Publications

Peer-Reviewed Papers (in counter chronological order):

• Han YS, Li L, Zhang YP, Yuan H, Ye L, Zhao JZ, and Duan DD: Phenomics of vascular disease: the systematic approach to the combination therapy Current Vascular Pharmacology (in press); 2014
• Yu YN, Liu J, Zhang L, Wang Z, Duan DD, and Wang YY. Clinical Zheng-hou Pharmacology: the Missing Link between Pharmacogenomics and Personalized Medicine? Current Vascular Pharmacology (in press); 2014
• Wang Z, Duan DD, Wang YY: Combination Therapy of Vascular Diseases and Fangjiomics: When West meets East in the era of Phenomics. Current Vascular Pharmacology (in press); 2014
• Ye Z, Wu MM, Wang CY, Li YC, Yu CJ, Gong YF, Zhang J, Wang QS, Song BL, Yu K, Hartzell HC, Duan DD, Zhao D, Zhang ZR: Characterization of cardiac Anoctamin1 Ca2+ -activated chloride channels and functional role in ischemia-induced arrhythmias. J Cell Physiol. 2014 Jun 24. doi: 10.1002/jcp.24709. [Epub ahead of print] PMID:24962810
• Wu MM, Lou J, Song BL, Gong YF, Li YC, Yu CJ, Wang QS, Ma TX, Ma K, Hartzell HC, Duan DD, Zhao D, Zhang ZR. Hypoxia augments anoctamin 1-encoded calcium-activated chloride current in cardiac vascular endothelial cells of neonatal mouse. J Br Pharmacol. 2014.doi:10.1111/bph.12730. [Epub ahead of print] (PMID:24758567)
• Duan DD. Han Y-S, Li L, Zhao J-Z, Wang Z. Pharmacophenomics: a new paradigm for pharmacology, toxicology, and personalized medicine. Chin J Pharmacol Toxicol. 28 (1):1-9; 2014
• Zhang YP, Zuo XC, Huang ZJ, Kuang ZM, Lu MG, Duan DD, Yuan H. The Impact of Blood Pressure on Kidney Function in the Elderly: A Cross-Sectional Study. Kidney Blood Press Res. 38(2-3):205-216. 2014; (PMID:24732208)
• Zhang YP, Zuo XC, Huang ZJ, Cai JJ, Wen J, Duan DD, Yuan H. CYP3A5 polymorphism, amlodipine and hypertension. J Hum Hypertens. 2014 Mar;28(3):145-149. (PMID:23863802) (IF:2.818)
• Duan DD. Phenomics of cardiac chloride channels. Compr Physiol. 1;3(2):667-692; 2013 (PMID: 23720326)(IF:)
• Wang WE, Yang D, Li L, Wang W, Peng Y, Chen C, Peng C, Xia X, Wang H, Jiang J, Liao Q, Li Y, Xie G, Huang H, Guo Y, Ye L, Duan DD, Chen X, Houser SR, Zeng C. PHD2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium. Circ Res. 113(3):288-300, 2013 May 21. [Epub ahead of print] (PMID 23694817) (IF:11.861)
• Zhang YP, Zhang H, Duan DD. The chloride channels in stroke. Acta Pharmacol Sin. 34:17-23; 2013 (PMID: 23103617)(IF: 2.383)
• Yu Y, Zhang H, Li Y-G, Zhang YP, and Duan DD. Chloride channels and cardiac arrhythmia: novel therapeautic targets？European Pharmaceutical Review, 17 (6):8-13, 2012
• Liu J, Zhang ZJ, Zhou CX, Wang Y, Cheng YY, Duan DD, Wang YY, Wang Z. Outcome-dependent global similarity analysis of imbalanced core signaling pathways in ischemic mouse hippocampus. CNS Neurol Disord Drug Targets. 11 (8): 1070-1082; 2012 (PMID:22998140) (IF: 3.818)
• Duan DD and Wang G. Double the keys, double the control: xoupled phosphorylation sites provide novel molecular targets for precise control of ion channel function. Am J Physiol Cell Physiol. 302(12):C1699-701, 2012 (PMID22492642 ) (IF 4.345)
• Forrest AS, Joyce TC, Huebner ML, Ayon RJ, Wiwchar M, Joyce J, Freitas N, Davis AJ, Ye L, Duan DD, Singer CA, Valencik ML, Greenwood IA, Leblanc N. Increased TMEM16A-encoded calcium-activated chloride channel activity Is associated with pulmonary hypertension. Am J Physiol Cell Physiol. 2012 Oct 3. [Epub ahead of print] (PMID:23034390)
• Wang G, Duan DD. Regulation of Activation and Processing of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by a Complex Electrostatic Interaction between the Regulatory Domain and Cytoplasmic Loop 3. J Biol Chem. 287(48):40484-40492; 2012 (PMID:23060444)
• Li C, Pei F, Zhu X, Duan DD, and Zeng C. Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction. Clin Biochem. 45(10-11):727-32; 2012 (PMID: 22713968) (IF: 2.079)
• Bozeat ND, Xiang SY, Dwyer L, Ye L,Yao TY, Duan ML, Burkin DJ, Lamb FS, and  Duan DD. Activation of volume regulated chloride channels protects myocardium from ischemia/reperfusion damage in second-window ischemic preconditioning. Cellular Physiology and Biochemistry. 28:1265-1278, 2011 (PMID22179014 ) (IF 3.585)
• Duan DD, Ma TH. The Channelopathies and drug discovery in the postgenomic era. Acta Pharmacologica Scinica. 32:673-674, 2011 (PMID: 21642942) (IF: 1.783)
• Duan DD. The ClC-3 chloride channels in cardiovascular disease. Acta Pharmacol Sin 32:675-684, 2011 (PMID: 21602838) (IF: 1.783)
• He X, Gao XR, Peng LY, Wang SM, Zhu YY, Ma H, Lin J, Duan DD. Atrial Fibrillation Induces Myocardial Fibrosis through Angiotensin II AT1 Receptor-specific Arkadia-mediated Downregulation of Smad7. Circulation Research. 108:164-75,2011 (PMID: 21127293) (IF: 9.745)
• Xiang YS, Ye L, Duan LM, Liu L, Ge ZD, Auchampach JA, Gross GJ, Duan DD. Characterization of a novel and critical role of CFTR chloride channels in cardioprotection against ischemia/reperfusion injury. Acta Pharmacologica Scinica. 32:824-833 2011 (PMID: 21642951) (IF: 1.783)
• Duan DD, Kwan C-Y. A molecular switch of “Yin and Yang”: S-glutathionylation of eNOS turns off NO synthesis and turns on superoxide generation. Acta Pharmacologica Scinica 32(4):415-416. 2011 (PMD: 21441949) (IF: 1.783)
• Duan DD. Volume matters: the role of ClC-3 volume-regulated chloride channels in hypertensive cerebrovascular remodeling. Hypertension  56:346-348. 2010 (IF: 7.368) (PMID: 20644007)
• Duan DD. CaMKII the downstream hypertrophic signaling pathway in the heart: the 2009 Benedict R. Lucchesi Distinguished Lectureship Award. Journal of Cardiovascular Pharmacology. 56(6):596-597, 2010 (IF: 2.290) (PMID: 20966760)
• Hume JR, Wang GX, Yamazaki J, Ng LC, Duan D.   CLC-3 Chloride Channels in the Pulmonary Vasculature.  Advances in Experimental Medicine and Biology. 661:237-47, 2010 (IF: 0.663) (PMID: 20204734)
• Duan DD. A leakage leads to failure: Roles of sarcoplasmic reticulum Ca2+ leak via RyR2 in heart failure progression. Hypertension 55:849-851, 2010 (IF: 7.368) (PMID: 20157050)
• Xiong DZ, Heyman NS, Airey J, Ye L, Singer CA, Rawant S, Zhang M, Evans R, Burkin DJ, McCloskey DT, Britton FC, Duan D, Hume JR. Cardiac specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice. Journal of Molecular and Cellular Cardiology 48:211–219, 2010 (IF: 5.054) (PMID: 19615374)
• Zhu X, Duan D, Madsen S, Publicover NG. Compatibility of quantum dots with immunobuffers, and its effect on signal/background of quantum dot-based immunoassay. Analytical and Bioanalytical Chemistry 396:1345–1353, 2010 (IF: 2.867) (PMID: 19946678)
• Zhu X, Duan D, Publicover NG. Magnetic bead based assay for C-reactive protein using quantum-dot fluorescence labeling and immunoaffinity separation Analyst 135:381–389 2010 (IF: 3.553) (PMID: 20098774)
• Duan D. Phenomics of cardiac chloride channels: the systematic study of functional role of chloride channel function in the heart. Journal of Physiology (Lond)587(10): 2163–2177, 2009(IF: 4.646) (PMID: 19171656)
• Huang ZM, Prasad C, Britton FC, Ye L, Hatton WJ, and Duan D: The inward rectifier chloride channels in sinoatrial node cells play an important role in pacemaker activity of the heart. Journal of Molecular and Cellular Cardiology 47:121-132, 2009 (IF: 5.054) (PMID19376127)
• Buxton I, Duan D. Cyclic GMP/PKG phosphorylation of Smad3 blocks TGF-b-induced nuclear Smads translocation: A key antifibrogenic mechanism of atrial natriuretic peptide. Circulation Research 102:151-153, 2008 (IF: 10.445)
• Xiong DZ, Wang GX, Yamboliev I, Miller L, Evans R, Ye L, Hatton W, Tian H, Keller P, McCloskey D, Duan D, Hume JR. Cardiac specific overexpression of the human short ClC-3 chloride channel isoform in mice. Clinical and Experimental Pharmacology and Physiology, 36: 386-393, 2008 (IF: 2.196)
• Jiang L, Tang D, Wang K, Zhang H, Yuan C, Duan D, Xiao X. Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. Biochemistry and Biophysics Research Communications. 356(4):829-35. 2007 ((IF: 2.749)
• Rossow CF, Duan D, Hatton WJ, Britton FC, Hume JR, and Horowitz B. Functional role of amino terminus in ClC-3 chloride channel regulation by phosphorylation and cell volume. Acta Physiologica. 187:5-19, 2006 (PMID:16734738) (IF: 1.602)
• Liu L, Ye L, Tan Y, Liu Z, Hatton WJ, and Duan D. A novel method for easy and reliable endotracheal intubation in the mouse. Journal of Chin Physician 8:1019-1020, 2006
• Wang G-L, Wang G-X, Yamamoto S, Ye L, Baxter H, Hume JR, and Duan D. Molecular mechanisms of regulation of fast-inactivating voltage-dependent transient outward K+ current in mouse heart by cell volume changes. Journal of Physiology. 568(Pt 2):423-43, 2005 (IF: 4.646)
• Britton F, Wang G, Huang Z, Ye L, Hume JR, Horowitz B, and Duan D: Functional characterization of novel alternatively spliced ClC-2 chloride channel variants in the heart. Journal of Biological Chemistry. 280(27):25871-25880. 2005 (IF: 5.581)
• Duan D, Liu L, Bozeat N, Huang Z, Xiang SY, Wang G, Hume J. Functional role of anion channels in cardiac diseases. Acta Pharmacologica Sinica. 26(3):265-78, 2005 (IF: 1.783)
• Chen H, Liu L, Ye L, Murry K, McGuckin C, Tamowski S, Scowen P, Tian H, Hatton WJ and Duan D. Targeted inactivation of CFTR chloride channel gene prevents ischemic preconditioning in isolated mouse heart. Circulation 110:700-704, 2004 (IF: 13..583)
• Yamamoto-Mizuma S, Wang GX, Liu L, Schegg K, Hatton WJ, Duan D, Horowitz B, Lamb FS, and Hume JR. Altered properties of volume-sensitive osmolyte and anion channels (VSOACs) and membrane protein expression in cardiac and smooth muscle myocytes from Clcn3-/- mice. J Physiol (Lond) 557.439–456, 2004 (IF: 4.646)
• Peng S, Publicover NG, Kargacin GJ, Duan D, Airey JA, and Sutko JL. Imaging Single Cardiac Ryanodine Receptor Ca2+ Fluxes in Lipid Bilayers. Biophys J.  86:134-144, 2004 (IF: 4.627)
• Wang GX, Hatton WJ, Wang GL, Zhong JM, Yamboliev I, Duan DY, Hume JR. Functional effects of novel anti-ClC-3 antibodies on native volume-sensitive osmolyte and anion channels in cardiac and smooth muscle cells. Am J Physiol-Heart 285 (4): H1453-H1463, 2003 (IF: 3.973)
• Gao X, Peng L, Mai W, Zheng Z, Chen H, Duan D. Protein Expression of Matrix Metalloproteinase-2 in Heart of Hypertensive Rats and Its Changes After Blockage of RAS.J Sun Yat-Sen University (Medical Sciences) 24(1):30-35, 2003
• Chen A, Duan D: New therapeutic approaches to cardiovascular diseases: Gene therapy. in: On the frontiers of Science. G Liu (editor) Chicago, Interpress Inc. Beijing, Tsinghua University Press, pp 93-117, 2003
• Gao X, Peng L, Zeng C, Ma H, Lou B, Xie Y, Duan D. Aldosterone escape in CHF patients after ACEI treatment and its correlation to the power special component of heart rate variability. J Chin Clin Med. 4 (9): 14-17, 2003
• Duan D. Volume-regulated chloride channels in cardiovascular system. Chinese J. Pathophysiol. 18:1646-1647. 2002
• Wang XL, Guan YY, Duan D: Ion channels in cardiovascular system. in: Cardiovascular Pharmacology. (Third Edition) X Chen, W-Z Chen, and G-Y Zeng (eds.). Beijing, People's Health Publisher, pp 71-99, 2002
• Duan D, Zhong J, Hermoso M, Satterwhite CM, Rossow CF, Hatton WJ, Horowitz B, and Hume JR: Functional inhibition of native and recombinant volume-regulated outwardly rectifying anion channels by anti-ClC-3 antibody. (Rapid Report)  J Physiol (Lond) 531(2):437-444, 2001 (IF: 4.646)
• Duan D, and Hume JR: NO and the regulation of VSOACs. (Perspectives) J Physiol (Lond) 528:2, 2000 (IF: 4.646)
• *Duan D, Ye L, Britton F, Horowitz B, and Hume JR: A novel anionic inward rectifier in native cardiac myocytes. (Ultra Rapid Communication) Circ Res 86:e63-e71, 2000 (* Corresponding Author) (IF: 10.445) (PMID: 10700456)
• Hume JR, Duan D, Collier M-L, Yamazaki J, and Horowitz B: Anion transport in the heart. Physiol Rev 80:31-81, 2000 (IF: 35.855)(PMID: 10617765)
• Nagasaki M, Ye L, Duan D, Horowitz B, and Hume JR: Intracellular Cyclic AMP inhibits native and recombinant volume-regulated chloride channels from heart. J Physiol (Lond) 523 (3):705-717, 2000 (IF: 4.646)
• Britton F, Hatton W, Rossow C, Duan D, Hume JR, and Horowitz B: Molecular distribution of volume-regulated chloride channels (ClC-2, ClC-3) in cardiac tissues. .Am J Physiol  279:H2225-H2233, 2000 (IF: 3.973)
• Duan D, Cowley S, Horowitz B, and Hume JR: A serine residue in ClC-3 chloride channel links phosphorylation-dephosphorylation to channel regulation by cell volume. J Gen Physiol 113:57-70, 1999 (IF: 5.120) (PMID: 9874688)
• Duan D, Ye L, Britton F, Miller L, Yamazaki J, Horowitz B, and Hume JR: Purinoceptor-coupled chloride channels in mouse heart: A novel, alternative pathway for CFTR regulation. J Physiol (Lond) 521:43-56, 1999 (IF: 4.646) (PMID
• Yamazaki J, Duan D, Janiak R, Kuenzli K, Horowitz B, and Hume JR: Functional and  molecular expression of  volume-regulated chloride channels in vascular smooth muscle cells.  J Physiol (Lond), 507:729-736, 1998 (IF: 4.646)
• Duan D, Winter C, Cowley S, Hume JR, and Horowitz B: Molecular identification of a volume-regulated chloride channel. Nature  390:417-421, 1997 (IF: 30.979) (PMID: 9389484)
• Duan D, Hume JR, and Nattel S: Evidence that outwardly rectifying chloride channels underlying volume-regulated chloride currents in heart. Circ Res  80:103-113, 1997 (IF: 10.445) (PMID: 8978329)
• Hu K, Duan D and Nattel S: Protein kinase C activates ATP-sensitive potassium current in human and rabbit ventricular myocytes. Circulation Research. 78:492-498, 1996 (IF: 10.445)( PMID:8593708)
• *Duan D: Characterization of a novel cardiac chloride channel and its regulation by cell volume and protein kinase C. Ph.D. Thesis. Library, McGill University, Montreal, 1996 (* Dean’s Honour List)
• Duan D, Fermini B and Nattel S: Alpha-adrenergic control of volume-regulated chloride currents in rabbit atrial myocytes - characterization of a novel ionic regulatory mechanism. Circulation Research. 77:379-393, 1995 (IF: 10.445) (PMID: 7542183)
• Duan D and Nattel S:  Properties of single outwardly rectifying chloride channels in heart. (Definitive Comunication)  Circulation Research. 75:789-795, 1994  (IF: 10.445) (PMID: 7923623)
• Duan D, Fermini B and Nattel S:  Potassium channel blocking properties of propafenone in rabbit atrial myocytes. Journalof Pharmacology and Experimental Therapeutics 264:1113-1123, 1993. (IF: 4.109)(PMID: 7542183)
• Fermini B, Wang Z, Duan D, and Nattel S:  Differences in the rate dependence of the transient outward current in rabbit and human atrium. American Journalof Physiology 263 (Heart Circ Physiol 32):H1747-H1754, 1992 (IF: 3.973) (PMID:1481900)
• Duan D, Fermini B and Nattel S:  Sustained outward current observed after Ito1 inactivation in rabbit atrial myocytes is a novel chloride current. (Rapid Communication) American Journalof Physiology 263 (Heart Circ Physiol 32):H1967-H1971,   1992 (IF: 3.973) (PMID: 1481920)
• Duan D, Guan R, Sun J and Tan XC:  A microcomputer system of medical examination and its application in pharmacology.  Chinese Pharmacological Bulletin  7(2):94-95, 1991.
• Duan D, Chen Z and Sun J:  Microcomputer data processing of haemodynamic effects of a cardiotoxic fraction (Fr.19-2) from southern Chinese cobra (Naja naja Canton) in anaesthetized cats. Academic Journal of Sun Yat-sen University of Medical Sciences (in English)  160:54-60, 1990
• Guan Y, Duan D, Wu J, Sun J and Kwan CY: Determining effects of cardiotoxin from southern Chinese cobra venom on the cytoplasmic calcium concentration of rat lacrimal acinar cells with fura-2 fluorescence technique. Chinese Pharmacological Bulletin  6(5):296-299, 1990

Book Chapters:

• Duan D: Proteomics and Functional Proteomics. In Textbook of Pulmonary Vascular Disease (1st Edition) Yuan, J.X.-J.; Garcia, J.G.N.; Hales, C.A.; Rich, S.; Archer, S.L.; West, J.B. (Eds.) Springer. p 649-662, (ISBN: 978-0-387-87428-9) 2011
• Yin HJ, Duan D: Cardiovascular Diseases Genomics, Proteomics, Cardiovascular Pharmacogenomics and Pharmacoproteomics. in: Cardiovascular Pharmacology. (Forth Edition) DF Su, AF Chen, and CY Miao (eds.). Beijing, People's Health Publisher, ISBN978-7-117-14028-7, pp125-146 , 2011
• Huang ZM and Duan DD. The functional role of chloride channels in cardiac pacemaker activity, Modern Pacemakers - Present and Future, M. K. Das (Ed.), ISBN: 978-953-307-214-2, InTech, 2011 (http://www.intechopen.com/articles/show/title/the-functional-role-of-chloride-channels-in-cardiac-pacemaker-activity)
• Zhang M, Duan D: Methods in Chloride Channel Research. in: Experimental Methodology of Pharmacology. Wei W, Wu XM and Li YJ (eds.) Beijing, People's Health Publisher, pp975-977, 2010
• Duan D: Anion Channels: New Therapeutic Targets for Cardiovascular Diseases. in: Discovery of New Drugs in the Postgenomic Era.. F. C. He, S. M. Du, J. Z Sun. (eds) Beijing, Military Medical Science Press, pp 23-28, 2004
• Duan D: Methods in Research of Cardiac Chloride Channels. in: Methods and Technology in Pharmacological Experiments. Xu S-Y, Bian R-L, and Chen X (eds.) Beijing, People's Health Publisher, pp 1166-1169, 2002
• Chen A, Duan D: Gene therapy and its potential application in the treatment of cardiovascular diseases. in: Cardiovascular Pharmacology. (Third Edition) X Chen, W-Z Chen, and G-Y Zeng (eds.) Beijing, People's Health Publisher,  pp 831-857, 2002
• Chen A F-Y and Duan D: Gene therapy of cardiovascular diseases. In: Therapeutics of Cardiovascular Diseases. Chen W-Z, Xu Y-Y, Lu J-S (eds.), Hanzhou, Zhejian Science and Technology Publisher, pp 578-597, 2001
• Horowitz B, Duan D, Dick GM, Yamazaki J, and Hume JR: Volume-regulated chloride channels in heart and smooth muscle. In: Chloride Channels. R Kozlowski (ed) Isis Medical Media, Oxford, pp.109-120, 1999
• *Wang XL, Duan D: Ion channels in cardiovascular system. in: Cardiovascular Pharmacology. (Second Edition) X Chen, W-Z Chen, and G-Y Zeng (eds.). Beijing, People's Health Publisher, p43-62,1997 (* award winning textbook)
• *Duan D:  Gene therapy and its potential application in the treatment of cardiovascular diseases. in: Cardiovascular Pharmacology. (Second Edition) X Chen, W-Z Chen, and G-Y Zeng (eds.) Beijing, People's Health Publisher,  p630-641, 1997 (* award winning textbook)