akira-sugawara
Akira Sugawara, MD, PhD
Professor of Molecular Endocrinology

Tohoku University Graduate School of Medicine
Sendai, Japan
Phone: +81-22-717-7483
E-mail: akiras2i@med.tohoku.ac.jp

Education

1991 PhD- Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
1987 MD, Tohoku University School of Medicine, Sendai, Japan

Biography

Professor Akira Sugawara belongs to the Department of Molecular Endocrinology. He performed Postdoctoral Fellowship in William Chin’s laboratory at the Women’s Hospital/Harvard Medical School in Boston from 1991 to 1994. His major is general internal medicine, endocrinology and metabolism and hypertension and nephrology.


Research Interest

  • Molecular Biology of Nuclear Hormone Receptors
  • Etiology of High Blood Pressure
  • Pathophysiology of Diabetic Nephropathy
  • Gene Regulation of Aldosterone Synthesis
  • Epigenetics of Hypertension and Diabetes Mellitus

Scientific Activities

Professional Experience
2012-Present Professor, Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine
2011-2012 Professor, Department of Pathophysiology, Tohoku University Graduate School of Medicine
2009-2011 Chief, Department of Endocrinology and Diabetes, Miyagi Cancer Center
2007-2009 Professor, Department of Advanced Biological Sciences for Regeneration, Tohoku University Graduate School of Medicine
2002-2007 Lecturer, Department of Comprehensive Medicine, Tohoku University Graduate School of Medicine
1994-2002 Assistant Professor in Medicine, The 2nd Department of Internal Medicine, Tohoku University School of Medicine
Other Activities

Professional Societies

2009 The International Society of Nephrology
2007 The Japanese Biochemical Society
2006 The Japan Geriatrics Society
2005 Japanese College of Angiology
American Diabetes Association
2003 Japan Society for Medical Education
Japan Neuroendocrine Society (Councilor)
2002 The Japanese Society of Nephrology
Japan Steroid Hormone Society (Councilor)
Japanese Society for Circulation Research
2001 Japan Diabetes Society
2000 The Society of Cardiovascular Endocrinology and Metabolism (Councilor)
1999 The Japanese Society of Hypertension (Councilor)
1998 Society for Hypertension Related Disease Model Research (Councilor)
1997 The Japan Thyroid Association (Councilor)
1994 FASEB Society
American Thyroid Association
The Endocrine Society
1988 The Japanese Society of Internal Medicine
1987 The Japan Endocrine Society (Councilor)
Honors and Awards
2006 The Japan Endocrine Society Award
2005 Medical Education Award, Tohoku University School of Medicine
Research Award, Miyagi Medical Association
Gold Prize, Tohoku University School of Medicine
2003 Award, 8th Grants for Hypertension and Atherosclerosis
2000 Research Award Recommended by President, The Society of Cardiovascular Endocrinology and Metabolism
The Highest Award, 8th Grants for Hypertension and Vascular Metabolism, Japan Heart Foundation

Publications

  1. Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K. The expression and function of histamine H3 receptor in pancreatic β-cells. Br J Pharmacol. 2014; 171: 171-185.
  2. Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, Yamamoto M. Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes. 2014; 63: 605-618.
  3. Ito R, Katsura S, Shimada H, Tsuchiya H, Hada M, Okumura T, Sugawara A, Yokoyama A. TET3-OGT interaction increases the stability and the presence of OGT in chromatin. Genes Cells. 2014; 19: 52-65.
  4. Matsuda K, Uruno A, Kogure N, Sugawara K, Shimada H, Nezu M, Saito-Ito T, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T, Satoh F, Ito R, Yokoyama A, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A. Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells. Mol Cell Endocrinol. 2014; 383: 60-68.
  5. Felizola SJ, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, Ise K, Takase K, Sugawara A, Hattangady N, Rainey WE, Satoh F, Sasano H. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. J Mol Endocrinol. 2014; 52: 159-167.
  6. Nakamura Y, Hattangady NG, Ye P, Satoh F, Morimoto R, Ito-Saito T, Sugawara A, Ohba K, Takahashi K, Rainey WE, Sasano H. Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA). Mol Cell Endocrinol. 2014; 384: 102-108.
  7. Kudo M, Matsuda K, Sugawara K, Iki Y, Kogure N, Saito-Ito T, Shimizu K, Sato I, Takeo Yoshikawa T, Uruno A, Ito R, Yokoyama A, Saito-Hakoda A, Ito S, Sugawara A. ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells. World J Hypertens. 2014; 4: 7-14.
  8.  Saito-Hakoda A, Kogure N, Yoshikawa T, Shimizu K, Iki Y, Sato I, Kudo M, Uruno A, Matsuda K, Parvin R, Sugawara K, Yokoyama A, Ito S, Sugawara A. Is heparan sulfate in the glomerular basement membrane necessary for the etiology of diabetic nephropathy? J Biomol Res Ther. 2014; 3: e127.
  9. Kudo M, Satoh F, Aoki S, Morimoto R, Iwakura Y, Ono Y, Matsuda K, Sugawara A, Yoshida K, Sato K, Ito S. Assisting the diagnosis of Cushing syndrome by pattern recognition methods, using a combination of eight routine tests, and their multiple correlation with serum cortisol. Biomedicine & Aging Pathology. 2014; 4: 257-264.
  10. Yokoyama A , Igarashi K, Sato T, Takagi K, Otsuka I. M, Shishido Y, Baba T, Ito I, Kanno J, Ohkawa Y, Morohashi K, Sugawara A. Identification of Myt1 as a subunit of the neural cell type-specific LSD1 complex. J Biol Chem. 2014; 289: 18152-18162.
  11. Katsura S, Okumura T, Ito R, Sugawara A, Yokoyama A. Identification of posttranslational modifications in peroxisome proliferator-activated receptor γ using mass spectrometry. PPAR Res. 2014; 2014:468925. doi: 10.1155/2014/468925. Epub 2014 Jun 25.
  12. Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, Shimizu K, Sato I, Kudo M, Yoshikawa T, Kagechika H, Iwasaki Y, Ito S, Sugawara A. Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells. Endocr J. 2014; 61: 1105-1114.
  13. Nakamura T, Yoshikawa T, Naganuma F, Mohsen A, Iida T, Miura Y, Sugawara A, Yanai K. Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells. FEBS Open Bio. 2015; 5: 36-41.
  14. Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, Saito-Ito T, Sato I, Kogure N, Suzuki D, Shimada H, Yoshikawa T, Fujiwara I, Kagechika H, Iwasaki Y, Kure S, Ito S, Sugawara A. Effects of RXR agonists on cell proliferation/apoptosis and ACTH secretion/Pomc expression. PLoS One. 2015; 10: e0141960.
  15. Ito R, Shimada H, Yazawa K, Sato I, Imai Y, Sugawara A, Yokoyama A. Hydroxylation of methylated DNA by TET1 in chondrocyte differentiation of C3H10T1/2 cells. Biochem Biophys Rep. 2016; 5: 134-140.

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