andres-r-alcantara
Andres R Alcantara PhD
Associate Professor with Habilitation

Department of Organic & Pharmaceutical Chemistry
Pharmacy Faculty, Complutense University
Plaza De Ramon y Cajal, S/N University City, Madrid, Spain
Phone: (+34)-913941820
E-mail: andalcan@ucm.es

Education

  1989 Ph.D. (Chemical Science, orientation Organic Chemistry), University of Cordoba, Spain   SPAIN
  1985 B. S. (Chemical Science, orientation Organic Chemistry), University of Cordoba, Spain   SPAIN

Biography

Prof. Dr. Andres R. Alcantara was born in Cordoba (Spain) in 1962 and received his B.S. (1985) and Ph.D. (1989) degrees in Chemistry (Organic Chemistry area) from the University of Córdoba. He was a postdoctoral fellow at the University of Kent at Canterbury (UK) from 1989 to 1991, after which he began his career at the Faculty of Pharmacy, Complutense University of Madrid (Spain), becoming Assistant Professor (permanent position) since 1993, and has also received (April 2012) the positive accreditation to become Full Professor (tentative date for habilitation: first semester, 2018).


Research Interest

  • Applied Biocatalysis
  • Biotransformations
  • Drug synthesis using biocatalysts
  • Green solvents
  • Green Chemistry

Scientific Activities

  • Member of the Editorial Board of Current Green Chemistry
  • Associate Editor of Biocatalysis and Biotransformation
  • Coordinator of the Applied Biocatalysis section of the Spanish Society of Biotechnology (SEBiot), 2000-2004
  • Member of the Directive of SEBiot (2004-2008)
  • General Secretary of SEBiot (2008-2012)
Professional Affiliations
  • Member of the Spanish Society of Biotechnology (SEBiot)
  • Member the European Federation of Biotechnology (EFB)
  • Member of the Spanish Platform of Sustainable Chemistry (SusChem)
  • Member of the Spanish Society of Chemistry.

Publications

  1. Alcántara, A.; Marinas, J. M.; Sinisterra, J. V., Ba(OH)2 as catalyst in organic-reactions .8. Nature of the adsorbed species in Claisen-Schmidt reaction. Reaction Kinetics and Catalysis Letters 1986, 32 (2), 377-385. DOI: 10.1007/BF02068339
  2. Aguilera, A.; Alcántara, A. R.; Marinas, J. M.; Sinisterra, I. V., Ba(OH)2 as the Catalyst in Organic-Reactions .14. Mechanism of Claisen-Schmidt Condensation in Solid Liquid Conditions. Can. J. Chem. 1987, 65 (6), 1165-1171. DOI: 10.1139/v87-195.
  3. Alcántara, A.; Ballesteros, A.; Heras, M.; Marinas, J.; Montero, J.; Sinisterra, J., Activity of staphylococcal nuclease in water-organic media. Studies in organic chemistry 1987, 29, 337-342
  4. Alcántara, A. R.; Marinas, J. M.; Sinisterra, J. V., Synthesis of 2'-hydroxychalcones and related compounds in interfacial solid-liquid conditions. Tetrahedron Lett. 1987, 28 (14), 1515-1518. DOI: 10.1016/S0040-4039(01)81030-3.
  5. Sinisterra, J. V.; Alcántara, A. R.; Marinas , J. M., Ba(OH)2 as the catalyst in organic reactions : 9. Influence of the solid catalyst structure in the Wittig-Horner reaction in the heterogeneous phase. Journal of Colloid and Interface Science 1987, 115 (2), 520-528. DOI: 10.1016/0021-9797(87)90070-1.
  6. Alcántara, A.; Ballesteros, A.; Heras, A. M.; Montero, J. M. S.; Sinisterra, J. V., Behavior and Application of Immobilized Micrococcal Nuclease. Annals of the New York Academy of Sciences 1988, 542 (1), 1-6. DOI: 10.1111/j.1749-6632.1988.tb25801.x.
  7. Barrios, J.; Rojas, R.; Alcántara, A. R.; Sinisterra, J. V., Ba(OH)2 as the Catalyst in Organic-Reactions .18. Influence of the Microcrystalline Structure and the Nature of Active-Sites on Catalytic Activity. Journal of Catalysis 1988, 112 (2), 528-542. DOI: 10.1016/0021-9517(88)90168-6.
  8. Alcántara, A. R.; Garcia Blanco, F.; Heras, A. M.; Sinisterra, J. V.; Ballesteros, A., Influence of Organic Aqueous-Media in the Dnase Activity of Micrococcal Endonuclease. Journal of Molecular Catalysis 1989, 52 (3), 323-336. DOI: 10.1016/0304-5102(89)85042-4.
  9. Alcántara, A.; Ballesteros, A.; Sinisterra, J. V., New methodology for tosylation of hydroxylic supports as exemplified by the immobilization of micrococcal endonuclease on agarose. Appl. Biochem. Biotechnol. 1990, 26 (3), 297-310. DOI: 10.1007/BF02921508
  10. Alcántara, A. R.; Sinisterra, J. V.; Guanti, G.; Thea, S.; Williams, A., Microgels as soluble supports for enzyme active against polymeric substrates: micrococcal nuclease. Journal of Molecular Catalysis 1991, 70 (3), 381-389. DOI: 10.1016/0304-5102(91)80133-N
  11. Alcántara, A. R.; Sinisterra, J. V.; Torres, C.; Guisán, J. M.; Gil, M. H.; Williams, A., Peptide Synthesis in Organic-Aqueous Media Catalysed by α-Chymotrypsin Immobilised Over Different Supports. In Progress in Biotechnology, J. Tramper, M. H. V. H. H. B.; Stockar, U. v., Eds. Elsevier: 1992; Vol. Volume 8, pp 443-450. DOI: 10.1016/B978-0-444-89046-7.50066-7
  12. Alcántara, A.; Sinisterra, J.; Torres, C.; Romanelli, P., Immobilisation of alpha-chymotrypsin on soluble acrylic microgels; activity and stabilization. STUDIES IN ORGANIC CHEMISTRY-AMSTERDAM- 1993, 167-167.
  13. Alcántara, A. R.; Sinisterra, J. V.; Guanti, G. G.; Thea, S.; Williams, A., Importance of Hansch's [π] parameter in the catalytic action of microgel-immobilised subtilisin dissolved in tetrahydrofuran solvent. Journal of Molecular Catalysis 1993, 80 (1), 137-143. DOI: 10.1016/0304-5102(93)87116-P
  14. Alcántara, A. R.; Sinisterra, J. V.; Torres, C.; Romanelli, P.; Williams, A., Immobilization of alpha-chymotrypsin on soluble acrylic microgels - activity and stabilization. Stability and Stabilization of Enzymes 1993, 47, 167-174.
  15. Evans, D. J.; Williams, A.; Alcántara, A. R.; Pryce, R. J., Specificity to Leaving Group in Transesterification of Substituted Phenyl-Esters in Organic-Solvents Catalyzed by Subtilisin Microgel Sols. Journal of Molecular Catalysis 1993, 81 (1), 119-131. DOI: 10.1016/0304-5102(93)80026-Q
  16. Sinisterra, J. V.; Alcántara, A. R., Synthesis of peptides catalysed by enzymes: A practical overview. Journal of Molecular Catalysis 1993, 84 (3), 327-364. DOI: 10.1016/1381-1169(95)00076-3
  17. Alcántara, A. R.; Gil, M. H.; Guiomar, A. J.; Lopez-Belmonte, M. T.; Sobral, M. C. M.; Torres, C.; Sinisterra, J. V., Organic reactions catalyzed by insolubilized enzymes. Part III. Synthesis of peptides catalyzed by [alpha]-chymotrypsin immobilized on graft copolymers. J. Mol. Catal. A-Chem. 1995, 101 (3), 255-265. DOI: 10.1016/1381-1169(95)00076-3
  18. Otero, C.; Robledo, L.; Alcántara, A. R., Study of the stabilization of pure lipases: Comparison of two different lipase-microgel derivatives. J. Mol. Catal. B-Enzym. 1995, 1 (1), 23-28. DOI: 10.1016/1381-1177(95)00006-2
  19. López-Belmonte, M. T.; Alcántara, A. R.; Sinisterra, J. V., Enantioselective esterification of 2-arylpropionic acids catalyzed by immobilized Rhizomucor miehei lipase. J. Org. Chem. 1997, 62 (6), 1831-1840. DOI: 10.1021/jo961342j
  20. Alcántara, A. R.; Borreguero, I.; Lopez-Belmonte, M. T.; Sinisterra, J. V., Covalent immobilization of crude and partially-purified lipases onto inorganic supports: stability and hyperactivation. Stability and Stabilization of Biocatalysts 1998, 15, 571-576. DOI: 10.1016/S0921-0423(98)80086-5.
  21. Alcántara, A. R.; de Fuentes, I. E.; Sinisterra, J. V., Rhizomucor miehei lipase as the catalyst in the resolution of chiral compounds: an overview. Chemistry and Physics of Lipids 1998, 93 (1-2), 169-184. DOI: 10.1016/S0009-3084(98)00041-3.
  22. Chamorro, S.; Alcántara, A. R.; Sanchez-Montero, J. M.; Sinisterra, J. V., Biotransformations catalyzed by Candida rugosa lipase partially purified by precipitation and by organic solvents treatment. Stability and Stabilization of Biocatalysts 1998, 15, 741-746. DOI: 10.1023/A:1005448431237
  23. Chamorro, S.; Sanchez-Montero, J. M.; Alcántara, A. R.; Sinisterra, J. V., Treatment of Candida rugosa lipase with short-chain polar organic solvents enhances its hydrolytic and synthetic activities. Biotechnol. Lett. 1998, 20 (5), 499-505. DOI: 10.1023/A: 1005448431237.
  24. Borreguero, I.; Sinisterra, J. V.; Rumbero, A.; Hermoso, J. A.; Martínez-Ripoll, M.; Alcántara, A. R., Acyclic phenylalkanediols as substrates for the study of enzyme recognition. Regioselective acylation by porcine pancreatic lipase: a structural hypothesis for the enzymatic selectivity. Tetrahedron 1999, 55 (52), 14961-14974. DOI: 10.1016/S0040-4020(99)00942-4
  25. Rumbero, A.; Borreguero, I.; Sinisterra, J. V.; Alcántara, A. R., Acyclic phenylalkanediols as substrates for the study of enzyme recognition: Synthesis of substrates and enzymatic resolution via hydrolysis and transesterification. Tetrahedron 1999, 55 (52), 14947-14960. DOI: 10.1016/S0040-4020(99)00941-2
  26. Sanchez-Montero, J. M.; Hernaiz, M. J.; Moreno, F.; Alcántara, A. R.; Garcia-Blanco, F.; Sinisterra, J. V., Fluorescence intensity decay and interaction between effectors and the isoenzymes A and B of Candida rugosa lipase. In Recent Research and Development in Biotechnology & Bioengineering, Pandalai, S. G., Ed. Research signpost, Trivandrum, INDIA: 1999; Vol. 2, pp 255-271.
  27. Sinisterra, J. V.; Sanchez-Montero, J. M.; Alcántara, A. R., Chemoenzymatic Preparation of Enantiomerically Pure S(+)-2-Arylpropionic Acids with Anti-inflammatory Activity. In Stereoselective Biocatalysis, CRC Press: 2000; pp 659-702.
  28. Borreguero, I.; Carvalho, C. M. L.; Cabral, J. M. S.; Sinisterra, J. V.; Alcántara, A. R., Enantioselective properties of Fusarium solani pisi cutinase on transesterification of acyclic diols: activity and stability evaluation. J. Mol. Catal. B-Enzym. 2001, 11 (4-6), 613-622. DOI: 10.1016/S1381-1177(00)00072-2
  29. Borreguero, I.; Sánchez-Montero, J. M.; Sinisterra, J. V.; Rumbero, A.; Hermoso, J. A.; Alcántara, A. R., Regioselective resolution of 1,n-diols catalysed by lipases: a rational explanation of the enzymatic selectivity. J. Mol. Catal. B-Enzym. 2001, 11 (4-6), 1013-1024. DOI: 10.1016/S1381-1177(00)00086-2
  30. Chamorro, S.; Alcántara, A. R.; de la Casa, R. M.; Sinisterra, J. V.; Sánchez-Montero, J. M., Small water amounts increase the catalytic behaviour of polar organic solvents pre-treated Candida rugosa lipase. J. Mol. Catal. B-Enzym. 2001, 11 (4-6), 939-947. DOI: 10.1016/S1381-1177(00)00168-5
  31. de Fuentes, I. E.; Viseras, C. A.; Ubiali, D.; Terreni, M.; Alcántara, A. R., Different phyllosilicates as supports for lipase immobilisation. J. Mol. Catal. B-Enzym. 2001, 11 (4-6), 657-663. DOI: 10.1016/S1381-1177(00)00069-2.
  32. Pregnolato, M.; Terreni, M.; de Fuentes, I. E.; Leon, A. R. A.; Sabuquillo, P.; Fernandez-Lafuente, R.; Guisan, J. M., Enantioselective enzymatic hydrolysis of racemic glycidyl esters by using immobilized porcine pancreas lipase with improved catalytic properties. J. Mol. Catal. B-Enzym. 2001, 11 (4-6), 757-763. DOI: 10.1016/S1381-1177(00)00168-5
  33. Domínguez de María, P.; Martínez-Alzamora, F.; Moreno, S. P.; Valero, F.; Rúa, M. L.; Sánchez-Montero, J. M.; Sinisterra, J. V.; Alcántara, A. R., Heptyl oleate synthesis as useful tool to discriminate between lipases, proteases and other hydrolases in crude preparations. Enzyme Microb. Technol. 2002, 31 (3), 283-288. DOI: 10.1016/S0141-0229(02)00108-4
  34. Martinez-Alzamora, F.; Alcántara, A. R.; Sinisterra, J. V.; Montero, J. M. S., Characterisation of two new lipases from Pseudomonas cepacia and Fusarium oxysporum. Recent Research Developments in Biotechnology & Bioengineering, Vol 5 2003, 5, 55-64.
  35. Alcántara, A. R.; de María, P. D.; Fernández, M.; Hernáiz, M. J.; Sánchez-Montero, J. M.; Sinisterra, J. V., Resolution of racemic acids, esters and amines by Candida rugosa lipase in slightly hydrated organic media. Food Technology and Biotechnology 2004, 42 (4), 343-354. http://hrcak.srce.hr/110911
  36. de Maria, P. D.; Sanchez-Montero, J. M.; Alcántara, A. R.; Valero, F.; Sinisterra, J. V., Rational strategy for the production of new crude lipases from Candida rugosa. Biotechnol. Lett. 2005, 27 (7), 499-503. DOI: 10.1007/s10529-005-2540-0.
  37. Hischer, T.; Gocke, D.; Fernandez, M.; Hoyos, P.; Alcántara, A. R.; Sinisterra, J. V.; Hartmeier, W.; Ansorge-Schumacher, M. B., Stereoselective synthesis of novel benzoins catalysed by benzaldehyde lyase in a gel-stabilised two-phase system. Tetrahedron 2005, 61 (31), 7378-7383. DOI: 10.1016/j.tet.2005.05.082
  38. Nieto, I.; Rocchietti, S.; Ubiali, D.; Speranza, G.; Morelli, C. F.; Fuentes, I. E.; Alcántara, A. R.; Terreni, M., Immobilization of different protein fractions from Rhizomucor miehei lipase crude extract - Enzymatic resolution of (R,S)-2-Tetralol. Enzyme Microb. Technol. 2005, 37 (5), 514-520. DOI: 10.1016/j.enzmictec.2005.03.027
  39. Condezo, L. A.; Jesús Fernández-Lucas; Carlos A. García-Burgos; Alcántara, A. R.; Sinisterra, J. V., Enzymatic Synthesis of Modified Nucleosides. In Biocatalysis in the Pharmaceutical and Biotechnology Industries, Patel, R. N., Ed. Taylor & Francis: 2006; pp 401-423.
  40. de Maria, P. D.; Alcántara, A. R.; Carballeira, J. D.; de la Casa, R. M.; Garcia-Burgos, C. A.; Hernaiz, M. J.; Sanchez-Montero, J. M.; Sinisterra, J. V., Candida rugosa lipase: A traditional and complex biocatalyst. Curr. Org. Chem. 2006, 10 (10), 1053-1066. DOI: 10.2174/138527206777698057
  41. de Maria, P. D.; Sanchez-Montero, J. M.; Sinisterra, J. V.; Alcántara, A. R., Understanding Candida rugosa lipases: An overview. Biotechnol. Adv. 2006, 24 (2), 180-196. DOI: 10.1016/j.biotechadv.2005.09.003.
  42. de Maria, P. D.; Sinisterra, J. V.; Sanchez-Montero, J. M.; Lotti, M.; Valero, F.; Alcántara, A. R., Acyl transfer strategy for the biocatalytical characterisation of Candida rugosa lipases in organic solvents. Enzyme Microb. Technol. 2006, 38 (1-2), 199-208. DOI: 10.1016/j.enzmictec.2005.06.001
  43. de Maria, P. D.; Sinisterra, J. V.; Tsai, S. W.; Alcántara, A. R., Carica papaya lipase (CPL): An emerging and versatile biocatalyst. Biotechnol. Adv. 2006, 24 (5), 493-499. DOI: 10.1016/j.biotechadv.2006.04.002
  44. Hoyos, P.; Fernández, M.; Sinisterra, J. V.; Alcántara, A. R., Dynamic kinetic resolution of benzoins by lipase-metal combo catalysis. J. Org. Chem. 2006, 71 (20), 7632-7637. DOI: 10.1021/jo061060b
  45. Alcántara, A. R., Dynamic Kinetic Resolution of Benzoins by Lipase-Ru Catalysis. Synfacts 2007, 2007 (01), 0070,0070. DOI: 10.1055/s-2006-955731.
  46. Bogar, K.; Hoyos Vidal, P.; Alcántara Leon, A. R.; Backvall, J. E., Chemoenzymatic dynamic kinetic resolution of allylic alcohols: A highly enantioselective route to acyloin acetates. Org. Lett. 2007, 9 (17), 3401-3404. DOI: 10.1021/ol071395v
  47. Pace, V.; Martinez, F.; Fernandez, M.; Sinisterra, J. V.; Alcántara, A. R., Effective monoallylation of anilines catalyzed by supported KF. Org. Lett. 2007, 9 (14), 2661-2664. DOI: 10.1021/ol070890o
  48. Estruch, I.; Tagliani, A. R.; Guisan, J. M.; Fernandez-Lafuente, R.; Alcántara, A. R.; Toma, L.; Terreni, M., Immobilization of the acylase from Escherichia coli on glyoxyl-agarose gives efficient catalyst for the synthesis of cephalosporins. Enzyme Microb. Technol. 2008, 42 (2), 121-129. DOI: 10.1016/j.enzmictec.2007.08.013.
  49. Hoyos, P.; Buthe, A.; Ansorge-Schümacher, M. B.; Sinisterra, J. V.; Alcántara, A. R., Highly efficient one pot dynamic kinetic resolution of benzoins with entrapped Pseudomonas stutzeri lipase. J. Mol. Catal. B-Enzym. 2008, 52-3, 133-139. DOI: 10.1016/j.molcatb.2007.10.009.
  50. Hoyos, P.; Sansottera, G.; Fernández, M.; Molinari, F.; Sinisterra, J. V.; Alcántara, A. R., Enantioselective monoreduction of different 1,2-diaryl-1,2-diketones catalysed by lyophilised whole cells from Pichia glucozyma. Tetrahedron 2008, 64 (34), 7929-7936. DOI: 10.1016/j.tet.2008.06.019.
  51. Hoyos, P.; Sinisterra, J. V.; De María, P. D.; Alcántara, A. R., Hydrolase-based synthesis of enantiopure α-hydroxy ketones: From racemic resolutions to chemo-enzymatic dynamic kinetic resolutions. In Biotechnology: Research, Technology and Applications, Nova Science Publishers, Inc.: 2008; pp 97-119.
  52. Hoyos, P.; Sinisterra, J. V.; Domínguez de María, P.; Alcántara, A. R., Hydrolase-Based Synthesis of Enantiopure α-Hydroxy Ketones: From Racemic Resolutions to Chemo-Enzymatic Dynamic Kinetic Resolutions. In Biotechnology: Research, Technology and Applications., Richter, F. W., Ed. Nova Science Publishers, Inc.: New York, 2008; pp 97-119.
  53. Carballeira, J. D.; Fernandez-Lucas, J.; Quezada, M. A.; Hernaiz, M. J.; Alcántara, A. R.; Simeó, Y.; Sinisterra, J. V., Biotransformations. In Encyclopedia of Microbiology, Moselio, S., Ed. Academic Press: Oxford, 2009; pp 212-251.
  54. Carballeira, J. D.; Quezada, M. A.; Hoyos, P.; Simeo, Y.; Hernaiz, M. J.; Alcántara, A. R.; Sinisterra, J. V., Microbial cells as catalysts for stereoselective red-ox reactions. Biotechnol. Adv. 2009, 27 (6), 686-714. DOI: 10.1016/j.biotechadv.2009.05.001.
  55. Pace, V.; Martinez, F.; Fernandez, M.; Sinisterra, J. V.; Alcántara, A. R., Highly Efficient Synthesis of New alpha-Arylamino-alpha '-chloropropan-2-ones via Oxidative Hydrolysis of Vinyl Chlorides Promoted by Calcium Hypochlorite. Adv. Synth. Catal. 2009, 351 (18), 3199-3206. DOI: 10.1002/adsc.200900565.
  56. Pace, V.; Martínez, F.; Nova, C. I.; Fernández, M.; Sinisterra, J. V.; Alcántara, A. R., Efficient Horner-Wadsworth-Emmons intramolecular cyclisation of a N-substituted phthalimide promoted by KF-Alumina: a general tool for the synthesis of functionalised isoindolinones. Tetrahedron Lett. 2009, 50 (25), 3050-3053. DOI: 10.1016/j.tetlet.2009.04.029.
  57. Pace, V.; Sinisterra, J. V.; Alcántara, A. R., Potassium Fluoride on Celite. In Encyclopedia of Reagents for Organic Synthesis [Online], John Wiley & Sons Ltd: 2009.
  58. Simeó, Y.; Sinisterra, J. V.; Alcántara, A. R., Regioselective enzymatic acylation of pharmacologically interesting nucleosides in 2-methyltetrahydrofuran, a greener substitute for THF. Green Chem. 2009, 11 (6), 855-862. DOI:10.1039/b818992g.
  59. Hernáiz, M.; Alcántara, A. R.; García, J. I.; Sinisterra, J. V., Applied Biotransformations in Green Solvents. Chem. Eur. J. 2010, 16 (31), 9422-9437. DOI: 10.1002/chem.201000798.
  60. Hoyos, P.; Sinisterra, J. V.; Molinari, F.; Alcántara, A. R.; De María, P. D., Biocatalytic Strategies for the Asymmetric Synthesis of alpha-Hydroxy Ketones. Accounts Chem. Res. 2010, 43 (2), 288-299. DOI: 10.1021/ar900196n.
  61. Leon, A. R. A.; Montero, J. M. S., Hydrolases use in the preparation of drugs and homochiral intermediates. Anales De La Real Academia Nacional De Farmacia 2010, 76 (2), 259-305.
  62. Pace, V.; Cabrera, A. C.; Fernandez, M.; Sinisterra, J. V.; Alcántara, A. R., First General Route to Substituted alpha-Arylamino-alpha '-chloropropan-2-ones by Oxidation of N-Protected Aminohalohydrins: The Importance of Disrupting Hydrogen Bond Networks. Synthesis 2010, (20), 3545-3555. DOI: 10.1055/s-0030-1257938.
  63. Pace, V.; Hoyos, P.; Fernandez, M.; Sinisterra, J. V.; Alcántara, A. R., 2-Methyltetrahydrofuran as a suitable green solvent for phthalimide functionalization promoted by supported KF. Green Chem. 2010, 12 (8), 1380-1382. DOI: 10.1039/c0gc00113a.
  64. Pace, V.; Sinisterra, J. V.; Alcántara, A. R., Celite-Supported Reagents in Organic Synthesis: An Overview. Curr. Org. Chem. 2010, 14, 2384-2408. DOI: 10.2174/138527210793358213.
  65. Pace, V.; Verniest, G.; Sinisterra, J. V.; Alcántara, A. R.; De Kimpe, N., Improved Arndt-Eistert Synthesis of alpha-Diazoketones Requiring Minimal Diazomethane in the Presence of Calcium Oxide as Acid Scavenger. J. Org. Chem. 2010, 75 (16), 5760-5763. DOI: 10.1021/jo101105g.
  66. Sinisterra, J. V.; Alcántara, A. R.; Almendros, M.; Hernáiz, M. J.; Sánchez-Montero, J. M.; Trelles, J., Enzyme-catalyzed synthesis of nonnatural or modified nucleosides. In Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology., Flickinger, M. C., Ed. John Wiley and sons, Inc.: 2010.
  67. Sinisterra, J. V.; Alcántara, A. R.; Almendros, M.; Hernáiz, M. J.; Sánchez‐Montero, J. M.; Trelles, J., Enzyme‐Catalyzed Synthesis of Nonnatural or Modified Nucleosides. Encyclopedia of Industrial Biotechnology 2010.
  68. Alcántara, A. R.; Hernaiz, M. J.; Sinisterra, J. V., 3.28 - Biocatalyzed Production of Fine Chemicals. In Comprehensive Biotechnology (Second Edition), Editor-in-Chief: Murray, M.-Y., Ed. Academic Press: Burlington, 2011; pp 309-331.
  69. Hoyos, P.; Pace, V.; Sinisterra, J. V.; Alcántara, A. R., Chemoenzymatic synthesis of chiral unsymmetrical benzoin esters. Tetrahedron 2011, 67 (38), 7321-7329. DOI: 10.1016/j.tet.2011.07.030.
  70. Hoyos, P.; Quezada, M. A.; Sinisterra, J. V.; Alcántara, A. R., Optimised Dynamic Kinetic Resolution of benzoin by a chemoenzymatic approach in 2-MeTHF. J. Mol. Catal. B-Enzym. 2011, 72 (1-2), 20-24. DOI: 10.1016/j.molcatb.2011.04.018.
  71. Pace, V.; Alcántara, A. R.; Holzer, W., Highly efficient chemoselective N-TBS protection of anilines under exceptional mild conditions in the eco-friendly solvent 2-methyltetrahydrofuran. Green Chem. 2011, 13 (8), 1986-1989. DOI: 10.1039/c1gc15574a
  72. Pace, V.; Cabrera, Á. C.; Ferrario, V.; Sinisterra, J. V.; Ebert, C.; Gardossi, L.; Braiuca, P.; Alcántara, A. R., Structural bases for understanding the stereoselectivity in ketone reductions with ADH from Thermus thermophilus: A quantitative model. J. Mol. Catal. B-Enzym. 2011, 70 (1-2), 23-31. DOI: 10.1016/j.molcatb.2011.01.017.
  73. Pace, V.; Hoyos, P.; Sinisterra, J. V.; Alcántara, A. R.; Holzer, W., Highly Regioselective and Efficient Synthesis of Aminoepoxides by Ring Closure of Aminohalohydrins Mediated by KF-Celite. Synlett 2011, (13), 1831-1834. DOI: 10.1055/s-0030-1260961.
  74. Pace, V.; Hoyos, P.; Sinisterra, J. V.; Alcántara, A. R.; Holzer, W., Highly Regioselective and Efficient Synthesis of Aminoepoxides by Ring Closure of Aminohalohydrins Mediated by KF-Celite. Synlett 2011, 2011 (13), 1831,1834. DOI: 10.1055/s-0030-1260961.
  75. Pace, V.; Hoyos, P.; Sinisterra, J. V.; Alcántara, A. R.; Holzer, W., Synthesis of 2-Aminoepoxides from Aminohalohydrins Using. Synfacts 2011, 2011 (10), 1051,1051. DOI: 10.1055/s-0030-1261104.
  76. Sánchez Montero, J. M.; Alcántara, A. R., Aplicaciones del modelado molecular a la biocatálisis. In Biocatalizadores. Del laboratorio a la industria, Lewkovicz, E., Ed. Universidad Nacional de Quilmes Editorial: Quilmes, Buenos Aires, 2011; pp 125-149.
  77. Fragnelli, M. C.; Hoyos, P.; Romano, D.; Gandolfi, R.; Alcántara, A. R.; Molinari, F., Enantioselective reduction and deracemisation using the non-conventional yeast Pichia glucozyma in water/organic solvent biphasic systems: preparation of (S)-1,2-diaryl-2-hydroxyethanones (benzoins). Tetrahedron 2012, 68 (2), 523-528. DOI: 10.1016/j.tet.2011.11.014.
  78. Hoyos, P.; Pace, V.; Alcántara, A. R., Dynamic Kinetic Resolution via Hydrolase-Metal Combo Catalysis in Stereoselective Synthesis of Bioactive Compounds. Adv. Synth. Catal. 2012, 354 (14-15), 2585-2611. DOI: 10.1002/adsc.201200365.
  79. Muñoz Solano, D.; Hoyos, P.; Hernáiz, M. J.; Alcántara, A. R.; Sánchez-Montero, J. M., Industrial biotransformations in the synthesis of building blocks leading to enantiopure drugs. Bioresour. Technol. 2012, 115, 196-207. 10.1016/j.biortech.2011.11.131.
  80. Pace, V.; Castoldi, L.; Alcántara, A. R.; Holzer, W., Robust eco-friendly protocol for the preparation of γ-hydroxy-α,β-acetylenic esters by sequential one-pot elimination-addition of 2-bromoacrylates to aldehydes promoted by LTMP in 2-MeTHF. Green Chem. 2012, 14 (7), 1859-1863. DOI: 10.1039/c2gc35305a
  81. Pace, V.; Hoyos, P.; Castoldi, L.; Domínguez de María, P.; Alcántara, A. R., 2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry. ChemSusChem 2012, 5 (8), 1369-1379. DOI: 10.1002/cssc.201100780.
  82. Hoyos, P.; Pace, V.; Alcántara, A. R., Biocatalyzed On Water Synthesis of Chiral Building Blocks for the Preparation of Anti-Cancer Drugs: a Greener Approach. Curr. Org. Chem. 2013, 17 (11), 1132-1157. DOI: 10.2174/1385272811317110003
  83. Maraite, A.; Hoyos, P.; Carballeira, J. D.; Cabrera, Á. C.; Ansorge-Schumacher, M. B.; Alcántara, A. R., Lipase from Pseudomonas stutzeri: Purification, homology modelling and rational explanation of the substrate binding mode. J. Mol. Catal. B-Enzym. 2013, 87 (0), 88-98. DOI: 10.1016/j.molcatb.2012.11.005.
  84. Pace, V.; Castoldi, L.; Alcántara, A. R.; Holzer, W., Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water. RSC Adv. 2013, 3 (26), 10158-10162. DOI: 10.1039/c3ra41262h.
  85. Pace, V.; Castoldi, L.; Hernaiz, M. J.; Alcántara, A. R.; Holzer, W., Chemoselective oxidative hydrolysis of EWG protected alpha-arylamino vinyl bromides to alpha-arylamino-alpha '-bromoacetones. Tetrahedron Lett. 2013, 54 (33), 4369-4372. DOI: 10.1016/j.tetlet.2013.05.118.
  86. Pace, V.; Holzer, W.; Verniest, G.; Alcántara, A. R.; De Kimpe, N., Chemoselective Synthesis of N-Substituted alpha-Amino-alpha '-chloro Ketones via Chloromethylation of Glycine-Derived Weinreb Amides. Adv. Synth. Catal. 2013, 355 (5), 919-926. DOI: 10.1002/adsc.201201043.
  87. Pace, V.; Hoyos, P.; Alcántara, A. R.; Holzer, W., Chemoselective CaO-Mediated Acylation of Alcohols and Amines in 2-Methyltetrahydrofuran. ChemSusChem 2013, 6 (5), 905-910. DOI: 10.1002/cssc.201200922.
  88. Alcántara, A.; Hernáiz, M.; Sánchez-Montero, J.; Saco, M.; Martín, M.; Torres, M.; Sanchez-Muñoz, A.; Guillén, C.; Heras, A.; Elorza, M., Biotecnología Farmacéutica, asignatura optativa de «obligado conocimiento» en el Grado de Farmacia (UCM). SEM@Foro, publicación semestral de la Sociedad Española de Microbiología (SEM) 2014.
  89. Alcántara, A. R.; Pace, V.; Hoyos, P.; Sandoval, M.; Holzer, W.; Hernaiz, M. J., Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs. Curr Top Med Chem 2014, 14 (23), 2694-2711. DOI: 10.2174/1568026614666141215151056.
  90. Hoyos, P.; Pace, V.; Hernáiz, M. J.; Alcántara, A. R., Biocatalysis in the Pharmaceutical Industry. A greener future. Curr. Green Chem. 2014, 1 (2), 155-181. DOI: 10.2174/2213346101666131113201722.
  91. Pace, V.; Holzer, W.; Hoyos, P.; Hernáiz, M. J.; Alcántara, A. R., 2-Methyltetrahydrofuran. In Encyclopedia of Reagents for Organic Synthesis [Online], John Wiley & Sons Ltd., http://onlinelibrary.wiley.com/book/10.1002/047084289X [accessed date]. 2014.
  92. Aires-Trapote, A.; Hoyos, P.; Alcántara, A. R.; Tamayo, A.; Rubio, J.; Rumbero, A.; Hernaiz, M. J., Covalent Immobilization of Pseudomonas stutzeri Lipase on a Porous Polymer: An Efficient Biocatalyst for a Scalable Production of Enantiopure Benzoin Esters under Sustainable Conditions. Org. Process Res. Dev. 2015, 19 (7), 687-694. DOI: 10.1021/op500326k.
  93. Pizzilli, A.; Zoppi, R.; Hoyos, P.; Gómez, S.; Gatti, F. G.; Hernáiz, M. J.; Alcántara, A. R., First stereoselective acylation of a primary diol possessing a prochiral quaternary center mediated by lipase TL from Pseudomonas stutzeri. Tetrahedron 2015, 71 (48), 9172-9176. DOI: 10.1016/j.tet.2015.09.056.
  94. Serra, I.; Daly, S.; Alcántara, A. R.; Bianchi, D.; Terreni, M.; Ubiali, D., Redesigning the synthesis of vidarabine via a multienzymatic reaction catalyzed by immobilized nucleoside phosphorylases. RSC Adv. 2015, 5 (30), 23569-23577. DOI: 10.1039/c4ra15018j.
  95. Hoyos, P.; Pace, V.; Hernáiz, M. J.; Alcántara, A. R., Dynamic Kinetic Resolution via Hydrolase–Metal Combo Catalysis. In Green Biocatalysis, John Wiley & Sons, Inc: 2016; pp 373-396.
  96. Alcántara, C. M.; Alcántara, A. R., Biocatalyzed synthesis of antidiabetic drugs: A review. Biocatal. Biotransform. 2017, 1-35. DOI: 10.1080/10242422.2017.1323887.
  97. Hoyos, P.; Hernáiz, M. J.; Alcántara, A. R., Biocatalyzed Production of Fine Chemicals. In Reference Module in Life Sciences, Elsevier: 2017.
  98. Hoyos, P., Pace, V.; Hernáiz, M. J.; Alcántara. A. R. Statins: new uses, greener synthesis. Current Medicinal Chemistry, 2017, Accepted.

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