Martha L. Arellano
Martha L. Arellano
Associate Professor

Department of Hematology and Medical Oncology
Emory University School of Medicine


Bachelor Degree 12/1991 – 04/1996 Georgia State University – Atlanta, USA
Medical Degree 08/1996 – 05/2000 Emory University School of Medicine – Atlanta, USA
Postgraduate Training- Internal Medicine 07/2000 – 06/2003 Emory University School of Medicine, Atlanta, GA, USA
Fellow – Department of Hematology and Medical Oncology 06/2003 – 06/2006 Emory University School of Medicine, Atlanta, GA, USA



Dr. Arellano received her Medical Degree in 2000, completed her internship in 2001, and Residency in 2003 at Emory University School of Medicine.  She conducted her Hematology/Oncology fellowship at Winship Cancer Institute at Emory. Dr. Arellano currently specializes in hematology and oncology.


Research Interest

Research interests include adoptive immunotherapy for hematopoietic malignancies and novel therapies for acute leukemia and MDS.  She has published in a number of leading journals including however not limited to, Cancer, British Journal of Haematology, and the Journal of Clinical Oncology.


Professional Activities:




  1. Michael K. Leonard, Nina Larsen, Henning Drechsler, Henry Blumberg, Jeffrey L. Lennox, Martha Arellano, Jennifer Filip, and C. Robert Horsburgh, Jr. (2002) Increased Survival of Persons with Tuberculosis and Human Immunodeficiency Virus Infection, 1991–2000. Clinical Infectious Diseases. 34; 1002-1007.
  2. 2006

  3. Lonial, S., Arellano, M., Hutcherson, D., Langston, A., Flowers, C., Heffner, L. T., Winton, E., Jo Lechowicz, M. and Waller, E. K. (2006) Results of a clinical phase I dose-escalation study of cytarabine in combination with fixed-dose vinorelbine, paclitaxel, etoposide and cisplatin for the treatment of relapsed/refractory lymphoma. Erratum in: Leuk Lymphoma. Dec; 47(12); 2676-7.
  4. 2007

  5. Arellano, M. L., Langston, A., Winton, E., Flowers, C. R. and Waller, E. K. (2007) Treatment of relapsed acute leukemia after allogeneic transplantation: a single center experience. Biol Blood Marrow Transplant. Jan; 13(1); 116-123.
  6. Ninan, M. J., Flowers, C. R., Roback, J. D., Arellano, M. L. and Waller, E. K. (2007) Posttransplant thrombopoiesis predicts survival in patients undergoing autologous hematopoietic progenitor cell transplantation. Biol Blood Marrow Transplant. Aug;13(8): 895-904.
  7. 2008

  8. Lonial, S., Torre, C., David, E., Harris, W., Arellano, M. and Waller, E. K. (2008) Regulation of alloimmune responses by dendritic cell subsets. Exp Hematol. Oct;36(10): 1309-1317.
  9. Murali, S., Winton, E., Waller, E. K., Heffner, L. T., Lonial, S., Flowers, C., Kaufman, J., Arellano, M., Lechowicz, M. J., Mann, K. P., Khoury, H. J. and Langston, A. A. (2008) Long-term progression-free survival after early autologous transplantation for mantle-cell lymphoma. Bone Marrow Transplant. Oct; 42(8): 529-534.
  10. 2009

  11. Akhtari, M., Waller, E. K., Jaye, D. L., Lawson, D. H., Ibrahim, R., Papadopoulos, N. E. and Arellano, M. L. (2009) Neutropenia in a patient treated with ipilimumab (anti-CTLA-4 antibody). J Immunother. Apr;32(3): 322-324.
  12. 2010

  13. Kantarjian, H. M., Erba, H. P., Claxton, D., Arellano, M., Lyons, R. M., Kovascovics, T., Gabrilove, J., Craig, M., Douer, D., Maris, M., Petersdorf, S., Shami, P. J., Yeager, A. M., Eckert, S., Abichandani, R. and Faderl, S. (2010) Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol. Feb 1;28(4); 549-555.
  14. Lima, L. M., Arellano, M., Holloway, S., Shepard, M., McMillan, S. and Khoury, H. J. (2010) Efficacy of dasatinib for the treatment of intractable chronic myeloid leukemia. J Blood Med. 2010;1: 221-225.
  15. Tran, H., Arellano, M., Chamsuddin, A., Flowers, C., Heffner, L. T., Langston, A., Lechowicz, M. J., Tindol, A., Waller, E., Winton, E. F. and Khoury, H. J. (2010) Deep venous thromboses in patients with hematological malignancies after peripherally inserted central venous catheters. Leuk Lymphoma. Aug; 51(8): 1473-7.
  16. Arellano, Martha, Bernal-Mizrachi, Leon, Pan, Lin, Tighiouart, Mourad, Souza, Liliana, Guo, Xiangxue, McLemore, Morgan, Lima, Lisa, Sunay, Susan, Heffner, Leonard T., Chen, Zhengjia, Chen, Georgia Zhou, Langston, Amelia, Winton, Elliott and Khoury, H. Jean (2011) Prognostic Significance of Leukopenia at the Time of Diagnosis in Acute Myeloid Leukemia. Clinical Lymphoma Myeloma Leuk. Oct;11(5); 427-432.
  17. Lima, L., Bernal-Mizrachi, L., Saxe, D., Mann, K. P., Tighiouart, M., Arellano, M., Heffner, L., McLemore, M., Langston, A., Winton, E. and Khoury, H. J. (2011) Peripheral blood monitoring of chronic myeloid leukemia during treatment with imatinib, second-line agents, and beyond. Cancer. Mar 15;117(6):1245-52.
  18. Lima, L. M., Sampat, K., Assouline, S., Saxe, D., Nault, S., Tighiouart, M., McLemore, M., Arellano, M., Winton, E., Bernal-Mizrachi, L., Cortes, J. and Khoury, H. J. (2011) Does pretreatment fluorescence in situ hybridization for BCR-ABL predict imatinib-associated hematologic toxicity in chronic myeloid leukemia? Leuk Lymphoma. Jun; 52(6):1010-6.
  19. Stock, W., Douer, D., DeAngelo, D. J., Arellano, M., Advani, A., Damon, L., Kovacsovics, T., Litzow, M., Rytting, M., Borthakur, G. and Bleyer, A. (2011) Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel. Leuk Lymphoma. Dec;52(12):2237-53.
  20. 2012

  21. Arellano, Martha, Winton, Elliott, Pan, Lin, Lima, Lisa, Tighiouart, Mourad, Bhalla, Kapil, Heffner, Leonard T., Neely, Jessica, Hutcherson, Donald, McLemore, Morgan, Langston, Amelia and Khoury, H. Jean (2012) High-dose cytarabine induction is well tolerated and active in patients with de novo acute myeloid leukemia older than 60 years. Cancer. Jan 15;118(2):428-33.
  22. Claxton, David, Erba, Harry P., Faderl, Stefan, Arellano, Martha, Lyons, Roger M., Kovacsovics, Tibor, Gabrilove, Janice, Huebner, Dirk, Gandhi, Pritesh J. and Kantarjian, Hagop (2012) Outpatient consolidation treatment with clofarabine in a phase 2 study of older adult patients with previously untreated acute myelogenous leukemia. Leukemia & Lymphoma. Mar;53(3): 435-40.
  23. Holloway, S., Lord, K., Bethelmie-Bryan, B., Shepard, M. W., Neely, J., McLemore, M., Reddy, S. K., Montero, A., Jonas, W. S., Gladney, S. P., Khanwani, S. L., Reddy, S. C., Lahiry, A. K., Heffner, L. T., Winton, E., Arellano, M. and Khoury, H. J. (2012) Managing Chronic Myeloid Leukemia: A Coordinated Team Care Perspective. Clin Lymphoma Myeloma Leuk. Apr;12(2):88-93.
  24. Muringampurath-John, D., Flowers, C. R., Toscano, M., Zhengjia, C., Kaufmann, J., Arellano, M., Bernal-Mizrachi, L., Heffner, L. T., Lechowicz, M. J., McLemore, M., Winton, E., Jaye, D. L., Lonial, S. and Khoury, H. J. (2012) Rituximab-hyperfractionated cyclophosphamide, vincristine, adriamycin and dexamethasone alternating with high-dose cytarabine and methotrexate for aggressive non-Hodgkin lymphoma. Leuk Lymphoma. Apr; 53(4):725-7.
  25. Khoury, H. J., Garcia-Manero, G., Borthakur, G., Kadia, T., Foudray, M. C., Arellano, M., Langston, A., Bethelmie-Bryan, B., Rush, S., Litwiler, K., Karan, S., Simmons, H., Marcus, A. I., Ptaszynski, M. and Kantarjian, H. (2012) A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias. Cancer. Jul 15;118(14):3556-64.
  26. Muringampurath-John, D., D.L. Jaye, C.R. Flowers, D. Saxe, Z. Chen, M.J. Lechowicz, D.D. Weisenburger, M. Bast, M.L. Arellano, L. Bernal-Mizrachi, L.T. Heffner, M. McLemore, J.L. Kaufman, E.F. Winton, S. Lonial, J.O. Armitage, and H.J. Khoury. (2012).Characteristics and outcomes of diffuse large B-cell lymphoma presenting in leukaemic phase. British Journal of Haematology. Br J Haematol. Sep;158(5):608-14.
  27. Hagop Kantarjian, Stefan Faderl, Guillermo Garcia-Manero, Selina Luger, Parameswaran Venugopal, Lori Maness, Meir Wetzler, Steven Coutre, Wendy Stock, David Claxton, Stuart Goldberg, Martha Arellano, Stephen Strickland, Karen Seiter, Gary Schiller, Elias Jabbour, Judy Chiao, and William Plunkett (2012) Results of a Randomized Phase II Study of Oral Sapacitabine in Elderly Patients with Previously Untreated or First Relapsed Acute Myeloid Leukemia. The Lancet Oncology. October 15. doi:10.1016/S1470-2045(12)70436-9.
  28. Arellano M, Pakkala S, Langston A, Tighiouart M, Pan L, Chen Z, Heffner LT, Lonial S, Winton E, and Khoury HJ. (2012) Early clearance of peripheral blood blasts predicts response to induction chemotherapy in acute myeloid leukemia. Cancer. Nov 1;118(21):5278-82.
  29. Zhou Amy, Winkler Anne, Emamifar Amir, Gartland Bryce, Duncan Alexander, Antun Anna, Arellano Martha, Tindol Allen, Levy JH, Bornstein WA, Horowitz Ira, and Khoury, Hanna Jean. (2012) Is the Incidence of Heparin-Induced Thrombocytopenia Affected by the Increased Use of Heparin for VTE Prophylaxis? Chest. Nov;142(5):1175-78.
  30. Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Alečković M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C, Chen J. (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. Nov 13;22(5): 585-600.
  31. 2013

  32. Bethelmie-Bryan, B., K. Lord, S. Holloway, F. Safavi, M. Shepard, S. Rogers, R.D. Harvey, K. Rodger, E.K. Waller, B. El-Rayes, M. Arellano, and H.J. Khoury. (2013) Tools to optimize the functionality of a leukemia clinical trial team. Leukemia & Lymphoma. Jan;54(1):110-6. Epub 2012 Aug 13. PMID: 22762552
  33. Bachanova V, Marks DI, Zhang MJ, Wang H, de Lima M, Aljurf MD, Arellano M, Artz AS, Bacher U, Cahn JY, Chen YB, Copelan EA, Drobyski WR, Gale RP, Greer JP, Gupta V, Hale GA, Kebriaei P, Lazarus HM, Lewis ID, Lewis VA, Liesveld JL, Litzow MR, Loren AW, Miller AM, Norkin M, Oran B, Pidala J, Rowe JM, Savani BN, Saber W, Vij R, Waller EK, Wiernik PH, and Weisdorf DJ. (2013) Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: Impact of tyrosine kinase inhibitor and minimal residual disease. Leukemia. Aug 30. doi: 10.1038/leu.2013.253. [Epub ahead of print]. PMID: 23989431
  34. Hitosugi T, Zhou L, Fan J, Elf S, Zhang L, Xie J, Wang Y, Gu TL, Alečković M, LeRoy G, Kang Y, Kang HB, Seo JH, Shan C, Jin P, Gong W, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C, and Chen J. (2013) Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumors by stabilizing the active conformation. Nat Commun. 2013;4:1790. PMID: 23653202
  35. Antun AG, Gleason S, Arellano M, Langston AA, McLemore ML, Gaddh M, El Rassi F, Bernal-Mizrachi L, Galipeau J, Heffner LT Jr, Winton EF, and Khoury HJ. (2013) Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies. Cancer. Aug 6. doi: 10.1002/cncr.28253. [Epub ahead of print]. PMID: 23921838
  36. Mitri Z, Siddiqui MT, El Rassi F, Holden JT, Heffner LT, Langston A, Waller EK, Winton E, McLemore M, Bernal-Mizrachi L, Jaye D, Arellano M, Khoury HJ. (2013) Sensitivity and Specificity of Cerebrospinal Fluid Flow Cytometry for the Diagnosis of Leukemic Meningitis in Acute Lymphoblastic Leukemia/Lymphoma. Leuk Lymphoma. Oct 18. doi: 10.3109/10428194.2013.852667. [Epub ahead of print]. PMID: 24134778
  37. Sinha, Rajni, King, Nassoma, Shenoy, Pareen J, Lechowicz, Mary Jo, Bumpers, Kevin, Hutcherson, Donald, Arellano, Martha, Langston, Amelia, Kaufman, Jonathan L., Heffner, Leonard T., Waller, Edmund K, Flowers, Christopher R and Lonial, Sagar (2013) Vinorelbine, Paclitaxel, Etoposide, Cisplatin and Cytarabine (VTEPA) Is An Effective Second Salvage Therapy for Relapsed/Refractory Hodgkin Lymphoma. Clin Lymphoma Myeloma Leuk. Dec;13(6):657-63. doi: 10.1016/j.clml.2013.05.007. Epub 2013 Oct 2. PMID: 24094894
  38. 2014

  39. Jun Fan, Changliang Shan, Hee-Bum Kang, Shannon Elf, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Mike Aguiar, Scott Lonning, Huaibin Chen, Moosa Mohammadi, Laura-Mae P. Britton, Benjamin A. Garcia, Maša Alečković, Yibin Kang, Stefan Kaluz, Narra Devi, Erwin G. Van Meir, Taro Hitosugi, Jae Ho Seo, Sagar Lonial, Manila Gaddh, Martha Arellano, Hanna J. Khoury, Fadlo R. Khuri, Titus J. Boggon, Sumin Kang, and Jing Chen. Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex. Molecular Cell. 2014 Feb 20;53(4):534-48. doi: 10.1016/j.molcel.2013.12.026. Epub 2014 Jan 30. PMID: 24486017
  40. Roboz GJ, Khoury HJ, Jabbour E, Session W, Ritchie EK, Miao H, Faderl S, Zheng W, Feldman EJ, Arellano M, Morrison JG, Ravandi F. Phase I trial of SAR103168, a novel multi-kinase inhibitor,in patients with refractory/relapsed acute leukemias or high-risk myelodysplastic syndromes. Leuk Lymphoma. 2014 May 2. [Epub ahead of print]. PMID: 24794806.
  41. Roboz GJ, Rosenblat T, Arellano M, Gobbi M, Altman JK, Montesinos P, O'Connell C, Solomon SR, Pigneux A, Vey N, Hills R, Jacobsen TF, Gianella-Borradori A, Foss O, Vetrhusand S, Giles FJ. International Randomized Phase III Study of Elacytarabine Versus Investigator Choice in Patients With Relapsed/Refractory Acute Myeloid Leukemia. J Clin Onco. 2014 May 19: Epub ahead of print. PMID: 24841975.
  42. Martha L. Arellano, Gautam Borthakur, Mark Berger, Jill Luer, & Azra Raza. A Phase II, Multicenter, Open-Label Study of Obatoclax Mesylate in Patients With Previously Untreated Myelodysplastic Syndromes With Anemia or Thrombocytopenia. Clin Lymphoma Myeloma Leuk. 2014 Jun 12. [Epub ahead of print]. PMID: 25052051.
  43. Mitri Z, Siddiqui MT, El Rassi F, Holden JT, Heffner LT, Langston A, Waller EK, Winton E, McLemore M, Bernal-Mizrachi L, Jaye D, Arellano M, Khoury HJ. Sensitivity and specificity of cerebrospinal fluid flow cytometry for the diagnosis of leukemic meningitis in acute lymphoblastic leukemia/lymphoma. Leuk Lymphoma. 2014 Jul; 55(7): 1498-500. [Epub 2014 May 2]. PMID: 24134778.
  44. Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth. Mol Cell. 2014 Jul 16. [Epub ahead of print] PMID: 25042803.
  45. El Rassi F, Ward KC, Flowers CR, Heffner LT, Waller EK, Winton EF, Vaughn J, Hill BG, Langston A, Nooka A, Arellano M, Khoury HJ. Incidence and geographic distribution of adult acute leukemia in the state of Georgia. South Med J. 2014 Aug; 107(8):497-500. PMID: 25084186.
  46. Shan C, Kang HB, Elf S, Xie J, Gu TL, Aguiar M, Lonning S, Hitosugi T, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Fan J. Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth. J Biol Chem. 2014 Aug 1;289(31): 21413-22. [Epub ahead of print]. PMID: 24962578.
  47. Fan J, Kang HB, Shan C, Elf S, Lin R, Xie J, Gu TL, Aguiar M, Lonning S, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Kang S, Chen J. Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding, and promotes the Warburg effect. J Biol Chem. 2014 Aug 7. [Epub ahead of print]. PMID: 25104357.
  48. Stock W, DeAngelo DJ, Douer D, Advani A, Arellano M, Rytting M, Kovacsovics T, Litzow M, Damon L, Borthakur G, Luger S, Seibel N, Bleyer A. Applying pediatric therapeutic strategies to adults with acute lymphoblastic leukemia and lymphoma. I. Role of asparaginase. Amer Oncol & Hemat Rev Sep 2014,2014:38-46.
  49. Douer D, DeAngelo DJ, Advani A, Arellano M, Litzow M, Damon L, Kovacsovics T, Luger S, Seibel N, Bleyer A. Applying pediatric therapeutic strategies to adults with acute lymphoblastic leukemia and lymphoma. II. Comparison with adult treatment regimens, including hyper-CVAD. Amer Oncol & Hemat Sep 2014, Rev 2014:47-53.
  50.  Fuad El Rassi,  John D Bergsagel,  Martha Arellano,  Manila Gaddh,  Anand Jillella,  Vamsi Kota,  Leonard T Heffner,  Elliott F Winton,  Hanna Jean Khoury. Predicting early blast transformation in chronic-phase chronic myeloid leukemia: Is immunophenotyping the missing link? Cancer 2014 Nov. DOI: 10.1002/cncr.29142
  51. Jin L, Li D, Alesi GN, Fan J, Kang HB, Lu Z, Boggon TJ, Jin P, Yi H, Wright ER, Duong D, Seyfried NT, Egnatchik R, DeBerardinis RJ, Magliocca KR, He C, Arellano ML, Khoury HJ, Shin DM, Khuri FR, Kang S.  Glutamate Dehydrogenase 1 Signals through Antioxidant  Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth. Cancer Cell. 2015 Feb 9;27(2):257-70. doi: 10.1016/j.ccell.2014.12.006.
  52. Zhang L, Ramjit RT, Hill CE, Arellano M, Khoury HJ, Mann KP.  Clinical significance of  quantitative monitoring and mutational analysis of BCR-ABL1 transcript in Philadelphia  chromosome positive B lymphoblastic leukemia. Leuk Lymphoma. 2015 Jan 9:1-24. [Epub ahead of print]
  53.  Guillermo Garcia-Manero,  Raoul Tibes,  Tapan Kadia,  Hagop Kantarjian,  Martha Arellano,  Emily A Knight,  Hao Xiong,  Qin Qin,  Wijith Munasinghe,  Lisa Roberts-Rapp,  Peter Ansell,  Daniel H Albert,  Brian Oliver,  Mark D McKee,  Justin L Ricker,  Hanna Jean Khoury.  Phase 1  dose escalation trial of ilorasertib, a dual Aurora/VEGF receptor kinase inhibitor, in patients with  hematologic malignancies. Invest New Drugs 2015 Aug 2;33(4):870-80. Epub 2015 May 2.
  54. Zeichner SB, Arellano ML, Secondary Adult Acute Myeloid Leukemia: a Review of Our Evolving Understanding of a Complex Disease Process,Curr Treat Options Oncol. 2015 Aug;16(8):37. doi: 10.1007/s11864-015-0355-3.PMID:26143266


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