liang-xue
Liang Xue, Ph. D
Associate Professor of Organic Chemistry

Department of Chemistry
University of the Pacific
Stockton, CA
Phone: 209-946-2360
E-mail: lxue@pacific.edu

Education

Sep. 2004 – Aug. 2007 Postdoctoral Fellow, Bioorganic Chemistry, Johns Hopkins University, Baltimore, MD US
Aug. 1999 – Sep. 2004 Ph.D., Organic Chemistry, Clemson University, Clemson, SC US
Jul. 1996 – Jul. 1999 Research Scientist, Polymer Science, Unilever R. & D., Shanghai, China CHINA
Sep. 1991 – Jul. 1996 Bachelor of Science, Organic Chemistry, Fudan University, Shanghai, China CHINA

Biography

Dr. Liang Xue is currently an Associate Professor in the Department of Chemistry at the University of the Pacific. He received a Bachelor of Science degree in Chemistry from Fudan University in China in 1996. He joined the graduate school at Clemson University in 1999, and in 2004 was awarded a Ph. D. degree in Bioorganic Chemistry for research undertaken with Professor Dev Arya. From 2004 to 2007, he was a postdoctoral fellow under the mentorship of Professor Marc Greenberg at Johns Hopkins University. Dr. Xue began his academic career as Assistant Professor at the University of the Pacific in 2007 and was promoted to Associate Professor in 2013. Dr Xue’s research efforts focus primarily on studying the effect of DNA lesions on G-quadruplex DNA and small molecule-DNA interactions.


Research Interest

  • Design and synthesis of small molecules for targeting oxidized DNA lesions in DNA G-quadruplex structures
  • Design and synthesis of small molecules for targeting DNA abasic sites
  • Study of the effect of DNA damage sites on the stability and conformation of DNA G-quadruplex structures
  • Study of small molecule-DNA interactions
  • Investigation of the fragmentation patterns of DNA oligonucleotides, nucleotides, nucleosides, and nucleobases in Direct Analysis in Real Time mass spectrometry

Scientific Activities

ACADEMIC HONORS
  • Outstanding Graduate Researcher Award of Chemistry Department of Clemson University, 2003
  • Outstanding Graduate Researcher Award of The College of Engineering and Science of Clemson University (Recognized by Sigma Xi – Scientific Research Society), 2004
  • Outstanding Graduate Researcher Award of Clemson University, 2004
  • The Advisor of the Year Award, The PCSP Program, The University of the Pacific, 2013
MEMBERSHIPS
  • Membership of American Chemical Society, 2001-present
  • Membership of Phi Kappa Phi (Honored Society), 2003-present
  • Membership of AEL (Honored Graduate Society), 2003-present
  • Membership of American Society for Mass Spectrometry, 2008-present
  • Membership of AX∑ Chemistry Fraternity, 2007-present

Publications

  1. Xue, L., Charles, I., Arya, D. P. Pyrene-neomycin conjugate: dual recognition of a DNA triple helix. Chem. Commun. 2002, 1, 70-71.
  2. Charles, I., Xue, L., Arya, D. P. Synthesis of aminoglycoside-DNA conjugates. Bioorg. Med. Chem. Lett. 2002, 12, 1259-1262.
  3. Arya, D. P., Micovic, L., Charles, I., Coffee, Jr. R. L., Willis, B., Xue, L. Neomycin binding to Watson-Hoogsteen (W-H) triplex groove: a model. J. Am. Chem. Soc. 2003, 125, 3733-3744. (Highlighted in Chemical and Engineering News)
  4. Arya, D. P., Xue, L., Tennant, P. Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. J. Am. Chem. Soc. 2003, 125, 8070-8071.
  5. Arya, D. P., Xue, L., Willis, B. Aminoglycoside (neomycin) preference is for A-form nucleic acids, not just RNA: results from a competition dialysis study. J. Am. Chem. Soc. 2003, 125, 10148-10149.
  6. Arya, D. P., Coffee, Jr. R. L., Xue, L. From triplex to B-form duplex stabilization: reversal of target selectivity by aminoglycoside dimers. Bioorg. Med. Chem. Lett. 2004, 14, 4643-4646.
  7. Xue, L., Greenberg, M. M. Use of fluorescent sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA. Angew. Chem. Intl. Ed., 2007, 46, 561-564. (Highlighted as hot topic in Angew. Chem. Intl. Ed.)
  8. Xue, L., Greenberg, M. M. Facile quantification of lesions derived from 2’-deoxyguanosine in DNA. J. Am. Chem. Soc. 2007, 129, 7010-7011.
  9. Liu, W., Navarro, E., Franz, A. H., Xue, L.* Regioselective bromination of a thymine-acridine conjugate by N-bromosuccinimide. Synth. Commun. 2010, 40, 1192-1201.
  10. Chitranshi, P., Chen, C.-N., Jones, P. R., Faridi, J. S., Xue, L.* Mechanistic studies on interactions of NiCR and NiCR-2H with DNA. Bioinorg. Chem. Appl. 2010, 869569.
  11. Curtis, M., Minier, M. A., Chitranshi, P., Sparkman, O. D., Jones, P. R., Xue, L.* Direct analysis in real time (DART) mass spectrometry of nucleotides and nucleosides: Elucidation of a novel fragment [C5H5O]+ and its in-source adducts. J. Am. Soc. Mass. Spectrom. 2010, 21, 1371-1381.
  12. Xue, L., Xi, H., Kumar, S., Gray, D., Erick, D., Paris, H., Michael, S, Arya, D. P. Probing the recognition surface of a DNA triplex: Binding studies with intercalator-neomycin conjugates. Biochemistry, 2010, 49, 5540-5552.
  13. Xue, L., Ranjan, N., Arya, D. P. Synthesis and spectroscopic studies of aminoglycoside (neomycin)-perylene conjugate binding to human telomeric DNA. Biochemistry, 2011, 50, 2838-2849.
  14. Kumar, S., Xue, L., Arya, D. P. Neomycin-neomycin conjugate: a carbohydrate scaffold with high affinity for AT rich DNA duplexes. J. Am. Chem. Soc., 2011, 133, 7361-7375.
  15. Minier, M., Shaheen, F., Lee, A., Xue, L.* Determination of the effects of water-miscible organic solvents on the stability of DNA duplexes via UV thermal denaturation and circular dichroism. J. Under. Chem. Res., 2011, 10, 146-153.
  16. Chitranshi, P., Xue, L.*, Utilizing G-quadruplex formation to target 8-oxoguanosine in telomeric sequences. Bioorg. Med. Chem. Lett., 2011, 21, 6357-6361.
  17. Xi, H., Davis, E., Ranjan, N., Xue, L., Hyde-Volpe, D., Arya, D. P. Thermodynamics of nucleic acid shape readout by aminosugars, Biochemistry, 2011, 50, 9088-9113.
  18. Liu, W., Minier, M. A., Franz, A. H., Curtis, M., Xue, L.* Synthesis of nucleobase-calix[4]arenes via click chemistry and evaluation of their complexation and self-assembly. Supramol. Chem., 2011, 23, 806-818.
  19. Wang, Y., Yang, D., Chang, A., Chan, W. K., Zhao, B., Denison, M. S., Xue, L.* Synthesis of a ligand-quencher conjugate for the ligand binding study of aryl hydrocarbon receptor using a FRET assay. Med. Chem. Res., 2012, 21, 711-721.
  20. Manali, A., Joo, H., Liu, W., Tsai, J., Xue, L.* 8-Oxo-7,8-dihydrodeoxyadenosine: The first example of native DNA lesion that stabilizes human telomerase G-quadruplex DNA. Biochem. Biophys. Res. Commun., 2012, 421, 671-677.
  21. Ranjan, N., Davis E., Xue, L. Arya, D. P. Dual recognition of human telomeric G-quadruplex by neomycin-anthraquinone conjugate. Chem. Commun. 2013, 49, 5796-5798.
  22. Xue, L.*, Guillen, A., Aggrawal, M., Xue, J. Topological characterization of oxodG containing G-quadruplexes via thermal difference spectra and circular dichroism. J. Under. Chem. Res. 2014, 13, 50-54.
  23. Xue, L., Ling, M., Wang, S. A reliable method to measure the melting temperatures of DNA oligonucleotide triplexes, J. Under. Chem. Res. 2016, 16, 30-34.
  24. Chahal, S., Wei, P, Moua, P., Park, S. P. J., Kwon, J., Patel, A., Vu, A. T., Catolico, J. A., Tsai, Y., Shaheen, N., Chu, T. T., Tam, V., Khan, Z., Joo, H., Xue, L., Lin-Creghino, J., Tsai, J., Lin-Cereghino, G. P. Structural characterization of the α-mating factor prepro-peptide for secretion of recombinant proteins in Pichia Pastoris, Gene, 2017, 598, 50-62.
  25. Liu, W., Wang, S., Dotsenko, I., Samoshin, V., Xue, L. Use of 5-substituted phenanthroline as a scaffold to study the effect of side chains on G-quadruplex recognition and telomerase inhibition. J. Inorg. Biochem. 2017, 173, 12-20.

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