Education

Biography

Prof. Shail K. Chaube is a Ph.D. in Zoology from BHU (1996) and post doctoral fellow from CCMB, Hyderabad (1996-97). After working as ARO/RO for 10 years at National Institute of Health and Family Welfare, New Delhi (MOHFW, Govt. of India), he joined as a Reader in the Department of Zoology, BHU, Varanasi in 2007. He was then promoted as Associate Professor in 2010 and Professor in 2013. His area of specialization includes cell physiology particularly in the field of meiotic cell cycle regulation, cell signaling and apoptosis in female germ cells. He has authored more than 95 reviewed original research articles and 13 review articles in highly reputed international journals. He received Prof. G.P. Talwar gold medal award for Middle Career Scientist at Rajiva Gandhi Centre for Biotechnology, Thiruvananthapuram in 2013 for his contribution in the area of cell signaling during meiotic cell cycle regulation and apoptosis in oocytes/eggs. Recently he has received Outstanding Faculty award in the field of Zoology (Cell Physiology) by Venus International Faculty Award 2016 at Chennai dated 9th July 2016.  Researcher under his dynamic leadership are currently working on the role of various signal molecules including reactive oxygen species on meiotic cell cycle regulation, achievement of meiotic competency, apoptosis, postovulatory egg aging and development of potential biomarkers for egg quality using rat as animal model. He serves as an editorial board member of 6 highly-valued international journals.

Research Interest

• Cell physiology
• Meiotic cell cycle progression and arrest in oocytes and eggs
• Cell Signaling and
• Apoptosis: Steroid Biochemistry

Scientific Activities

Employment History

Professional Activities

Membership in Scientific/Professional Organizations

Member of Scientific Society:

1. Life member of Indian Society of Cell Biology
2. Life Member of Indian Society for Study in Reproduction and Fertility

Consultative and Advisory Positions Held

Association with International Journals:

Advisory Board Member:

1. World Research Journal of Cell Biology
2. Translational Medicine and Biotechnology

Editorial Board Member:

1. Open Journal of Apoptosis
2. Asian Journal of Pharmacological Sciences
3. Reactive Oxygen Species
4. Research and Reviews: Zoological Sciences
5. Global Journal of Zoology
6. Histology, Cytology and Embryology
7. Global Journal of Reproductive Medicine
8. Biomedical Research & Public Health

Honors and Awards

• Received Post Doctoral Fellowship at Center for Cellular and Molecular Biology (1996-1997), Uppal Road, Hyderabad.
• Received Prof. G.P. Talwar Gold Medal award for Middle Career Scientist by ISSRF dated 7th Feb, 2013
• Received Outstanding Scientist Award-2016 (in Science/Zoology category) by Venus International Foundation, Chennai dated 9th July 2016
• Received Labhsetwar award by ISSRF dated 23th Feb, 2017
• Received best Speaker award by World congress on drug development and discovery at Science city Kolkata dated 23 Sept, 2017

Publications

1. Chaube, S.K. and Haider S (1995) The in-vitro effect of theophylline on 17a, 20 b - dihydroxy-4-pregnen-3-one -induced germinal vesicle breakdown in the catfish, Clarias batrachus. J. Biosci, 20;439-444. IF(2004)=1.10
2. Haider, S. and Chaube S.K. (1995) Changes in total cAMP levels during oocyte maturation in the catfish, Claris batrachus. Comp. Biochem. Physiol.A 112; 379-385. IF(2004)=1.64
3. Haider S, and Chaube S.K. (1996).In-vitro effects of forskolin, IBMX and cyanoketone on meiotic maturation in follicle-enclosed catfish, Clarias batrachus oocytes.Comp.Biochem.Physiol.115C;117-123. IF(2004)=1.65
4. Chaube, S.K,. and Haider S. (1997) Evidence for the stimulation of cyclic  AMP phosphodiesterase in the catfish, Clarias batrachus oocytes by17a ,20b-dihydroxy-4-pregnen-3-one. J. Exp. Zool.277, 166-170. IF(2004)=1.17
5. Chaube S.K. and Haider S.(1997)Effects of cAMP forskoline and cyanoketone  on in vitro oocyte maturation in the catfish, Clarias batrachus J. Biosci.22; 1-11. IF(2004)=1.10
6. Misro M.M., Chaki. S.P. Shrinivas M and Chaube S. K. (1999).Effect of cyclosporine on human spermatozoa motality in vitro.  Arch. Androl.43;215-220. IF(2004)=0.64
7. Gopalakrishna P, Chaube S.K., Manogaran P.S.and Pande  G ( 2000) Modulation of a5 b1 integrin functions  by the phospholipid and cholesterol contents of cell membranes. J Cell. Biochem. 77; 517-528. IF(2004)=3.32
8. Chaki, SP., Chaube, SK. & Misro, M.M. (2000) A simple and unified procedure for assessment of hypo osmotic swelling and nuclear decondensation in ejaculated human spermatozoa. Intl. J. Urology (Suppl) 7: S78. IF(2004)=3.71
9. Misro, M.M., Chaube, S.K. and Chaki, S.P (2000) Spontaneous oocyte maturation in vitro: Design and development of a system for compounds to test toxicity or inhibition of oocyte maturation. Mol. Cell. Endocrinol.164:274. IF(2011)=4.19
10. Chaube S.K., Chaki S.P. and Misro M.M. (2001) Effects of pentoxifylline and caffeine on spontaneous maturation of rat oocytes in vitro. Health and Population, 23;177-189.
11. Chaube S.K. (2001) Role of meiotic maturation regulatory factors in the meiotic competence of mammalian oocytes. Health and Population, 24 (4) pp218-231.
12. Chaube S.K. (2002) Does cAMP act as a regulator for oocyte meiotic resumption in mammal?  Health and Population, 25 (2) pp74-85.
13. Chaube, S.K. and Misro, M.M. (2002) Effects of the Intra-vasal male contraceptive, styrene maleic anhydride (SMA) on the morphology and viability of rat oocytes in vitro. Contraception, 66,469-472. IF(2011)=2.72
14. Chaube, S.K., Chaki, S.P. and Misro, M.M. (2003) Induction of maturation and fertilizing ability of rat oocytes in vitro: Role of cumulus cells and human chorionic gonadotropin. Modern J of Life Sciences, 1(1-2),pp40-45
15. Thakur S.C., Thakur S.S., Chaube S.K. and Singh S.P. (2003). Long-Term Exposure of Lithium Carbonate Induces Reproductive System Impairment in Male Rat. Reprod. Toxicol, 17;683-690. IF(2012)= 3.23
16. Chaube, S.K. Prasad P.V., Thakur S.C. and Srivastava T.G. (2005) Hydrogen peroxide modulates meiotic cell cycle and induces morphological features charecteritics of apoptosis in rat oocytes cultured in vitro. Apoptosis, 10: 863-875. IF(2011)=4.78
17. Thakur S.C., Thakur S.S., Chaube S.K. and Singh S.P. (2005).  An ethereal extract of Kamala seed induces adverse effects on reproductive parameters of female rat. Reprod. Toxicol., vol 20,149-156. IF(2012)=3.23
18. Chaube, S.K. Prasad P.V., Thakur S.C. and Srivastava T.G. (2005) Estradiol protects clomiphene citrate induced apoptosis in rat ovarian follicles and superovulated cumulus oocyte complexes. Fertility Sterility; 84; 1163-1172. IF(2012)=4.59
19. Prasad PV, Chaube SK, Kumari GL, Murlidher K and Srivastava TG (2005) Isolation of hCG and its characterization by radioimmunoassay, Enzyme-Immunoassay, and radio-Recepter assay. J Immunoassay Immunochem.; 26; 325-344. IF(2005)=0.89
20. Prasad PV, Chaube SK, Kumari GL,Murlidher K and Srivastava TG (2005) Isolation of α- and β-subunits of peak-I and generation of highly specific polyclonal antisera. J Immunoassay Immunochem.; 26; 345-355. IF(2005)=0.89
21. Thakur S.C., Thakur S.S., Chaube S.K. and Singh S.P. (2005).Emisan-6 induces visceral organ toxicity in female rats. Biochem. Cell. Arch.5, 145-152.
22. Prasad PV, Chaube SK, Kumari GL,Murlidher K and Srivastava TG (2006) Enzyme-linked immunosorbent assay for human chorionic gonadotropin. J of Immunoassay Immunochem.;27; 15-30. IF(2005)=0.89
23. Chaube S.K., Prasad P.V., Khillare B, Shrivastav T.G. (2006) Extract of Azadirachta indica (Neem) leaf induces apoptosis in rat oocytes cultured in vitro. Fertility Sterility; 85: suppl.1: 1223-1231. IF(2012)=4.59
24. Chaube, S.K. Prasad PV, Tripathi V and Srivastava T.G. (2006) Clomiphene citrate inhibits superovulation induction by modulating cAMP and prostaglandin in rat. Fertility Sterility; 86, suppl.1: 1106-1111. IF (2012)=4.59
25. Basu A, Nara S, Chaube SK, Kariya KP, Shrivastav TG (2006). The influence of spacer-containing enzyme conjugate on the sensitivity and specificity of enzyme immunoassays for hapten. Clin Chim Acta ; 366:287-292.  IF (2005)=2.54
26. Chaube S.K., Dubey P.K., Mishra SK., Shrivastav T.G. (2007) Effects of verapamil on meiotic cell cycle regulation and apoptosis in rat oocytes cultured in vitro. Cloning and Stem Cells; 9:615-624. IF (2005)=3.026
27. Prasad P.V., Chaube S.K., Panchal M., Chaudhary R., Muralidhar K., Rohil V., Kumari G.L., Kumar A., Ashish B, Murthy G. S., and Shrivastav  T.G. (2007) Molecular dissection of an hCG-β epitope using single-step solid phase radioimmunoassay. Clinica Chimica Acta, 367 376(1-2):52-9. IF(2005)=2.54
28. Chandra A.K., Chatterjee A., Ghosh R., Sarkar M, Chaube S.K. (2007) Chromium Induced Testicular Impairment in Relation to Adrenocortical Activities in Adult Albino Rats. Reprod. Toxicol. 24; 388-396. IF (2011)= 3.22
29. Shrivastav T.G., Nara S., Tripathi V, Sayeed, Rangari K, Chaube S.K.,  Singh H. (2007) Preparation of hoshradish peroxidase-carbamide and its use in haptan immunoassays. J Endocrinol Repord:11; 15-21.
30. Nara S, Singh H., Chaube S.K., Rangari K., Shrivastav T.G. (2008). Influence of hydrophobic and hydrophilic spacer-containing enzyme conjugate on functional parameters of immunoassay for cortisol. Analytical Biochem. 325; 18-25. IF (2011)=2.22
31. Tripathi, V., Nara S., Chaube, S.K., Rangari, K., Saroha A., Karia KP., Singh H., Shrivastav T.G. (2008) Development of Rapid and Sensitive One Step Direct Enzyme Linked Immunosorbent Assay for 17- -OH-Progesterone in serum. J of Immunoassay Immunochem. 29; 117-127. IF (2005)=0.89
32. Chaube S.K., Khatun S., Mishra S.K., Shrivastav T.G. (2008). Calcium ionophore-induced egg activation or apoptosis is associated with the generation of intracellular hydrogen peroxide. Free Radical Research, 42:212-220 IF (2012)=2.98
33. Sharma S., Haldar C. and Chaube S.K. (2008) Effect of exogenous melatonin on X-ray induced cellular toxicity in lymphatic tissue of Indian tropical male squirrel, Funambulus pennanti. International J Rad. Biol. 84:363-74. IF (2005) IF=1.69
34. Nara S., Tripathi V., Chaube S.K., Rangari K., Singh H., Kariya K.P. and Shrivastav  T.G. (2008) Use of biotin-streptavidin system for developing a viable, sensitive and specific antigen heterologous assay for hapten. Talanta 77: (1):210-6. IF (2005)=3.55
35. Nara S, Chaube S.K., Rangari K., Singh H, Shrivastav T.G. (2008). A novel enzyme-linked immunosorbent assay for cortisol using a long-chain biotinylated cortisol-3-CMO derivative. J of Immunoassay Immunochem. 2008;29:390-405. IF (2005)=0.89.
36. Prasad PV, Rani A, Chaube SK, Rohil V, Shrivastav TG (2008) Kinetic analysis of a human chorionic gonadotropin-beta epitope-paratope interaction. Growth Factors, 26:331-42. IF (2008)=3.39
37. Prasad P.V., Rani A., Chaube S.K., Shrivastav T.G. (2009). Deciphering a Conformation-Specific Epitope of hCG-beta Through Immunokinetics. J Immunoassay Immunochem. 2009;30(1):1-17 IF (2007)=0.89
38. Chaube S. K., Tripathi A., Khatun S., Mishra S. K., Prasad P.V. and Shrivastav T.G. (2009) Extracellular calcium protects against verapamil-induced metaphase-II arrest and initiation of apoptosis in aged rat eggs. Cell Biology Intl., 33; 337-343. IF (2009)=1.98
39. Tripathi A, Khatun S, Pandey A.N., Mishra S. K., Chaube R, Shrivastav T.G., and Chaube S. K. (2009) Intracellular levels of hydrogen peroxide and nitric oxide in oocyte at various stages of meiotic cell cycle and apoptosis.  Free Radical Research, 43, 287-294. IF (2008)=2.98
40. Khatun S, Nara S., Tripathi V., Rangari K., Chaube S.K., Kariya K.P., Kumar S. and Shrivastav T.G. (2010). Development of ELISA for measurement of progesterone employing 17-a-OH-P-HRP as enzyme label. J of Immunoassay Immunochem. 30; 186-196. IF (2009)=0.89
41. Tripathi A., Premkumar K.V. and Chaube S.K. (2010) Meiotic cell cycle arrest in mammalian oocyte. J Cell Physiology 223; 592-600.IF = 4.6
42. Pandey A.N., Tripathi A., Premkumar K.V., Shrivastav T.G. and Chaube S.K. (2010) Reactive Oxygen and Nitrogen Species during Meiotic Resumption from Diplotene Arrest in Mammalian Oocytes. J. Cell. Biochem. 111: 521-8. IF (2010)=3.33
43. Shrivastav T.G., Chaube S.K., Kariya K.P., Bhanot S., Singh R., and Kumar D. (2010). Development of heterologous enzyme linked immunosorbent assay for Dehydroepiandrosterone in serum. J Immuno Immunochem. 31:266-278. IF=0. 89
44. Shrivastav T.G. , Chaube S.K., Charu, Rangari K., Kariya K.P., Singh R., and Nagendra A. (2010). Enzyme linked immunosorbent assay for milk progesterone. J Immuno Immunochem. 31:301-313. IF=0. 89.
45. Joshi NR, Banerjee S, Mukherjee R, Chaube SK, Srivastava TG,  Ramachandran AV  (2010) In Vivo and In Vitro Studies on Nickel Induced Reproductive Toxicity and the Protective Role of Melatonin. Biol. Reprod. 83 (suppl. 1), 114 (abstract).  IF=3.32
46. Shrivastav T.G., Chaube S.K., Kariya K.P., Kumari P., Singh R., and Kumar D. (2011) Influence of different homologous and heterologous combinations of antibodies and enzyme conjugates of Dehydroepiandrostosterone on the sensitivity and specificity of DHEA ELISA. J  Immunoassay Immunochemistry, 32:114–127. IF=0. 89
47. Shrivastav,T.G. Chaube, S.K. Kariya, K.P. Rangari, K, Singh, R. (2011). Development of an antigen heterologous enzyme linked immunosorbent assay for measurement of corticosterone in rat serum. Journal Immunoassay Immunochemistry, 32: 244-257. IF=0. 89
48. Tripathi A., Premkumar K.V., Pandey A.N., Khatun S., Mishra S.K., Shrivastav T.G. and Chaube S.K. (2011) Melatonin protect against clomiphene citrate-induced generation of free radicals and egg apoptosis in rat. Eur J Pharmacol. 667; 419-424. IF =2.53
49. Shrivastav TG, Chaube SK, Kariya KP, Singh R, Kumar D, Pandit D, Ujawane P, Kumari P, Pandey B. (2011) Influence of different length linker containing dhea-7-cmo-enzyme conjugates on sensitivity and specificity of dhea-17-cmo-antibody. J Immunoassay Immunochem. 32:269-83. IF=0. 89
50. Shrivastav TG, Chaube SK, Kariya KP, Kumar D, Singh R. (2011) Antigen heterologous enzyme linked immunosorbent assay for the measurement of dhea in serum. J Immunoassay Immunochem. 32:326-41. IF=0. 89
51. Tripathi A,  Shrivastav TG, Chaube  SK (2012) Aqueous extract of Azadirachta indica (Neem) leaf-induced apoptosis is mediated through generation of ROS in rat eggs. J Asst. Reprod. Genet. 29, 15-23.  IF = 1.98
52. Shrivastav TG, Chaube SK, Kariya KP, Singh R, Kumar D, Jain P, Karwar S, Uyake J, Deshmukh B (2012): Influence of different length linker containing DHEA-7-CMO-enzyme conjugates on sensitivity and specificity of DHEA-3-hs-antibody, Journal of Immunoassay Immunochem., 33:1, 1-17. IF=0. 89
53. Tripathi A, Chaube SK (2012) High level of cytosolic free calcium signals apoptosis through the mitochondria-caspase mediated pathway in rat eggs cultured in vitro. Apoptosis 17, 439-448. IF = 4.00