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Prabodh Kapoor, Ph.D.
Assistant Professor
  • Department of Cellular and Molecular Biology
    The University of Texas Health Science Center at Tyler
    USA
    Phone: 903-877-7684
    Email: prabodh.kapoor@uthct.edu

Education

2002

University of Lucknow.

B.Sc, Biology

2004

University of Lucknow

M.Sc. Biochemistry

2010

Jawaharlal Nehru University

Ph.D.

 POSTDOCTORAL TRAINING

2010-2015

Department of Epigenetics and Molecular Carcinogenesis, The UT MD Anderson Cancer Center

Postdoctoral Fellow

2015-2016

Department of Epigenetics and Molecular Carcinogenesis, The UT MD Anderson Cancer Center

Instructor

 

Biography

Dr. PrabodhKapoor was born, raised, and educated in Lucknow, India. He pursued his graduation in the Molecular & Structural Biology department at Central Drug Research Institute (CDRI), Lucknow, India. He submitted his PhD thesis with dissertation entitled “Functional and structural characterization of actin from Leishmaniadonovani” under the supervision of Dr. C.M. Gupta and obtained Doctorate degree in 2010 from Jawaharlal Nehru University, New Delhi, India. He then joined the lab of Dr. Xuetong “Snow” Shen at The UT M.D. Anderson Cancer Center, USA as an Odyssey Fellow for his postdoctoral research training. After six years of postdoctoral training, he is now a Principal Investigator at The University of Texas Health Science Center at Tyler, Texas, USA.

 

Research Interest

His current research interests include the Biochemistry, molecular biology, genetics, epigenetics, chromatin biology, actin biology, and cancer biology.

 

Scientific Activities

 

Publications

  1. Kapoor, P.*, Shen, X*. (2016) Stringing Nucleosome Necklaces in the Yeast Genome. Leading edge preview. Cell 2016 Oct 20;167(3):600-601.*=corresponding author.
  2. Kapoor, P., Shen, X., (2015) SWI/SNF chromatin remodeling complex regulates a non-chromatin substrate. Featured editorial review. Cell Cycle 14(15): 2379-80.
  3. Shen, J., Peng, Y., Lan, L., Zhang, W., Yang, L., Uray, I.P., Wu, X., Kapoor, P., Shen, X., Brown, P.H., Mills, G.B., Peng, G., (2015) ARID1A deficiency impaired the DNA damage checkpoint and sensitizes cells to PARP inhibitors.Cancer Discovery 5(7): 752-67.
  4. Kapoor, P., Bao, Y., Xiao, J., Espejo, A., Shen, J., Bedford, M.T., Peng, G., Shen, X. (2015) Phosphorylation-dependent enhancement of Rad53 kinase activity through the INO80 chromatin remodeling complex. Molecular Cell 58: 863-869.
  5. Kapoor, P., Bao, Y.*, Xiao, J., Luo, J., Shen, J., Persinger, J., Peng, G., Ranish, J., Bartholomew, B., Shen, X. (2015) Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex. Genes & Development Mar; 29(6): 591-602. (Highlighted on cover page of the journal, and in Genes &DevelopmentNews section).
  6. Kapoor, P., Shen, X., (2014) Mechanisms of nuclear actin in chromatin remodeling complexes. Trends in Cell Biology Apr; 24(4): 238-46.
  7. Kapoor, P., Chen, M.*, Winkler. D.D., Luger, K., Shen, X. (2013) Evidence for monomeric actin function in INO80 chromatin remodeling. Nature Structural&MolecularBiologyApr; 20, 426-32. (Cover page article, recommended by Faculty of 1000, F1000 prime, Comment in: Monomeric actin required for INO80 remodeling. Nature Structural&Molecular Biology 2013 Apr; 20(4):405-7).
  8. Kapoor, P., Kumar, A., Naik, R., Ganguli, M., Siddiqi, M.I., Sahasrabuddhe, A.A., Gupta, C.M. (2010) Leishmania actin binds and nicks kDNA as well as inhibits the decatenation activity of type II topoisomerase. Nucleic Acids Research 38, 3308-3317.
  9. Kapoor, P., Sahasrabuddhe, A.A., Kumar, A., Mitra, K., Siddiqi, M.I., Gupta, C.M. (2008) An unconventional form of actin in protozoan hemoflagellate, Leishmania.TheJournal of Biological Chemistry 283, 22760-22773.
Book Chapters
  1. Kapoor, P., Shen, X., (2014) Chromatin remodeling in DNA Repair and Replication. Fundamentals of Chromatin (Springer), edited by; Jerry L. Workman and Susan M. Abmayr. (2014) XIII, 587 p. 491-528.

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