Education

Biography

Professor Hamid Irannejad is born in 1980, Tehran, Iran. He obtained his Pharm.D at Faculty of Pharmacy, Kerman University of Medical Sciences, Iran in 2004. He received PhD of Medicinal Chemistry at Tehran University of Medical Sciences, Iran in 2010. He spent one year for research at University of Siena, Italy under the supervision of Prof. Maurizio Botta for research on anti-HIV and anti-cancer compounds in 2009.

Research Interest

• Molecular modelling
• In silico drug design
• Synthesis, investigation and development of new lead compounds as anti-cancer, anti-Alzheimer’s, anticonvulsant, and anti- inflammatory compounds.

Scientific Activities:

Awards

1. Receiving a grant for six months’ research at university of Siena (Italy) by Ministry of Health and Medical Education, Tehran, Iran. (2009)
2. Elected as Young Assistant Professor in December 2014 by Ministry of Health and Medical Education and receiving a grant (100,000,000 IRR).
3. Receiving a grant (125,000,000 IRR) by Iran National Science Foundation (INSF).
4. Receiving a grant (300,000,000 IRR) by National Institute for Medical Research & Development (NIMAD).

Other Activities

Achieving the top mark in the 17^th PhD. student entrance exam (2005) and being accepted in Tehran University of Medical Sciences.

Skills and Lab Experiences

• Synthetic Organic Chemistry
• NMR AVANCE 400 Bruker
• NMR AC 200 Bruker
• HPLC (Knauer)
• IR Spectroscopy (Shimadzu)
• UV-Visible (Shimadzu)
• Microwave Assisted Organic Synthesis (CEM)
• LC-MSD (Agilent)
• Polarimeter
• AutoDock 4 (Docking software)
• 2D and 3D-QSAR
• Molecular Dynamic Simulation (Gromacs) & Gaussian calculations

Teaching Skills

• General chemistry for Pharm.D
• Organic chemistry 1 & 2 for Pharm.D
• Medicinal Chemistry 1
• Medicinal Chemistry 2
• Medicinal Chemistry 3
• Instrumental Analysis for MSc and Pharm.D: Chromatography (TLC, HPLC, GC), NMR, UV, IR
• Advanced Medicinal Chemistry for PhD students: Pharmacokinetic, Renin Inhibitors

Publications

1. Dadashpour S, Tuylu Kucukkilinc T, Ayazgok B, Chippindale AM, Foroumadi A, Hosseinimehr SJ, Irannejad H*. Discovery of novel 6-Aryl-[1,2,4]triazolo[4,3-b][1,2,4]triazines with pyridine moiety as potent c-Met kinase inhibitors. Future Medicinal Chemistry, 2018, submitted.
2. Hosseini Balef SS, Piramoon M, Hosseinimehr SJ*, Irannejad H*. In vitro and in silico evaluation of P-glycoprotein inhibition through 99mTc-MIBI uptake. Chemical Biology & Drug Design, 2018, Accepted. DOI: 10.1111/cbdd.13411. Article in Press.
3. Arab HA, Faramarzi MA, Samadi N, Irannejad H, Foroumadi A, Emami S. New 7-piperazinylquinolones containing (benzo[d]imidazol-2-ylmethyl moiety as potent antibacterial agents. Molecular Diversity, 2018, DOI: 10.1007/s11030-018-9834-3. Article in Press.
4. Naderi N, Ghasemi Najarkolae SM, Modanlou M, Shokrzadeh M, Irannejad H*, Genoprotective effect of new triazine derivatives in Endosulfan mediated toxicity, an in vivo and in vitro study. Letters in Drug Design & Discovery, 2019, 16, 52-57.
5. Hosseini Balef SS, Chippindale AN, Irannejad H*, A crystallographic and theoretical study of an (E)-2-Hydroxyiminoethanone derivative: prediction of cyclooxygenase inhibition selectivity of stilbenoids by MM-PBSA and the role of atomic charge. Journal of Biomolecular Structure & Dynamics, 2018, https://doi.org/10.1080/07391102.2018.1462256.
6. Dehestani L, Ahangar N, Hashemi SM, Irannejad H, Honarchian Masihi P, Shakiba A and Emami, S. Design, synthesis, in vivo and in silico evaluation of phenacyl triazole hydrazones as new anticonvulsant agents. Bioorganic Chemistry, 2018, 78, 119-129.
7. Ahangar N, Hafezi S, Irannejad H, Emami S. Anticonvulsant Activity of 3-imidazolylflavanones and Their Flexible Analogs: 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanones as New Lead Compounds. Pharmaceutical Chemistry Journal, 2017, 51 (9), pp. 787-792.
8. Tuylu Kucukkilinc T, Safari Yanghagh K, Ayazgok B, Roknipour MA, Homayouni Moghadam F, Moradi A, Emami S, Amini M, Irannejad H*. Synthesis and neuroprotective activity of novel 1,2,4-triazine derivatives with ethyl acetate moiety against H2O2 and Aβ-induced neurotoxicity. Medicinal Chemistry Research, 2017, 26, 3057- 3071.
9. Irannejad S, Amini M, Modanlookordi M, Shokrzadeh M, Irannejad H*. Preparation of Diaminedicarboxyplatinum (II) Functionalized Single-Wall Carbon Nanotube via Bingel Reaction as a Novel Cytotoxic Agent. Iranian Journal of Pharmaceutical Research, 2016, 15 (4): 753-762
10. Bekhradnia AR, Gilannejad B, Qaraje S, Irannejad H. Synthesis of New 2,3-diarylquinoxaline and Quinoxaline Oxide Derivatives as Potential Anticancer and Anti-microbial Agents. J Mazandaran Univ Med Sci., 2015; 25(121), 48-54.
11. Hashemi SM, Badali H, Irannejad H, Shokrzadeh M, Emami S. Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents, Bioorganic and Medicinal Chemistry, 2015, 23(7), 1481-1491.
12. Dadashpour S, Tuylu Kucukkilinc T, Unsal Tan O, Ozadali K, Irannejad H*, Emami S. Design, synthesis and in vitro study of 5,6-diaryl-1,2,4-triazine-3-ylthioacetate derivatives as COX-2 and β-amyloid aggregation inhibitors. Archiv der Pharmazie, 2015, 348 (3), 179-187.
13. Irannejad H*, Unsal Tan O, Ozadali K, Dadashpour S, Tuylu Kucukkilinc T, Ahangar N, Ahmadnejad M and Emami S. 1,2-Diaryl-2-hydroxyiminoethanones as Dual COX-1 and b-Amyloid Aggregation Inhibitors: Biological Evaluation and In Silico Study, Chemical Biology & Drug design, 2015, 85(4), 494-503.
14. Irannejad H*, Nadri H, Naderi N, Rezaeian SN, Zafari N, Foroumadi A, Amini M, Khoobi M. Anticonvulsant activity of 1,2,4-triazine derivatives with pyridyl side chain: synthesis, biological, and computational study. Medicinal Chemistry Research, 2015, 24, 2505-2513.
15. Hashemi SM, Badali H, Faramarzi MA, Samadi N, Afsarian MH, Irannejad H,Emami S, Novel triazole alcohol antifungals derived from fluconazole: design, synthesis, and biological activity, Molecular Diversity, 2015, 19, 15-27.
16. Alipour F, Oryan S, Sharifzadeh M, Karimzadeh F, Kafami L, Irannejad H, Amini M, Hassanzadeh G. The neuroprotective effect of a triazine derivative in an Alzheimer's rat model. Acta Medica Iranica. 2015 Jan;53(1), 8-16.
17. Irannejad H, Kebriaieezadeh A, Zarghi A, Montazer-Sadegh F, Shafiee A,Assadieskandar A, Amini M., Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors, Bioorganic and Medicinal Chemistry, 2014, 22, 865-873.
18. Irannejad H*, Naderi N, Emami S, Foroumadi A, Qobadi Ghadikolaei R, Zafari T, Mazar Atabaki A, Dadashpour S. Microwave assisted synthesis and anticonvulsant activity of 5,6-bisaryl-1,2,4-triazine-3-thiol derivatives, Medicinal Chemistry Research, 2014, 23, 2503-2514.
19. Babazadeh-Qazijahani M, Badali H, Irannejad H, Afsarian MH, Emami S, Imidazolyl chromanones containing non-benzylic oxime ethers: Synthesis and molecular modeling study of new azole antifungals selective against Cryptococcus gattii. European Journal of Medicinal Chemistry, 2014, 76, 264-273.
20. Emami S, Banipoulad S, Irannejad H, Foroumadi A, Falahati M, Ashrafi-Khozani M, Sharifynia S. Imidazolylchromanones containing alkyl side chain as lanosterol 14a-demethylase inhibitors: synthesis, antifungal activity and docking study. Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, 29(2), 261-271.
21. Emami S, Shojapour S, Faramarzi M A, Samadi N, Irannejad H, Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl) flavanones, European Journal of Medicinal Chemistry, 2013, 66, 480-485.
22. Emami S, Ghafouri E, Faramarzi M A, Samadi N, Irannejad H, Foroumadi A, Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study, European Journal of Medicinal Chemistry, 2013, 68, 185-191.
23. Ayati A, Falahati M, Irannejad H, Emami S. Synthesis, in vitro antifungal evaluation and in silico study of 3-azolyl-4-chromanone phenylhydrazones. DARU Journal of Pharmaceutical Sciences, 2012, 20, 46.
24. Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti M, Garbelli A, Samuele A, Zanoli S, Esté J A, González E, Zucca E, Paolucci S, Baldanti F,Rijck J D, Debyser Z, Botta M., Toward the Discovery of Novel Anti-HIV Drugs. Second Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation. ChemMedChem, 2011, 6(8), 1371-1389.
25. Ansari N, Khodagholi F, Ramin MR, Amini M, Irannejad H, Dargahi L, Dehghani Amirabad A, Inhibition of LPS-induced apoptosis in differentiated-PC12 cells by new triazine derivatives through NF-kB-mediated suppression of COX-2. Neurochemistry International, 2010, 57(8), 958-968.
26. Irannejad H, Amini M, Khodaghi F, Ansari N, Khoramian Tusi S, Sharifzadeh M, Shafiee A, Synthesis and In vitro Evaluation of Novel 1,2,4-Triazine Derivatives as Neuroprotective Agents. Bioorganic and Medicinal Chemistry, 2010, 18 (12), 4224-4230.