Professional Activities

Brief Chronology of Employment:

1985 –1988 Scientist I, Biological Carcinogenesis and Development Program, Program Resources, Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, Frederick, MD
1988 – 1992 Scientist, Biological Carcinogenesis and Development Program, Program Resources, Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, Frederick, MD
1992 – 1994 Sr. Scientist, Head, Hematopoiesis Section, Biological Carcinogenesis and Development Program, Program Resources Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, Frederick, MD
1995 – 2001 Principal Investigator, Sr. Scientist, Hematopoiesis and Gene Therapy Section, Intramural Research Support Program, SAIC-Inc., NCI-Frederick Cancer Research and Development Center, Frederick, MD
Adjunct Professor, Genetics Department, George Washington University, Washington, DC
2001 – 2005 Principal Investigator, Senior Principal Scientist, Hematopoiesis and Gene Therapy Section, Laboratory of Molecular Immunoregulation and Research Program, SAIC-Inc, Center for Cancer Research, National Cancer Institute, Frederick, MD
Adjunct Professor, Genetics Department, George Washington University, Washington, DC
2005 – Date Principal Investigator, Senior Principal Scientist, Hematopoiesis and Stem Cell Biology Section, Mouse Cancer Genetics Program, and Basic Research Program, SAIC-Inc, Center for Cancer Research, National Cancer Institute, Frederick, MD
Adjunct Professor, Genetics Department, George Washington University, Washington, DC
Faculty, Institute for Biomedical Sciences, George Washington University, Washington, DC

Honors:

  • 1999 Division of Basic Science - National Cancer Institute - Collaborative Project Award
  • 2000 SAIC ESTC Publication Prize for Biochemistry and Molecular Biology
  • Section Editor:  Journal of Leukocyte Biology 2001-2005
  • Associate Editor:  Experimental Hematology, 2001-2003.
  • Session Chair, American Society of Hematology, San Diego CA, 2004
  • Session Chair, 6th and 7th International Workshop on Myeloid Stem Cell Dev., Annapolis,       MD, 2005,2007.
  • Editorial Board Member: Cell Communication Insights (2008-present)
  • Highlighted in The Poster, National Cancer Institute – Frederick, “Researchers Discover Regulator of Blood Cell Development in Bone Marrow Niche.”  September 2009.
  • Organizer, Basic Science Program Retreat, Gettysbury, Maryland, September 2009.
  • Highlighted in News and Views, SAIC-Frederick, Inc., “LCP’s New Finding: Id2 Protein Regulates Blood Cell Development,” Vol. 15, July 2009
  • Highlighted in The NIH Catalyst, National Institutes of Health, “The Future of Cancer Stem Cell Research,” Vol.16 (6), November-December 2009
  • Publication Prize for Biochemistry and Molecular Biology 2011- SAIC
  • Editorial Board Member: Stem Cell Discovery (SCD)-(2011-Present)
  • Editorial Board Member: Open Journal of Blood Diseases (OJBD) (2011-present)

Societies:

  • American Society of Hematology
  • International Society of Experimental Hematology
Recent Review Activities
  • Member of DOD grant review panel for the Prostate Cancer Research Program (1999-2006, 2008, 2011)
  • Program Project Grant -Hematopoietic Stem Cells – NIDDK (2005 and 2007)
  • Member of the Nordic Stem Cell Mobility Program grant review panel (2007-2010)
  • Program Project Grant: Molecular mechanism(s) of blood cell transfusion (2008/2009)
  • Stem Cell Grant Reviewer: American Reinvestment Act, 2009
  • Grant Review for Welcome Trust (Hematopoiesis) 2009 - 2012
  • Member of grant review panel for the DOD Breast Cancer Research Program 2010
  • Member of Grant Review Panel for Empire State Stem Cell Board NYSTEM (2012-2013)
  • Member Grant Review Panel for Leukemia and Lymphoma Society (2012-2013)

Mentoring Activities:

  • Mentor for Ph.D.Graduate students:  Karen Muszynski, Ph.D., Jeff Smith, Ph.D., Denise Sabatino Ph.D., Christine McCauslin, Ph.D., Mariaestela Ortiz Ph.D, Hyung-Chan Suh, Kristbjorn Orri Gudmundsson, Ph.D., and Masha Droutskaya, Ph.D., and Currently Mentoring: Bjorg Gundmundsdottir
  • Mentor for Post-Doctoral Fellows:  Sten E.W. Jacobsen, Ph.D., Kjetil Hestdal, Ph.D., Claire Dubois, Ph.D., Paul Schwartzenberger, Ph.D., Sarah Weiler, Ph.D., Jonathan Dermott, Ph.D, Matthew Holman, Ph.D., Hui Wang, Ph.D., Kimberly Klarmann, Ph.D., Ben Asefa, Ph.D, Hyung-Chan Suh, Ph.D. MD., Wiliarat Leeanansaksiri, Ph.D., K. Orri Gudmundsson, Ph.D, Huajie Li, Ph.D, Ande Satyanarayana, Ph.D., and Ming Ji, Ph.D.,  Currently Mentoring: Wonil Kim, Ph.D., Lei Sun, Ph.D., Satyendra Singh, Ph.D.
  • Mentoring Committee member for NCI Postdoctoral fellows: Dr. Balamurugan Kuppusamy and Dr. Chris Huggins.
  • Member of Doctoral Advisory Committee:  Hyungtae Kim, Jennifer Mariner, Rima L. Adler (George Washington University), and Kim Schafer-Weaver (GWU), Currently: Bandana Ajay Vishwakarma and Vijay Negi (USUHS)
  • Mentor for Master Degree Students: Mariaestella Ortiz, M.S. (Hood College) and Christine McCauslin, M.S. (Hood College).
  • Member of Master Degree Committee: Parirokh Awasthi (George Washington University)
  • Mentor for Student Internship ProgramsCurrently: Emilie Bowers

Professional Activities at NCI/NIH:

2002 – Present Member of SAIC Senior Staff Promotion Review Board
2002 – 2010

Reviewer for ESTC Publication Awards
2002 – 2008

Member of Stem Cell Interest Group
2003 – 2008

Member of Cellular, Molecular and Developmental Biology Faculty
2008 – Present

Member of Cancer Stem Cell Consortium –NCI

2008 – Present

Member of Flow Cytometry Core User Group-NCI-Frederick
2011 – 2012

Member of  Stadtman Stem Cell Search Committee –NIH

2011 – Present Reviewer: Fellows Award for Research Excellence (FARE) –NCI

2012 – Present

Cancer Genetics Signaling - Seminar Speaker Committee

Recent Invited Presentations and Symposiums:

  • Function of Inhibitor of DNA binding 1 (Id1) in hematopoietic development,  Department of Microbiology & Immunology Seminar Series, University of Nevada School of Medicine, April 2005.
  • Oncogenic properties of Inhibitor of DNA Binding 1 (Id1) protein in Hematopoietic Cells In vitro and In vivo,  Sixth International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, Marylnad, May 2005.
  • Transcriptional Regulation of Cell Fate Decisions in Hematopoietic Stem and Progenitor Cells,  Experimental Transplantation and Immunology Laboratory Seminar Series, Experimental Therapeutics Branch, NCI-NIH, January 2006.
  • Molecular Regulation of Hematopoietic Cell Growth, Cancer Research Moscow lecture series (Three Lectures), Moscow, Russia, April 2006
  • The Biology of Embryonic, Adult and Cancer Stem Cells, Mount Saint Mary's University Special Seminar Series, Emmitsburg, Maryland, - August 2006.
  • The Ids and Outs of Hematopoietic Development, Faculty Seminar Series, Frederick, Maryland, - November, 2007.
  • A Role for Inhibitor of DNA-Binding Protein 1 (Id1) in the Hematopoietic Microenvironment, Molecular aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, Maryland, - May 2007.
  • Embryonic, Adult and Cancer Stem Cells, Frederick Memorial Hospital Staff Seminar Series, Frederick, Maryland, June 2007.
  • Stem Cells, Past, Present and Future. Life Long Learning Institute, Vero Beach, Florida, March 2008.
  • Id Proteins as Potential Therapeutic targets in Hematopoietic Malignancies, NIH Research Festival, Cancer Stem Cells and Tumor Biology Symposia, October 2008.
  • Inhibitor of DNA-Binding (Id) Proteins Regulate Cell Fate Decisions in Hematopoietic Progenitors, Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, Maryland, 2009.
  • Id Genes and Transcription Factor Networks in Hematopoietic Development, Uniformed Services University of the Health Sciences, Bethesda, Maryland, September 2009
  • Repression of Id2 by Gfi-1 is required for B cell and myeloid cell development” Transcriptional Mechanisms of Early Lymphocyte Development Symposia, La Jolla, California, November 2009.
  • Transcription Factor Networks in Hematopoietic Stem Cells, National Cancer Institute-Frederick, Maryland, May, 2010.
  • Id genes regulate cell fate decisions in hematopoietic development, The Cancer Stem Cell Consortium, National Cancer Institute, Bethesda, Maryland,, March, 2011.
  • Embryonic Stem Cells, Adult Stem Cells, Cancer Stem Cells, Biotech Conference, Frederick, Maryland, September, 2011.
  • Id Genes Link Transcriptional Networks That Regulate Cell Fate in Hematopoietic Progenitors, Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Cincinatiti, OH, May 2012.
  • Id Genes are Linked to Transcriptional Networks That Regulate Cell Fate in Hematopoietic Progenitors, Hematology/Oncology Grand Rounds, Johns Hopkins University, Baltimore Maryland, June 2013
  • Id Proteins: The Id proteins: Molecular Regulators of Normal and Malignant Hematopoietic Stem and Progenitor Cell Development. Biochemistry and Molecular Biology Seminar, University of Georgia, Athens, Georgia, November, 2013

 

Jonathan R. Keller

Senior Principal Investigator

 

  • :301-846-1461
    Fax:301-846-6646

  • DEPARTMENTHematopoiesis and Stem Cell Biology Section
    Frederick National Laboratory for Cancer Research
  • COUNTRY USA