Research Interest

Studies indicate arginine methylation is an important posttranslational modification that has been implicated in nuclear export, mRNA splicing, transcriptional control and DNA repair. Recently, more evidence has linked this modification to carcinogenesis and metastasis. The focus of my research is to investigate the biological role of arginine methylation and develop specific protein arginine methyltransferase inhibitors as valuable tools for probing protein functions and therapeutic agents.

Thus, my research is divided into three projects:
1) Functional analysis arginine methyltransferase,
2)Characterizing the role of PRMTs in tumorigenesis
3) Identify and characterize specific inhibitors of PRMTs for cancer treatment and prevention.