Publications

Peer-Reviewed Publications (List in chronological order with complete pagination. Authors should be listed in the same order as they appear in the published article. Do not include abstracts or submitted works.)

Souza RF, Huo X, Mittal V, Schuler C, Zhang HY, Zhang X, Hormi-Carver K, Genta RM,   Spechler SJ.Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury.Gastroenterology. 2009;137(5):1776-84.

Huo X, Zhang HY,  Zhang X, Lynch JP, Strauch ED, Wang JY , Spechler SJ, Souza RF. Acid and Bile Salt-Induced CDX2 expression differs In  in Esophageal Squamous Cell from GERD Patients with and without Barrett’s Esophagus. Gastroenterology. 2010;139:194-203.

Zhang X, Yu C, Wilson K, Zhang HY, Melton SD, Huo X, Wang DH, Genta RM, Spechler SJ, Souza RF.Malignant transformation of non-neoplastic Barrett's epithelial cells through well-defined genetic manipulations.PLoS One. 2010 Sep 30;5(9). pii: e13093.

Zhang HY, Zhang Q, Zhang X, Yu C, Huo X, Cheng E, Wang DH, Spechler SJ, Souza RF. Cancer-Related Inflammation and Barrett's Carcinogenesis: Interleukin-6 and STAT3 Mediate Apoptotic Resistance in Transformed Barrett's Cells. Am J PhysiolGastrointest Liver Physiol. 2011 Mar;300(3):G454-60

HuoX, Juergens S, Zhang X, Rezaei D, Yu C, Strauch ED, Wang JY, Cheng E, Meyer F, Wang DH, Zhang Q, Spechler SJ, Souza RF. Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett's epithelial cells. Am J PhysiolGastrointest Liver Physiol. 2011 Aug;301(2):G278-86.

Zhang X, Cheng E, Huo X, Yu C, Zhang Q, Pham TH, Wang DH, Spechler SJ, Souza RF. Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells. PLoS One. 2012;7(11):e50037.

Yu C, Zhang Q, Zhang HY, Zhang X, Huo X, Cheng E, Wang DH, Arbiser JL, Spechler SJ, Souza RF. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. Am J PhysiolGastrointest Liver Physiol. 2012 Sep 1;303(5):G561-9

Cheng E, Zhang X, Huo X, Yu C, Zhang Q, Wang DH, Spechler SJ, Souza RF. Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilicoesophagitis and GORD. Gut. 2013 Jun;62(6):824-32.

Huo X, Zhang X, Yu C, Zhang Q, Cheng E, Wang DH, Pham TH, Spechler SJ, Souza RF.
In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-κB and activator protein-1.
Gut. 2013 Sep 18. doi: 10.1136/gutjnl-2013-305533.

Zhang Q, Yu C, Peng S, Xu H, Wright E, Zhang X, Huo X, Cheng E, Pham TH, Asanuma K, Hatanpaa KJ, Rezai D, Wang DH, Sarode V, Melton S, Genta RM, Spechler SJ, Souza RF.
Autocrine VEGF Signaling Promotes Proliferation of Neoplastic Barrett's Epithelial Cells Through a PLC-Dependent Pathway.
Gastroenterology. 2014 Feb;146(2):461-472.e6. doi: 10.1053/j.gastro.2013.10.011. Epub 2013 Oct 9.

Peng S, Huo X, Rezaei D, Zhang Q, Zhang X, Yu C, Asanuma K, Cheng E, Pham TH, Wang DH, Chen M, Souza RF, Spechler SJ.
In Barrett's Esophagus Patients and Barrett's Cell Lines, Ursodeoxycholic Acid Increases Antioxidant Expression and Prevents DNA Damage by Bile Acids.
Am J Physiol Gastrointest Liver Physiol. 2014 May 22. pii: ajpgi.00085.2014. [Epub ahead of print]

Reviews, Chapters, Monographs and Editorials

Huo X, Souza RF.Acid burn or cytokine sizzle in the pathogenesis of heartburn?J GastroenterolHepatol. 2013 Mar;28(3):385-7

 

 


Xiaofang Huo

Associate Professor

 

  • :214-857-2235
    Fax No.: 214-857-0328

  • DEPARTMENTInternal Medicine—Liver and Digestive Diseases
    University of Texas Southwestern Medical Center at Dallas
  • COUNTRY USA