Education

Biography

Research Interest

Cancer, breast cancer, genomics, genetics, germline mutation, bioinformatics.

Professional Activities:

• Epigenetic Core, Children’s Memorial Research Center, Northwestern University, 2005-2010
• Genomics Core, Center for Genetic Medicine, Northwestern University, 2005-2010
• Cancer Biology and Epigenomics Program Faculty Search Committee, Children's Memorial Research Center, Northwestern University, 2007-2008
• The Kamie K. Preston Hereditary Cancer Foundation, Board of Directors. 2015-

Publications

1. SM Wang, CF Guan. The effects of cordyceps sinensis on Interleukin-2 secretion. Chinese Journal of Experimental & Clinical Immunology. 2:40-42, 1990
2. CF Guan, LC Wang, YZ Xie, SL Xu, YX Zhang, SM Wang, J Jin, YZ Wang. Immunological alternation in weakness syndrome modeled in donkey and rat. Chinese Journal of Veterinary Medicine 3:40-42, 1990
3. P Sperisen, SM Wang, P Reichenbach, M Nabholz. A PCR-based assay for reporter gene expression. PCR Methods and Applications 1:164-170, 1992
4. P Sperisen, SM Wang, P Bucher, P Corthesy, P Reichbach, M Nabholz. The Biphasic Transcriptional Response of the IL2R Gene to IL1 and IL2 reflects bipartotie structure of the 5' flanking region. Journal of Biological Chemistry 270(18):10743-10753, 1995
5. M Nabholz, E Soldani, P Sperisen, M Pla, SM Wang, HR MacDonald, P Reichenbach, F Beermann, P Bucher. The Cis-acting elements controlling mouse IL2R transcription. Immunology 193: 259-262, 1995
6. SM Wang, JD Rowley. A Strategy for Gene Identification: Integrated Procedure for Gene Identification. Proc. Natl. Acad. Sci. USA 95: 11909-11914, 1998
7. SM Wang, J Khandekar, K Kaul, D Winchester, R Morimoto. A method for the quantitative analysis of human heat shock gene expression using a multiplex RT-PCR assay. Cell Stress and Chaperones 4: 77-82, 1999
8. J Chen, JD Rowley, SM Wang. Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification. Proc. Natl. Acad. Sci. USA 97: 349-353, 2000
9. SM Wang, SC Fears, L Zhang, J-J Chen, JD Rowley. Screening poly dA/dT(-) cDNAs for gene identification. Proc. Natl. Acad. Sci. USA 97:4162-4167, 2000. (Commentary by KJ Martin and AB Pardee. Identifying expressed genes. Proc. Natl. Acad. Sci. USA  97: 3789-3791, 2000)
10. X Yang, AT Ferguson, SJ Nass, P Kim, A Butash, SM Wang, JG Herman, NE Davidson. Transcriptional activation of estrogen receptor in human breast cancer cells by histone deacetylase inhibition. Cancer Res. 60: 6890-6894, 2000
11. S Lee, J Chen, G Zhou, SM Wang. Generation of high quantity and quality tag/ditag cDNAs for SAGE analysis. BioTechniques 31: 348-354, 2001
12. S Lee, G Zhou, T Clark, J Chen, JD Rowley, SM Wang. The pattern of gene expression in human CD15+ myeloid progenitor cells. Proc. Natl. Acad. Sci. USA 98: 3340-3345, 2001
13. J Chen, D Rowley, T Clark, S Lee, G Zhou, C Cheers, JD Rowley, SM Wang. Genome-level identification of expressed genes in mouse Gr-1+ myeloid progenitor cells. Genomics 77: 149-162, 2001
14. G Zhou, J Chen, S Lee, T Clark, JD Rowley, SM Wang. The pattern of gene expression in human CD34+ hematopoietic stem/progenitor cells. Proc. Natl. Acad. Sci. USA 98: 13966-13971, 2001
15. J Chen, S Lee, G Zhou, SM Wang. High-throughput GLGI procedure for converting a large number of serial analysis of gene expression tag sequences into 3’ complementary DNAs. Genes, Chromosomes & Cancer 33: 252-261, 2002
16. S Lee, T Clark, J Chen, G Zhou, LR Scott, JD Rowley, SM Wang. Correct identification of genes from SAGE tag sequences. Genomics 79: 598-599, 2002
17. D Nam, S Lee, G Zhou, X Cao, C Wang, J Chen, T Clark, JD Rowley, SM Wang. Oligo dT primer generates a high frequency of truncated cDNAs through internal poly A priming during reverse transcription. Proc. Natl. Acad. Sci. USA. 99: 6152-6156, 2002
18. T Clark, S Lee, LR Scott, SM Wang. Computational analysis of gene identification with SAGE.  Journal of Computational Biology  3: 513-526, 2002
19. M Müschen, S Lee, G Zhou, N Feldhahn, VS Barath, J Chen, C Moers, M Krönke, JD Rowley, SM Wang. Molecular portraits of B cell lineage commitment. Proc. Natl. Acad. Sci. USA 99:10014-10019, 2002
20. J Chen, M Sun, S Lee, G Zhou, JD Rowley, SM Wang. Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. Proc. Natl. Acad. Sci. USA 99: 12257-12262, 2002
21. SM Wang. The new role of SAGE in gene discovery. Trends in Biotechnology 21: 57-58, 2003
22. M Sun, G Zhou, S Lee, J Chen, RZ Shi, JD Rowley, SM Wang. SAGE is far more sensitive than EST for detecting low abundant transcripts. BMC Genomics 5: 1-4, 2004
23. A Silva, J Chen, DM Carraro, SM Wang, AA Camargo. Convert Massive Parallel Signature Sequencing Tags into 3’ cDNA. Nucleic Acid Research 32: e94, 2004
24. S Lee, J Bao, G Zhou, J Shapino, J Xu, RZ Shi, X Lu, T Clark, D Johnson, YC Kim, C Wing, C Tseng, M Sun, W Lin, J Wang, W Du, CI Wu, X Zhang, SM Wang. Detecting novel low-abundant transcripts in Drosophila. RNA 11: 939-946, 2005
25. J Bao, S Lee, C Chen, XQ Zhang, Y Zhang, SQ Liu, T Clark, J Wang, ML Cao, HM Yang, SM Wang, J Yu. SAGE (Serial Analysis of Gene Expression) Study of a Hybrid Rice Strain (LYP9) and Its Parental Cultivars. Plant Physiology, 138: 1216-1231, 2005
26. X Ge, S Yamamoto, S Tsutsumi, Y Midorikawa, S Ihara, SM Wang, H Aburatani. Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics, 86: 127-141, 2005
27. S Lee, D Johnson, K Dunbar, H Dong, X Ge, YC Kim, C Wing, N Jayathilaka, N Emmanue, CQ Zhou, HL Gerber, CC Tseng, SM Wang. 2.45 GHz Radiofrequency fields alter gene expression in cultured human cells. FEBS Letters 579:4829-4836, 2005
28. HS Kang, EM Kim, S Lee, SR Yoon, T Kawamura, YC Lee, S Kim, PK Myung, SM Wang, I Choi. Stage-dependent gene expression profiles during natural killer cell development. Genomics 86: 551-65, 2005
29. X Ge, YC Jung, Q Wu, WA Kibbe, SM Wang. Annotating non-specific SAGE tags with microarray data, Genomics 87:173-180, 2006
30. S Lee, J Chen, G Zhou, RZ Shi, G Bouffard, M Kocherginsky, X Ge, M Sun, N Jayathilaka, YC Kim,  N Emmanuel, S Bohlander, M Minden, J Kline, O Ozer, R Larson, M LeBeau, E Green,  J Trent, T Karrison, P Liu, SM Wang, JD Rowley. Gene Expression Profiles in Acute Myeloid Leukemia with Common Translocations using SAGE, Proc. Natl. Acad. Sci. USA 103: 1030-1035, 2006
31. SM Wang. Applying the SAGE technique to study the effects of electromagnetic field on biological systems. Proteomics. 6: 4765-4768, 2006 (Invited review)
32. X Ge, Q Wu, YC Jung, J Chen, SM Wang. A large quantity of novel human antisense transcripts detected by LongSAGE. Bioinformatics. 22: 2475-2479, 2006. (This paper was determined as “the Hot Paper in Computer Science” in 2008 by Essential Science Indicators of Thompson Scientific)
33. HL Gerber, A Bassi, M Khalid, C Zhou, SM Wang, CC Tseng. Analytical and Experimental Dosimetry of a T-25 Flask in a thermally controlled waveguide. IEEE Transactions on Plasma Science 34: 1449-1454, 2006
34. X Ge, Q Wu, SM Wang. SAGE detects microRNA precursors. BMC Genomics 7: 285-287, 2006
35. YC Kim, Y-C Jung, Z Xuan, MQ Zhang, SM Wang. Pan-genome isolation of low abundant transcripts through SAGE tag mis-priming. FEBS Letters 580: 6721–6729, 2006
36. Q Wu Q, N Tommerup, SM Wang, L Hansen. A novel primate specific gene, CEI, is located in the homeobox gene IRXA2 promoter in Homo sapiens. Gene 371: 167-73, 2006
37. S Lee, J Hwang, J Ulaszek, YC Kim, H Dong, HS Kim, JW Seok, BK Suh, SJ Yim, D Johnson, NH Choe, KT Chang, ZY Ryoo, CC Tseng, A Wickrema, SM Wang. Stable transcriptional status in the apoptotic erythroid genome. Biochem Biophys Res Commun. 359: 556-562, 2007
38. SM Wang. Understanding SAGE data. Trends in Genetics 23: 42-50, 2007 (Invited Review)
39. J Lu, Y Shen, Q Wu, S Kumar, B He, RW Carthew, SM Wang, CI Wu. The birth and death of microRNA genes in Drosophila. Nature Genetics 40: 351-355, 2008.
40. J Chen, YC. Kim, Y-C Jung, Z Xuan, G Dworkin, Y Zhang, MQ Zhang, SM Wang. Scanning the human genome at kilobase resolution. Genome Research 18: 751-762, 2008
41. SM Wang. Long-short-long games in transcript identification: the length matters. Current Pharmaceutical Biotechnology, 9: 362-367, 2008 (Invited Review)
42. Q Wu, YC Kim, J Lu, Z Xuan, J Chen, YL Zheng, T Zhou, MQ Zhang, CI Wu, SM Wang. Poly A- transcripts expressed in HeLa cells. PLoS ONE 3: e2803. doi:10.1371/journal.pone.0002803, 2008
43. Z Li, RT Luo, S Mi, M Sun, P Chen, J Bao, MB Neilly, N Jayathilaka, DS Johnson, L Wang, C Lavau, Y Zhang, C Tseng, X Zhang, J Wang, J Yu, H Yang, SM Wang, JD Rowley, J Chen, MJ Thirman. Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. Cancer Res. 69: 1109-1116, 2009
44. YC. Kim, Q Wu, J Chen, Z Xuan, Y-C Jung, MQ Zhang, JD Rowley, SM Wang. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Proc. Natl. Acad. Sci. USA 106: 8278-8283, 2009
45. YC Jung, J Xu, J Chen, YC Kim, DJ Winchester, SM Wang. Simplified DGS procedure for large-scale genome structural study. BioTechniques 47: 969-971, 2009
46. Lu J, Shen Y, Carthew RW, Wang SM, Wu CI. Reply to “A conservative assessment of microRNA flux in Drosophila. Nature Genetics. 42, 9-10, 2010.
47. SM Wang, MQ Zhang. The progress and challenge for transcriptome study on human CD34+ hematopoietic stem-progenitor cells. Journal of Cellular Physiology J Cell Physiol. 223:549-552, 2010
48. X Huang, H Guo, S Tammana, YC Jung, E Mellgren, P Bassi, L Ma, ZJ Tu, SC Ekker, X Wu, SM Wang, XZ Zhou. Gene Transfer Efficiency and Genome-Wide Integration Profiling of Sleeping Beauty, Tol2 and PiggyBac Transposons in Human Primary T Cells. Molecular Therapy. 18(10):1803-13, 2010
49. YC. Kim, YC Jung, J Chen, AH Alhasan, P kaewsaard, Y Zhang, CI Wu, S Ma, S Rosen, SM Wang, Evidence for widely presence of genomic aberrations in chronic lymphocytic leukemia. BMC Research Notes, 3:341, 2010
50. J Xu, D Wang, C Zhang, J Song, T Liang, YC Kim, WR Jin, SM Wang, GH Hou. The alternatively expressed genes identified in the CD4+ T cells of skin allograft rejection mice Cell Transplantation 20:333-50, 2011
51. Gong Q, Tao T, Yang J, Cai J, Yuan Y, Ruan J, Yang J, Lu X, Zhuang S, Wang SM, Wu CI. Identification of medium-sized genomic deletions with low coverage, mate-paired restricted tags. BMC Genomics, 14:51, 2013
52. Ling M, Ban L, Wen H, Wang SM, Ge SX. Conserved Expression of Natural Antisense Transcripts in Mammals. BMC Genomics, 14:243, 2013
53. Lynch H, Wen H, Kim YC, Snyder C, Kinarsky Y, Chen PX, Xiao F, Goldgar D, Cowan KH, Wang SM. Can unknown predisposition in familial breast cancer be family-specific? The Breast Journal, 19:520-528, 2013
54. Xiao F, Kim YC, Wen H, Luo J, Chen P, Cowan K, Wang SM. The genome of polymorphonuclear neutrophils maintains normal coding sequences. PLOSOne 8(11):e78685, 2013
55. COMPLEXO, Southey MC, Park DJ, Nguyen-Dumont T, Campbell I, Thompson E, Trainer AH, Chenevix-Trench G, Simard J, Dumont M, Soucy P, Thomassen M, Jønson L, Pedersen IS, Hansen TV, Nevanlinna H, Khan S, Sinilnikova O, Mazoyer S, Lesueur F, Damiola F, Schmutzler R, Meindl A, Hahnen E, Dufault MR, Chris Chan T, Kwong A, Barkardóttir R, Radice P, Peterlongo P, Devilee P, Hilbers F, Benitez J, Kvist A, Törngren T, Easton D, Hunter D, Lindstrom S, Kraft P, Zheng W, Gao YT, Long J, Ramus S, Feng BJ, Weitzel JN, Nathanson K, Offit K, Joseph V, Robson M, Schrader K, Wang SM, Kim YC, Lynch H, Snyder C, Tavtigian S, Neuhausen S, Couch FJ, Goldgar DE. COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration. Breast Cancer Res. 15(3):402, 2013
56. Xiao F, Kim YC, Snyder C, Wen H, Chen PX, Luo J, Becirovic D, Downs B, Cowan KH, Lynch H, Wang SM. Genome instability in blood cells of a BRCA1+ breast cancer family. BMC Cancer 14:342  doi:10.1186/1471-2407-14-342, 2014
57. Wen H, Kim Y, Snyder C, Xiao F, Fleissner EA, Becirovic D, Luo J, Downs B, Sherman S, Cowan KH, Lynch HT, Wang SM. Family-specific, novel, deleterious germline variants provide a rich source to identify genetic predispositions for BRCAx familial breast cancer. BMC Cancer, 14:470, 2014
58. Lynch H, Synder C, Wang SM. Considerations for comprehensive assessment of genetic predisposition in familial breast cancer. Breast J. 2015;21(1):67-75. PMID: 25472498.
59. Downs B, Wang SM. Epigenetic changes in BRCA1-mutated familial breast cancer. 208(5):237-40, 2015. PMID: 25800897
60. Downs B, Kim YC, Xiao F, Snyder C, Chen P, Fleissner EA, Becirovic D, Wen H, Sherman S, Cowan KH, Lynch HT, Wang SM. Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer. Breast Cancer Res Treat. 151(1):219-24. 2015. PMID: 25833210.
61. Angulo-Ibáñez M, Rovira-Clavé X, Downs B, Kim YC Wang SM, Tournier C, Reina M, Espel E. Erk5 contributes to balance cellular nucleotide levels and avoid replicative stress, Cell Cycle, 14(24):3864-76, 2015, PMID: 26697837
62. Kim KC, Zhao L, Zhang H, Huang Y, Cui J, Xiao F, Downs F, Wang SM. Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients. Oncotarget (in press), 2016
63. Kim KC, Zhao L, Zhang H, Huang Y, Cui J, Xiao F, Downs F, Wang SM. Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients. doi: 10.18632/oncotarget.7144, 2016
64. Cui J, Luo L, KimYC, Synder C, Becirovic D, Downs B, Lynch H, Wang SM. Differences of variable number tandem repeats in XRCC5 promoter are associated with increased or decreased risk of familial breast cancer (in press)