Bibliographic Production

A total of ~130 peer-reviewed papers by Pubmed-search for “chang kp, leishmania (101); “chang kp,symbiotes (10) or symbionts (2) or endosymbionts (3) or endosymbiosis (9)”

Journal Articles:

  1. Chang, K.-P. & Musgrave, A.J. (1969) Histochemistry and ultrastructure of the mycetome and its “symbiotes” in the pear psylla, Psylla Pyricola Foerster (Homoptera). Tissue and Cell 1: 597-606.
  2. Chang, K.-P. & Musgrave, A.J. (1970) Ultrastructure of rickettsia-like microorganisms in the midgut of a plant bug, Stenotus binotatus Jak. (Heteroptera:  Miridae). Can. J. Microbiol. 16: 621-622.
  3. Chang, K.-P. & Musgrave, A.J. (1972) Multiple Symbiosis in a leafhopper, Helochara  communis fitch (Cicadellidae: Homoptera): envelopes, nucleoids and inclusions of the symbiotes. J. Cell Sci. 11: 275-293.
  4. Chang, K.-P. & Musgrave, A.J. (1973) Morphology, histochemistry and ultrastructure of mycetome and its rickettsial symbiotes in Cimex lectularius (L.) Can. J. Microbiol. 19: 1075-1081.
  5. Chang, K.-P. (1974) Effects of elevated temperature on mycetome and its symbiotes of Cimex lectularius (L.) J. Invertebr. Pathol. 23: 333-340.
  6. Chang, K.-P. & Trager, W. (1974) Nutritional significance of symbiotic bacteria in two species of hemoflagellates. Science 183: 531-532.
  7. Chang, K.-P. (1974) Ultrastructure of symbiotic bacteria in normal and antibiotic-treated Blastocrithidia culicis and Crithidia oncopelti. J. Protozool. 21: 699-707.
  8. Chang, K.-P. & Musgrave, A.J. (1975) Conversion of spheroplast symbiotes in a leafhopper, Helochara communis Fitch (Cicadellidae:  Homoptera). Can. J. Microbiol. 21: 196-204.
  9. Chang, K.-P. & Musgrave, A.J. (1975) Endosymbiosis in a leafhopper Helochara communis Fitch (Cicadellidae:  Homoptera): symbiote translocation and auxillary cells in the mycetome. Can J. Microbiol. 21: 186-195.
  10. Tuan, R.S. & Chang, K.-P. (1975) Isolation of intracellular symbiotes from flagellate protozoa by immune lysis and characterization of their DNA. J. Cell Biol. 65: 309-323.
  11. Chang, K.-P., Chang, C.S. & Sassa, S. (1975) Heme biosynthesis in bacterium-protozoan symbioses: enzymic defects in host hemoflagellates and complemental role of their intracellular symbiotes. Proc. Nat. Acad. Sci. USA 72: 2979-2983.
  12. Chang, K.-P. (1975) Reduced growth of Blastocrithidia culicis and Crithidia oncopelti freed of intracellular symbiotes by chloramphenicol. J. Protozool. 22: 271-276.
  13. Dwyer, D.M. & Chang, K.-P. (1976) Surface membrane carbohydrate alteration of a flagellate protozoan mediated by bacterial endosymbionts. Proc. Nat. Acad. Sci. USA  73: 852-856.
  14. Chang, K.-P. (1976) Symbiont-free hemoflagellates (Blastocrithidia culicis and Crithidia oncopelti): Their liver factor requirement and their serological identity with infected strains.J. Protozool. 23: 241-244.
  15. Chang, K.-P. & Dwyer, D.M. (1976) Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitro. Science 193: 678-680.
  16. Meshnick, S.R., Chang, K.-P., & Cerami, A. (1977) Heme lysis of the bloodstream forms of Trypanosoma brucei. Biochem. Pharmacol. 26: 1923-1928. 
  17. Chang, K.-P., Steiger, R.F., Dave, C. & Cheng, Y.-C. (1978) Effects of methylglyoxal bis (guanylhydrazone) on trypanosomatid flagellates:  inhibition of growth and nucleoside incorporation in Trypanosoma brucei. J. Protozool. 25: 145-149.
  18. Chang, K.-P. & Dwyer, D.M. (1978) Leishmania donovani-hamster macrophage interactions in vitro: cell entry, intracellular survival and multiplication of amastigotes. J. Exp. Med. 147: 515-530.
  19. Chang, K.-P. (1978) Hamster peritoneal macrophages in vitro: substratum adhesion, spreading, phagocytosis and phagolysosome formation. In vitro14: 663-674.
  20. Chang, K.-P. (1978) Intracellular multiplication of Leishmania donovani during repeated passages in primary cultures of hamster peritoneal macrophages. J. Parasitol. 64: 931-933.
  21. Chang, K.-P. (1978) Leishmania infection of human skin fibroblasts in vitro: absence of phagolysosomal fusion after induced phagocytosis of promastigotes and their intracellular transformation.  Am. J. Trop. Med. Hyg. 27: 1084-96.
  22. Chang, K.-P. (1979) Leishmania donovani: Promastigote-macrophage surface interactions in vitroExp. Parasitol. 48: 175-189.
  23. Chang, K.-P. (1980) Human cutaneous leishmania in a macrophage line: Propagation and isolation of intracellular parasite. Science 209: 1240-2.
  24. Chang, K.-P. (1980) endocytosis of FITC dextran by leishmania-infected macrophages, fluorimetry of pinocytosis, lysosome-phagosome fusion and intralysosomal pH, In Host-Invader Interplays, Ed. van den Bossche, North Holland, 231-4.
  25. Chang, K.-P. (1981) Leishmanicidal mechanisms of human polymorphonuclear phagocytes. Am. J. Trop. Med. Hyg. 30: 322-33.
  26. Chang, K.-P. (1981) Antibody-mediated inhibition of phagocytosis in Leishmania donovani-human phagocyte interactions in vitro. Am. J. Trop. Med. Hyg. 30: 334-39.
  27. Chang, K.-P. (1981) Leishmania donovani-hamster macrophage binding mediated by their surface glycoproteins/antigens: Characterization in vitro by a radioactive assay. Mol. Biochem. Parasitol. 4: 67-76.
  28. Carson, D.A. & Chang, K.-P. (1981) Phosphorylation and anti-leishmania activity of formycin B. Biochem. Biophys. Res. Comm. 100: 1377-83.
  29. Carson, D.A. & Chang, K.-P. (1981) Selective killing of leishmania-infected mouse macrophages by 6-methylpurine 2’-deoxyriboside. Life Sci. 29: 1617-21.
  30. Chang, K.-P., Bray, R.S. & Leaney, A.J. (1981). Infection of mouse macrophages in vitro by sandfly-derived promastigotes of Leishmania mexicana amazonensis. Trans. Roy. Soc. Trop. Med. Hyg. 75: 475-6.
  31. Fong, D. & Chang, K.-P. (1981) Tubulin biosynthesis in the developmental cycle of a parasitic protozoan, Leishmania mexicana:  Changes during differentiation of motile and non-motile stages. Proc. Nat. Acad. Sci. USA 78: 7624-8. 
  32. Chang, K.-P. & Chiao, D.W. (1981) Cellular immunity of mice to Leishmania donovani in vitro: Lymphokine-mediated intracellular killing of parasites in macrophages. Proc. Nat. Acad. Sci. USA 78: 7083-7.
  33. Chang, K.-P. & Fong, D. (1982) Antigenic changes during intracellular transformation of leishmanias in cultured macrophages. Infect. Immun. 36: 430-431.
  34. Fong, D. & Chang, K.-P. (1982) Surface antigenic change during differentiation of a parasitic protozoan, Leishmania mexicana:  Identification by monoclonal antibodies. Proc. Nat. Acad. Sci. USA 79: 7366-70.
  35. Wallach, M., Fong, D., & Chang, K.-P. (1982) Post-transcriptional control of tubulin biosynthesis in leishmanial differentiation. Nature 299: 650-2.
  36. Hu, X.-S. & Chang, K.-P. (1984) Vaccination of mice with formalin-killed amastigotes of Leishmania mexicana against Leishmania donovani: Muramyl dipeptide-enhanced protection. Acta Acad. Med. Sichuan 15: 91-97.
  37. Fong, D., Wallach, M., Keithly, J., Melera, P.W. & Chang, K.-P. (1984) Differential expression of mRNAs for tubulin during differentiation of a parasitic protozoan, Leishmania mexicana. Proc. Nat. Acad. Sci. USA 81: 5782-5786.
  38. Kiehlbauch, J.A., Albach, R.A., Baum, L.L. & Chang, K.-P. (1985) Phagocytosis of Campylobacter jejuni and its intracellular survival in mononuclear phagocytes. Infect.Immun. 48: 446-451.
  39. Hu, X.-S. & Chang, K.-P. (1985) Immunization of BALB/c mice with cultured amastigotes of Leishmania mexicana amazonensis: Protection by gamma-irradiated parasites. Acta Acad. Med. Sichuan 16: 1-5.
  40. Chang, C.S. and Chang, K.-P. (1985) Heme acquisition and utilization by intracellular and extracellular stages of L. m. amazonensis. Mol. Biochem. Parasitol. 16: 267-276.
  41. Chang, C.S. and Chang, K.-P. (1986) Monoclonal antibody affinity purification of a leishmania membrane glycoprotein and its inhibition of leishmania-macrophage binding. Proc. Nat. Acad. Sci. USA 83: 100-104.
  42. Chang, C.S., Inserra, T.J., Kink, J.A., Fong, D., and Chang, K.-P. (1986) Expression and size heterogeneity of a 63 kDa membrane glycoprotein during growth and transformation of Leishmania mexicana amazonensisMol. Biochem. Parasitol. 18: 197-210.
  43. Kink, J.A. & Chang, K.-P. (1987) Tunicamycin-resistant Leishmania mexicana: Virulent  phenotype associated with increased N-acetylglucosamine-1-phosphate transferase activity and amplification of its gene. Proc. Nat. Acad. Sci. USA 84: 1253-1257.
  44. Kink, J.A. & Chang, K.-P.  (1987) Biological and biochemical characterization of tunicamycin-resistant Leishmania mexicana. Infect. Immun. 55: 1692-1700.
  45. Kink, J.A. & Chang, K.-P.  (1988) N-glycosylation as a biochemical basis for virulence in Leishmania mexicana amazonensis. Mol. Biochem. Parasitol. 27: 181-190.
  46. Chaudhuri, G. & Chang, K.-P. (1988) Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes. Mol. Biochem. Parasitol. 27: 43-52. 
  47. Detke, S., Chaudhuri, G., Kink, J.A., & Chang, K.-P. (1988) DNA amplification in tunicamycin-resistant Leishmania mexicana amazonensis.  Multiple copies of a single 63 Kilobase supercoiled molecule. J. Biol. Chem. 263: 3418-24.
  48. Chaudhuri, G. & Chang, K.-P. (1988) A simple method for isolation of extrachromosomal circular DNA in unicellular eukaryotes. Nucleic Acids Research 16: 2341.
  49. Detke, S. & Chang, K.-P. (1989) DNA amplification in sodium arsenite-resistant Leishmania mexicana amazonensis.  Exp. Cell Res. 180: 161-170.
  50. Chaudhuri, G., Chaudhuri, M., Pan, A. & Chang, K.-P. (1989) Surface acid protease (gp63) of Leishmania mexicana.  A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation. J. Biol. Chem. 264:7483-9.
  51. Katakura, K. & Chang, K.-P. (1989) H-DNA amplification in Leishmania resistant to both arsenite and methotrexate. Mol. Biochem. Parasitol. 34: 189-192.
  52. Olafson, R.W., Thomas, J.R., Ferguson, M.A.J., Dwek, R.A., Chaudhuri, M., Chang, K.-P. & Rademacher, T.W. (1990) Structures of the N-linked oligosaccharides of gp63, the major surfact glycoprotein, from Leishmania mexicana amazonensis. J. Biol. Chem. 256:12240-12247.
  53. Katakura K., Peng, Y., Pithawalla, R., Detke, S. & Chang, K.-P. (1991) Tunicamycin-resistant variants from five species of Leishmania contain amplified DNA in extrachromosomal circles of different sizes with a transcriptionally active homologous region. Mol. Biochem Parasitol. 44:233-244.
  54. Lee, S.-Y., Lee, S.-T. & Chang, K.-P. (1992) Transkinetoplastidy - A novel phenomenon involving bulk alteration of mitochondrion-kinetoplast DNA of a trypanosomatid protozoan. J. Protozool. 39:190-196.
  55. Liu, Xuan & Chang, K.-P. (1992) Extrachromosomal genetic complementation of surface metalloproteinase-deficient Leishmania increases its binding to macrophages. Proc. Nat. Acad. Sci. USA 89: 4991-4995.
  56. Liu, Xuan & Chang, K.-P. (1992) The 63 kb circular amplicon of tunicamycin-resistant Leishmania contains a functional N-acetylglucosamine-1-phosphate transferase gene that can be used as a dominant selectable marker in transfection. Mol. Cell. Biol. 12: 4112-4122.
  57. Liu, Xuan & Chang, K.-P. (l993) N-acetylglucosamine-1-phosphate transferase gene is conserved in five Leishmania species and overexpressed due to its amplification in their tunicamycin-resistant variants. Mol. Biochem. Parasitol. 59: 177-180.
  58. Lee, S.-T., Tarn, C. & Chang, K.-P. (l993) Characterization of the switch of kinetoplast DNA minicircle dominance during development and reversion of drug resistance in Leishmania. Mol. Biochem. Parasitol. 58: 187-204.
  59. Mensa-Wilmot, K., LeBowitz, J. H., Chang, K.-P., Al-Qahtani, A., McGwire, B. S., Tucker, S. and Morris, J. C. (l994) A Glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: Topology of two GPI pathways. J. Cell Biol. 124: 935-947. 
  60. Lu, H. -G., Zhong, L., Guan, L. -R., Qu, J. -Q, Hu, X. -S., Chai, J. -J., Xu, Z. -B., Wang, C. -T. and Chang, K. -P. (l994) Separation of Chinese Leishmania isolates into five genotypes by kinetoplast and chromosomal DNA heterogeneity. Am. J. Trop. Med. Hyg. 50: 763-770.
  61. Qu, J. -Q., Zhong, L., Masoom-Yasinzai, M., Rab, M. A., Aksu, H. S. Z., Reed, S. G., Chang, K. -P. and Gilman-Sachs, A. (l994) Serodiagnosis of Asian leishmaniasis with a recombinant antigen from the repetitive domain of a Leishmania kinesin. Trans. Roy. Soc. Trop. Med. Hyg 88:543-545.
  62. Liu, Xuan & Chang, K. -P. (l994) Identification by extrachromosomal amplification and over-expression of alpha-crystallin/NADPH-oxidoreductase homologue constitutively expressed in Leishmania spp. Mol. Biochem. Parasitol. 66:201-210.
  63. McGwire, B.S. & Chang, K.-P. (l994) Genetic rescue of surface metalloproteinase-deficiency in Leishmania amazonensis  variants increases their infection of macrophages at the early phase. Mol. Biochem. Parasitol. 66:345-347.
  64. Du, Yubin & Chang, K. -P. (l994) Phylogenetic heterogeneity of three Crithdia spp. vs. Crithidia fasciculata . Mol. Biochem. Parasitol. 66:171-174.
  65. Du, Yubin, McLaughlin, G. and Chang, K.-P. (1994) 16S ribosomal DNA sequence identities of  beta-proteobacterial endosymbionts in three Crithidia species. J. Bacteriol. 176: 3081-3084.
  66. Du, Y., Maslov, D.A. and Chang, K.-P. (1994) Monophyletic origin of Beta-division proteobacterial endosymbionts and their coevolution with insect trypanosomatid protozoa Blastocrithidia culicis and Crithidia spp. Proc. Natl. Acad. Sci. USA 91: 8437-8441.
  67. Guan, L.-R., Yang, Y.-Q., Xu, Y.-X., Qu, J.-Q., Zho, X.-P., Wang, G., Lu, H.-G., Zhong, L & Chang, K.-P. (1994) Leishmaniasis in Karamay. XIV: Identification of isolates from naturally infected Phlebotmus major wui. Chin. J. Parasitol. Parasit. Dis. 12: 257-261.
  68. Huang, M., Albach, R.A., Chang, K.-P., Tripathi, R.L.and Kemp. R.G. (1995) Cloning and sequencing a putative pyrophosphate-dependent phosphofructokinase gene from Entomoeba histolytica. Biochim. Biophys. Acta 1260: 215-217.
  69. Aksoy, S., Arturk, S., Armstrong, M.Y.K., Chang, K.-P., Gottlieb, M., Ozcel, M.A., Richards, F.F. and Western, K. (1995) The GAP project in southern Turkey: The potential for emergence of diseases. Emerg. End. Dis. 3: 45-48.
  70. Singh, S., Gilman-Sachs, A., Chang, K.-P. And Reed, S.G. (1995) Diagnostic and prognostic value of K39 recombinant antigen in Indian leishmaniasis. J. Parasitol. 81: 1000-1003.
  71. Singh, S., McGwire, B.S. and Chang, K.-P. (1995) Kinetoplast and nuclear DNA polymorphism of visceral Leishmania isolates from northern India. J. Protozool. Res. 5: 27-32.
  72. Brittingham, A., Morrison, C.J., McMaster, W.R., McGwire, B. S., Chang, K.-P. and Mosser, D.M. (1995) The role of the Leishmania surface protease, gp63, in complement fixation, cell adhesion and resistance to complement-mediated lysis. J. Immunol. 155: 3102-3111.  
  73. McGwire, B.S. and Chang, K.-P. (1996) Posttranslational regulation of a Leishmania HEXXH-metalloproteinase (gp63). The effects of site-specific mutagenesis of catalytic, zinc-binding, N-glycosylation and GPI-addition sites on N-terminal end cleavage, intracellular stability and extracellular exit. J. Biol. Chem. 271: 7903-9.
  74. Chakrabarty, R., Mukherjee, S., Lu, H.-G., McGwire, B.S., Chang, K.-P. & Basu, M.K. (1996) Kinetics of entry of virulent and avirulent strains of Leishmania donovani into macrophages: A possible of virulence gene. J. Parasitol. 82: 632-635.
  75. Yasinzai-Masoom, M. & Chang, K.-P. (1996) Characterization of gp63, a major surface glycoprotein on Leishmania isolates of Pakistan. J. Parasit. Dis. 20: 11-16.
  76. Kawazu, S.-I., Lu, H.G. & Chang, K.-P. (1997) Stage-independent splicing of transcripts from two heterlogous neighboring genes in Leishmania amazonensis. Gene  196: 49-59.
  77. Lu, H.G., Li, Z., Chang, K.-P. & Docampo, R. (1997) Intracellular Ca2+ pool content and signaling and                        expression of a calcium pump are linked to virulence in Leishmania mexicana amazonensis amastigotes. J. Biol. Chem. 272: 9464-9473.
  78. Ozensoy, S., Ozbel, Y., Turgay, N., Alkan, M.Z., Gul, K., Gilman-Sachs, A., Chang, K.-P., Reed. S.G. & Ozcel, M. A. (1998) Sero-diagnosis and epidemiology of visceral leishmaniasis in Turkey. Am. J. Trop. Med. Hyg. 59: 363-369.
  79. Katakura, K., Kawazu, S.-I., Naya, T., Nagakura, K., Ito, M., Aikawa, M., Qu, J.-Q., Guan, L.-R., Zuo, X.-P., Chai, J.-J., Chang, K.-P. and Matsumoto, Y. (1998) Diagnosis of Kala-azar by nested PCR based on amplification of the Leishmania mini-exon gene. J. Clin. Microbiol. 36: 2173-2177.
  80. Mensa-Wilmot, K., Garg, N., McGwire, B.S., Lu, H.-G., Zhong, L., Armah, D.A., LeBowitz, J.H., Chang, K.-P. (1999) Roles of free GPIs in amastigotes of Leishmania Mol. Biochem. Parasitol. 99: 103 – 116.
  81. Chen, D.Q.. Lu, H.G. and Chang, K.-P. (1999) Replacement of the gene encoding N-acetylglucosamine-1-phosphate transferase requires episomal rescue in Leishmania amazonensis. Mol. Biochem. Parasitol. 100: 223-227.
  82. Brittinggham, A., Chen, G., McGwire, B. S., Chang, K.-P. and Mosser, D. (1999) Interaction of Leishmania gp63 with cellular receptors for fibronectin. Inf. Immun. 67: 4477-4484.
  83. Chen, D.-Q, Kolli, B.K., Yadava, N., Lu, H.-G., Gilman-Sachs, A., Peterson, D.A.  and Chang, K.-P. (2000) Episomal expression of specific sense- and anti-sense mRNAs in Leishmania amazonensis; Modulation of gp63 level in promastigotes and their infection of macrophages in vitro. Inf. Immun. 68: 80-86.
  84. Chai J, Chang KP, Zuo X, Yan L, Hou Y, Zhang S, Ruziguli, Jiang W, Zhang L. (1999) [Protective effects of leishmanial antigens against Leishmania infantum infection in Lagurus lagurus]. Chin. J. Parasitol. Parasit. Dis. [Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi.]. 17: 237-40.
  85. Akman, L., Ozensoy, S., Ozbel, Y., Turgay, N., Alkan, M.Z., Ozcel, M.A., Culha, G., Ozcan, K., Aksu, H.A.Z. and Chang. K.-P. (2000) Multi-site DNA polymorphism analyses of Leishmania isolates define their genotype predicting clinical epidemiology of leishmaniasis in a specific region. J. Euk. Microbiol. 47: 545-554.   
  86. Qu JQ, Guan LR, Shulidan I, Zuo XP, Chai JJ, Chen SB, Kawazu S, Katakura K, Matsumoto Y, Reed SG, Chang KP (2000) Rapid screening with a recombinant antigen (rK39) for diagnosis of visceral leishmaniasis using dipstick. Chin. J. Parasitol. Parasit. Dis. 18:155-8.
  87. Ma Y, Hu XS, Chang KP (2000) [Diagnosis of kala-azar by rK39 dipstick assay] Chin. J. Parasitol. Parasit. Dis. [Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi] 18: 252. Chinese.
  88. Terabe, M., Kuramochi, T., Ito, M., Hatabu, T., Sanjoba, C., Chang, K.-P., Onodera, T., Matsumoto, Y. (2000) CD4(+) cells are indispensable for ulcer development in murine cutaneous leishmaniasis. Infect Immun. 68:4574-4577.
  89. Guan LR, Qu JQ, Cai JJ, Matsumoto Y, Chang KP. (2001) [Detection of canine visceral leishmaniasis by rK 39 antigen dipstick method] Chin. J. Parasitol. Parasit. Dis. 19: 58.
  90. Sah, J.F., Ito, H., Kolli, B.K., Peterson, D.A., Sassa, S. and Chang, K.-P. (2002) Genetic rescue of Leishmania deficiency in porphyrin biosynthesis creates mutants suitable for analysis of cellular events in uroporphyria and for photodynamic therapy. J. Biol. Chem. 277: 14902-14909.
  91. Volf, P., Ozbel, Y.,Akkafa, F., Svobodová, M., Votpka, J., and Chang, K.-P. (2002). Sand Flies (Diptera: Phlebotominae) in Sanliurfa, Turkey: Relationship of Phlebotomus sergenti with the Epidemic of Anthroponotic Cutaneous Leishmaniasis. J. Med. Entomol. 39: 12-15.
  92. McGwire, B.S., O'Connell, W.A., Chang, K.-P. and Engman, D.M. (2002) Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis. J. Biol. Chem. 277: 8802-8809.
  93. Hatabu T, Matsumoto Y, Kawazu S, Nakamura Y, Kamio T, Lu HG, Chang KP, Hashiguchi Y, Kano S, Onodera T, Matsumoto Y. (2002) The expression system of biologically active canine interleukin-8 in Leishmania promastigotes. Parasitol. Int. 51: 63-71.
  94. McGwire BS, Chang KP, Engman DM.(2003) Migration through the Extracellular Matrix by the Parasitic Protozoan Leishmania Is Enhanced by Surface Metalloprotease gp63. Infect Immun. 71(2):1008-1010.
  95. Rosypal AC, Troy GC, Zajac AM, Duncan RB Jr, Waki K, Chang KP, Lindsay DS. (2003) Emergence of zoonotic canine leishmaniasis in the United States: isolation and immunohistochemical detection of Leishmania infantum from foxhounds from Virginia. J Eukaryot Microbiol. 2003;50 Suppl:691-3.
  96. Chan, M.M.Y., Bulinski, J.C., Chang, K.-P. and Fong. D. (2004) Leishmania amazonensis expressing highly fluorescent green fluorescent protein (GFP) multimer: Their use for rapid in vitro and in vivo drug screening assays. Parasitol. Res. 89: 266-271.
  97. Toz SO, Chang KP, Ozbel Y, Alkan MZ. (2004) Diagnostic value of rK39 dipstick in zoonotic visceral leishmaniasis in Turkey J Parasitol. 90: 1484-6.
  98. Katakura K, Fujise H, Takeda K, Kaneko O, Torii M, Suzuki M, Chang KP and Hashiguchi Y (2004) Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensis. Febs Lett 561(1-3):207-12.
  99. Thiakaki M., Rohousova I., Volfova V., Volf P , Chang  K.-P., Soteriadou K (2005) Sand fly species-specificity of saliva-mediated protective immunity in Leishmania amazonensis-BALB/c mouse mode. Microbes Infect. 7: 760-6. 
  100. Dutta, S, Ray, D, Kolli, BK, Chang, KP (2005) Photosensitization of Leishmania amazonensis in both extracellular and intracellular stages with phthalocyanine chloride for photolysis in vitro. Antimicrobial Ag Chemother 49: 4474-84.
  101. Sivakumar R, Sharma P, Chang KP, Singh S. (2005) Cloning, expression, and purification of a novel recombinant antigen from Leishmania donovani. Protein Expr Purif. 6 (1):156-65.
  102. Culha G, Uzun S, Ozcan K, Memisoglu HR, Chang KP. (2006) Comparison of conventional and polymerase chain reaction diagnostic techniques for leishmaniasis in the endemic region of Adana, Turkey. Int J Dermatol. 45(5):569-572.
  103. Thiakaki M, Kolli B, Chang KP, Soteriadou K. (2006) Down-regulation of gp63 level in Leishmania amazonensis promastigotes reduces their infectivity in BALB/c mice. Microbes Infect. 8(6):1455-63.
  104. Waki, K., Dutta, S., Ray, D., Kolli, B., Kawazu, S.I., Lin, C.-P. and Chang, K.-P. (2007) Transmembrane molecules for phylogenetic analysis of pathogenic protists: Leishmania-specific informative sites in hydrophilic loops of trans-ER N-acetylglucosamine-1-phosphate transferase. Eukaryotic Cell 6: 198-210.
  105. Mehmet S. Serin, Kayoko Waki, Kwang-Poo Chang, Gonul Aslan, Sahin Direkel, Feza Otag, Begum Kayar, Fatih Koksal, Gurol Emekdas (2007) Consistence of miniexon polymerase chain reaction–restriction fragment length polymorphism and single-copy gene sequence analyses in discriminating Leishmania genotypes. Diagn. Microbiol. Inf. Dis. 57: 295–299.
  106. Kolli, B.K., Costa, J, Chakrabarty, A. and Chang, K.-P.(2008) Leishmania release nucleoside diphosphate kinase to prevent ATP-dependent apoptosis of infected macrophages Mol Biochem Parasitol 158:163-75. Epub 2007 Dec 25.
  107.  Dutta, S., Sassa, S., Chang, KP (2008) Leishmania spp.: Delta-aminolevulinate-inducible porphyria by genetic complementation of incomplete heme biosynthesis. Exp Parasitol 118: 629-36.
  108. Dutta,S., Kolli,BK, Tang, A., Sassa, S. and Chang, KP (2008) Transgenic Leishmania model for delta-aminolevulinate-inducible monospecific uroporphyria: Cytolytic phototoxicity initiated by singlet oxygen-mediated inactivation of functional proteins and its ablation by evacuation of cytosolic uroporphyrin. Eukaryot. Cell 7: 1146-1157.
  109. Mehta SR, Huang R, Yang M, Zhang XQ, Kolli B, Chang KP, Hoffman RM, Goto Y, Badaro R, Schooley RT.(2008) Real time in vivo gfp imaging in a murine leishmaniasis model: a new tool for leishmania vaccine and drug discovery. Clin. Vaccine Immunol. 15, 1764–1770.
  110.  Kumari S, Samant M, Khare P, Misra P, Dutta S, Kolli BK, Sharma S, Chang KP and Dube A. (2009) Photodynamic vaccination of hamsters with inducible suicidal mutants of Leishmania amazonensis elicits T cell-transferable immunity against visceral leishmaniasis. Eup. J. Immunol. 38: 1-14.
  111. Varela M RE, Lorena Muñoz D, Robledo SM, Kolli BK, Dutta S, Chang KP, Muskus C. (2009) Leishmania (Viannia) panamensis: An in vitro assay using the expression of GFPfor screening of antileishmanial drug. Exp Parasitol. 122:134-9.
  112. Mehta SR, Zhang XQ, Badaro R, Spina C, Day J, Chang KP, Schooley RT. (2010) Flow cytometric screening for anti-leishmanials in a human macrophage cell line. Exp Parasitol. 126(4):617-20.
  113. Wang Y, Chen Y, Xin L, Beverley SM, Carlsen ED, Popov V, Chang KP, Wang M, Soong L (2011) The differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes. Infect Immun. 79(3):1124-33.
  114. Working Group on Research Priorities for Development of Leishmaniasis Vaccines, Costa CH, Peters NC, Maruyama SR, de Brito EC Jr, Santos IK, et al. (2011) Vaccines for the leishmaniases: proposals for a research agenda. PLoS Negl Trop Dis. 5(3):e943.
  115. Dutta, S., Ongarora, B.G., Li, H., Vicente, MGH, Kolli, BK and Chang, KP. (2011) Intracellular targeting specificity of novel phthalocyanines assessed in a host-parasite model for developing potential photomedicine. PLoS ONE 6(6):e20786.
  116. Dutta S, Waki K, Chang KP. (2012) Combinational Sensitization of Leishmania with Uroporphyrin and Aluminum Phthalocyanine Synergistically Enhances their Photodynamic Inactivation in vitro and in vivo. Photochem Photobiol. 88(3):620-5.
  117. Dutta, S, Chang, C, Kolli, BK, Sassa, S, Yousef, Showe, M, Showe, L, and Chang, KP. (2012) Delta-aminolevulinate-induced host-parasite porphyric disparity for selective photolysis of transgenic Leishmania in the phagolysosomes of mononuclear phagocytes: A potential novel platform for vaccine delivery Euk Cell 11: 430-441.
  118. Kaur J, Dutta S, Chang KP, Singh N A (2013) Member of the Ras oncogene family, RAP1A, mediates antileishmanial activity of monastrol. J Antimicrob Chemother. 68:1071-80.
  119. Jecna, L, Dostalova, A, Wilson, R, Seblova, V, Chang, KP, Bates, PA, Volf, P (2013) The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies. Parasitology 140:1026-32.
  120. Alam MZ, Nakao R, Sakurai T, Kato H, Qu JQ, Chai JJ, Chang KP, Schönian G, Katakura K. (2014) Genetic diversity of Leishmania donovani/infantum complex in China through microsatellite analysis. Infect Genet Evol. 22C:112-119.
  121. Chang, KP. (2014) Vaccination for Disease Prevention and Control: The Necessity of Renewed Emphasis and New Approaches. J Immunol Immunotech. 1(1): 1-4.
  122. Kayoko Waki, Leyla Akman, Reha Toydemir, Seray Osenzoy-Toz, Yusuf Ozbel, Gulnaz Culha, Henk Schallig, Max Grogl, Mehdi Mohebali, Hatice Ertabaklar, Petr Volf, Milena Svobodova, Ikram Guizani and Kwang-Poo Chang. Dominant heterozygous genotype of Leishmania tropica in cyclic epidemics of anthroponotic cutaneous leishmaniasis of Asia Minor. (Under revision).
  123. Kolli, BK, Dutta, S., Cedeno, D, Francis, K. and Chang, KP. Cytolysis of genetically and chemically photosensitized Leishmania by luciferase-generated luminescence. J. Biol. Chem. (In preparation).
  124. Kolli BK, Dutta, S, Soteriadou, K and Chang KP. Transfection of Leishmania to over-express nucleoside diphosphate kinase increases their in vivo activity to recruit macrophages and other mononuclear cells in rodents (In preparation).
  125.  Kolli, B., Chang, K.-P. Activities of nucleoside diphophate kinase and its genomic polymorphism in New World and Old World Leishmania subgenus (In preparations).
  126. Lu, H.-G., Chen, D.-Q. and Chang, K.-P. The absence of apparent phenotypic changes with null mutation of a highly conserved gene encoding oxidoreductase in Leishmania amazonensis. Episomal and chromosomal expression of foreign genes at this site. (In preparation).

   Reviews:

  1. Chang, K.-P. (1983) Molecular and biochemical mechanisms of intracellular symbiosis in leishmaniasis Int. Rev. Cytol. Suppl. 14: 267-302.
  2. Chang, K.-P. (1983) Leishmania-macrophage cellular and molecular interactions in vitro. Microbiology 380-383.
  3. Chang, K.-P., Chaudhuri, G. & Fong D. (1990) Molecular determinants of Leishmania virulence. Ann. Rev. Microbiol. 44:499-529.
  4. Chang, K.-P. & McGwire, B.S. (2002) Molecular determinants and regulation of Leishmania virulence Kinetoplastid Biology and Disease 1:1-7. (http://www.kinetoplastids.com/content/1/1/1).
  5. Chang, K.-P., Reed, S.G., McGwire, B.S. & Soong, L. (2003) Leishmania model for microbial virulence: The relevance of parasite multiplication and pathoantigenicity. Acta Trop. 85: 375-90.

Book Chapters:

  1. Chang, K.-P. & Fish, W.R. (1983) Leishmaniasis.  In In vitro cultivation of pathogenic protozoa of man and domestic animals, Ed. J. B. Jensen, CRC Uniscience pp. 111-153.
  2. Chang, K.-P., Dasch, G. & Weiss, E. (1984). Endosymbionts of fungi and invertebrates other than insects, In: Bergey’s Manual of Systematic Bacteriology, Ed. N.R. Krieg, Vol. I, 853-863, William & Wilkins, Baltimore.
  3. Dasch, G., Chang, K.-P. & Weiss, E. (1984) Endosymbionts of insects.  In: Bergey’s Manual of Systematic Bacteriology, Ed. N.R. Krieg, Vol. I, 811-830, Williams & Wilkins, Baltimore.
  4. Weiss, E., Dasch, G., & Chang, K.-P. (1984) Wolbacheae.  In: Bergey’s Manual of Systematic Bacteriology, Ed. N.R. Krieg, Vol. I, 711-717, Williams & Wilkins, Baltimore.
  5. Chang, K.-P., Fong, D and Bray, R.S. (1985) Biology of Leishmania and leishmaniasis.  In: Leishmaniasis, Eds. K.-P. Chang and R.S. Bray, Elsevier Biomedical Press, Amsterdam, pp. 1-27.
  6. Chang, K.-P. & Hendricks, D.L. (1985) Laboratory maintenance of leishmaniae.  In: Leishmaniasis, Eds. K.-P. Chang & R.S. Bray, Elsevier Biomedical Press, Amsterdam, pp. 213-246.
  7. Chang, K.-P., Nacy, C.A. & Pearson, R.D. (1986) Intracellular parasitism of macrophages in leishmaniasis: In vitro systems and their applications.  In: Phagocytosis and cytotoxicity of macrophages  Methods in Enzymol.  132: 603-625.
  8. Chang, K.-P. (1990) Cell biology of Leishmania.  In: Modern Parasite Biology-Cellular, immunological and molecular aspects.  Ed. D.J. Wyler, W.H. Freeman Co., New York, Chapter 5 pp. 79-90
  9. Singh, S. & Chang, K.-P. (1996) Genetic heterogeneity among Indian Leishmania donovani isolates. In Indian Kala-Azar. Ed. S. Sundar, Banaras Hindu University, Varanasi, pp. 197-204.
  10. Chang, K.-P. (1995) LeishmaniasisIn: Encyclopedia of human biology.  Ed. R. Dubelcco, Academic Press, San Diego, Vol. 5, pp. 275-281.
  11. Chang, K.-P. (1997) Leishmaniasis.  In: Encyclopedia of human biology. 2nd Edition, Ed. R. Dubelcco, Academic Press, San Diego. Vol. 5, pp. 275-281.
  12. Chang, K.-P. (1999) Leishmaniasis in the Old World. In: Epidemiology and control of leishmaniasis in central Eurasia, Research report series No. 1 (1996-1998), Ed. Y. Matsumoto, Int. Press Edit. Cent. Inc., Tokyo, pp. 1-14.
  13. Katakura, K., S.-I. Kawazu, T. Naya, K. Nagakura, M. Ito, M.Aikawa, J.-Q. Qu , L.-R. Guan , X.-P. Zuo , J.-J. Chai, K.-P. Chang and Y. Matsumoto (1999) PCR-Based Diagnosis of Kala-Azar in Xinjiang-Uigur Autonomous Region, China. In: Epidemiology and control of leishmaniasis in central Eurasia, Research report series No. 1 (1996-1998), Ed. Y. Matsumoto, Int. Press Edit. Cent. Inc., Tokyo, pp.37-44.
  14. Nakakura, K., T. Naya, K. Katakura, J.-J. Chai, S.-I. Kawazu, M.Ito, J.-Q. Qu, L.-R. Guan, K.-P. Chang, M. Aikawa and Y. Matsumoto (1999) IFA is a Powerful Tool to Monitor the Progression of Visceral Leishmaniasis In: Epidemiology and control of leishmaniasis in central Eurasia, Research report series No. 1 (1996-1998), Ed. Y. Matsumoto, Int. Press Edit. Cent. Inc., Tokyo, pp. 45-47.
  15. Qu, J.-Q., Q. Feng, I. Shulidan, X.-P. Zuo, J.J. Chai, S.-I. Kawazu, K. Katakura, Y. Matsumoto, S. G. Reed and K.-P. Chang (1999) Serodiagnosis of Visceral Leishmaniasis in Northwestern China: Rapid Screening with a Recombinant Antigen (rK39) in Dipstick Format and Its Specificity vs.Promastigote Antigens In: Epidemiology and control of leishmaniasis in central Eurasia, Research report series No. 1 (1996-1998), Ed. Y. Matsumoto, Int. Press Edit. Cent. Inc., Tokyo, pp.48-56.
  16. Nagakura, K., T. Naya, K. Katakura, J.-J. Chai, S.-I. Kawazu, M. Ito, J.-Q. Qu, L.-R. Guan, K.-P. Chang, M. Aikawa and Y. Matsumoto (1999) Parasites Detection Using Biopsies from Chinese Patients with Visceral Leishmaniasis In: Epidemiology and control of leishmaniasis in central Eurasia, Research report series No. 1 (1996-1998), Ed. Y. Matsumoto, Int. Press Edit. Cent. Inc., Tokyo, pp.75-77
  17. Kawazu, S.-I., K. Katakura, K. Nagakura. T. Naya, Mamoru Ito, Y. Nakai, M. Aikawa, Jing-Qi Qu, L.R. Guan, X.-P. Zuo, J.-J. Chai, K.-P. Chang and Yoshitsugu Matsumoto (1999) Zeta-crystallin/NADPH oxidoreductase homologue (p36) gene sequences for analysis of the phylogenetic relationships among Leishmania spp In: Epidemiology and control of leishmaniasis in central Eurasia, Research report series No. 1 (1996-1998), Ed. Y. Matsumoto, Int. Press Edit. Cent. Inc., Tokyo, pp.78-82.
  18. Chang, K.-P., Akman L. and Nielson, J. (1999) Leishmania virulence and genetic heterogeneity, Ed. O. Omeish, Clin. Dermatol. 17: 269-273.
  19. Motta, M.C.M., De Souza, W. and Chang, K.-P. (2002) Endosymbiosis of beta-Proteabacteria with trypanosomatid protozoa. In: Symbiosis, Ed. J. Seckbach, Hebrew University Press, Jerusalem (In press).
  20. Chang K-P (2002) Leishmaniases. In: Encyclopedia of Life Sciences, vol. 11, pp. 10-18. London: Nature Publishing Group. http://www.els.net/
  21. Chang K-P (2005) Leishmaniases. In: Encyclopedia of Life Sciences, doi: 10.1038/npg.els.0003824, John Wiley & Sons, Ltd. http://www.els.net/
  22. Chang, K.-P. (2006) Molecular and immunological aspects of Leishmania relevant to control and treatment of leishmaniasis and other diseases in China [English with translation in Chinese]. In: Leishmaniasis and Phlebotomine sandflies in Xinjiang Uygur Autonomous region of the People’s Republic of China, Eds. J.J. Chai and L.R. Guan, Xinjiang People’s Publishing Co, pp. 51-79.
  23. Chang K-P (2012) Leishmaniases. In: Encyclopedia of Life Sciences, DOI: 10.1002/9780470015902.a0001954.pub3, John Wiley & Sons, Ltd. http://www.els.net/
  24. Chang, K.-P. (2013)  Forward Summary  “Drug Resistance in Leishmania Parasites, Consequences, Molecular Mechanisms and Possible Treatments”, Ponte-Sucre, Alicia; Diaz, Emilia; Padrón-Nieves, Maritza (Eds.) XIV, Springer.
  25. Chang, KP. (2014) Leishmaniasis.  Chapter # 688. In: Reference module in Biomedical Sciences, Michael Caplan Ed., Elsevier, Oxford, UK
  26. Chang K-P. (2014) Leishmaniases. In: Encyclopedia of Life Sciences,  3rd Edition..

Symposium and Workshop Papers:

  1. Chang, K.-P. (1975) Haematophagous insects and haemoflagellates as hosts for prokaryotic endosymbiotes.  Symp. Soc. Exp. Biol. 29: 407-428.
  2. Chang, K.-P. and Dave, C. (1980) Modulation of polyamine biosynthesis enzymes by bacterial endosymbionts in trypanosomatid protozoa.  In: Int. Proc. Endosymb. Cell Res., Eds. W. Schwemmler & H. Schenk, Walter de Gruyter, Berlin, 1: 349-360.
  3. Chang, K.-P. & Fong, D. (1983) Cell biology of host-parasite membrane interactions in leishmaniasis.  Cytopathology of Parasitic Diseases. Ciba Foundation Symp. 99: 113-131.
  4. Fong, D. and Chang, K.-P. (1986) Changes in tubulin mRNAs during differentiation of a parasitic protozoan, Leishmania mexicana. Ann. N.Y. Acad. Sci. 466: 129.
  5. Chang, K.-P., Kink, J.A., and Detke, S. (1987) Tunicamycin-resistant Leishmania mexicana: Increased N-acetylglucosaminyltransferase, its gene and virulence.  In: Molecular Strategy of Parasite Invasion UCLA Winter Symposium., NS 42: 77-86.
  6. Chang, K.-P. (1987) Molecular pathogenicity of Leishmania in intracellular parasitism of macrophages: Association of virulent phenotype with increased expression of a major membrane glycoprotein and microsomal N-acetylglucosaminyltransferase. In: Host-parasite cellular and molecular interactions in protozoal infections, Eds. K.-P. Chang & D. Snary, Springer-Verlag, Heidelberg NATO ASI Series Vol. H11, 107-116.
  7. Chaudhuri, G. & Chang, K.-P. (1987) Acid protease activity of Leishmania gp63 and its possible role in virulence. In: Host-parasite cellular and molecular interactions in protozoal infections, Eds. K.-P. Chang & D. Snary, Springer-Verlag, Heidelberg, NATO ASI Series H11, 169-173.
  8. Kahl, L.P., Chang, K.-P., & Liu, F.Y. (1988) the 63kDa promastigote protease of Leishmania: Assessment of host-protection in BALB/c mice using liposomes as adjuvant. In: Leishmaniasis: The new strategies for control, Ed. D.T. Hart, NATO ASI Series. A, Vol 163, pp 417-422.
  9. Olafson, R.W.,Chang, K.-P., & Ferguson, A.J.M. (1988) Biochemical characterization of Leishmania gp63 as an acid protease.  In: Leishmaniasis: The new strategies for control, Ed. D.T. Hart, NATO ASI Series. A, Vol 163, pp. 619-625.
  10. Chang, K.-P., Chaudhuri, G., Chaudhuri, M., Katakura, K., Detke, S., & Zhang, R. (1989) Molecular determinants of Leishmania virulence: Surface metallo-proteinase, N-glycosylation and DNA amplification.  In: Current Perspectives in Parasitic Diseases, Ed. R.C. Ko, Hong Kong, University Press, Hong Kong, pp.111-128.
  11. Chang, K.-P. Chaudhuri, G., Chaudhuri, M. & Katakura, K. (1990) Gp63 as a surface metalloproteinase in Leishmania virulence: Molecular determinants of proteolytic activity and N-glycosylation.  In: Immune Recognition and Evasion: Molecular Aspects of Host-Parasite Interaction, Eds. Lex H.T. Van der Ploeg, C.R., Cantor and H.J. Vogel, P & S Biomedical Science Symposium, Academic Press, New York, pp. 279-293.
  12. Chang, K.-P.(l993) Evolution and regulation of Leishmania virulence. Proc. CSIR Symp., Current Trends in Leishmania Research, CSIR Press, New Dehli, pp. 15-28.

Abstracts:

  1. Chang, K.-P. (1968) Studies on the structure, ultrastructure and cytochemistry of the mycetome of the pear psylla.  Proc. Ent. Soc. Ont. 99, 81.
  2. Tuan, R.S. & Chang, K.-P. (1974) Isolation and characterization of DNA from symbiotic and aposymbiotic strains of Blastocrithidia culicisProc. 3rd Int. Cong. Parasitol. 3, 1453.
  3. Chang, K.-P., Chang, C.S., Tuan, R.S. & Sassa, S. (1974) Ultrastructure and heme biosynthesis of symbiotic bacteria in two species of hemoflagellates.  Proc. 3rd Int. Congr. Parastiol. 2, 26.
  4. Dwyer, D.M. & Chang, K.-P. (1975) Surface saccharide alterations in a flagellate protozoan mediated by bacterial endosymbiotes.  J. Cell Biol. 67, 102a.
  5. Dwyer, D.M. & Chang, K.-P. (1975) Surface membrane terminal saccharides of Leishmania donovani promastigotes.  J. Protozool. 22, 37-8A.
  6. Chang, K.-P. & Dwyer, D.M. (1975) Leishmania donovani-hamster macrophage interaction in vitroJ. Parasitol. 61 (Suppl.), 71.
  7. Meshnick, S., Chang, K.-P. & Cerami, A. (1976) The effects of hemin on salivarian trypanosomes.  J. Parasitol. 62 (Suppl.), 33.
  8. Dave, C., Chang, K.-P. & Cheng, Y.C. (1976). Activity of polyamine biosynthesis enzymes in trypanosomatid protozoa.  J. Parasitol. 62 (Suppl.), 32.
  9. Chang, K.-P. & Steiger, R.F. (1976) Anti-trypanosome activity of methylgloxal bis (guanylhydrazone).  J. Parasitol. 62 (Suppl.), 32.
  10. Chang, K.-P. (1977) Leishmania infection of human skin fibroblasts in vitroAm. Soc. Trop. Med. Hyg. 25th Ann. Meeting.
  11. Chang, K.-P. (1977) Leishmania donovani-hamster macrophage surface interactions in vitro: Quantitation and characterization of host-parasite attachment using tritium-labeled promastigotes.  Int. Cong. Protozool. 5, 463.
  12. Chang, K.-P. (1977) Survival and growth of Leishmania donovani in human and murine mononuclear phagocytes.  J. Parasitol. 63 (Suppl.), 43.
  13. Chang, K.-P. (1977) Endosymbiosis in trypanosomatid flagellates. Int. Congr. Protozool. 5, 438.
  14. Chang, K.-P. & Chiao, J.W. (1978) Visceral leishmaniasis in congenitally athymic mice.  Ann. Meet. Am. Soc. Microbiol.
  15. Chang, K.-P. & Chiao, J.W. (1978) Comparison of in vitro leishmanicidal activity in macrophages mediated by lymphocytes from normal and nude mice.  IV Int. Cong. Parasitol.
  16. Chang, K.-P. (1978) Phagocytosis and intracellular digestion of leishmanial amastigotes by human polymorphonuclear phagocytes.  J. Protozool. 25, 20A.
  17. Chang, K.-P. (1978) Lysosome-phagosome fusion in polymorphonuclear phagocyte-Leishmania donovani interactions in vitroJ. Parasitol. 64 (Suppl.), 84. 
  18. Chang, K.-P. (1979) Interactions of leishmanias with mammalian cells in vitro, WHO Workshop on in vitro cultivation of pathogens of tropical diseases, ILRAD, Nairobi, Kenya.
  19. Chang, K.-P. (1980) Endocytosis of FITC-dextran by leishmania-infected macrophages in vitro: Fluorometry of pinocytosis, lysosome-phagosome fusion and intralysosomal pH.  3rd Int. Symp. Biochemistry of Parasites & Host-Parasite Relationships, Beerse, Belgium.
  20. Chang, K.-P. (1981) A complete development cycle of leishmanias in vitro: Some biological and biochemical studies.  Ann. Meet. Am. Soc. Trop. Med. Hyg.
  21. Chang, K.-P. (1981) Surface antigen/glycoprotein-mediated binding of Leishmania donovani to hamster macrophages.  Ann. Meet. Soc. Parasitol.
  22. Fong, D. & Chang, K.-P. (1981) Protease activities of a parasitic protozoan, Leishmania mexicanaJ. Cell Biol. 9, 43a.
  23. Chang, K.-P. & Fong, D. (1982) Identification of surface antigenic proteins of Leishmania mexicana amazonensisJ. Protozool. 29, 295.
  24. Fong, D., Chan, M.M., Chang, K.-P. (1983) Stage-specific monoclonal antibodies specific to Leishmania mexicana.  5th Int. Cong. Immunol. 806-810.
  25. Rivas, L. and Chang, K.-P. (1983) Intraparasitophorous vacuolar pH of leishmania-infected macrophages.  Biol. Bull. 165, 536.
  26. Anaya-Velazquez, L.F. & Chang, K.-P. (1983) Phagocytosis and intralysosomal killing of Leishmania mexicana by Entamoeba histolyticaBiol. Bull. 165, 534.
  27. Chang, C.S. & Chang, K.-P. (1984) Heme biosynthesis in Leishmania-macrophage interactions in vitroASBC/AAI Minisymposium KM2 Biochemistry of Protozoa.
  28. Chang, K.-P. & Prachayasittikul, V. (1984) Nucleotide heterogeneity of restriction fragments from kinetoplast DNAs of three Chinese Leishmania species.  Eroup. Multicolloq. Parasitol. IV, Izmir, Turkey.
  29. Prachayasittikul, V. & Chang, K.-P. (1984) Kinetoplast DNA heterogeneity and homogeneity of three Chinese Leishmania species determined by dot-blot hybridization.  Ann. Meet. Am. Soc. Parasitol.
  30. Chang, K.-P. & Chang, C.S. (1984) Leishmanial infection of macrophages in vitro: A quest for biological and biochemical basis.  XI. Int. Cong. Trop. Med. Malaria, Calgary, Canada.
  31. Chang, K.-P. (1985) Phagocytosis of leishmanias by macrophages in vitro. VII Int. Cong. of Protozoo., Nairobi, Kenya.
  32. Chang, K.-P. (1985) Stage-specific molecules of LeishmaniaImpact of modern genetic, biochemical and immunological techniques on human leishmaniasis, Coltswald, UK p. 6.
  33. Detke, S., Kink, J.A. & Chang, K.-P. (1986) Characterization of amplified DNA from tunicamycin resistant Leishmania mexicana.  J. Cell. Biochem. 10a (Suppl.), 129.
  34. Chang, K.-P., Kink, J.A., Detke, S., & Chang, C.S. (1986) Molecular mechanism of parasite virulence in leishmaniasis:  Possible role of a 63 kDa membrane glycoprotein and glycoglytransferase gene amplification.  1st SCBA Int. Symp., p. 37.  
  35. Chang, K.-P., Chaudhuri, G., Peng, Y., Detke, S., Chang, C.S. & Fong, D. (1986) Leishmania gp63 as a major surface glycoprotein: Molecular heterogeneity and possible biological functions, NATO ARW “Host-parasite molecular recognition and interactions in protozoal infections”, Proc. p. 6.
  36. Chaudhuri, G. & Chang, K.-P. (1986) Acid protease activity of leishmania gp63:  Possible role in virulence, NATO ARW “Host-parasite molecular recognition and interactions in protozoal infections”, Proc., p. 7.
  37. Detke, S., Kink, J.A., Chaudhuri, G. & Chang, K.-P. (1986) Structure of the amplified DNA in tunicamycin-resistant Leishmania mexicana. NATO ARW “Host-parasite molecular recognition and interactions in protozoal infections”, Proc. p. 10.
  38. Kink, J.A. & Chang, K.-P. (1986) N-acetylglucosaminyltransferase gene amplification associated with virulent phenotype of Leishmania mexicana. NATO ARW “Host-parasite molecular recognition and interactions in protozoal infections”, Proc., p. 24.
  39. Chang, K.-P. (1987) Cellular and molecular aspects of extrachromosomal genetic elements in parasitism and symbiosis.  Symp. Recent Adv. Biol. & Med. Sci., Taipei, Taiwan, Program & Abstract, p. 14.
  40. Chang, K.-P. (1987) Molecular determinants of Leishmanial virulence.  NATO Adv. Study Inst. on Leishmaniasis, Program & Abstracts, p. 23.
  41. Chang, K.-P. (1988) N-glycosylation of a dominant surface antigen in its diagnostic and prophylactic potential for leishmaniasis.  2nd SCBA Int. Symp., San Francisco.
  42. Chang, K.-P. (1989).  Molecular determinants of Leishmania virulence.  Int. Symp. Mol. Parasitol., Acad. Sinica, Taipei, Taiwan.  Program and abstract, p. 22.
  43. Chang, K.-P. (1989). Molecular determinants of Leishmania virulence.  VIII Int. Cong. Protozool., Tsukuba, Japan, p. 59.
  44. Chang, K.-P. (1989) Molecular determinants of Leishmania virulence. 2nd SE Asian Symposium Parasitology & Modern Medicine, Molecular Basis of Pathogenesis in Parasitic Diseases, Hong Kong, p.8.
  45. Chaudhuri, G., Chaudhuri, M., Latshaw, S.P., Moberley, L., Kemp, R.G., Chang, K.-P. (1989). Biochemical characterization of gp63 as a metallo-proteinase from Leishmania mexicana amazonensisGordon Research Conference, New Hampshire.
  46. Katakura, K., Peng, Y., Liu, X., Pithawalla, R., Chaudhuri, M., Detke, S., Chang, K.-P. (1989).  DNA amplification in five species of tunicamycin-resistant Leishmania: Extrachromosomal circles of different sizes with a 20-kb consensus DNA region and over-expression of N-acetylglucosamine-1-phosphate transferase protein.  Gordon Research Conference, New Hampshire.
  47. Chang, K.-P. (1990) Searching for the molecular determinants of Leishmania virulence -  A rational approach to the control of parasitic diseases.  Proc. Symp. Med. Parasitol., Shanghai, pp. 47-48.
  48. Chaudhuri, G., Chaudhuri, M., Latshaw, S.P., Moberley, L., Kemp, R.G., Chang, K.-P. (1990).  Surface metallo-proteinase (gp63) of Leishmania mexicana amazonensis-specific primary structure, extended substrate binding site and implication of metallo-enzyme-conserved residues.  AAAS Annual Meeting-Biology of Partasitism Seminar, New Orleans
  49. Katakura, K., Pithawalla, R., Peng, Y., Chaudhuri, G., Chaudhuri, M., Chang, K.-P. (1990).  DNA amplification in tunicamycin-resistant Leishmania spp.: Consensus region in extrachromosomal circles of variable sizes, mutiple transcripts with translational activity and over-production of N-acetylglucosamine-1- phosphate transferase.  AAAS Annual Meeting-Biology of Parasitism Seminar, New Orleans.
  50. Chang, K.-P. (1990).  Surface antigens of Leishmania3rd SCBA Int. Symp. Inf. Dis., Hong Kong.
  51. Chang, K.-P. (1991) Molecular biology of Leishmania virulence.  Proc. Soc. Protozool., Bozman, Montana, p. 23.
  52. Liu, X. & Chang, K.-P. (1991) Leishmania DNA sequence responsible for tunicamycin-resistance.  Proc. Am. Soc. Trop. Med. Hyg. 40, 107.
  53. Chang, K.-P. Du, Y. & Liu, X. (1991) Transfection of Leishmania with gp63 metalloproteinase gene and its expression in the transfectants.  Proc. Am. Soc. Trop. Med. Hyg. 40, 108.
  54. Chang, K.-P. (1992) Cellular and molecular biology of Leishmania virulence.  Proc. Int. Symp. Curr. TrendLeishmania Res., Calcutta, p. 8.
  55. Chang, K.-P. (1992) Chromosomal and extrachromosomal genes in Leishmania virulence.  Symp. Mol. Parasitol. 4th Int. SCBA Symp. P. 256.
  56. Du, Yubin, Chang, K.-P. (1992) PCR amplification of bacterial pre-rRNA genes in endosymbionts-containing Crithidisa spp., V Int. Coll. Endocytobiology Symbiosis, Kyoto, Japan. P. 73.
  57. McGwire, B.S. & Chang, K.-P. (l993) Functional analysis of Leishmania metalloproteinase (gp63) by site-specific mutagenesis. MBL Mol. Parasitol. Meet. No. 185.
  58. Liu, X. & Chang, K.-P. (l993) An overexpressed gene coamplified with tunicamycin-resistance marker is a _-crystallin/NADPH-oxidoreductase homolog constitutively expressed in Leishmania spp.  MBL Mol. Parasitol. Meet. No. 179.
  59. Lu, H.G. & Chang, K.-P. (l993) Extrachromosomal rescue of lethal null mutants of N-acetylglucosamine-1-phosphate transferase gene in Leishmania.  MBL Mol. Parasitol. Meet. No. 180.
  60. Lu, H.-G. and Chang, K.-P. (l993) Heterogeneity of kinetoplast minicircles is independent of chromosomal DNA alterations in Leishmania amazonensis. MBL Mol. Parasitol. Meet. No. 176.
  61. Kojo, Mensa-Wilmot, Tucker, S., McGwire, B.S., Chang, K.-P. and LeBowitz, J. (l993) Expression of a glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei in Leishmania causes secretion of gp63: Implications for the topology of glycosylPhosphatidyl inositol biosynthesis in vivo. MBL Mol. Parasitol. Meet. No. 272.
  62. Lu, H.G., Zhong, Li, Chai, T. Z., Qu, J.Q. & Chang, K.-P. (l993) Genotype and phenotype heterogeneity of Leishmania isolates from western China. Joint Meet. Am. Soc. Trop. Med. & Hyg./Parasitol. P. 373.
  63. Yasinzai, M. M. & Chang, K.-P. (l993) Characterization of parasites causing cutaneous and visceral Leishmania from Pakistan. Joint Meet. Am. Soc. Trop. Med. & Hyg./Parasitol. P. 380.
  64. Chang, K.-P. (l993) Molecular basis of Leishmania virulence. Joint Meet. Am. Soc. Trop. Med. & Hyg./Parasitol. P. 417. 
  65. Chang, K.-P. (l993) New perspectives of an ancient disease along the “Silk Roads” - Leishmaniasis. XXVI Congr. Turk. Soc. Microbiol. P. 429.
  66. Kawazu, S.-I. and Chang, K.-P. (1994) Transcriptional mapping of two closely linked heterogenous genes expressed constitutively in Leishmania. 8th Intl. Congr. Parasitol. Abst. 2: 264.
  67. Aksu, H.S.Z., Chang, K.-P., Reed, S.G., Ak, M., Ozbel, Y. and Ozcel, M.A. (1994) Serodiagnostic potential of specific antigens to discirminate cutaneous and visceral leishmaniasis due to genetically heterogenous isolatres. 8th Intl. Congr. Parasitol. Abst. 2: 291.
  68. Yasinzai-Masoom, M. and Chang, K.-P. (1994) Leishmaniasis in Pakistan: Parasite characterization and chemotherapy. 8th Intl. Congr. Parasitol. Abst. 2: 387.
  69. Singh, S. and Chang, K.-P. (1994) Genetic heterogeneity of Indian Leishmania donovani isolates. 8th Intl. Congr. Parasitol. Abst. 2: 344.
  70. Guan, L.R., Yang, T.Q., Xu, Y.X., Qu, J.Q., Zho, X.P., Wang, G., Lu, H.G., Zhing, L. and Chang, K.-P. (1994) Genetically different parasites cause human and gerbil cutaneous leishmaniasis in northwest China.  8th Intl. Congr. Parasitol. Abst. 2: 344.
  71. Chang, K.-P. (1994) Hypothetical consideration of Leishmania virulence and control of leishmaniasis. 8th Intl. Congr. Parasitol. Abst. 1: 59.
  72. McGwire, B., Lu, H.G., Zhong, L., Du, Y.B., Kawazu, S.-I., Yang, X.X. and Chang, K.-P. (1994) Extrachromosomal expression of Leishmania surface zinc proteinase (gp63) and their site-specific mutants.  8th Intl. Congr. Parasitol. Abst. 1: 57.
  73. Reed, S.G., Burns, J.M., Chang, K.-P., Chung, P. and Badaro, R. (1994) Cloning and expression of a Leishmania donovani specific antigen gene and clinical application of its encoded protein.  8th Intl. Congr. Parasitol. Abst. 1: 56.
  74. Qu, J.Q., Boa, Y.F., Wuli, G., Reed, S.G. and Chang, K.-P. (1995) Serodiagnosis of leishmaniasis in Northwest China using a recombinant antigen. Proc. Chin. Protozool. Soc. 8, 114.
  75. 75           Guan, L.R., Xu, Y.X., Yang, Y.C., Qi, J.Q., Tsio. X.P., Wang, G., Chai, J.J., Lu, H.G., Li, C. and Chang, K.-P. (1995) Discovery of cutaneous leishmaniasis due to Leishmania infantum in Nothern Xinjiang, China. Proc. Chin. Protozool. Soc. 8, 115.
  76. Chang, K.-P. (1995) A personal view from a leishmaniac on the importance of cooperative and multidisciplinary research on parasitic diseases in Turkey. Turk. Natl. Congr. Parasitol.
  77. Chang, K.-P., Lu, H.G., Wang, R.Q., Aksu, H.A.Z., Culha, G., Ozcan, K., Ozbel, Y., Ozensoy, S., Alkan, Z. and Ozcel, M.A. (1995) Grouping of Turkish Leishmania isolates by nuclear and kinetoplast DNA polymorphisms. Turk. Natl. Congr. Parasitol.. P. 8
  78. Chang, K.-P. (1995) New perspectives of an ancient disease along the “Silk Road” - Leishmaniasis. 1st Intl. Congr. Fever/Environ. P. 1.
  79. Chang, K.-P. (1995) Genetic heterogeneity of Leishmania and their virulence in the strategies of control for leishmaniasis. Pan Arab Seminar Zoonost. Dis. P. 38-39.
  80. Chang, K.-P. (1996) Genetic heterogeneity of Leishmania and their virulence in leishmaniasis: Strategies of control. Plenary Lecture, Symposium on leishmaniasis. Glob Meet. Parasitic Diseases. P. 3.
  81. Masoom-Yasinzai, M. and Chang, K.-P. (1996) Leishmaniasis in Pakistan: Development of potent chemotherapeutic agent. Glob Meet. Parasitic Diseases. P. 39.
  82. Chang, K.-P. (1996) Leishmania determinants of virulence and genetic heterogeneity: Strategies of control for leishmaniasis. Leishmaniasis State-of-The-Art Session. 14th Int. Cogr. Trop. Med. P. 238.
  83. Kawazu, S-I., Lu, H.G., Zhong, L., Ito, H., Kamio, T. and Chang, K.-P. (1996) Stage-independent co-transcription of tunicamycin-resistance and neighboring genes in a DNA region suitable for construction of a constitutive expression vector specific to Leishmania. Leishmania Molecular Biology Symp.14th Int. Cogr. Trop. Med. p. 88.
  84. Chang, K.-P., Chai, J.J., Zuo, X.-P., Qu, J.Q., Sundar, S., Singh, S. and Reed, S.G. (1996) RK39 distick vs. conventional procedures for diagnosis of Chinese and Indian visceral leishmaniasis. 14th Int. Cogr. Trop. Med. P. 238.
  85. Chang, K.-P. (1996) Leishmania determinants of virulence and genetic heterogeneity: Strategies of control for leishmaniasis. 14th Int. Cogr. Trop. Med. P. 30.
  86. Akman, L., Lu, H.G., Wang, R.Q., Chang, K.-P., Aksu, H.A.Z., Culha, G., Ozcan, K., Ozbel, Y., Ozensoy, S., Turgay, N., Alkan, Z. and Ozcel, M.A. (1996) Grouping of Turkish Leishmania isolates by nuclear and kinetoplast DNA polymorphisms. 14th Int. Cogr. Trop. Med. P. 91.
  87. Chai, J.J., Zuo, X.-P., Lei, Y., Hou, Y.Y., Ruziguli, Zhang, S. and Chang, K.-P. (1996) Preliminary vaccination trials against visceral leishmaniasis in rodent model indigenous to northwestern regions of China. 14th Int. Cogr. Trop. Med. P. 359.
  88. Chang, K.-P., Lu, H.G., McGwire, B.S. and Kawazu, S.-I. (1997) Functional significance of Leishmania gene encoding N-acetylglucosamine-1-phosphate transferase. WorldLeish I. p. 72.
  89. Lu, H.G., Zhong, L., Chang, K.-P. and Docampo, R. (1997) Calcium and cell invasion in Leishmania amazonensis. WorldLeish I. p. 74.
  90. Chang, K.-P., Chai, J.J., Zuo, X.P., Qu, J.Q., Kawazu, S.-I., Katakura, K. and Matsumoto, Y., and Reed, S.G. (1997) RK39 dipstick vs. conventional procedures for diagnosis of visceral leishmaniasis in northwestern China. WorldLeish I. p.127.
  91. Katakura, K., Kawazu, S.-I., Ito, M., Naya, T., Pang, H., Nagakura, K., Aikawa, M., Qu, J.-Q., Guan, L.-R., Chai, J.-J., Chang, K.-P. & Matsumoto, Y. (1997) PCR diagnosis of kala-azar patients in Xinjiang, China. WorldLeish I. p. 128.
  92. Ozensoy, S., Ozbel, Y., Alkan, M.Z., Turgay, N., Gul, K., Chang, K.-P., Reed, S.G. & Ozcel, M.A. (1997) The current status of leishmaniasis in Turkey. WorldLeish I. p. 129.
  93. Akman, L., Wang, R.Q., Aksu, H.A.Z., Culha, G., Ozcan, K., Ozbel, Y., Ozensoy, S., Turgay, N., Alkan, Z., Ozcel, M.A. and Chang, K.-P. (1997) Grouping of Turkish Leishmania isolates by nuclear and kinetoplast DNA polymorphisms. WorldLeish I. p. 128.
  94. Ozensoy, S., Akman, L., Ozbel, Y., Turgay, N., Korkmaz, M., Ozcel, M.A., Alkan, M.Z., Skeiky, Y., Reed, S.G. & Chang, K.-P. (1997) Kinensin K39 repetitive epitope found by PCR and Southern analyses in Turkish isolates causing cutaneous and visceral leishmaniasis. WorldLeish I. p. 152.
  95. Singh, S., Chang, K.-P. & Reed, S.G. (1997) Blood transfusion transmitted kala-azar: Indian Scene. WorldLeish I. p. 158. 
  96. H.-G. Lu, S.-I. Kawazu, H. Ito, D.-Q. Chen, M. Fakruddin, L. Akman, N. Yadava and K.-P. Chang (1998) Replacement of P36 with foreign genes for their chromosomal and extrachromosomal expression in Leishmania amazonensis. Parasitol Internation. 47 (Suppl.): 219
  97. J.-Q. Qu, L.R. guan, I. Shulidan, X.-P. Zuo, J.-J. Chai, S.-B. Chen, D.-K. Wang, S.-I. Kawazu, K. Katakura, Y. Matsumoto, S.G. Reed and K.-P. Chang  (1998) Rapid serodiagnosis with rk39 dipsticks for viscerla leishmaniasis of low endemicity in northwestern China. Parasitol Internation. 47 (Suppl.): 227.
  98. Ozensoy, S., Y. Ozbel, N. Turgay, M.Z. Alkan, M.A. Ozcel, K. Gul, S.G. Reed, A. Gilman-Sachs and K.-P. Chang (1998) Recombinant K39 antigen for sero-diagnosis and -epidemiology of human and canine visceral leishmaniasis in western Turkey. Parasitol Internation. 47 (Suppl.): 227.
  99. Chang, K.-P., J. F. Sah, H. Ito, B. K. Kolli and S. Sassa (2000) Defects of trypanosomatid protozoa in heme biosynthesis: Porphyria of xenotransgenic Leishmania with mammalian heme pathway enzymes. Mill. Meet. Porphyrins Porphyrias 2000 P. 45.
  100. Chang, K.-P. (2001) A “leishmaniac” manifesto. WorldLeish II P. 1.
  101. Aguiar F., Cupolillo E., Chang K-P., Kemp S.J., Noyes H.A. (2001) Comparative evolution of the N-glycosylation associated N-acetylglucosamine-1-phosphate transferase gene and the houskeeping 6-phosphogluconate dehydrogenase gene. WorldLeish II  P. 46
  102. Culha, G. & Chang, K.-P. (2001) Conventional and PCR methods for diagnosis of cutaneous leishmaniasis in Cukurova region of Turkey. WorldLeish II P. 115.
  103. Hajmova M., Volf P., Kolli B. K. & Chang, K.-P. (2001) Gp63 expression of Leishmania amazonensis affects their early infection in the midgut of Lutzomyia longipalpis. WorldLeish II P. 124.
  104. Hwa K.Y., Khoo K.H., Chang, K.-P. (2001) Correlation between pathological spectra of leishmaniasis and parasite glycoconjugate structures. WorldLeish II P. 29.
  105. Kawazu S.-I., Katakura K., Ozbel Y., Nagakura K., Hatabu T., Ito M., Nakai Y.,Qu J.-Q., Aikawa M., Chang K.-P., Kamio T., Kano S., and Matsumoto Y. (2001) Differentiation of Leishmania species complexes based on PCR amplification of a highly conserved gene (p36). WorldLeish II P. 48
  106. Kolli, B. K., McGwire, B. S., Mottram, J. C and Chang, K.-P. (2001) Release of gp63 and diminished in vitro infectivity of a GPI -lacking null mutant from Leishmania mexicana. WorldLeish IIP. 26.
  107. Lu H.G., Chen D.-Q., Kolli B.K.and Chang K.-P. (2001) Replacement of two highly conserved neighboring genes in Leishmania amazonensis: Lethal single knockout of N-acetylglucosamine-1-phosphate transferase and lack of effect for double knockout of NADPH-oxidoreductase (p36). WorldLeish II P.64.
  108. Matsumoto Yasunobu, Hatabu T., Ito M., Sanjoba C., Chang K.-P.& Kawazu S. (2001) Role of polymorphonuclear leucocytes in cutaneous leishmaniasis. WorldLeish II P.36.
  109. Matsumoto Yoshitsugu, Terabe M., Kuramochi T., Ito M., Hatabu T., Sanjoba C., Matsumoto Yasunobu, Kawazu S., Ondera T., and Chang K.-P (2001) CD4+ cells are indispensable for ulcer development in murine cutaneous leishmaniasis. WorldLeish II P. 8.
  110. McGwire, B. S., Chang, K.-P. and Engman, D. M. (2001) Cell Surface Autoproteolytic and secretory release of leishmanial Ecto-Metalloprotease (gp63): Evidence of a Conserved, Virulence-associated Phenotype. WorldLeish II P. 26. 
  111. Özensoy Töz, S. & Chang, K.-P. (2001) rK39 dipstick for diagnosis of visceral leishmaniasis in Turkey. WorldLeish II P. 58.
  112. Qu J.-Q., Guan L.-R., Chen S.-B., Shulida I., Kawazu. S., Katakura K., Matsumoto Y., Reed S. G. and Chang, K.-P. (2001) rK39 dipstick rapid diagnosis for visceral leishmaniasis of Low endemicity. WorldLeish II P. 116.
  113. Singh N., Schneider J., Ramsing Th., Rastogi A.K., Sundar S., & Chang K.-P. (2001) DNA homology of leishmania donovani isolates from Indian patients of kala azar sensitive and refractory to chemotherapy. Is PG1 relevant to antimonial resistance ? WorldLeish II P.99.
  114. Svobodová M., Chang K.-P., Volf P. (2001) Laboratory evidence suggestive of Phlebotomus sergenti–rat transmission cycle in the endemic focus of cutaneous leishmaniasis due to Leishmania tropica in Sanliurfa, Turkey. WorldLeish II P. 51.
  115. Thiakaki M., Konidou G., Chang K.-P. and Soteriadou K. (2001) Modulation of gp63 level in promastigotes affects the outcome of Leishmania amazonensis infection in BALB/c mice. WorldLeish II P. 100.
  116. Kolli, B.K., Kostal, J., Zaborina, A.M., Chakraborty, A.M. and Chang, K.-P. (2002) Leishmania model for microbial virulence: Secretion of nucleoside diphosphate kinase prevents apoptosis of the host macrophages. 5th Ann. Meet. New & Re-emerging Dis., Urbana-Champaign University of Illinois, P. 25-26.
  117. Waki, K., Nordstrom, M., Akman, L., Tdymir, R., Mukhtar, M.M., Schallig, H., Chulha, G., Singh, N. & Chang, K.-P. (2002) N-acetylglucosmine-1-phosphate transferase gene as a potential marker for genotyping Old World Leishmania isolates. 5th Ann. Meet. New & Re-emerging Dis., Urbana-Champaign University of Illinois, P. 25.
  118. Waki K, Akman L, Toydemir R, Schallig H, Mukhtar M, Chai JJ, Guan LR, Culha G, Ozensoy S, Ozbel Y, Singh N, Saliba EK, Krasnonos L., Nahhas S, Chang KP  (2003) Separation of ~100 Old World Leishmania isolates into fourteen genotypes of N-acetylgluocsamine-1-phosphate transferase, Ann Meet Am Soc Trop Med Hyg.
  119. Dutta, S., Kolli, B.K., Chang, K.-P. (2003) Therapeutic and prophylactic potentials of Leishmania forward and reverse genetic mutants in heme biosynthesis pathway. Ann Meet Am Soc Trop Med Hyg.
  120. Dutta S, Kolli BK and Chang KP 2004. Forward and Reverse Genetic Mutants in the Heme Biosynthesis Pathway of Leishmania. Chicago Area Mol. Parasitol. and Mycol. Poster.
  121. Ray D., Kolli B.K., Chang, K.-P. 2004. Phototoxicity of Al-phthalocyanine against Leishmania amastigotes and promastigotes. Chicago Area Mol. Parasitol. and Mycol. Poster.
  122. Tang, A.H., Dutta, S., Kolli, B.K., Waki, K., Sassa, S., Chang, K.-P. 2004. Stability of transgenes responsible for ALA-induced uroporphyria of Leishmania engineered as suicidal mutants. Chicago Area Mol. Parasitol. and Mycol.Poster
  123. Kolli, B.K., Chang, C., Showe, L.C., Showe, M., Chang, K.-P. 2004. Expression profiles of macrophages and their intracellular parasites in infected cultures predict vaccinability of oprphyric suicidal Leishmania. Chicago Area Mol. Parasitol. and Mycol. Poster.  
  124. Chang, K.-P., et al. 2004. In vivo pathogenicity and immunogenicity of light-sensitive Leishmania suicidal mutants transgenetically engineered to develop poprhyria: Preliminary appraisals for their potential application as a universal platform for vaccination. Chicago Area Mol. Parasitol. and Mycol. Poster.
  125. Waki, K., Chang. K.-P. et al. 2004. Virulence genes of repetitive A2 and K39 present in both cutanotropic and visceralizing Leishmania infantum. Chicago Area Mol. Parasitol. and Mycol. Poster.
  126. Chang, K.-P. et. al. 2005. Porphyric Leishmania as inducible suicidal mutants for photodynamic vaccination. Chicago Area Mol. Parasitol. and Mycol. Poster.
  127. Dutta S, Kolli BK and Chang KP 2005. Genetic Mutants in the Heme Biosynthesis Pathway of Leishmania. Chicago Area Mol. Parasitol. and Mycol. Poster.
  128. Waki, K., Dutta, S., Ray, D., Kolli, B. K. and Chang, K.-P. 2005 Sequence bioinformatics of Leishmania single-copy genes and repetitive sequences in relation to phylogenetic genotypes and disease phenotypes. Chicago Area Mol. Parasitol. and Mycol.Poster.
  129. Kolli, B.K., Chang, C., Showe, L.C., Showe, M. and Chang, K.-P.2005. Expression profiles of macrophages and their intracellular parasites in infected cultures predict safety and vaccinability of porphyric suicidal Leishmania. Chicago Area Mol. Parasitol. and Mycol. Poster.
  130. Kolli, B.K., Kostal, J., Zaborina, O, Chakraborty, A.M. and Chang, K.-P. 2005.Intracellular Leishmania release molecules to prevent apoptosis of macrophages. Chicago Area Mol. Parasitol. and Mycol. Poster.
  131. Kuo-yuan Hwa, Kay-hooi Khoo, Chan-Wei Chen and Kwang-Poo Chang 2006. Structural correlation of glycoinositol phospholipids and pathological spectra of leishmaniasis from the Old World parasite isolates FASEB J., March 20 (Meeting Abstract Supplement) LB57.
  132. Chang, K.P., Kolli, B.K., Waki, K., Dutta, S., Folkova, D. and Volf, P. 2006. Let the evils fight the devisls: Parasites against infectious diseases and cancer ? 4th Med. Congr. Pharm., Med. J. Sci. Tech. 2, P. 26.
  133. Chang, KP, Kolli, B., Dutta, S. (2007).Leishmaniac jihad, Int Conf Env Parasit/Commun Heal Initiativ., Aug Found Dayalbagh Educational Institute. Proceeding book.
  134. Chang, KP, Waki, K., Kolli, B, Dutta, S. (2009) Ambiguity of multiple DNA versus single-copy protein coding genes for Leishmania genotyping. # 10,  Feb. 2, “WorldLeish 4”, Lucknow, India.
  135. Chang, KP, Kolli, B, Dutta, S. (2009) Photodynamic vaccination with porphyric suicidal mutants against leishmaniasis, Feb. 4, #. 45, “WorldLeish 4”, Lucknow, India
  136. Kolli, B., Dutta, S., Chang, KP (2009) Leishmania releases nucleoside diphosphate kinase to prevent apoptosis of macrophages. Feb. 8, #323, “WorldLeish 4”, Lucknow, India
  137. Chang, KP, Dutta, S., Kolli, B (2009) Immunity to Leishmaniasis and Vaccination”, International Symposium on Leishmaniasis Vaccines, # 25, Mar. 9-11, Recife, Brazil
  138. Chang, KP (2009) Elucidation of parasitic mechanisms from laboratory to clinico-epidemiologically relevant Leishmania for developing effective prophylactic and therapeutic strategies”, US-NIH-NIAID/Inst Pasteur Tunis Joint Conference Leishmania: Collaborative Research Opportunities in North Africa and the Middle East”, May 5-9, Tunis, Tunisia.
  139. Chang, KP (2009) Genetic and chemical engineering of Leishmania for photodynamic vaccination, XIV Colombia Cong Parasitol/Trop Med., Medellin, Colombia.
  140. Mehta, SJ, , Huang R, Yang M, Zhang XQ, Kolli B, Chang KP, Hoffman, Schooley RT. (2010) Evaluation of SLC11A1 role in host response to Leishmania amazonensis in vitro and in vivo. P. 40, #25, Ann Meet Soc Trop Med Hyg, Nov. 4, Atlanta, GA.
  141. Chang, KP (2012) Photodynamically inactivated Leishmania as a potential novel carrier for vaccine delivery against infectious and non-infectious diseases. #. 22,  2nd Int Conference Vaccine/Vaccination, Aug. 20-22, Northbrook, IL
  142. Chang, KP (2012) Toward automation of Leishmania photodynamic vaccination. 2nd Int. Symp. Leishmaniasis vaccines. Sep. 2-7, Ouro Preto, Brazil.
  143. Chang, KP (2013) Photo-inactivation of Leishmania with ROS for safe and effective delivery of vaccines against infectious and malignant diseases, P. 6, # 17,  Mar. 19, BIT World Vaccine Conference, Hanzhou, China.
  144. Shio, MT, Jung JY, Chang, KP, Olivier M. (2013) Impact of Leishmania Metalloprotease GP63 on NLRP3 Inflammasome Complex. #1243. May 13-18, Worldleish 5, Recife, Brazil.
  145. Chang, KP (2013) A call for long-term investigation of all endemic sites to elucidate global clinico-epidemiology of leishmaniasis: a multidisciplinary consortium is required to complete the database and to archive clinical samples for 'leishmaniome’ analysis. #1370. May 13-18, Worldleish 5, Recife, Brazil.
  146. Chang, KP (2013) Photoinactivation of leishmania with ROS  provides a safe and effective vaccine/vaccine carrier for photodynamic vaccination. #1319. May 13-18, Worldleish 5, Recife, Brazil.
  147. Mishra, AK, Singh SP, Kolli, BK, Bansal, M, Chang, KP and J Pratap, JV(2013) Cloning, overexpression, purification, crystallization and data processing of Nucleoside Diphosphatase Kinase (NDK) from Leishmania amazonensis.#109, May 13-18, Worldleish 5, Recife, Brazil.
  148. Linchangco, R, Tripathi, P, Chang KP (2013) Additional transfection of porphyrinogenic Leishmania with ALA synthase for automatic production of uroporphyrin. Oct. 20, CMS Summer Fellowship Poster Session, North Chicago, IL.
  149. Chang KP, Kolli BK, Tripathi P, Ng DKP, Chang CS, Alkahtani S, Al-Qahtani A, de Oliveira CI, Mello S, Manna L, Head JF, Elliott RL, Batchu RB (2014). Photodynamic vaccination: Novel strategies of vaccine delivery by intraphagolysosomal parasites and their oxidative inactivation for safe and effective applications, Nov. 17. 2nd Int Congr Bacteriol Inf Dis, Chicago, IL, USA.

 

Kwang Poo Chang

Professor

 

  • : 847-578-8837
  • : 847-578-3349

  • DEPARTMENTDepartment of Microbiology / Immunology Chicago Medical School / RFUMS
  • COUNTRY USA