Papadopoulou Lefkothea
James M Cook, PhD
Professor

  • Department of Chemistry
    University of Wisconsin-Milwaukee
    Milwaukee, Wisconsin, USA
    Phone: 414-229-5856
    E-mail: capncook@uwm.edu

     

Education

1986-1971

PhD Organic Chemistry

University of Michigan

 

Biography

 

Research Interest

Professor Cook’s group is working in several related fields including Natural Products, Medicinal Chemistry, and Organic Synthesis. More specifically, he is interested in the enantiospecific synthesis of natural products with biological activity and the construction of related heterocycles with enhanced activity. Research of this type has led him into the indole, benzylisoquinoline, and isoquinoline alkaloid areas, as well as the chemistry of the important alkaloids quinine, quinidine and reserpine. His group is also currently involved in the study of ligand-receptor interactions at the molecular level.

Professional Activities:

Teaching Experience:

1986- Present

Professor of Chemistry, University of Wisconsin-Milwaukee

1979-1986

Associate Professor of Chemistry, UW-Milwaukee

1973-1979

Assistant Professor of Chemistry, UW-Milwaukee
Professional Activities

The American Chemical Society: Organic & Medicinal Chemistry Divisions

  • The Chemical Society
  • Society of Neuroscience
  • College on Problems of Drug Dependence
  • International Congress on Heterocyclic Chemistry
Honors & Awards

2009- 2016

Member, Editorial Advisory Board, International Journal of Drug Design and Discovery.
Member, Editorial Board, Journal of Clinical Pharmacology

2007- 2016

Member, Editorial Board, Drug Design, Development and Therapy

2002- 2016

Member, Editorial Advisory Board, Current Organic Synthesis

2001- 2016

Member, Editorial Advisory Board, Current Topics in Medicinal Chemistry

1999- 2016

Member, Editorial Board, Expert Opinion on Therapeutic Patents

1996- 2015

Editorial Advisory Board, Medicinal Chemistry Research

1996- 2001

Member, Editorial Advisory Board, Journal of Medicinal Chemistry

1989

Milwaukee Section ACS Award in Chemistry

1997

NIMH Study Panel-Program on Psychotherapeutic Drug Development

 

Publications

  1. "Alstonerine, a New Indole Alkaloid from Alstonia muelleriana," J.M. Cook and P.W. LeQuesne, Chem. Commun., 1306-1307 (1969).
  2. "The Structure of Alstonisidine: A Novel Dimeric Indole Alkaloid," J.M. Cook and P.W. LeQuesne, J. Org. Chem., 36, 582-586 (1970).
  3. "Some Aspects of Drug Usage, Trade and Plant Domestication Among the Yanomamo Indians of Venezuela and Brazil," N. Chagnon, P.W. LeQuesne, and J.M. Cook, Acta Cient. Venezolana, 21, 186-193 (1970).
  4. "Yanomamo Hallucinogens: Anthropological, Botanical and Chemical Findings," N. Chagnon, P.W. LeQuesne, and J.M. Cook, Current Anthropology, 12, 72-74 (1971).
  5. "Macralstonine from Alstonia muelleriana," J.M. Cook and P.W. LeQuesne, Phytochem., 10, 737-738 (1971).
  6. "A Model Iron-Catalyzed Biomimetic Cyclization of a Cyclic Tryptamine N-Oxide," G. Scherer, C. Dorschel, J.M. Cook, and P.W. LeQuesne, J. Org. Chem., 37, 1083-1085 (1971).
  7. "Biomimetic Synthesis and Structure of the Bisindole Alkaloid Alstonisidine," D.E. Burke, J.M.Cook, and P.W. LeQuesne, Chem. Commun., 697 (1972).
  8. "Biomimetic Synthesis of the Bisindole Alkaloid Macralstonine," D.E. Burke, J.M. Cook, C. DeMarkey, and P.W. LeQuesne, Chem. Commun., 1346-1347 (1972).
  9. "Further Alkaloids of Alstonia muelleriana," D.E. Burke, G.A. Cook, J.M. Cook, H. Lazar, K. Heller, and P.W. LeQuesne, Phytochem., 12, 1467-1474 (1973).
  10. "Biomimetic Synthesis of Villalstonine and Alstonisidine," D.E. Burke, J.M. Cook, and P.W. LeQuesne, J. Amer. Chem. Soc., 95, 546-553 (1973).
  11. "Studies on Vinca Alkaloids. The Structure of Vincarodine," J.P. Kutney, G. Cook. J. Cook, I. Itoh, J. Clardy, J. Fayos, P. Brown, and G. Svoboda, Heterocycles, 2, 73-78 (1974).
  12. "11-Methoxyakuammicine from Alstonia muelleriana," J.M. Cook and P.W. LeQuesne, J. Org. Chem., 1367 (1975).
  13. "Studies on the Synthesis of Bisindole Alkaloids. Structure and Absolute Configuration of 18'-Epi-4'-Epi-Vinblastine, 18'-Decarbometh-oxy-18'-Epi-4'-Epi- Vinblastine and 18'-Epi-3',4'-Dehydrovinblastine," J.P. Kutney, J. Cook, K. Fuji, A. Treasurywala, J. Clardy, J. Fayos, and H. Wright, Heterocycles, 3, 205-212 (1975).
  14. "Total Synthesis of Indole and Dihydroindole Alkaloids. VIII. Studies on the Synthesis of Bisindole Alkaloids in the Vinblastine-Vincristine Series. The Chloro-indolenine Approach," J.P. Kutney, J. Beck, F. Bylsma, J.M. Cook, W. Cretney, K. Fuji, R. Imhof, and A. Treasurywala, Helv. Chim. Acta, 58, 1690-1719 (1975).
  15. "Reaction of 1,2 and 1,3 Dicarbonyl Compounds with Dimethyl ß-Ketoglutarate. I. Synthesis of Methyl 5,6,7,8-Tetrahydro-5-oxocoumarin-ß(41H)-Acetate," D. Yang, J. Oehldrich, D. Foerst, and J.M. Cook, J. Org. Chem., 41(4), 743 (1976).
  16. "Reactions of Dicarbonyl Compounds with Dimethyl ß-Ketoglutarate. II. Simple Synthesis of Compounds of the [10.3.3] and [6.3.3] Propellane Series," J.M. Cook and D. Yang, J. Org. Chem., 41, 1903-1907 (1976).
  17. "Pictet-Spengler Condensations in Refluxing Benzene," J. Sandrin, D. Soerens, L. Hutchins, E. Richfield, F. Ungemach, and J.M. Cook, Heterocycles, 4, 1101-1105 (1976).
  18. "13C-NMR of 1,3-Disubstituted 1,2,3,4-Tetrahydro-ß-Carbolines," J. Sandrin, D. Soerens, and J.M. Cook, Heterocycles, 4, 1249-1255 (1976).
  19. "Reactions of Dicarbonyl Compounds with Dimethyl ß-Ketoglutarate. IV. Isolation of 1:1 Adducts," J. Oehldrich, M. Mueller, D. Wichman, D. Yang, J.M. Cook, and U. Weiss, J. Org. Chem., 41, 4053-4058 (1976).
  20. "Reactions of Dicarbonyl Compounds with Dimethyl ß-Ketoglutarate. V. Simple Synthesis of Tricyclo [6.3.0.01,5]undecane-3,7,9-Trione: A Novel Cyclopentanoid Compound," J. Oehldrich, J.M. Cook, and U. Weiss, Tetrahedron Lett., 4549- 4552 (1976).
  21. "Reactions of Dicarbonyl Compounds with ß-Ketoglutaric Acid III: Synthesis of 4-Hydroxy-3,4-diphenylcyclopent-2-enone-2-carboxylic Acid," J. Oehldrich and J.M. Cook, Can. J. Chem., 55, 82-84 (1977).
  22. "Reactions of Dicarbonyl Compounds with Dimethyl ß-Ketoglutarate. VI. Revision of the Structure of the Reaction Product of Cyclohexane-1,3-dione and Dimethyl ß-Ketoglutarate and Conversion into 4-Substituted-5,6,7,9 -Tetrahydro-5-oxo-2- quinolones," J. Oehldrich and J.M. Cook, J. Org. Chem., 42, 889-894 (1977).
  23. "Synthesis of 1,2,3,4-Tetrahydro-ß-Carbolines," J. Sandrin, D. Soerens, P. Mokry, and J.M. Cook, Heterocycles, 6, 1133-1139 (1977).
  24. "Reaction of Carbonyl Compounds with Dimethyl ß-Ketoglutarate. Synthesis of Bicyclic Furan Derivatives," O. Campos and J.M. Cook, J. Hetero. Chem., 14(5), 711-715 (1977).
  25. "General Method for the Synthesis of [n.3.3]Propellanes, n > 3," R. Weber and J.M. Cook, Can. J. Chem., 56, 198-192 (1978).
  26. "Synthesis of the Antibiotic (±)-Pyridindolol," G.S. Wu, E. Yamanaka, and J.M. Cook, Heterocycles, 9, 175-183 (1978).
  27. "Synthesis of a Tetraketone of the Tetracyclo[5.5.1.0.4,13O10,13]tridecane ("Staurane") Series," R. Mitschka, U. Weiss, and J.M. Cook, J. Am. Chem. Soc., 100, 2973-2974 (1978).
  28. "The Spiroindolenine Intermediate: A Review," F. Ungemach and J.M. Cook, Heterocycles, 9, 1089-1119 (1978).
  29. "Simple Entry into the 1,6-Diazaphenalene Ring System," M.I. El-Sheikh, J.-C. Chang, and J.M. Cook, Heterocycles, 9, 1561-1570 (1978).
  30. "Study of the Pictet-Spengler Reaction in Aprotic Media: Synthesis of the ß-Galactosidase Inhibitor, Pyridindolol," D. Soerens, J. Sandrin, F. Ungemach, P. Mokry, G.S. Wu, E. Yamanaka, L. Hutchins, M. DiPierro, and J.M. Cook, J. Org. Chem., 44, 535-545 (1979).

 

 

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