Education

Biography

Prof/Dr. Zuhair Muhi-eldeen has received his PhD in Ohio State University Columbus, USA. Currently, he/she is working as Professor of Medicinal chemistry in Petra University. He has successfully completed his Administrative responsibilities Professor and Chairman of Medicinal Chemistry and Phamacognosy Department at College of Pharmacy, Baghdad University. His Paper were accepted for presentation orally at many local, regional and international congress of Pharmaceutical science, Pharmacology and Chemistry in countries such as Egypt, Tunisia, Jordan, France, Japan, United State, Austria, England, Switzerland, Lebanon, UAE, and Spain. He has authored for Essentials of Medicinal Chemistry books.

Research Interest

• Radio protective agents
• Antihistaminic
• Acetylenic compounds of various biological activity
• Prodrugs
• NMR studies of certain acetylenic amines
• Thermal stability in relation to biological activity free radical in relation to human disease.

Scientific Activities

Publications

1. L(S) & (R) –3-amino-1-phenyl-pyrrolidines, Stereoselective Antagonists for    Histamine & Acetylcholine Receptors in Vitro.J. Med. Chem., 14, 24, (1971).
2. Pharmacological Studies on the Stereoselective Antihistaminic &    Anticholinergic Properties of L (S) and D (R) –3-Ethylaminopyrrolidine. Archives Internationals de Pharmacodynamic et de Therapie, 78, 192, (1971).
3. Product Ratio Analysis of the Reaction of Ethyldiazoacetate & Allylthiotetrahydropyran, Bull Coll, Sci., 189, 15, (1974).
4. Note on the First Order Analysis of the Alpha-amino-N-PhenylSuccinimide & Related Alpha-Amino-Derivatives. Proc. XIII Conf. Pharm. Sci., Cario, Egypt (Feb., 1974).
5. Chemistry of Prostaglandines, Bull, Sci., 89, 16, (1975).
6. Synthesis of N-(4-pyrrolidino-2-butynyl) L-Pyroglutamide & its (DL) Isomer as Potential Antiparkinsonian Agent. Iraqi J. Sci., 70, 18 (1977).
7. Acetylene Compounds of Potentail Pharmacological Value. Acta, Pharm, Suec., 16, 89, (1979).
8. Synthesis & Pharmacological Properties of N-{4-(azetidinyl)-2-butynyl} –2- Pyrrolidone, a Highly Potent Oxotermorine like Agent. J. Pharm. Pharmacol., 439, 32, (1980).
9. Synthesis & Biological Evaluation of N-(4-t-amino-2 butynyl-oxy) & N-(4-amino-2- butynyl) Phathalimides. Eur. J. Med. Chem., 89, 15, (1980).
10. Synthesis & Biological Evaluation of N-(4-t-amino –2- butynyl) Pyromellitic Acid Diimides. Eur. J. Med. Chem., 89, 15, (1980).
11. Pharmacological Activity of N-(perhydrozaocino-2-butynyl) phthalimide, A New Analgesic Agent. Iraqi J. Pharm. Sci., 42, 1, (1982).
12. Synthesis & Biological Evaluation of L-5-{N-(4-tert-amino –2-butynyl) carbamoyl}-2-Pyrrolidones & Their Racemates. Eur. J. Med. Chem., 49, 17, (1982).
13. Biological Evaluation of Bis- (4-t-amino-2-butynyl) Phthalamides. Iraqi J. Sci., 155, 22, (1982).
14. Carbon-13-Nuclear Magnetic Resonance Spectra of Selected Acetylenic Amines. Org. Magn. Reson., 91, 91, (1982).
15. Synthesis & Biological Evaluation of 2-(4-Tert-amino-2-butynyl) thio-5-aryl-1, 3, 4-Thiadiazoles. Eur. J. Med. Chem., 470, 17, (1982).
16. Monoamine Oxidase Inhibitory Activity of Recently Synthesized Acetylenic Oxyphathalimide Derivatives. Iraqi J. Pharm. Sci. 65, 2(1), (1983).
17. Is Aspirin Phenylanaline Ethylester A Prodrug For Aspirin. Am. J. Pharm. Sci., 1093, 72(9), (1983).
18. - Synthesis & Biological Evaluation of 5-Aryl-3-(4-tert-amino-2-butynyl) –1, 3, 4-Thiadiazol-2-(3H) ones. Eur. J. Med. Chem., 33, 20(1), (1985).
19. Kinetic & Mechanism of the Enzymatic Hydrolysis of Aspirin Phenylanaline Ethylester. Int. J. Pharmac., 15, 26, (1985).
20. Synthesis & Biological Evaluation of N-{5-alkyl-3-(4-tert-amino-2-butynyl)-1, 3, 4-Thiadiazol –2- (3H)-ylidene] Benzamides. Eur. J. Med. Chem., 219, 21, (1986).
21. Carbon-13-NMR Investigation of Some Pharmacologically Important Heterocyclic N- Alkylamines. Mag. Reson. In. Chem., 271 (1986).
22. Synthesis & Biological Evaluation of 3, 4 Diaryl –1-(4-tert-amino-2-butynyl) –1, 2, 4- Triazoline –5-ones. Iraqi J. Chem., 201, 12(2), (1987).
23. Synthesis & Antimicrobial Evaluation of N- [(5- thiol-1, 3, 4- thiadiazol-2yl]-2-phenoxy-acetamides. Eur. J. Med. Chem., 133, (23), (1988).
24. Analgesic & Anti-inflammatory Activity of N-(4-tert-amino-2-butynyl) Phthalimides & Related Pyromellitic Acid diimide Derivative. Iraqi J. Sci., 25, 32 (1), (1991).
25. Carbon –13- NMR Study of Some Heterocyclic N-alkynylamines. Iraqi J. Chem., 149, 132(2), (1988).
26. Acute Toxoicological Studies of N-(perhydroazocino-2-butynyl) Phthalimide. A new Analgesic And Anti-inflammatory Agent. J. Comm. Med. Iraq, 35, 2(1), (1989) .
27. Kinetics and Mechanism of Hydrolysis of N-[4-(2,6-dimethylpiperidino)-2-Butynyl] Phthalimide. Iraqi J. Pharm. Sci., 23, 2(2), (1989).
28. Acetylenic Oxyphthalimide, New Convulsogenic and Pscychometor Stimulant. Proc. 2nd. Sci., Poster Congress, University of Baghded. 369, 1 (1989).
29. New Triazoline Derivatives of Antispasmodic Activity, Proc. 2nd. Sci., Poster Congress, University of Baghdad. 305, 2, (1989).
30. Effect of Acetylenic Oxyphthalimide on Locomotor Activity and Behaviour of Rats. Iraqi J. Pharm. Sci., 34, 3 (1), (1990).
31. New Prodrugs for Naloxone. Iraqi J. Sci., 895, 31 (4), (1990.
32. Synthesis & Study of Substituted Mercaptotriazoles of Transition Metal Complexes Iraqi J. Sci., 127, 31(4), (1990).
33. The Transition to a More Clinically Oriented Pharmacy Education. J. Clin. Pharm. Therap., 345-45, 15, (1990).
34. Synthesis and Biological Evaluation 3-(4-Tert-amino-2-butynyl) thio-4, 5-disubstituted –4H-1, 2, 4-Triazoles. Eur. J. Med. Chem., 237, 26, (1991).
35. Evaluation of Potential Chemoprotectants Against Microcystin-LR Heptatotoxicity in Mice. J. Appl. Toxicol, 65, 11(1), (1991).
36. Thermal Stability of Some Biologically Active Acetylenic Triazole  Derivatives. Iraqi J. Pharm. Sci., 4(1), (1991).
37. The Synthesis of Glutathionmonoethyl Ester and Its Effect on Sulfhydryl  Content of Liver and Kidneys of Rats. Nephron, 192, 62, (1992).
38. Synthesis and Antimicrobial Activity of Ni (II), Co(II), Zn(II) and Cd(II) complexes of 3-Mercapto-4-substituted-5-phenyl-4h-1,2, 4-Triazoles. Eur. J. Med. Chem., 101, 27, (1992).
39. Synthesis of New Series of 2- Thio-Derivatives of 5-Substituted 1,3,4- Oxadiazoles of Anticipated Antimicrobial Activity. Iraqi J. Sci., (1992).
40. Evaluation of the Acute Toxicity and Anti-Inflammatory of N-(4-(2, 6-dimethylpiperidino)-2-Butynyl) Phthalimide Hydrochlorid in Mice and Rats. Kufa J. Med., (1990).
41. Antibacterial Activity of 2-(4-Tert-amino-2-butynyl)thio-5-aryl-1,3,4-Thiadizoles, Iraqi J. Pharm. Sci., 4 (1), (1993).
42. Stability and Kinetics of Hydrolysis of Newly Prepared Esters of Metronidazole As Possible Prodrugs. Iraqi J. Pharm. Sci., 4(1), (1993).
43. Kinetics and Mechanism of Hydrolysis of N-[4-(2,6-dimethylpiperidino)-2- butynyloxy] Phthalimide. Iraqi J. Pharm. Sci., 4(1), (1993).
44. Synthesis of New Organophosphorus Compounds Containing A Heterocyclic ring, of Anticipated Insecticidal activity. Iraqi J. Sci., 1,33 (1-2), (1992).
45. Preliminary Screening and Pharmacological Activity of Oxotremorine Antagonists Iraqi-Jordanian Scientific Proceeding (1992).
46. Synthesis of 5-Substitiuted–2-Mercaptooxadiazoles of Anticipated Antimicrobial Activity. Iraqi-Jordanian Scientific Proceeding (1992).
47. Thermal Stability of Some Thiadiazole Derivatives in Relation to Antimicrobial Activity. Thermo chemica Acta., (1993).
48. Investigation of Possible Relationships between Thermal Stability And Antibacterial Activity of Some Triazole Derivatives. Iraqi J. Sci., 34, (1993).
49. Glaser Coupling Under Mannich Reaction Conditions. Iraqi J. Sci., 33, (1992) accepted for publication.
50. Synthesis and Pharmacological Evaluation of N- (4-tert –amino-2-Butynyl) Dibenzazepine. Iraqi J. Pharm. Sci., (2001), (accepted for publication).
51. Effect of Tricyclic Acetylenic Compounds on Pentobarbitone Sleeping-time. Iraqi, J. Pharm. Sci.,  (2002).
52. Synthesis and characterization of 2(2-tetrahydropyranylthio)   methylcyclopropylamine. Iraqi. J. pharm. Sci., 2004 (accepted for publication).
53. Synthesis and Antibacterial Evaluation of some oxdiazole Derivatives. American Bulletin of Scientific research. Accepted for publication 2005. In press
54. Synthesis and Antibacterial Evaluation of Some thiadiazole and Bicyclic  thiadiazole Derivatives European of scientific Research Accepted for publication 2006.
55. Synthesis and anti-inflammatory activities of Novel Salicylic acid and Diflunisal amide Derivatives. Jordanian S.pharm.sci.2.99 (2009)
56. The role of Human xanthine oxidoreductase (HXOR), anti-HXOR antivodies and microorganisms in synovial fluid of patients with joint inflammation, Rheumatology international, 32(8): 2355-2362,2012.
57. Synthesis and Pharmacological evaluation of amino acetylenic isoindoline -1, 3-dione derivatives as anti-inflammatory agents, Arabian.J of Chemistry Accepted, (2011)
58. Anti-inflammatory aminoacetylenic 1, 3-isoindoline derivatives modulate cytokines production international Immunopharmacology. 296-301, 14, 2012
59. Synthesis and biological evaluation of N1, N2-bis – ( 4-( t-amino)-2-butynyl ) phhalamides as oxotermorine ans acetylcholine antagonists . Medicinal Chemistry Reasearch . 1597-1603,22(4),2013
60. Non-selective inhibition of cyclooygenase enzymes by aminoacetylenic isoindoline 1,3-dione Inflammation and allergy-Drug target. 900-90, (11) No.5, 2012
61. Synthesis and pharmacological evaluation of N-[4-(t-amino) 2-butynyloxy] phthalimide. Journal of Pharmacy, 15th Feb, 1-8(1), 2012
62. The role of humanxanthine oxidoreductase (HXOR) antibodes and microorganism in synovial fluid of patiens with Joints inflammation. Eur.J.sci.Res. 102 – 118, 1(99) , 2013
63. Synthesis and anfimicrobiol activity of 4, 5- diaryl-2- [4-( t-amino ) -2- butynyl ] 2.4-dihydro-3H- 1,2,4-triazol-3-ones J.of  Medicinal Chemistry research 3390-3395,21(11) 2912]
64. Analesic and toxicity studies of aminoacetylenic isoindoline -1.3- dione derivatives. ISRN pharmacology .1-8, ID, 657472, 2012
65. Synthesis of 2-[{4-(t-amino-1-yl) but-2-yn-1}oxy]-1,3-benzothiazole derivatives as H3-antagonists. IOSRPHR. Volume4-Issue9, pp.44-49, Sept.2014.
66. Essentials of Medicinal Chemistry Update. Desciptor No. 394/2/2008, Desciptor: Medical Science /Drugs/Chemistry.  مطابع الدستور التجارية 2010/2011
67. Synthesis and biological evaluation of N1, N2-bis – (4-(t-amino)-2-butynyl) pthalamides as oxotermorine ans acetylcholine antagonists. Medicinal Chemistry Research. 1597-1603, 22(4), 2013
68. The role of human xanthine oxido reductase (HXOR) antibodes and microorganism in synovial fluid of patiens with Joints inflammation. Eur.J.sci.Res. 102 – 118, 1(99), 2013
69. Synthesis of 2-[{4-(t-amino-1-yl) but-2-yn-1} oxy]-1, 3-benzothiazole derivatives as H3- antagonists. IOSRPHR. Volume 4- Issue 9, pp.44-49, Sept.2014.