaluation of 18F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1, 2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors, G. Yuan,  G. B. Jones,  N. Vasdev, and S. H. Liang, Bioorg. Med. Chem. Lett. 2016, 26, 4857-4860.
  7. Biomimetic oxidation of acetaminophen prodrugs catalyzed by iron porphyrins: Effect of nitrogen and thiolate axial ligands on drug and metabolite formation. Chapman, C.M., Pruneau, J.M., Laverack, C.A., Dutton, A.S., and Jones, G.B. Applied Catalysis A, 2016, 510, 204-215
  8. Biomimetic Oxidations of Xenobiotics by Metalloporphyrin Catalysts: Design Considerations. Chapman, C.M., and Jones, G.B. Current Catalysis. 2015, 4, 166-213.
  9. Biomimetic Oxidations of Xenobiotics by Metalloporphyrin and Salen Catalysts: Recent Applications. Chapman, C.M., and Jones, G.B. Current Catalysis. 2015, 4, 77-110.
  10. Protein and antibody functionalization using continuous flow microreactor technology. Sebeika, M.M., Gedeon, N.G., Sadler, S., Kern, N.L., Wilkins, D.J., Bell, D.E., and Jones, G.B. Journal of Flow Chemistry. 2015, 5(3), 151-154.
  11. Flow and Microwave Assisted Synthesis of Medicinally Relevant Indoles. Ranasinghe, N., and Jones, G.B. Current Green Chemistry. 2015, 2(1), 66-71.
  12. Novel Approaches for Targeting the Adenosine A2A Receptor. Yuan, G., Gedeon, N.G., Jankins, T.C., and Jones, G.B. Expert Opinion in Drug Discovery. 2015, 10(1), 63-80.
  13. History of Anticancer Drugs. Jones, G.B. eLS.  2014, John Wiley & Sons Ltd.  DOI: 10.1002/9780470015902.a0003630.pub2.
  14. A Facile Route to Triazolopyrimidines Using a [3+2] Cycloaddition and Continuous Flow Chemistry.Sadler, S., Sebeika, M.M., Kern, N.L., Bell, D.E., Laverack, C.A., Wilkins, D.J., Moeller, A.R., Nicolaysen, B.C., Kozlowski, P.N., Wiles, C., Tinder, R.J. and Jones, G.B. Journal of Flow Chemistry. 2014, 4(3), 140-147.
  15. Towards Next Generation Adenosine A2A Receptor Antagonists. Yuan, G. and Jones, G.B. Current Medicinal Chemistry 2014, 21(34), 3918-3935.
  16. Safer, Greener, and more Facile Alternatives for Synthesis of Organic Azides. Sebeika, M.M.; Jones, G.B. Current Organic Synthesis. 2014. 11(5), 732-750.
  17. Accelerated Labeling Methods and Syntheses of Radiotracers Utilizing Microfluidic Technology. Hargrove, K.; Jones, G.B. Current Radiopharmaceuticals. 2014. 7(1), 36-48.
  18. Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible. Ohta, A.; Madasu, M.; Subramanian, M.; Kini, R.; Jones, G.; Chouker, A.; Ohta, A.; Sitkovsky, M. International Immunology. 2014, 26, 83-91.
  19. The Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL) and Potential Treatment Strategies with Novel Fatty Acid Synthase (FASN) Small Molecule Inhibitors. Dashnamoorthy, R., Abermil, N., Behesti, A., Kozlowski, P., Lansigan, F., Kinlaw, W.B., Gartenhaus, R., Jones, G., Hlatky, L., and Evens, A.M. Blood. 2014, 124(21), 4490.
  20. Design and evaluation of xanthine based adenosine receptor antagonists: Potential hypoxia targeted immunotherapies. Thomas, R.; Lee, J.; Chevalier, V.; Sadler, S.; Selesniemi, K.; Hatfield, S.; Sitkovsky, M.; Ondrechen, M. J.; Jones, G. B. Bioorganic & Medicinal Chemistry. 2013, 21, 7453-7464.
  21. Fluoroalkynylations of Aryl Halides under Continuous-Flow Homogeneous Catalysts. Placzek, M.S.; Chmielecki, J.M.; Houghton, C.; Calder, A.; Wiles, C.; Jones, G.B. J. Flow Chem. 2013, 3(2), 46-50.
  22. Extending the versatility of the Hemetsberger-Knittel indole synthesis through microwave and flow chemistry. Ranasinghe, N.; Jones, G. B., Bioorg. Med. Chem. Lett. 2013, 23(6), 1740-1742.
  23. Microwave and continuous flow technologies in drug discovery. Sadler, S.; Moeller, A.R.; Jones, G.B. Expert Opinion in Drug Discovery. 2012, 7(12), 1107-1128.
  24. The Forward Path for Biopharmaceuticals and Biosimilars: Emerging Options in the Selection of Host Cell Systems. Wager, K.; Jones, G.B. Current Biotechnology. 2012, 1(4), 297-317.
  25. Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Berkowitz, Steven A.; Engen, John R.; Mazzeo, Jeffrey R.; Jones, Graham B. Nature Reviews Drug Discovery, 2012, 11, 527-540.
  26. Synthesis and evaluation of potent and selective human V1a receptor antagonists as potential ligands for PET or SPECT imaging. Fabio, Karine; Guillon, Christophe; Lacey, Carl J.; Lu, Shi-fang; Heindel, Ned D.; Ferris, Craig F.; Placzek, Michael; Jones, Graham; Brownstein, Michael J.; Simon, Neal G. Bioorganic and Medicinal Chemistry, 2012, 20, 1337-1345.
  27. Microwave Accelerated Labeling Methods in the Synthesis of Radioligands for Positron Emission Tomography Imaging, Kallmerten, Amy; Alexander, Abigail; Wager, Krista; Jones, Graham, Current Radiopharmaceuticals, 2011, 4 (4), 343-354
  28. Internalization of C17α-alkynylestradiol-porphyrin conjugates into estrogen receptor positive MCF-7 breast cancer cells, Sadler, Sara; Persons, Kelly S.; Jones, Graham B.; Ray, Rahul, Bioorganic and Medicinal Chemistry Letters, 2011, 21(15), 4638-4641.
  29. Microwave accelerated three-component fluoroalkylations: expeditious routes to fluoropharmaceuticals and PET ligands, Placzek, Michael; LaBeaume, Paul; Harris, Luke; Ng, Patrick; Daniels, Mathew; Kallmerten, Amy; Jones, Graham B., Tetrahedron Letters, 2011, 52, 332.
  30. An efficient route to xanthine based A2A adenosine receptor antagonists and functional derivatives, LaBeaume, Paul; Dong, Ma; Sitkovsky, Michail; Jones, Elizabeth V.; Thomas, Rhiannon; Sadler, Sara; Kallmerten, Amy E.; Jones, Graham B. Organic and Biomolecular Chemistry, 2010, 8, 4155.
  31. Radio-Iodination Methods for the Production of SPECT Imaging Agents, Wager, K., Jones, G.B., Current Radiopharmaceuticals, 2010, 3 (1) 37.
  32. Microwave Accelerated Synthesis of PET Image Contrast Agents for AD Research, Kallmerten A.E., Jones, Graham B., Current Alzheimer Research, 2010, 7, 251.
  33. Microwave-accelerated fluorodenitrations and nitrodehalogenations: expeditious routes to labeled PET ligands and fluoropharmaceuticals, LaBeaume, P.,  Placzek, M., Daniels, M., Kendrick, I., Ng,  P., McNeel, M.,  Afroze, R.,  Alexander, A., Thomas, R., Kallmerten, A.E., Jones, G.B., Tetrahedron Letters, 2010 51(14), 1906-1909.
  34. Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates, LaBeaume, P., Wager, K.,  Falcone, D.,  Li, J.,  Torchilin, V.,  Castro, C.,  Holewa, C. Kallmerten, A.E., Jones, G.B. , Bioorganic and Medicinal Chemistry. 2009  17 (17), 6292.
  35. Designed DNA Probes from the Neocarzinostatin Family: Impact of Glycosyl Linkage Stereochemistry on Bulge Base Binding, Ma, D. ; Lin, Y. ;  Xiao, Z. ;   Kappen, L. ;   Goldberg, I. H. ; Kallmerten, A. E. ; Jones, G. B.  Bioorganic and Medicinal Chemistry.  2009, 17(6), 2428.
  36. An Efficient Route to Novel A2A Adenosine Receptor Antagonists, Analogues and Prodrugs, Ma, D, Sitkovsky, M., Kallmerten, A.E., Jones, G.B. Tetrahedron Letters, 2008, 49, 4633.
  37. Designed Molecular Probes of DNA Bulges:  Jones GB; Lin Y; Ma D; Xiao Z; Hwang G; Kappen L; Goldberg I. H. Current topics in medicinal chemistry 2008,  8,  436.
  38. Photoactivated Enediynes as Targeted Antitumoral Agents: Efficient Routes to Antibody and Gold Nanoparticle Conjugates, Danielle Falcone, Jane Li, Amit Kale and Graham B. Jones, Bioorganic and Medicinal Chemistry Letters. 2008, 18, 934.
  39. DNA Interactive Enediyne Antitumor Agents and their Congeners, Graham B. Jones and Danielle Falcone ed. M. Lee, in Synthetic and Biophysical Studies of DNA Binding Compounds, Lee, M.; Strekowski, L. Eds. 2007, Transworld Research, pp.169-196. ISBN: 978-81-7895-290-1.
  40. Chiral Auxiliaries derived from Biogenic Building Blocks bearing h6 Arene Cr(0) Complexes, Jane Li, Longfei Xie, Mustafa Guzel, Steven B. Heaton, Amy E. Kallmerten and Graham B. Jones, Journal of Organometallic Chemistry. 2007, 692, 5459.
  41. Solution Structure of a Designed Spirocyclic Helical Ligand Binding at a Two-Base Bulge Site in DNA. Zhang, Na; Lin, Yiqing; Xiao, Ziwei; Jones, Graham B.; Goldberg, Irving H. Biochemistry. 2007, 46, 4793.
  42. Probing DNA Bulges with Designed Helical Spirocyclic Molecules, Lizzy S. Kappen, Yiqing Lin, Graham B. Jones and Irving H. Goldberg, Biochemistry.  2007, 46, 561.
  43. Molecular Probes of DNA Bulges:  Functional Assay and Spectroscopic Analysis, Graham B. Jones, Yiqing Lin, Ziwei Xiao, Lizzy Kappen, and Irving H. Goldberg, Bioorg Med Chem.  2007, 15, 784.
  44. Spirocyclic Helical Compounds as Binding Agents for Bulged RNA, Including HIV-2 TAR, Ziwei Xiao, Na Zhang, Yiqing Lin, Graham B. Jones, and Irving H. Goldberg, Chem Commun.  2006, 4431.
  45. Nuclear Estrogen Receptor Targeted Photodynamic Therapy:  Selective Uptake and Killing of MCF-7 Breast Cancer Cells by a C17α-Alkynylestradiol-Porphyrin Conjugate, Swamy, N. ;  Purohit, A.; Fernandez-Gacio, A. ; Jones, G. B. ; and Ray, R. ;  Journal of Cellular Biochemistry.  2006, 99, 966.
  46. Microwave Expedited Synthesis of 5-Aminocamptothecin Analogs:  Inhibitors of Hypoxia Inducible Factor HIF-1α, Joelle Torregrossa, Glenn J. Bubley, and Graham B. Jones, Bioorganic & Medicinal Chemistry Letters.  2006, 16, 6082-6085.
  47. An Image contrast agent selectively activated by prostate specific antigen (PSA), Graham B. Jones, Curtis F. Crasto, Jude E. Matthews, Longfei Xie, Miguel O. Mitchell, Ahmed El-Shafey, Anthony V. D’Amico, and Glenn J. Bubley  Bioorganic and Medicinal Chemistry 2006, 14, 418.
  48. Functionalized heterobifunctional poly[ethylene glycol] templates for use in cellular trafficking and imaging studies, Dinesh Shenoy, Wei Fu, Curtis Crasto, Srinivas Sridhar, Mansoor Amiji, Jane Li, James Weinberg, Graham Jones, Int. Journal of Nanomedicine, 2006, 1, 51.
  49. Synthesis and Protein Degradation Capacity of Photoactivated Enediynes Fouad, F. S.; Wright, J. M.; Plourde, G., II.; Purohit, A. D.; Wyatt, J. K.; El-Shafey, A.; Hynd, G.; Crasto, C. F.; Lin, Y.; Jones, G. B. J. Org. Chem. 2005; 70, 9789.
  50. An Approach to Heterobifunctional Poly(ethyleneglycol) Bioconjugates, Jane Li, Curtis F. Crasto, James Weinberg, Mansoor Amiji, Dinesh Shenoy, Srinivas Sridhar, Glenn Bubley, and Graham B. Jones, Bioorg. Med. Chem. Lett. 2005, 15, 5558.
  51. Convenient synthesis of NCS-Chromophore metabolite isosteres: Binding agents for bulged DNA microenvironments, Yiqing Lin, Graham Jones, Geum-Sook Hwang, Lizzy Kappen, Irving Goldberg, Org. Lett. 2005, 7, 71.
  52. Exploiting pi Shielding Interactions: A Highly Selective Chiral Auxiliary derived from a Biogenic Building Block, Longfei Xie and Graham B. Jones, Tetrahedron Lett.  2005, 46, 3579.
  53. Photoactivated Enediynes: targeted chimeras which undergo photo-Bergman cyclization, Farid S. Fouad, Curtis F. Crasto, Yiqing Lin and Graham B. Jones, Tetrahedron Lett.  2004, 45, 7753.
  54. A Prospective, Multicenter, Randomized Phase II Trial of the Herbal Supplement, PC-SPES, and Diethylstilbestrol in Patients with Androgen-Independent Prostate Cancer, William K. Oh, Philip W. Kantoff, Vivian Weinberg, Graham Jones, Brian I. Rini, Mika K. Derynck, Robert Bok, Matthew R. Smith, Glenn J. Bubley, Robert T. Rosen, Robert S. DiPaola, Eric J. Small, J. Clin. Oncol. 2004, 22, 3705.
  55. Preparation of Alkylation Agents for Bulged DNA Microenvironments, Farid S. Fouad, Zhen Xie, Irving H. Goldberg, and Graham B. Jones, Bioorganic and Medicinal Chemistry Letters 2004, 14, 3337.
  56. A Practical method for preparation of b-glycosides of N-Acetylglucosamine, Curtis F. Crasto and Graham B. Jones, Tetrahedron Lett. 2004, 45, 4891.
  57. Image contrast agents activated by prostate specific antigen (PSA), Graham B. Jones, Longfei Xie, Ahmed El-Shafey, Curtis F. Crasto, Glenn J. Bubley and Anthony V. D’Amico, Bioorganic and Medicinal Chemistry Letters 2004, 14, 3081.
  58. Stereochemical Control of Small Molecule Binding to Bulged DNA: Comparison of Structures of Spirocyclic Enantiomer-Bulged DNA Complexes Hwang, G.-S.; Jones, G. B.; Goldberg, I. H.; Biochemistry, 2004, 43, 641.
  59. Designed Enediyne Antitumor Agents, Graham B. Jones and Farid S. Fouad, Frontiers in Medicinal Chemistry, 2004, 1, 189-214.
  60. The Photo-Bergman Cycloaromatization of Enediynes, Graham B. Jones and Keith C. Russell, CRC Handbook of Photochemistry, 2004, 29-1.
  61. History of Anticancer Drugs, Jones, G.B.; eLS, 2003. Published online.
  62. Solution structure of a wedge-shaped synthetic molecule at a two-base bulge site in DNA, Geum-Sook Hwang, Graham B. Jones, Irving H. Goldberg, Biochemistry, 2003, 42, 8472.
  63. CYP2D6 – catalyzes tamoxifen aromatic hydroxylation with an NIH-Shift, Yiding Hu, Shangara S. Dehal, George Hynd, Graham B. Jonesand David Kupfer, Xenobiotica, 2003, 33, 141.
  64. Stimulation of DNA strand slippage synthesis by a bulge binding synthetic agent, Lizzy S. Kappen, Zhen Xi, Graham B. Jones, Irving H. Goldberg, Biochemistry, 2003, 42, 2166.
  65. Halo-Enediynes: Probing the Electronic and Stereoelectronic Contributions to the Bergman Cycloaromatization, Gary W. Plourde II, Philip M. Warner, Dennis A. Parrish, Graham B. Jones, Journal of Organic Chemistry,  2002, 67, 5727.
  66. Oxa-Enediynes: Probing the Electronic and Stereoelectronic Contributions to the Bergman Cycloaromatization, Graham B. Jones, Justin M. Wright, George Hynd, Justin K. Wyatt, Philip M. Warner, Robert S. Huber, Aiwen Li, Michael W. Kilgore, Robert P. Sticca, and Richard S. Pollenz, Journal of Organic Chemistry,  2002, 67, 5369.
  67. Protein Degradation with Photoactivated Enediyne-Amino Acid Conjugates, Gary Plourde, Ahmed El-Shafey, Farid, S. Fouad, Ajay S. Purohit, Graham B. Jones, Bioorganic and Medicinal Chemistry Letters 2002, 12, 2985.
  68. Targeting DNA Bulged Microenvironments with Synthetic Agents: Lessons from a Natural Product, Zhen Xi, Guem-Sook Hwang, Irving H. Goldberg, Jeffrey L. Harris, William T. Pennington, Farid S. Fouad, Ghassan Qabaja, Justin M. Wright, Graham B. Jones, Chemistry & Biology, 2002, 9, 925.
  69. Designed Enediyne Antitumor Agents, Graham B. Jones and Farid S. Fouad Current Pharmaceutical Design, 2002, 8, 2415.
  70. Application of Affinity Capillary Electrophoresis for the Determination of Binding and Thermodynamic Constants of Enediynes with Bovine Serum Albumin and Histone H1, El-Shafey, A. ;  Zhong, H. ;  Jones, G. B. ; Krull, I. Electrophoresis 2002, 23, 945.
  71. DNA Cleavage by Aromatic Amines, Jiwei Qi, Bin Meng, Gang Li, Philip M. Warner and Graham B. Jones, Bioorganic and Medicinal Chemistry Letters 2002, 12, 1.
  72. Photoactivated Enediyne-Estrogens as Photochemical Proteases, Graham B. Jones, Ajay Purohit, Justin Wyatt, Narashima Swamy,and Rahul Ray, Tetrahedron Letters, 2001, 42, 8579.
  73. On the Mechanism of Quinone Formation from the Bergman Cyclization: Some Theoretical Insights, Philip M. Warner and Graham B. Jones, Journal of Organic Chemistry, 2001, 66, 8669.
  74. Butalene and Related Compounds- Aromatic or Antiaromatic?, Philip M. Warner and Graham B. Jones, Journal of the American Chemical Society, 2001, 123, 10322.
  75. Bidendate Planar Chiral (6-Arene Tricarbonyl Chromium(0) Complexes: Ligands for Catalytic Asymmetric Alkene Hydrosilylation, Weber, I. ; Jones, G. B. Tetrahedron Lett. 2001, 42, 6983.
  76. Pi Shielding in Organic Synthesis, Graham B. Jones, Tetrahedron, 2001, 57, 7999.
  77. Quinone Isomers of the WS-5995 Antibiotics: Synthetic Antitumor Agents that Inhibit Macromolecule Synthesis, Elisabeth M. Perchellet, Bonnie Sperfslage,  Ghassan Qabaja, Graham B. Jones, Jean-Pierre Perchellet,  Anti-Cancer Drugs, 2001, 12, 401.
  78. Electronic Control of the Bergman Cyclization: The Remarkable Role of Vinyl Substitution, Graham B. Jones and Philip M. Warner, Journal of the American Chemical Society, 2001, 123, 2134.
  79. Target Directed Enediynes: Designed Estramycins, Graham B. Jones, George Hynd, Justin M. Wright, Gary W. Plourde II, Robert S. Huber, Jude E. Mathews, Aiwen Li, Michael W. Kilgore, Molly Yancisin, and Myles Brown, Journal of Organic Chemistry,  2001, 66, 3688.
  80. Enantioselective Catalysis using Planar Chiral h6 Arene Chromium Complexes: 1,2-Diols as Cycloaddition Catalysts, Graham B. Jones, Mustafa Guzel, and Steven B. Heaton, Tetrahedron: Asymmetry 2000, 11, 4303.
  81. Annulation Strategies in Benzo[b]quinone Synthesis: Efficient Routes to Kinafluorenone and the WS-599A Antibiotics, Ghassan Qabaja, and Graham B. Jones, Journal of Organic Chemistry, 2000, 65, 7187.
  82. Synthesis and Photochemical Activity of Designed Enediynes, Graham Jones, Justin Wright, Gary Plourde II, Ajay D. Purohit, Justin Wyatt, George Hynd, and Farid Fouad, Journal of the American Chemical Society, 2000, 122, 9872.
  83. An Enzyme Activated Antiprostatic Prodrug, Graham B. Jones, Miguel O. Mitchell, James S. Weinberg,Anthony V. D’Amico, Glenn A. Bubley, Bioorganic and Medicinal Chemistry Letters, 2000, 10, 1987.
  84. An Intramolecular Arylation Route to the Kinafluorenones, Ghassan Qabaja, Graham B. Jones, Tetrahedron Letters, 2000, 41, 5317.
  85. Protein-Degrading Enediynes: Library Screening of Bergman Cycloaromatization Products, Graham B. Jones, Justin M. Wright, George Hynd, Justin K. Wyatt, Molly Yancisin, and Myles A. Brown Organic Letters, 2000, 2, 1863.
  86. Electronic Control of the Bergman Cycloaromatization: Synthesis and Chemistry of Chloroenediynes, Jones, G. B. ; Plourde, G. W.  Organic Letters,  2000, 2, 1757.
  87. Exploiting pi Shielding Interactions in a h6 Arene Complexed Chiral Auxiliary, Graham B. Jones and Mustafa Guzel, Tetrahedron Letters, 2000, 41, 4695.
  88. Catalytic Enantioselective Cycloadditions:  A Readily Available Diels-Alder Catalyst, Graham B. Jones and Mustafa Guzel, Tetrahedron: Asymmetry, 2000, 11, 1267.
  89. Regioselective Lactonization of Naphthoquinones:  Synthesis and Antitumoral Activity of the WS 5995 Antibiotics, Ghassan Qabaja, Elisabeth M. Perchellet, Jean-Pierre Perchellet and Graham B. Jones, Tetrahedron Letters, 2000, 41, 3007.
  90. Understanding Enediyne-Protein Interactions: Diyl Atom Transfer Results in Generation of Aminoacyl Radicals, Jones, G. B. ; Plourde, G. W. ; Wright, J. M. ; Organic Letters, 2000, 2, 811.
  91. A Direct and Stereocontrolled Route to Conjugated Enediynes, Graham B. Jones, Justin M. Wright,Gary W. Plourde II, George Hynd, Robert S. Huber, and Jude E. Mathews, Journal of the American Chemical Society, 2000, 122, 1937.
  92. Stereoselective Route to Mitosanes via Tricarbonyl h6 Arene Chromium Complexes, Graham Jones, Mustafa Guzel, and Jude E. Mathews, Tetrahedron Letters, 2000, 41, 1123.
  93. On the Selective Deprotection of Trityl Ethers, Jones, G. B. ; Hynd, G. ; Wright, J. W. ; Sharma, A , Journal of Organic Chemistry,  2000, 65, 263.
  94. Synthesis and DNA Binding of Spirocyclic Model Compounds Related to the Neocarzinostatin Chromophore, Xi, Z.; Jones, G. B. ; Qabaja, G. ;  Wright, J. W. ;  Johnson, F. S. ;  Goldberg, I. H. ; Org. Lett. 1999, 1, 1375.
  95. Stereoselective access to Substituted Enediyne Building Blocks, Hynd, G. ; Jones, G. B. ; Plourde, G. W. ; Wright, J. W. ; Tetrahedron Lett. 1999, 40, 4481.

     
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