collin-y-ewald
Collin Y Ewald, PhD
Assistant Professor of Aging

Eidgenossischen Technischen Hochschule Zurich
Zurich, Switzerland
Phone: +41 44 655 74 07
E-mail: collin-ewald@ethz.ch

Education

02/2011 PhD- Neuroscience, City University of New York, USA
05/2008 MPhil- Biology, City University of New York, USA
01/2007 MSc- Molecular Biology, University of Basel, Switzerland
11/2005 BSc- Molecular Biology, University of Basel, Switzerland
07/2001 Matura- Mathematics, Gymnasium am Kirschgarten, Basel, Switzerland

Biography

Collin Ewald has a longstanding interest in the molecular biology of healthy aging and age-related pathologies. His curiosity for aging research was ignited by the finding that neurons could regulate aging in model organisms and learning how to meditate could change the expression of stress-associated genes in humans. Fascinated by neurons and the mind, he went to New York to pursue a PhD in Neuroscience with Chris Li working on Alzheimer’s disease (AD) related proteins in C. Elegans and determined the molecular mechanisms of how AD proteins affect aging, metabolism, and learning. After a short junior faculty position at the Joslin Diabetes Center and as an Instructor in Medicine at Harvard Medical School working on how NADPH-oxidase-mediated ROS production affects aging.


Research Interest

  • Molecular Biology of Aging
  • Extracellular Matrix
  • Neurodegenerative Diseases

Scientific Activities

Professional Experience: Teaching
2015-present Teaching Volunteer, Department of Early Education and Care
01/2017-06/2017 Teaching Mentor/Supervisor, D-HEST, ETH Zurich
2014-2015 Teaching Assistant, Department of Genetics, Harvard Medical School
2006-2007 Teaching Assistant, Department of Biology, City College of New York
Professional Experience: Research
2016-present Assistant Professor, Eidgenossischen Technischen Hochschule Zurich
2015-2016 Instructor in Medicine at Harvard Medical School
Visiting Scholar at Whitehead Institute (Massachusetts Institute of Technology)
Research Associate in the Research Division at the Joslin Diabetes Center
Other Activities
2017-present President, Swiss Society for Aging Research
2016-present Vice-President, The Swiss Society for Matrix Biology
Young Investigator, The GENiE Network Europe
Member, The Molecular Life Science Graduate School Zürich
Member, The German Society for Aging Research
Member, The Federation of European Neuroscience Societies
2013-2016 Member, The Gerontological Society of America        
2011-2012 Member, The Society for Neuroscience
2006-present Member, The Genetics Society of America
2006-2012 Member, The New York Academy of Sciences
Honors and Awards
2016 Nomination for the 2016 Dick Heinegard European Young Investigator Award
2015 Featured Contributor for LIFEmag.org                                                                                                                    
Genetics Society of America (GSA)’sDeLill Nasser Award for Professional Development in Genetics
2013 Certificate for Mini Symposia/ Academy Center for Teaching and Learning, Harvard Medical School
2012 Swiss Spotlight Scientist of November 2012, Science-USA (Boston)
Honoree Mentioning at the 27th Annual Joslin Diabetes Center Marble Banquet (Harvard Club)

Publications

  1. Ewald CY*, Hourihan JM°, Bland MS, Obieglo C, Katic I, MoronettiMazzeo LE, Alcedo J, Blackwell TK*, Hynes NE*. (2017). NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans.Elife6. pii: e19493. doi: 10.7554/eLife.19493. PMID: 28085666
  2. Ewald, C.Y., Marfil, V., Li, C. (2016). Alzheimer-related Protein APL-1 modulates lifespan through heterochronic gene regulation in Caenorhabditis elegans.Aging Celldoi: 10.1111/acel.12509. PMID: 27557896
  3. Ewald, C.Y., Landis, J.N., Porter Abate, J., Murphy, C.T., Blackwell, T.K. (2015). Dauer-independent insulin/IGF-1 signalling implicates collagen remodelling in longevity. Nature 519, 97–101.doi: 10.1038/nature14021
  4. Ewald, C.Y., Cheng, R., Tolen, L., Shah, V., Gillani, A., Nasrin, A., Li, C. (2012). Pan-neuronal expression of APL-1, an APP-related protein, disrupts olfactory, gustatory and touch plasticity in Caenorhabditis elegans.J Neurosci. 32: 10156-69.doi: 10.1523/JNEUROSCI.0495-12.2012.PMID:22836251, PMCID:PMC3698849
  5. Ewald, C.Y., Raps D.A., Li, C. (2012). APL-1, the Alzheimer’s Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development. Genetics 191: 493-507. doi: 10.1534/genetics.112.138768. PMID:22466039, PMCID:PMC3374313
  6. Ewald, C.Y.& Li, C. (2012). The secreted Alzheimer-related protein fragment has an essential role in Caenorhabditis elegans. Prion 6: 433-6. doi: 10.4161/pri.22310.PMID:23044509, PMCID:PMC3510856
  7. Ewald, C.Y.& Li, C. (2012). Caenorhabditiselegansas a model organism to study APP function. Invited Review article for the 2012 special issue on "The physiological functions of APP". Experimental Brain Research 217: 397-411. doi: 10.1007/s00221-011-2905-7.PMID:22038715, PMCID:PMC3746071
  8. Ewald, C.Y.& Li, C. (2010). Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system. Brain Structure and Function214(2-3):263-83. doi: 10.1007/s00429-009-0235-3.PMID:20012092, PMCID:PMC3902020

Aging Studies and Therapies Flyer