daniel-louis-costa
Daniel Louis Costa, Sc.D., DABT
National Program Director for Air, Climate and Energy Research (ACE)

Education

1977 Sc.D. Physiology (Toxicology-Occupational Health) Harvard University, School of Public Health, Boston, MA. (Thesis: The Physical-Chemical and Physiological Effects of Oil Mists and Sulfur Dioxide).
1973 M.S. Physiology (Toxicology), Harvard University, School of Public Health, Boston, MA.
1973 M.S. Environmental Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ. (Thesis: Occupational Exposures to Oil Mists).
1970 B.S. Biology, Chemistry (cum laude); Providence College, Providence, RI.

Biography

Dan Costa, Sc.D., DABT is currently the National Program Director (NPD) for the Air Climate & Energy Research Program (ACE).  Dan earned his B.S. in Biology / Chemistry from Providence College, RI, an M.S. in Environmental Sciences from Rutgers, an M.S. and a Sc.D. (doctor of science) in Physiology / Toxicology from the Harvard School of Public Health.  He previously served as NPD for the Clean Air Research Program and was Chief of the Pulmonary Toxicology Branch of the National Health and Environmental Research Laboratory (NHEERL) for 18 years, where he led an active group investigating the health effects of ozone, particulate matter as well as other air pollutants.  He is a Diplomat and Past-President of the American Board of Toxicology (1994) and is Past-President of the Inhalation Specialty Section of the Society of Toxicology (1996) from which he received the Career Achievement Award (2003).   He has served on a number of national and international review committees involving grants and air quality issues. He has authored / co-authored more than 160 refereed publications, 4 book editorships, and over 30 book chapters, conference proceedings and monographs. He maintains his involvement in research through collaborations with NHEERL investigators, mainly focusing on the role of lung derived neurogenic modulation of cardiac function due to various stressors in animal models of cardiopulmonary disease.  Dan is the father of five grown children and through them has had a continued role in sports and other activities. He is a high school basketball referee, plays basketball regularly, and coaches a Special Olympics basketball team. He carries these team principles to the workplace.

Research Interest

Dan Costa’s primary career research interests have always focused on the potential for air pollutants to adversely affect health and how we might reduce the risk of adverse outcomes through physicochemical and biologic mechanistic understanding of how air pollutants impact health. Most of my work has utilized animal models of both healthy and susceptible human populations – with emphasis on pre-existent cardiac or pulmonary disease. This work utilizes both physiological and cellular approaches to develop and characterize the models, as well as to dissect the mechanisms by which pollutants induce or exacerbate injury or disease. Among the animal models of interest are rat models of: fibrosis, pulmonary and systemic hypertension, emphysema, bronchitis, congestive heart failure, and airway hyperreactivity (asthma). Most recently, my interest has been directed to the investigation of neurologic pathways  from the respiratory tract associated with irritant reflexes that may impact cardiac as well as respiratory function. We have revealed previously unappreciated priming mechanisms involving exposure to air pollutants that sensitize rodents (and likely people) responsiveness to subsequent normal daily changes that are under homeostatic control but now unveiled potentially life-threatening cardiac arrhythmias.

Scientific Activities

Awards
1990 Level III Scientific and Technological Achievement Awards (STAA): Tepper et al. (1989) – Unattenuated Structural and biochemical Alterations in the Rat Lung during Functional Adaptation to Ozone: Am. Rev. Respir. Dis. 140:493-501, 1989.
1992 Honorable Mention STAA: Wiester et al. (1991) - Ventilatory Responses in the Rat in Response to Chronic Ozone:
1996 Level II STAA: Pritchard et al. (1996) - Oxidant Generation and Lung Injury after particulate Air Pollutant Increases with the Concentrations of Associated Metals
  Level II STAA: Ghio et al. (1996) - Humic-like Substances in Air Pollution Particulates Correlate with Concentrations of Transition Metals and Oxidant Generation
1999 Level III STAA: Kodavanti, U.P., Hauser, R., Christian, D.C., Meng, Z.H., McGee, J., Ledbetter, A., Richards, J., and Costa, D.L. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol. Sciences 43:204-212, 1998.
1999                Level III STAA: Kodavanti, U.P. and Costa, D.L. Animal Models to Study for Pollutant Effects. Air Pollution and Health. Eds. S.T. Holgate, J.M. Samet, H.L. Koren, R. L. Maynard. Academic Press, NY. pp. 165-197, 1999.
1999 SOT Inhalation Specialty Section Paper of the Year: Kodavanti UP, Hauser R, Christian DC, Meng ZH, McGee J, Ledbetter A, Richards J, and Costa, DL Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol. Sci. 43:204-212, 1998.
2000 STAA - Honorable Mention. Awarded for its comprehensive and critical evaluation of the parallelisms between in vivo and in vitro investigations on ozone-induced pulmonary health effects.
2000 Level III STAA: Costa DL, Dreher KL, Jaskot R, Richards J., Su WY, Biologic Plausibility of Metals  as  a  Likely  Causal  Constituent  in  the  Adverse  Responses  Observed  in  Healthy  and Compromised Subjects. (series of papers)
2002 Level I STAA: Costa DL, Dye J, Lehmann JR, Ghio A, Devlin R. Effects of Air Pollution Particles from Utah Valley on Humans and Animals (series of papers)
2003 Inhalation Specialty Section (SOT): Career Achievement Award          
2003 Special Commemorative Award for September 11 Activities: Toxicological Studies of World Trade Center Particulate Matter in Mice
2003 SOT Paper of the Year Award: Kodavanti, U.P., Moyer, C., Ledbetter, A.D., Sschladweiler, M.C., Costa, D.L., Hauser, R., Christiani, D.C., and Nyska, A. Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat. Toxicol. Sci. 71: 237-245, 2003.
2005                Amer. Assoc. for Aerosol Research: Featured Invited Plenary Speaker 
2006 Level I STAA: Kodavanti UP, Costa DL. et al. Novel Insights from Ambient Particle concentrator Studies: Physiochemistry vs. susceptibility
2006   STAA - Honorable Mention. Nadadur S. and Costa DL. Efforts in the Development of Biomarkers of Acute Ozone Toxicity using gene Expression Profiling.
2008 STAA - Honorable Mention. Kodavanti UP….Costa DL. The Spontaneously Hypertensive Rat: An Experimental Model of Sulfur Dioxide-Induced Airways Disease. Tox Sci, 94(1):193-205, 2006
2009 STAA - Honorable Mention. Kodavanti UP….Costa DL. The Role of Inhaled Particulate Matter-Associated Zinc in Cardiac Injury [1) The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats Environmental Health Perspectives, 116(1):13-20 (2008); (2) Systemic Imbalance of Essential Metals and Cardiac Gene Expression in Rats Following Acute Pulmonary Zinc Exposure Journal of Toxicology and Environmental Health, 69(22):2011-2032 (2006)
2009 SOT Inhalation and Resp. Specialty Section Paper of the Year – 2009
2010 STAA – Honorable Mention. [A series of publications] Farraj A…. Costa DL New Paradigm Based on Altered Compensatory Responses to Inform Assessments of Cardiac Risk from Air Pollutants.
2010 STAA – Honorable Mention. Nadadur S…. Costa DL. Endothelial Effects of Emission Source Particles: Acute Toxic Response Gene Expression Profiles, 23(1):67-77 (2009)
2012 SOT Inhalation and Respiratory Specialty Section Paper of the Year Award: Hazari MS, Haykal-Coates N, Winsett DW, Krantz QT, King C, Costa DL, Farraj AK.TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust. Environ. Health Perspect 2011. 119:951-957.
2013 SOT Inhalation & Respiratory Specialty Section Paper of the Year Award: Carll AP, Lust   RM, Hazari MS, Perez CM, Krantz QT, King C, Winsett DW, Cascio WE, Costa DL, Farraj AK. Diesel Exhaust Inhalation Increases Cardiac Output, Bradyarrhythmias, and Parasympathetic Tone in Aged Heart Failure-Prone Rats. Toxicol. Sci. 2013; 131(2):583-95.            
2014 SOT CV Tox Specialty Section Impact Award; Carll AP, Hazari MS, Perez CM, Krantz QT, King C, Haykal-Coates N, Cascio WE, Costa DL, Farraj AK 2013. An Autonomic Link between Inhaled Diesel Exhaust and Impaired Cardiac Performance: Insight from Treadmill and Dobutamine Challenges in Heart Failure-Prone Rats. Toxicol. Sci. 35(2):425-36.           
2016 Assembly on Environmental and Occupational Public Health (ATS):   Val Vallyathan Senior Investigator Award
Institutional and Performance Awards
1989 Special Achievement (NHEERL/ETD)
1995 Bronze Metal for Commendable Service: Fuel Additives Health Effects Testing Rule
1996 Bronze Medal for Commendable Service as an author to the AQCD for Ozone
1994-2002 Special Achievement (NHEERL/ETD)
1997 Bronze Medal for Commendable Service in support of TSCA Section 4 Enforceable Consent Agreement for Hazardous Air Pollutants (Phenol)
2000-2003 Special Achievement
2002 Commemorative Award for September 11 Research Activities
2002 NHEERL Achievement: Integrated Synthesis Chapter for PM AQCD.
2002 Bronze Medal for Commendable Service to Special Olympics of Orange County
2003 Bronze Medal for senior authorship of ORD 5-Year PM Accomplishments Report
2003                 Gold Metal in recognition of outstanding achievements as a member of the National Health and Environmental Effects Research Laboratory in establishing and implementing an integrated research program to define the potential health threat of ambient PM on the American public.
2004 Bronze Medal for Commendable Service PM AQCD Team
2009 Bronze Medal for Commendable Service – Innovations in air Pollution Epidemiology Team
2010 Bronze Medal for Commendable Service – Combustion Emission Toxicity Team
2010 Bronze Medal for Commendable Service for PM Research Centers Synthesis Paper  
2010 ORD Teamwork Award – ORD Transformation Task Team for demonstrating integrated multidisciplinary teamwork in recommending how ORD can transform the way in which it selects and solves problems for EPA
2012                 Bronze Medal for Commendable Service for ORD Budget and Program Structure Implementation Team
2012                 Exceptional/Outstanding ORD Technical Assistance to the Regions or Program Offices: Diesel Exhaust Studies Team
2014 Bronze Medal for Commendable Service – So. Oxidant Aerosol Study Leadership and Vision Team
2006-2015 Special Achievement (IOAA)

Publications

  1. Costa, D.L. and Underhill, D.W. Solubility and reactivity of SO2 in various oils. Amer. Indust. Hygiene Assoc. J. 37(1): 46-51, 1976.
  2. Costa, D.L. and Amdur, M.O. Respiratory response of guinea pigs to oil mists. Amer. Indust. Hygiene Assoc. J. 40(8): 673-679, 1979.
  3. Costa, D.L. and Amdur, M.O. Effect of oil mists on the irritancy of sulfur dioxide. I. Mineral oils and light lubricating oil. Amer. Indust. Hygiene Assoc. J. 40(8): 680-685, 1979.
  4. Costa, D.L. and Amdur, M.O. Effect of oil mists on the irritancy of sulfur dioxide. II. Motor oil. Amer. Indust. Hygiene Assoc. J. 40(9): 809-815, 1979.
  5. Tice, R.R., Costa, D.L., and Drew, R.T. Effects of inhaled benzene on cellular proliferation kinetics, sister chromatid exchanges, and chromosomal aberrations in murine bone marrow. Proc. Nat. Acad. Science., U.S.A. 77(4): 2148-2152, 1980.
  6. Tice, R.R., Vogt, T.F., and Costa, D.L. Cytogenetic effects of inhaled benzene in murine bone marrow. In: Genotoxic Effects of Airborne Agents, (Tice, R.R., Costa, D.L., and Schaich, K.M., eds.), Vol. 25, p. 257-275, 1982.
  7. Costa, D.L., Kutzman, R.S., Lehmann, J.R., Popenoe, E.A., and Drew, R.T. A subchronic multidose ozone study in rats. Adv. Mod. Environ. Toxicol. Chapter 28: 369-393, 1983.
  8. Drew, R.T., Kutzman, R.S., Costa, D.L., and Iwai, J. Effects of sulfur dioxide and ozone on hypertension sensitive and resistant rats. Fund. Appl. Toxicol. 3: 298-302, 1983.
  9. Costa, D.L., Lehmann, J.R., Slatkin, D.N., Popenoe, E.A., and Drew, R.T. Chronic airway obstruction and bronchiectasis in the rat after intratracheal bleomycin. Lung 161: 287-300, (1983).
  10. Chanana, A.D., Joel, D.D., Costa, D.L., Janoff, A., Susskind, H., and Weiss, R.A. Large animal model for health hazard assessment of environmental pollutants. Immunol. Hematol. Res. 3: 125-130, 1984.
  11. Costa, D.L. Functional evaluation of pulmonary toxicity. Fund. Appl. Toxicol. 5: 423-434, 1985.
  12. Costa, D.L., Schafrank, S.H., Wehner, R.W., and Jellett, E. Alveolar permeability to protein in rats differentially sensitive to ozone. J. Appl. Toxicol. 5(3): 182-186, 1985.
  13. Costa, D.L., Lehmann, J.R., Harold, W.N., and Drew, R.T. Transoral tracheal intubation of rodents using a fiberoptic larynogscope. Lab. Animal Sci. 33(3): 256-261,1986.
  14. Costa, D.L. and Kutzman, R.S. Altered lung function and structure in the rat after subchronic exposure to acrolein vapor. Amer. Rev. Resp. Dis. 133(2): 248-260 1986.
  15. Shiotsuka, R.N., Costa, D.L., Osheroff, M.R., and Drew, R.T. Method of measuring deposition of unlabelled monodisperse micropheres in rat lungs. J. Toxicol. Environ. Health 21: 1-13, 1987.
  16. Tepper, J.S., Wiester, M.J., Costa, D.L., Watkinson, W.P., and Weber, M.F. Cardiopulmonary effects in awake rats four and six months after exposure to methylisocyanate. Environ. Health Perspect. 72: 95-103, 1987.
  17. Stevens, M.A., Fitzgerald, S., Menache, M.G., Graham, J.A., Costa, D.L. and Bucher, F.R. Functional airway obstruction in male F-344 rats exposed to methyl isocyanate (MIC). Environ. Health Perspect. 72: 89-94, 1987.
  18. Foster, W.M., Costa, D.L., and Langenback, E.G. Ozone exposure alters tracheobronchial mucociliary function in humans. J. Appl. Physiol. 63: 996-1102, 1987.
  19. Tepper, J.S., Wiester, M.J., King, M.E., Weber, M.F., and Costa, D.L. Use of carbon dioxide challenge to detect toxicant-induced changes in cardiopulmonary function of awake rats. Inhal. Toxicol., Premier Issue: 79-95, 1988.
  20. Wiester, M.J., Tepper, J.S., King, M.E., Ménache, M.G., and Costa, D.L. Comparative study of ozone (O3) uptake in three strains of rats and in the guinea pig. Toxicol. Appl. Pharmacol., 96: 140-146, 1988.
  21. Tepper, J.S., Costa, D.L., Lehmann, J.R., Weber, M.F., and Hatch, G.E. Functional adaptation to ozone: An evaluation of breathing patterns and anatomical and biochemical changes in the rat. Amer. Rev. Resp. Dis., 140: 493-501, 1989.
  22. Hatch, G.E., Selgrade, M.J., Costa, D.L., and Tepper, J. Commentary on Review Article: Cellular, Biochemical and Functional Effects of Ozone: New Research Perspectives on Ozone Health Effects. Toxicol. Let. 51: 119-123, 1990.
  23. Tepper, J.S., Wiester, M.J., Weber, M.F., Fitzgerald, S., and Costa D.L. Chronic exposure to a simulated urban profile of ozone alters ventilatory responses to CO2 challenge in rats. Fund. Appl. Toxicol. 17: 52-60, 1991.
  24. Hardy, R.J., Highsmith, V.R., Costa, D.L. and Krewer, J.A. . Indoor air concentrations associated with the use of asbestos-contaminated tap water in portable home humidifiers. Environ. Sci. & Technol. 26(4): 673-679, 1992.
  25. Hardy, R.J., Highsmith, V.R., Costa, D.L., and Germani,M.S.. Physical & chemical characterization of indoor aerosols resulting from the use of tap water in portable home humidifiers. Environ. Sc.i & Technol. 26(4): 680-689, 1992.
  26. Highfill, J.W., Hatch, G.E., Slade,R, Crissman,K.M. Norwood, J. Devlin, R.B. and Costa, D.L. Concentration-time models for the effects of ozone on bronchoalveolar lavage fluid protein from rats and guinea pigs. Inhal. Toxicol. 4: 1-16, 1992.
  27. Tepper, J.S., and Costa, D.L. Will the mouse bioassay for estimating sensory irritancy of airborne chemicals (ASTM E 981-84) be useful for evaluation of indoor air contaminants. Indoor Environ. 1: 367-372 (1992).
  28. Vincent, R., Mercer, R.R., Chang, L-Y., Miller, F.J., Costa, D.L., and Crapo, J.D. Quantitative ultrastructural analysis of connective tissue in the lungs. HEI Com. 1: 24-27, 1992.
  29. Chang, L-Y., Huang, Y., Stockstill, B.L., Graham, J.A., Grose, E., Ménache, M., Miller, F.J., Costa, D.L., and Crapo, J.D. Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated high ambient pattern of ozone. Toxicol. Appl. Pharm. 115: 241-252, 1992.
  30. Tepper, J.S., Costa, D.L., Winsett, C., Stevens, M.A., Doerfler, D.L., and W.P. Watkinson. Near lifetime exposure of the rat to a simulated urban profile of nitrogen dioxide: Pulmonary function evaluation. Fund. Appl. Toxicol. 20: 80-96, 1993.
  31. Tepper, J.S., Costa, D.L., Fitzgerald, S., Doerfler, D.L., and Bromberg, P.A. Role of tachykinins in ozone- induced acute lung injury in guinea pigs. J. Appl. Physiol. 75(3): 1404-1411, 1993.
  32. Watkinson, W.P., Aileru, A.A., Dowd, S.M., Doerfler, D.L., Tepper, J.S., and Costa. D.L. Acute effects of ozone on heart rate and body temperature in the unanesthetized, unrestrained rat maintained at different ambient temperatures. Inhal. Toxicol. 5:129-147, 1993.
  33. Jaskot, R.H. and D.L. Costa. Toxicity of an anthraquinone violet dye mixture following inhalation exposure, intratracheal instillation, or gavage. Fund. Appl. Toxicol. 22: 103-112, 1994.
  34. Hatch, G.E., Slade, R., Harris, L.P., McDonnell, W.F., Devlin, R.B., Koren, H.S., Costa, D.L., and McKee, J. Ozone dose and effect in humans and rats: A comparison using oxygen-18 labeling and bronchoalveolar lavage. J. Resp. & Crit. Care Med. 150(3): 676-683, 1994.
  35. Tepper, J.S., Moser, V.C., Costa, D.L., Mason, M.A., Roache, N., Guo, Z., Dyer, R.S. Toxicological and chemical evaluation of emissions from carpet samples. Am. Ind. Hyg. Assoc. J. 56: 158-170, 1995.
  36. Cheng, P., Hu, P., Costa, D.L., and Boat, T. Epithelial lung fluid in the rat: Effect of O3 on albumin permeability and fluid accumulation. Exp. Lung Res. 21: 351-365, 1995.
  37. Highfill, J.W. and Costa, D.L. Statistical response models for ozone exposure: their generality when applied to human spirometric and animal permeability functions of the lung. J. Air & Waste Manage. Assoc. 45: 95- 102, 1995.
  38. Costa, D.L., Tepper, J.S., Stevens, M.A., Watkinson, W.P., Doerfler, D.L., Gelzleichter, T.R., and Last, J.A. Restrictive lung disease in rats exposed chronically to an urban praofile of ozone. Am. J. Resp. Crit. Care Med. 151: 1512-18, 1995.
  39. Tepper, J.S., Jackson, M.C., McGee, J.K., Costa, D.L., and Graham, J.A. Estimation of respiratory irritancy from inhaled methyl-tertiary-butyl ether (MTBE) in mice. Inhal. Toxicol. 6(6): 563-569, 1994.
  40. Wiester, M.J., Tepper, J.S., Doerfler, D.L., and Costa, D.L. Ozone adaptation in rats after chronic exposure to a simulated urban profile of ozone. Fund. Appl. Toxicol. 24: 42-51, 1995.
  41. Mercer R.R, Costa D.L., and Crapo, J.D. Effects of prolonged exposure to low doses of nitric oxide on the alveolar septa of the adult rat lung. Lab Invest. 73(1): 1-9, 1995.
  42. Kodavanti, U.P., Costa, D.L., Dreher, K.L., Crissman, K., and Hatch, G.E. Ozone-induced tissue injury and changes in antioxidant homeostasis in normal and ascorbate-deficient guinea pigs. Biochem. Pharmacol. 50(2): 243-251, 1995.
  43. Kodavanti, U.P., Hatch, G.E., Starcher, B., Girii, S.N., Winsett, D., and Costa, D.L. Ozone-induced pulmonary functional, pathological, and biochemical changes in normal and vitamin C-deficient guinea pigs. Fundam. Appl. Toxicol. 24: 154-164, 1995.
  44. Ghio, A.J., Stonehuemer, J., Pritchard, R.J., Piantadosi, C.A., Quigley, D.R., Dreher, K.L., and Costa, D.L. Humic-like substances in air pollution particulates correlate with concentrations of transition metals and oxidant generation. Inhal. Toxicol. 8:479-494, 1996.
  45. Pritchard, R.J., Ghio, A.J., Lehmann, J.R., Winsett, D.W., Tepper, J.S., Park, P., Gilmour, M.I., Dreher, K.L., and Costa, D.L. Oxidant generation and lung injury after particulate air pollutant exposure increase with the concentrations of associated metals. Inhal. Toxicol. 8: 457-477, 1996.
  46. Dye, J.A., Morgan, K.T., Neldon, D.L., Tepper, J.S., Burleson, G.R., and Costa, D.L. Characterization of upper respiratory disease in rats following neonatal inoculation with a rat-adapted influenza virus. Vet. Pathol. 33: 43-54, 1996.
  47. Bascom, R., Bromberg, P.A., Costa, D.L., Devlin, R., Dockery, D.W., Frampton, M.W., Lambert, W., Samet, J.M., Speizer, F.E., Utell, M.  State of the Art. Health Effects of Outdoor Air Pollution. Part I. Am. J.  Respir. Crit. Care Med., Vol. 153: 3-50, 1996.
  48. Bascom, R., Bromberg, P.A., Costa, D.L., Devlin, R., Dockery, D.W., Frampton, M.W., Lambert, W., Samet, J.M., Speizer, F.E., Utell, M.  State of the Art. Health Effects of Outdoor Air Pollution. Part II. Am. J. Respir. Crit. Care Med., Vol. 153: 477-498, 1996.
  49. Mason, M. A., Roache, N. F., Guo, Z. and Costa, D. L. Design and characterization of a small chamber for chemical and biological evaluation of sources of indoor air contamination. Ed.: Tichenor, B. A. Characterizing Sources of Indoor Air Pollution and Related Sink Effects. pp 112-122, 1996 ASTM Publication (PCN): 04-012870-17 ASTM 100 Barr Harbor Dr. West Conshohocken, PA 19428-2959.
  50. Su, W.Y., Kodavanti, U., Jaskot, R., Costa, D.L., and Dreher, K. Temporal expression and cellular distribution of pulmonary fibronectin gene induction following exposure to an emission source particle. J. Environ. Pathol. Toxicol. Oncol. 74: 213-223, 1997.
  51. Dreher, K.L., R.H. Jaskot, J.R. Lehmann, J.H. Richards, J.K. McGee, A.J. Ghio, and D.L. Costa.. Soluble transition metals mediate residual oil fly ash induced acute lung injury. J. Toxicol. Environ. Health 50: 285- 305, 1997.
  52. Kodavanti, U.P., R.H. Jaskot, W.Y. Su, D.L. Costa, J.R. Lehmann, A.J. Ghio, and K.L. Dreher. Genetic variability in combustion particle-induced lung injury. Am. J. Physiol. (Lung Cell Mol. Physiol. 16) 272: L521-L532, 1997.
  53. Kodavanti, U.P., R.H. Jaskot, D.L. Costa, and K.L. Dreher. Pulmonary proinflammatory gene induction following acute exposure to residual oil fly ash particles: roles of particle-associated metals. Inhal. Toxicol. 9: 679-701, 1997.
  54. Schulman, S.R., Canada, A.T., Fryer A.D., Winsett, D.W., and Costa, D.L. Airway hyperreactivity produced by short-term exposure to hyperoxia in neonatal guinea pigs. Amer. J. Physiol. 272 (Lung Cell Mol. Physiol). 16: L1211-1216, 1997.
  55. Ghio, A.J., Z.H. Meng, G.E. Hatch, and D.L. Costa. Luminol-enhanced chemiluminescence after in vitro exposures of rat liver macrophages to oil fly ash is metal dependent. Inhal. Toxicol. 9: 255-271, 1997.
  56. Gavett, S.H., S.L. Madison, D.W. Winsett, J.L. McGee, and D.L. Costa. Metal and sulfate composition of residual oil fly determines airway hyperreactivity and lung injury in rats. Environ. Res. 72: 162-172, 1997.
  57. Piedimonte, G., Pickles, R.J., Lehmann, J.R., McCarthy, D., Costa, D.L., and Boucher, R.C. Replication- deficient adenoviral vector for gene therapy potentiates airway neurogenic inflammation. Am. J. Resp. Crit. Care Med. 16(3): 250-260,1997.
  58. Canada, A.T., Schulman, S.R., Winsett, D.W., Pinkerton,K.E., and Costa, D.L.. Hyperoxia-induced airway hyperreactivity does not require inflammation: a difference in the mechanism compared to ozone. Inhal. Toxicol. 10:15-25, 1998.
  59. Costa, D.L., and Dreher, K.L.. Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy an compromised animal models. Environ. Health Perspect. 105 (Suppl. 5): 1053-1060, 1997.
  60. Kadiiska, M.B., Mason, R.P., Dreher, K.L., Costa, D.L., and Ghio, A.J. In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle. Chem. Res. Toxicol. 10(10): 1104-1108, 1997.
  61. Kodavanti, U.P., Hauser, R., Christian, D.C., Meng, Z.H., McGee, Ledbetter, A., Richards, J., and Costa, D.L. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol. Sci. 43:204-212, 1998.
  62. Watkinson, W.P., M.J. Campen, and D.L. Costa. Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertensive. Toxicol. Sci. 41, 209-216, 1998.
  63. Kodavanti, U.P., Costa, D.L., and Bromberg, P.A. Rodent models of cardiopulmonary disease: their potential applicability in studies of air pollutant susceptibility. Environ. Health Perspect. 106(1), 111-130, 1998.
  64. McKinney, W.J., Jaskot, R.H., Richards, J.H., Costa, D.L., Dreher, K.L. Cytokine mediation of ozone- induced pulmonary adaptation. Am. J. Respir. Cell Mol. Biol. 18, 696-705, 1998.
  65. Chapman, R.S., Watkinson, W.P., Dreher, K.S., and Costa D.L. Ambient particulate matter and respiratory and cardiovascular illness in adults: particle-borne transition metals and the heart-lung axis. Environ. Toxicol. Pharmacol. 4, 331-338, 1998.
  66. Lambert, A.L., Winsett, D.W., Costa, D.L., Selgrade, M.K., Gilmour, M.I. Transfer of allergic airway responses with serum and lymphocytes from rats sensitized to dust mite. Am J Respir Crit Care Med. 157(6 Pt 1):1991-1999, 1998.
  67. Lay, J.C., Bennett, W.D., Ghio, A.J., Bromberg, P.A., Costa, D.L., Kim, C.S., and Devlin, R.B. Cellular and biochemical response of the human lung following intrapulmonary instillation of insoluble ferric oxide particles. Am. J. Respir. Cell Mol. Biol. 1:20(4), 631-642, 1999.
  68. Kodavanti, U.P., Jackson., M.C., Ledbetter, A.D., Richards, J.R., Gardner, S.Y., Watkinson, W.P., Campen, M.J., and Costa, D.L. Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertension. J Toxicol Environ Health 57, 543-563, 1999.
  69. Dye, J.A., Madden, M.C., Richards, J.H., Lehmann, J.R., Devlin, R.B., and Costa, D.L. Ozone effects on airway responsiveness, lung injury, and inflammation. Comparative rat strain and in vivo/invitro investigations. Inhal Toxicol 11, 1015-1040, 1999.
  70. Gavett, S.H., Madison, S.L., Stevens, M.A., and Costa, D.L. Residual oil fly ash amplifies allergic cytokines, airway responsiveness, and inflammation in mice. Am. J. Respir Crit Care Med.1999, 160:1897-1904.
  71. Costa, D.L., and Dreher, K.L. What do we need know about airborne particles to make effective risk management decisions? Human and Ecological Risk Assessment 5(3), 481-492, 1999.
  72. Costa, D.L. Particulate matter and cardiopulmonary health: A perspective. Inhal. Toxicol. 12(3), 35-44, 2000.
  73. Gardner, S.Y., J.R. Lehmann, and Costa, D.L. Oil fly ash-induced elevation of plasma fibrinogen levels in rats. Toxicol. Sci. 56, 175-180, 2000.
  74. Kodavanti, U.P., Mebane, R., Ledbetter, A., Krantz, T., McGee, J., Jackson, M.C., Walsh, L., Hilliard, H., Chen, B.Y., Richards, J., and Costa, D.L. Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitis. Toxicol. Sci. 54, 441-451, 2000.
  75. Kodavanti, U.P., Schladweiler, M.C., Ledbetter, A.D., Watkinson, W.P., Campen, M.J., Winsett, D.W., Richards, J.R., Crissman, K.M., Hatch, G.E., and Costa, D.L. The spontaneously hypertensive rat as a model of human cardiovascular disease: evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter. Toxicol. Appl. Pharmacol. 164, 250-263, 2000.
  76. Kodavanti, U.P., Jackson, M.C., Ledbetter, A.D., Starcher, B.C., Evansky, P.A., Harewood, A., Winsett, D.W., and Costa, D.L. The combination of elastase and sulfur dioxide exposure causes COPD-like lesions in the rat. Chest 117, 299S-302S, 2000.
  77. Wiester, M.J., Winsett, D.W., Richards, J.H., Jackson, M.C., Crissman, K.M., and Costa, D.L. Ozone adaptation in mice and its association with ascorbic acid in the lung. Inhal. Toxicol. 12, 577-590, 2000.
  78. Campen, M.J., D.L. Costa, and W.P. Watkinson. Cardiac and thermoregulatory toxicity of residual oil fly ash in cardiopulmonary-compromised rats. Inhal Toxicol. 12:7–22, 2000.
  79. Watkinson, W.P., Campen, M.J., Nolan, J.P., Kodavanti, U.P., Dreher, K.L., Su, W-Y, Highfill, J.W., and Costa, D.L. Thermoregulatory effects following exposure to particulate matter in healthy and cardiopulmonary-compromised rats. J. Thermal Biol. 25: 131-137, 2000.
  80. Driscoll, K.E., Costa, D.L., Hatch, G.E., Henderson, R.F., Oberdorster, G., Salem, H., and Schlesinger, R.B. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol. Sci. 55:24-35, 2000.
  81. Samet, J.M., Ghio, A.J., Costa, D.L., and Madden, M.C. Increased expression of cyclooxygenase 2 mediates oil fly ash-induced lung injury. Exp. Lung Res. 23:57-69, 2000.
  82. Kodavanti, U.P., Schladweiler, M.C.J., Richards, J.R., and Costa, D.L. Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normo- and spontaneously hypertensive rats. Inhal. Toxicol. 13, 37-54, 2001.
  83. Dye, J.A., Lehmann, J.R., McGee, J.K., Winsett, D.W., Ledbetter, A.D., Everitt, J.I., Ghio, A.J., and Costa, D.L. Acute pulmonary toxicity of particulate matter (PM) filter extracts in rats: Coherence with epidemiological studies in Utah Valley residents. Environ. Health Perspec. 109 (Suppl. 3), 395-403, 2001.
  84. Watkinson, W. P. Campen, M.J., Witchers, L.B., Nolan, J.P., Kodavanti, U.P., and Costa, D.L. Impact of toxic agents or diverse conditions on thermoregulatory function in awake rodents. J. Thermal Biol. 26:331B338, 2001.
  85. Watkinson, W.P., M.J. Campen, J.P. Nolan, and D.L. Costa. Cardiovascular and systemic responses to inhaled pollutants in rodents: Effects of ozone and particulate matter. Environ. Health Perspect. 109:539B546, 2001.
  86. Campen, M.J., Nolan, J.P., Schladweiler, M.C.J., Kodavanti, U.P., Evansky, P.A., Costa, D.L., and Watkinson, W.P. Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: demonstrating a synergism between nickel and vanadyl sulfate. Toxicol Sci 64:243-252, 2001.
  87. Kodavanti, U.P., and Costa, D.L. Rodent models of susceptibility: what is their place in inhalation toxicology? Respir. Physiol. 128:57-70, 2001.
  88. Wiester, M.J., Winsett, D.W., Richards, J.H., Doerfler, D.L., and Costa, D.L. Partitioning of benzene in sickle cell and normal human blood and in the blood of the guinea pig, mouse, and rat. Environ. Health Perspec. 110:255-261, 2002.
  89. Campen, M.J., Nolan, J.P., Schladweiler, M.C.J., Kodavanti, U.P., Costa, D.L., and Watkinson, W.P. Cardiac and thermoregulatory effects of instilled particulate matter-associated transition metals in healthy and cardiopulmonary-compromised rats. J. Toxicol. Environ. Health, Part A, 65:101-117, 2002.
  90. Kodavanti, U.P., Schladweiler, M.C.J., Ledbetter, A.D., Hauser, R., Christiani, D.C., McGee, J., Richards, J.R., and Costa, D.L. Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised rats. J. Toxicol. Environ. Health, 65, Part A: 1545-1569, 2002.
  91. Wiester, M.J., Winsett, D.W., Richards, J.H., Doerfler, D.L., and Costa, D.L. Partitioning of benzene in blood: influence of hemoglobin type in humans and animals. Environmental Health Perspectives 110:255- 261, 2002.
  92. Savov, J.D., Gavett, S.H., Brass, D.M., Costa, D.L., and Schwartz, D.A. Neutrophils play a critical role in the development of LPS-induced airway disease. American Journal Physiology (Lung Cellular Mol. Physiology), 2002.
  93. Moyer, C.F., Kodavanti, U.P., Haseman, J.K., Maronpot, R.R., Costa, D.L., and Nyska, A. Systemic vascular disease in male B6C3F1 mice exposed to particulate matter by inhalation: studies conducted by the National Toxicology Program. Toxicologic Pathology 30:427-434, 2002.
  94. Kodavanti, U.P., Schladweiler,l M.C.J., Ledbetter, A.D., Hauser, R., Christiani, D.C., McGee, J., Richards, J.H., and Costa, D.L. Pulmonary and systemic effects of zinc-containing emission particles in three rat strains: Multiple exposure scenarios. Toxicological Sciences 70:73-85, 2002.
  95. Gavett, S.H., Haykal-Coates, N., McGee, J.K., Highfill, J.W., Ledbetter, A.D., and Costa, D.L. Toxicological effects of fine particulate matter derived from the destruction of the World Trade Center. EPA Report EPA/600/R-02/028, 2002.
  96. Watkinson, W.P., Nolan, J.P., Costa, D.L., Campen, M.J., and Wichers, L.B. Cardiac and thermoregulatory responses to inhaled pollutants in healthy and compromised rodents: Modulation via interaction with environmental factors. Environ. Res 92:35-47, 2003.
  97. Gavett, S.H., Haykal-Coates, N., Highfill, J.W., Ledbetter, A.D., Chen, L.C., Cohen, M.D., Harkema, J.R., Wagner, J.G., and Costa, D.L. World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice. Environ. Health Perspect, 111(7):981-991, 2003.
  98. McGee, J.K., Chen, L.C., Cohen, M.D., Chee, G.R., Prophete, C.M., Haykal-Coates, N., Wasson, S.J., Conner, T.L., Costa, D.L., and Gavett, S.H. Chemical analysis of World Trade Center fine particulate matter for use in toxicological assessment. Environ. Health Perspect. 111(7):972-980, 2003.
  99. Hatch, G.E., Kodavanti, U., Costa, D.L., Dreher, K., and Slade, R. An “injury-time integral” model for relating acute to chronic injury to phosgene. Toxicol. Indust. Health 17:285-293, 2002.
  100. Kodavanti, U.P., Moyer, C., Ledbetter, A.D., Sschladweiler, M.C., Costa, D.L., Hauser, R., Christiani, D.C., and Nyska, A. Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat. Toxicol. Sci. 71: 237-245, 2003.
  101. Watkinson, W.P., Campen, M.J., Wichers, L.B., Nolan, J.P., and Costa, D.L. Cardiac and thermoregulatory responses to inhaled pollutants in healthy and compromised rodents: modulation via interaction with environmental factors. Environ. Res. 92:35-47, 2003.
  102. Costa, D.L., Kodavanti, U.P. Toxic responses of the lung to inhaled pollutants: benefits and limitations of lung-disease models. Toxicol Let 140-141:195-203, 2003.
  103. Costa, D.L. Issues that must be addressed for risk assessment of mixed exposures: The EPA experience with air quality. J. Toxicol. Environ. Health 67:195-207, 2003.
  104. Pagan I, Costa DL, McGee JK, Richards JH, Dykstra MJ, and Dye JA. Metals mimic rat tracheal epithelial cell toxic responses induced by ambient particulate matter filter extracts. J Tox. Environ Health, Part A, 66:1-26, 2003.
  105. Kodavanti, U.P., Ledbetter, A.D., Schladweiler, M.C.J., Costa, D.L., Moyer, C., Hauser, R., Christiani, D.C., Nyska, A. Reply. Letter to the Editor. Toxicological Sciences 4:228-230, 2003.
  106. Wiester, M.J., Costa, D.L., Tepper, J.S., Winsett, D.W., and Slade, R. Agonist-mediated airway challenge: cardiopulmonary interactions modulate gas exchange and recovery. Resp. Physiol. & Neurobiol., 145(2- 3):183-99, 2005
  107. Wichers, L.B., Nolan, J.P., Winsett, D.W., Ledbetter, A.D., Kodavanti, U.P., Schladweiler, M.C.J., Hauser, R., Christiani, D.C., Costa, D.L., and Watkinson, W.P. Effects of instilled combustion-derived environmental particles in spontaneously hypertensive rats. Part I. Cardiovascular responses. Inhal. Toxicol 16:391–405, 2004.
  108. Wichers, L.B., Nolan, J.P., Winsett, D.W., Ledbetter, A.D., Kodavanti, U.P., Schladweiler, M.C.J., Hauser, R., Christiani, D.C., Costa, D.L., and Watkinson, W.P. Effects of instilled combustion-derived environmental particles in spontaneously hypertensive rats. Part II. Pulmonary responses. Inhal. Toxicol 16:407–419, 2004.
  109. Gardner, S.Y., McGee, J.K., Kodavanti, U.P., Ledbetter, A.D., Everitt, J.I., Winsett, D.W., Doerfler, D.L., and Costa, D.L. Emission particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension. Environ. Health Perspect. 112(8):872-8, 2004.
  110. Nadadur, S.S., Costa, D.L., Slade, R., Silbjoris, R., and Hatch, G.E. Acute ozone-induced differential gene expression profiles in rat lung. Environ. Health Perspect. 113(12):1717-22, 2005
  111. Lippmann M, Cassee FR, Costa DL, Costantini M, van Erp AM, Gordon T. International Workshop on the Design and Analysis of Experimental Studies using PM Concentrator Technologies, Inhal Toxicol. 17(14):839-50, 2005.
  112. Ghio, A., Lehmann, J.R., Winsett, D.W., Richards, J., Costa, D.L. Colchicine decreases airway hyperreactivity after phosgene exposure. Inhal Toxicol. 17(6):277-85, 2005
  113. Kodavanti, U.P., Schladweiler, M.C., Ledbetter, A.D., McGee, J.K., Walsh, L., Gilmour, P.S., Highfill, J.W., Davies, D., Pinkerton, K.E., Richards, J.H., Crissman, K., Andrews, D., Costa, D.L.. Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: roles of rat strains used and physicochemical properties. Environ Health Perspect. 113(11):1561-8, 2005.
  114. Aufderheide, M., Costa, D.L., Devlin, R., Feron, V., Harkema, J.R., Hayashi, Y., Pauluhn, J., Spielmann, H. Experimental Assessment of the Toxicological Effects of Inhaled Complex Mixtures on the Respiratory System. Exp Toxicol Path. 57 Sup.1:239-43, 2005.
  115. Costa, D.L., Lehmann, J.R., Winsett, D.W., Richards, J., Ledbetter, A.D., Dreher, K.L. Comparative Pulmonary Toxicological Assessment of Oil Combustion Particles Following Inhalation or Instillation Exposure. Toxicol Sci. 91(1):237-46, 2006.
  116. Wichers, L.B., Rowan, W.B., Nolan, J.P., Ledbetter, A.D., McGee, J.K., Costa, D.L., Watkinson, W.P. Particle Deposition in Spontaneously Hypertensive Rats Exposed Via Whole-Body Inhalation: Measured and Estimated Dose. Toxicol Sci. 93(2):400-10, 2006.
  117. Kodavanti, U.P., Schladweiler, M.C., Ledbetter, A.D., Ortuno, R.V., Suffia, M., Evansky, P,. Richards, J.H., Jaskot, R.H., Thomas, R., Karoly, E., Huang, Y.C.T., Costa, D.L., Gilmour, P.S., Pinkerton, K.E. The Spontaneously Hypertensive Rat: An Experimental Model of Sulfur Dioxide-Induced Airways Disease Toxicol Sci 94(1):193-205, 2006.
  118. Wichers, L.B., Ledbetter, A.D., McGee, J.K., Kellogg, R.B., Rowan, W.H. 3rd, Nolan, J.P., Costa, D.L., Watkinson WP. A method for exposing rodents to resuspended particles using whole-body plethysmography. Particle Fibre Toxicol. 3(1):12, 2006.
  119. Kodavanti, U.P., Schladweiler, M.C., Gilmour, P.S. Wallenborn, J.G.,Mandavilli, B.S., Ledbetter, A.D., Christiani, D.C., Runge, M.S., Karoly, E.D., Costa, D.L., Peddada, S., Jaskot, R., Richards, J.S., Thomas, R., Madamanchi, N.R., Nyska, A. The role of particulate matter-associated zinc in cardiac injury in rats. Environ. Health Perspect. (in press) 2007.
  120. Hazari, M.S., Rowan, W.H., Winsett, D.W., Ledbetter, A.D., Haykal-Coates, N., Watkinson, W.P. Costa, D.L.. Potentiation of pulmonary reflex response to capsaicin 24 hours following whole-body acrolein exposure is mediated by TRPV1. Respir. Physiol. Neurobiol. Accepted, 2007.
  121. Kodavanti UP, Schladweiler MC, Gilmour PS, Wallenborn JG, Mandavilli BS, Ledbetter AD, Christiani DC, Runge MS, Karoly ED, Costa DL, Peddada S, Jaskot R, Richards JH, Thomas R, Madamanchi NR, Nyska A. The role of particulate matter-associated zinc in cardiac injury in rats. Environ Health Perspect. 116(1):13-20, 2008.
  122. Hazari MS, Rowan WH, Winsett DW, Ledbetter AD, Haykal-Coates N, Watkinson WP, Costa DL. Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1. Respir Physiol Neurobiol. 160(2):160-71, 2008.
  123. Nadadur SS, Haykal-Coates N, Mudipalli A, Costa DL. Endothelial Effects of Emission Source particles: Acute Toxic Response Gene Expression Profiles. Toxicol. In Vitro 23(1):67-77, 2009.
  124. Farraj AK, Haykal-Coates N, Winsett DW, Hazari MS, Carll AP, Rowan WH, Ledbetter AD, Cascio WE, Costa DL. Increased Non-conducted P-wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats. Environ Health Perspect. Environ Health Perspect. 117(5):709-15 2009
  125. Hazari MS, Haykal-Coates N, Winsett DW, Costa DL, Farraj AK. A single exposure to particulate or gaseous air pollution increases the risk of aconitine-induced cardiac arrhythmia in hypertensive rats. Toxicol Sci. 112(2):532-42, 2009.
  126. Black K, Martinez V, Baldauf RW, Thoma ED, Costa DL. Study Design to Evaluate Mobile Source Air Toxics Compounds in the Near-Roadway Environment., Air & Waste Manage Assoc. Environmental Manager (EM) January 2009
  127. Hazari MS, Haykal-Coates N, Winsett DW, Costa DL, Farraj AK. Continuous electrocardiogram reveals differences in the short-term cardiotoxic response of Wistar-Kyoto and spontaneously hypertensive rats to doxorubicin. Toxicol Sci. 110(1):224-34, 2009. 128. 
  128. Carll AP, Haykal-Coates N, Winsett DW, Rowan WH, Hazari MS, Ledbetter AD, Nyska A, Cascio WE, Watkinson WP, Costa DL, Farraj AK Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy. Inhal Toxicol. 22(5):355-68, 2010.
  129. Farraj AK, Hazari MS, Haykal-Coates N, Lamb C, Winsett DW, Ge Y, Ledbetter AD, Carll AP, Bruno M, Ghio A, Costa DL. ST Depression, Arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats. Am J Respir Cell Mol Biol. 44(2):185-96, 2011.
  130. Hazari MS, Haykal-Coates N, Winsett DW, Costa DL, Farraj AK. Continuous electrocardiogram reveals differences in the short-term cardiotoxic response of Wistar-Kyoto and spontaneously hypertensive rats to doxorubicin Toxicol Sci.110(1):224-34, 2009.
  131. Carll AP, Haykal-Coates N, Winsett DW, Rowan WH, Hazari MS, Ledbetter AD, Nyska A, Cascio WE, Watkinson WP, Costa DL, Farraj AK Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy. Inhal Toxicol. 22(5):355-68, 2010.
  132. Padilla-Carlin DJ and Costa DL. Comparison of functional, biochemical, and morphometric alterations in the lungs of four rat strains and hamsters following repeated intratracheal instillation of crocidolite asbestos Exp. Lung Res. 37(4):212-26, 2011. 133.      
  133. Carll AP, Willis MS, Lust RM, Costa DL, Farraj AK. Merits of non-invasive rat models of left ventricular heart failure. Cardiovasc Toxicol. 11(2):91-112, 2011.
  134. Stanek LW, Brown JS, Stanek J, Gift J, Costa DL. Air pollution toxicology--a brief review of the role of the science in shaping the current understanding of air pollution health risk Toxicol Sci. 120 Suppl 1:S8-27, 2011
  135. Hazari MS, Haykal-Coates N, Winsett DW, Krantz QT, King C, Costa DL, Farraj AK. TRPA1 and Sympathetic Activation Contribute to Increased Risk of Triggered Cardiac Arrhythmias in Hypertensive Rats Exposed to Diesel Exhaust. Environ Health Perspect. 119(7):951-7, 2011.
  136. Farraj AK, Hazari MS, Winsett DW, Kulukulualani A, Carll AP, Haykal-Coates N, Lamb CM, Lappi E, Terrell D, Cascio WE, Costa DL. Overt and Latent Cardiac Effects of Ozone Inhalation in Rats: Evidence for Autonomic Modulation and Increased Myocardial Vulnerability. Environ Health Perspect. 120(3): 348-354, 2011
  137. Carll AP, Haykal-Coates N, Winsett DW, Hazari MS, Nyska A, Richards JH, Willis MS, Costa DL, Farraj AK. Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats. Toxicol Pathol. 39(6):925-37, 2011.
  138. Lamb CM, Hazari MS, Haykal-Coates N, Carll AP, Krantz QT, King C, Winsett DW, Cascio WE, Costa DL, Farraj AK. Divergent electrocardiographic responses to whole and particle-free diesel exhaust inhalation in spontaneously hypertensive rats. Toxicol Sci. 125(2):558-68, 2012.
  139. Hazari MH, Coates N, Winsett D, Perez CL, Carll A,. King C, Krantz Q, Costa DL, Farraj A Dobutamine “Stress” Test Uncovers Latent Cardiac Susceptibility to Inhaled Diesel Exhaust in Normal and Hypertensive Rats. Environ. Health Perspect. 120(8):1088-1093, 2012.
  140. Carll AP, Hazari MS, Perez CM, Krantz QT, King CJ, Winsett DW, Costa DL, Farraj AK. Whole and particle-free diesel exhausts differentially affect cardiac electrophysiology, blood pressure, and autonomic balance in heart failure-prone rats. Toxicol Sci. 2012: 128(2):490-9
  141. Johns DO, Stanek LW, Walker K, Benromdhane S, Hubbell B, Ross M, Devlin RB, Costa DL, Greenbaum DS. Practical advancement of multipollutant scientific and risk assessment approaches for ambient air pollution. Environ Health Perspect. 2012 120(9):1238-42. doi: 10.1289/ehp.1204939.
  142. Carll AP, Lust RM, Hazari MS, Perez CM, Krantz QT, King CJ, Winsett DW, Cascio WE, Costa DL, Farraj AK. Diesel exhaust inhalation increases cardiac output, bradyarrhythmias, and parasympathetic tone in aged heart failure-prone rats. Toxicol Sci. 2013 Feb; 131(2):583-95.
  143. Hazari MS, Griggs J, Winsett DW, Haykal-Coates N, Ledbetter A, Costa DL, Farraj AK. A Single Exposure to Acrolein Desensitizes Baroreflex Responsiveness and Increases Cardiac Arrhythmias in Normotensive and Hypertensive Rats. Cardiovasc Toxicol. 2013 Sep 27. [Epub ahead of print] PubMed PMID: 24078368.
  144. Carll AP, Hazari MS, Perez CM, Krantz QT, King CJ, Haykal-Coates N, Cascio WE, Costa DL, Farraj AK. An autonomic link between inhaled diesel exhaust and impaired cardiac performance: insight from treadmill and dobutamine challenges in heart failure-prone rats. Toxicol Sci. 2013: 135(2):425-36.
  145. Perez CM, Ledbetter AD, Hazari MS, Haykal-Coates N, Carll AP, Winsett DW, Costa DL, Farraj AK. Hypoxia stress test reveals exaggerated cardiovascular effects in hypertensive rats after exposure to the air pollutant acrolein. Toxicol Sci. 2013 Apr;132(2):467-77.
  146. Hazari MS, Griggs J, Winsett DW, Haykal-Coates N, Ledbetter A, Costa DL, Farraj AK. A single exposure to acrolein desensitizes baroreflex responsiveness and increases cardiac arrhythmias in normotensive and hypertensive rats. Cardiovasc Toxicol. 2014; 14(1):52-63.
  147. Kodavanti UP, Russell JC, Costa DL. Rat models of cardiometabolic diseases: baseline clinical chemistries, and rationale for their use in examining air pollution health effects. Inhal Toxicol. 2015;27 Suppl 1:2-13
  148. Dye JA, Ledbetter AD, Schladweiler MC, Costa DL, Kodavanti UP. Whole body plethysmography reveals differential ventilatory responses to ozone in rat models of cardiovascular disease. Inhal Toxicol. 2015;27 Suppl 1:14-25.
  149. Dye JA, Costa DL, Kodavanti UP. Executive Summary: variation in susceptibility to ozone-induced health effects in rodent models of cardiometabolic disease. Inhal Toxicol. 2015;27 Suppl 1:105-15.
  150. Kodavanti UP, Ledbetter AD, Thomas RF,Richards JE, Ward WO, Schladweiler MC, Costa DL Variability  in ozone-induced pulmonary injury and inflammation in healthy and cardiovascular-compromised rat models. Inhal Toxicol. 2015:27 Suppl 1:39-53.
  151. West J, Cohen A, Dentener F, Brunekreef B, Zhu T, Armstrong B, Bell M, Brauer M, Carmichael GR, Costa D, Dockery D, Kleeman MJ, Krzyzanowski M, Kunzli N, Liousse C, Lung SC, Martin RV, Pöschl U, Pope CA, Roberts JM, Russell AG, Wiedinmyer C. What we breathe impacts our health: improving understanding of the link between air pollution and health. Environ Sci Technol. 2016 Mar 24. [Epub ahead of print] PMID: 27010639
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