Research Interest

Clinical and "virtual" experimental research to optimize research, development and utilization of drugs, expecially in paediatrics, Systems pharmacology to characterize disease progression, efforts of disease on drugs and effects of drugs on disease in adults and paediatrics

Pharmacometrics (computer modeling & simulation) to identify and quantify pharmacogenetic and/or environmental factors that influence exposure or efficacy/safety response of drugs in adults and paediatrics, Software packages and web based platforms to facilitate integration, exploration, visualization and model-based analysis of large data bases (see example at http://keep.mashframe.com/); bedside decision support tools to evaluate and optimize dosing strategies in paediatrics.