Publications

1. Harper K, Sosa MS, Avivar Valderas A, Hosseini H, Klein C, Entenberg D, Condeelis J, Farias EF and Julio A. Aguirre-Ghiso. Epithelial identity and p38 signaling limit ErbB2-driven EMT and early dissemination in breast cancer. In Preparation(2014).
2. Sosa MS, Parikh F, Gaspar Maia A, Estrada Y, Bosch A, Zheng Y, Bragado P, Ekpin E, George A, , Chung C-Y, Bernstein E, Farias EF and Julio A. Aguirre-Ghiso*. NR2F1 controls tumor cell dormancy via SOX9 and RAR drivenquiescence and pluripotency programs. Accepted Nat. Comm. (2014).
3. Sosa MS, Bragado P. Julio A. Aguirre-Ghiso. Mechanisms of Cancer Dormancy: an awakening field.Nat Rev Cancer. (2014) Sep;14(9):611-22. PMID: 25118602 PMCID: not available
4. Bragado P., Estrada Y., Parikh F., Krause S., Capobianco C., Farina H.G., Schewe D.M.,  and Julio A. Aguirre-Ghiso JA. TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling. Nat. Cell. Bio. (2013).Nov;15(11):1351-61. doi: 10.1038/ncb2861. Epub 2013 Oct 27. PMID: 24161934; PMCID: PMC4006312. Featured in Nat Cell Bio Cover same issue. Highlighted in Science Signaling Editor’s Choice, Cancer Research Breaking Advances and public news outlets.
5. Aguirre-Ghiso, JA, Bragado P, Sosa MS. Targeting dormant cancer. Nature Medicine. (2013). Mar 6;19(3):276-7. doi: 10.1038/nm.3120. PMCID: PMC3651698
6. Avivar-Valderas A, Bobrovnikova-Marjon E, Diehl JA, Bardeesy N, Debnath J and Julio A. Aguirre-Ghiso. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.  Oncogene (2012), Nov 19. doi: 10.1038/onc.2012.512 PMCID: PMC3600386
7. Kim RS, Avivar-Valderas A, Estrada Y, Bragado P, Sosa MS, Aguirre-Ghiso JA*, Segall JE. Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PLoS One. (2012);7(4):e35569. PMCID: PMC3329481
8. Huei-Chi Wen, Alvaro Avivar-Valderas, M. Soledad Sosa, Nomeda Girinius, Eduardo F. Farias, Roger Davis and Julio A. Aguirre-Ghiso. p38 signaling regulates ATF2/c-Jun and BimEL to induce anoikis and lumen formation during mammary morphogenesis. Sci. Signal. (2011) May 24;4(174):ra34. doi: 10.1126/scisignal.2001684.. PMCID: PMC3229273
9. Alvaro Avivar-Valderas, Eduardo Salas, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Chandandeep Nagi, Jayanta Debnath, and Julio A. Aguirre-Ghiso*. PERK integrates autophagy and oxidative stress  responses to promote survival during ECM detachment. Mol Cell Biol. (2011) Sep;31(17):3616-29.. PMCID: PMC3165554
10. Adam AP, George A, Bragado P, Iglesias BV, Schewe D, Ranganathan A, Kourtidis A, Conklin DS and  Julio A. Aguirre-Ghiso*. Computational identification of a p38SAPK regulated transcription factor network required for tumor cell quiescence. Cancer Res. (2009) Jul 15;69(14):5664-72. PMCID: PMC2720524
11. Denis M. Schewe and Julio A. Aguirre-Ghiso*. ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci U S A. (2008) Jul 29;105(30):10519-24. PMCID: PMC2492459. This Week in PNAS section 7/23/08 Highlight. Faculty of 1000 evaluation:www.f1000biology.com/article/id/1119501/evaluation

Additional recent publications of importance to the dormancy and metastasis fields.

12. Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, Julio A. Aguirre-Ghiso, Sikora AG. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer Res. (2014) Feb 15;74(4):1067-78. PMID: 24398473, PMCID: PMC3960077
13. Bragado P, Estrada Y, Sosa MS, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC, Wen HC, Kapoor A, Bernstein E. and Julio A. Aguirre-Ghiso*. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PLoS One. (2012) ;7(1):e29974. PMCID: PMC3262798
14. Julio A. Aguirre-Ghiso, Ossowski L and Rosenbaum SK. GFP tagging of ERK and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res (2004); 64(20): 7336-45. Faculty of 1000 evaluation: www.f1000biology.com/article/15492254/evaluation. PMID: 15492254
15. Liu D, Julio A. Aguirre-Ghiso, Estrada Y and Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell (2002); 1: 445-457 (Cover).  Faculty of 1000 Evaluation: www.f1000biology.com/article/12124174/evaluation. PMID: 12124174; PMCID – not available