Education

Biography

Dr. Elżbieta Gocek, born in 1981 is an Assistant Professor at the Department of Protein Biotechnology, Faculty of Biotechnology, University of Wrocław, Poland. She received her PhD in 2009, defending thesis unanimously awarded by the Faculty board, entitled “The role of vitamin D receptor, C/EBP transcription factors and mutations of acute myeloid leukemia cells during differentiation.” She did her post-doctoral fellowship at the University of Medicine & Dentistry, New Jersey Medical School (currently Rutgers, The State University of New Jersey), Department of Pathology & Laboratory Medicine, USA. She worked in the laboratory of Professor George P. Studzinski. She has published over 20 publications and book chapters in the field of vitamin D-induced differentiation of acute myeloid leukemia cells. She has served as a reviewer for several journals, such as Journal of Steroid Biochemistry and Molecular Biology, Scientific Reports (Nature Publishing Group), Leukemia and Lymphoma, MicroRNA Journal. She was awarded for scientific achievements by several national and international organizations, such as Polish Ministry of Science and Higher Education, EMBO, FEBS.

Research Interest

1,25-dihydroxyvitamin D3, differentiation, microRNA,  acute myeloid leukemia, resistance

Professional Activities:

Awards and distinctions:

1. “SKILLS” Scholarship – Commercialization course; Polish Science Foundation (2015)
2. “SKILLS” Scholarship – Project Management  course; Polish Science Foundation (2015)
3. “SKILLS” Scholarship – Entrepreneurship course; Polish Science Foundation (2014)
4. “SKILLS” Scholarship – Negotiations course; Polish Science Foundation (2014)
5. Scholarship for the Best Young Researcher – financed by the European Union Social Fund, Human Capital Operational Program, Priority 4.3. (May 2014 – December 2015)
6. Scholarship for the Best Young Researcher – Polish Ministry of Science and Higher Education (2013)
7. “MOZART”-  business and science partnership – City Council of Wrocław (February 2012 – January 2013)
8.  Award for the scientific achievements – Rector of the University of Wrocław (2012)
9. Invited speaker at “17th World Congress on Advances in Oncology and 15th International Symposium on Molecular Medicine." Crete, Greece, Award for the best oral presentation (2012)
10. Scholarship covering short-time training at Ben-Gurion University of the Negev (Israel), financed by the European Union Social Fund, Human Capital Operational Program, Priority 4.4.1 under the project POKL.04.01.01-00-054/10-00 (2012)
11. Scholarship for the Best Young Researcher, financed by the European Union Social Found, Human Capital Operational Program, Priority 4.4.1 under the project POKL.04.01.01-00-054/10-00 (2011)
12. “START” Scholarship for The Best Polish Young Scientist of the year – Polish Science Foundation (2010)

Publications

1. Gocek E., Studzinski G.P. “The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy.” J. Clin. Med., 2015, 4(4), 504-534; doi:10.3390/jcm4040504
2. Gocek E., Marchwicka A., Bujko K., Marcinkowska E. „NADPH-cytochrome P450 reductase is regulated by all-trans retinoic acid and by 1,25-dihydroxyvitamin D3 in human acute myeloid leukemia cells.” PLOS One, 2014,  18;9(3):e91752. doi: 10.1371/journal.pone.0091752, IF2012: 3,73
3. Gocek E., Moulas A.N.,  Studzinski G.P. „Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells.” Crit Rev Clin Lab Sci., 2014, 51(3):125-37, IF2013: 7,0
4. Wang X., Pesakhov S., Weng A., Kafka M., Gocek E., Nguyen M., Harrison J.S., Danilenko M., Studzinski G.P.”Erk5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells.” J Steroid Biochem Mol Biol., 2013,  S0960-0760(13)00195-7, IF2012: 3,98
5. Gocek E., Marchwicka A., Baurska H., Kłopot A., Chrobak A., Marcinkowska E. „Opposite regulation of vitamin D receptor by ATRA in AML cells susceptible and resistant to vitamin D-induced differentiation.”, J Steroid Biochem Mol Biol. 2012, 132 (3-5):220-226. IF2011: 2,89
6. Gocek E., Baurska H., Marchwicka A., Marcinkowska E. „Regulation of leukemic cell differentiation through the vitamin D receptor at the levels of intracellular signal transduction, gene transcription, protein trafficking and stability.”, Leukemia Research and Treatment, 2012, Article ID 713243, doi: 10.1155/2012/713243
7. Gocek E., Studzinski G.P. „Genes encoding transcription factors have self-control; How important is this for cell differentiation?” Editorial Commentary for Leuk. Res., 2012, 36:672-674. IF2010: 2,55
8. Gocek E., Marcinkowska E. „Differentiation Therapy of Acute Myeloid Leukemia.” Invited chapter in a special issue of „Cancer Diagnosis and Targeted Therapy" entitled „Cancers” 3,  2402-2420, 2011
9. Gocek E., Wang X., Liu X., Liu C.G., Studzinski G. „MicroRNA-32 is up-regulated by 1,25-dihydroxyvitami D3, targets Bim and inhibits AraC-induced apoptosis of human myeloid leukemia cells.” Cancer Research 2011, 1;71(19):6230-9. IF2010: 8,23
10. Wang X., Gocek E., Rossova V., Harrison H.S., Danilenko M., Studzinski G.P. „Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3.” Cell Cycle, 2010, 9(22):4542-51. IF2009: 4,09
11. Marcinkowska E, Gocek E. Heat shock protein 90 interacts with vitamin D receptor in human leukemia cells. J Steroid Biochem Mol Biol. 2010, 121(1-2):114-6. IF2009: 2,65
12. Hughes P.J., Marcinkowska E., Gocek E., Studzinski G.P., Brown G. „Vitamin D3-driven intracellular signals for myeloid cell differentiation, Leuk. Res., 2010, 34: 553–565.  IF2008: 2,39
13. Gocek E., Kielbinski M., Baurska H., Haus O., Kutner A., Marcinkowska E. „Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations.” Leuk. Res. 2010, 34: 649–657. IF2008: 2,39
14. Studzinski G.P., Gocek E., Danilenko M. „Differentiation and cell cycle.” Invited chapter in ”Vitamin D” Third Edition, 2010, editor: Fieldman D.,Elsevier, California.
15. Wang X., Gocek E., Chang-Gong L., Studzinski G.P. „MicroRNAs 181, not miR221/222, regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1.25-dihydroxyvitamin D3.”, Cell Cycle, 2009, 8(5):736-41. IF2008: 4,12
16. 16.Gocek E., Studzinski G.P. „Vitamin D and Differentiation in Cancer.”, Crit. Rev. Clin. Lab. Sci., 2009, 46(4):190-209. IF2008: 5,15
17. Gocek E., Studzinski G.P. „Induction of differentiation  in cancer cells by vitamin D derivatives.” Invited chapter in  “Vitamin D and Cancer”, 2009, editors: Johnson C.S. & Trump D.L., Springer, New York.
18. Gocek E., Kiełbinski M., Wylob P., Kutner A., Marcinkowska E. „Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential.”, Steroids, 2008, 73(14):1359-66. IF2007: 2,14
19. Gocek E., Kielbinski M., Marcinkowska E. „Activation of intracellular signaling pathways is necessary for an increase in VDR expression and its nuclear translocation.”, FEBS Letters, 2007, 581(9):1751-7. IF2006: 3,4
20. Marcinkowska E., Gray E., Gocek E., Chrobak A., Wang X., Studzinski G.P. „Regulation of C/EBPβ isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3.”, Exp. Cell Res., 2006, 312(11):2054-65. IF2005: 4,15