Obesity and its Risk Associations in Older Mexicans Living with HIV

The mean age of the participants was 57.59 ± 7.8, and 13.8% were obese. Participants with obesity were more likely to have a CD4+ count <200 cell/mm3 (75%), and 50% were woman. The presence of frailty and depression was 21.4% and 19.8% respectively. The logistic regression analysis showed a positive association between obesity and being a woman, independently of CD4+, age at diagnosis of HIV and depression (OR 5.559, 95% CI 1.753-17.63, P=0.004) (Table 1).


Results
The mean age of the participants was 57.59 ± 7.8, and 13.8% were obese. Participants with obesity were more likely to have a CD4 + count <200 cell/mm 3 (75%), and 50% were woman. The presence of frailty and depression was 21.4% and 19.8% respectively. The logistic regression analysis showed a positive association between obesity and being a woman, independently of CD4 + , age at diagnosis of HIV and depression (OR 5.559, 95% CI 1.753-17.63, P=0.004) ( Table 1).

Discussion and Conclusion
In this study, 16 participants were classified with obesity and half of them were women, however according to sex, 36.5% of women classified as obese while the group of men only 7.3% (P=0.001). Our work provides some interesting observations in the light of other studies [7,8]. One of them is the clear tendency in the group of women to show a higher frequency of geriatric syndromes. For example, all women with obesity had frailty as opposed to men (0%). Also and statistically significantly, women were older than men at the time of HIV diagnosis (83% vs. 16%, P=0.039).
On the other hand, frequently, findings that demonstrate the existence of a trend are reported: the higher the leukocyte count, the greater the body mass index. However, not all studies have shown the same protective effect [9]. Our results add up to others, where women do not show the classic benefit association between BMI and CD4 count. In this work the frequency of CD4<200 in the group with obesity was 14.6%, but the distribution was identical in both sexes (P=1). Similarly, the result of the logistic regression did not change even after adding the CD4<200 count to the multivariate analysis.
The increase in the prevalence of obesity in elderly women living with HIV can be explained by several mechanisms. One of them

To the Editor
It is expected that by 2020, older adults living with HIV (OALHV) represents more than 50% of the population living with HIV worldwide [1,2]. It should be mentioned that some of them have aged with HIV and others have acquired the infection only in old age. In addition, OALHIV have a high risk for developing chronic diseases associated with age, but that occur earlier among people living with HIV, unlike those without the infection [3][4][5]. HIV infection causes premature aging and this seems to be caused by chronic immune activation as well as numerical loss and dysfunction of CD4 + cells. Others biological similarities between aging and HIV infection include DNA damage, loss of DNA repair capacity and altered mechanisms of apoptosis of immune system cells [6]. The increase in life expectancy and survival caused by advances in the treatment of HIV infection, resulted in an increase in the prevalence of some chronic diseases included obesity [7,8].
Thus, a 2-year longitudinal study of 116 participants was conducted to determine the prevalence of obesity and its risk associations in OALHIV. The participants were adults over 50 years of age living with HIV and attending an HIV clinic in a university hospital in the city of Guadalajara in Mexico. Recruitment occurred between January 2015 and January 2017. All participants underwent a geriatric evaluation with which the diagnoses of geriatric syndromes were obtained. In accordance with convention, we defined obesity as BMI ≥ 30 kg/m 2 . Correlates variables included age, sex, CD4 + count and some geriatrics syndromes. Frailty was defined according to phenotype proposed by Fried [5]. Depression was assessed using the Geriatric Depression Scale [3]. CD4 + T-lymphocyte count (CD4 + ) was measured by flow cytometry (BD FACSCalibur™).
Multivariate logistic regression analyses were created to identify the socio-demographic and health correlates of obesity. The final model included sex, and the CD4 count, age at the time of HIV diagnosis and the presence of symptoms of depression were included as confounding variables. All statistical tests were performed using are the anatomical changes which are more pronounced in women than in men: decrease in total body water, expansion of the fatty compartment and decreased muscle and bone mass [6]. It's known that education plays an important role in the development of obesity. Thus, obesity decreases as the educational level increases in the elderly [10]. Although no statistically significant difference was found, there is a clear tendency in the group of women in this study to present lower levels of schooling compared to that of men. And of course, the survival effect observed in the distribution of gender in the age groups of old age is maintained in the context of HIV infection: there are more women living with HIV than men with the infection.

Sci Forschen
In summary, our study showed that women were more at risk of being obese. Women also showed some significant compared to men: they were older at the time of HIV diagnosis and all were frailty. In this study, the CD4 count did not show an association with BMI. Obesity seems to be a continuum in the clinical spectrum of HIV infection, in which the pathophysiological pathways of frailty and immunodeficiency converge-as in biological aging. Thus, obesity can be the consequence of particular forms of aging, the confluence of HIV infection and altered immunological performance. This is a preliminary study; the results should also be interpreted in light of the limitations of any cross-sectional study. Future studies should be longitudinal to determine if older people, especially women, living with HIV have a higher risk of obesity over time.