Consolato M. Sergi
Consolato M Sergi, MD, PhD, FRCPC
Professor of Laboratory Medicine and Pathology

University of Alberta
Canada

Education

2004 – 2006 Master of Public Health (M.P.H.) University of Medical Information and Technology, Hall i.T, Austria
2004 Doctor of Philosophy (Ph.D.) University of Innsbruck, Austria
1994 – 2001 Pathology Resident University of Heidelberg, Germany
1994 – 1994 Molecular Biology Fellow Fornaroli Hospital,
Academic University Hospital

 

Biography

 

Research Interest

  • Congenital Heart Disease, Sequential Segmental Analysis, and Metabolic Diseases
  • Pathology & Genetics of Hepato‐Renal Fibrocystic Diseases & Dysmorphology
  • Pathogenesis of Hepatocellular and Cholangiocellular Carcinoma
  • Mitochondriome, Mitophagy & Mitochondrial DNA‐related Cardiomyopathies

 

Professional Activities:

1989-1993 Residency in Pediatrics Univ. of Genoa, Gaslini Children’s Hospital, Italy
1992-1994 Fellowship in Pediatric Pathology Gaslini Children’s Hospital, Italy
1994-2001 Residency in Pathology Univ. of Heidelberg, Germany
2001-2004 PhD/Habilitation Univ. of Innsbruck, Austria
2001-2002 Pathologist University of Heidelberg, Germany
2002-2004 Pediatric Pathologist and Hon. Clinical Reader Univ. of Bristol, UK
2004-2008 Pediatric Pathologist, Associate Professor of Pathology Univ. of Innsbruck, Austria
2008+ Professor of Pathology University of Alberta, Edmonton, AB, Canada
2012+ Professor of Pediatrics University of Alberta, Edmonton, AB, Canada

 

Publications

  1. Putko BN, Wen K, Thompson RB, Mullen J, Shanks M, Yogasundaram H, Sergi C,Oudit GY. Anderson-Fabry cardiomyopathy: prevalence, pathophysiology, diagnosisand treatment. Heart Fail Rev. 2015 Mar;20(2):179-91. doi:10.1007/s10741-014-9452-9. PubMed PMID: 25030479.
  2. Haberer K, Buffo-Sequeira I, Chudley AE, Spriggs E, Sergi C. A case of aninfant with compound heterozygous mutations for hypertrophic cardiomyopathyproducing a phenotype of left ventricular noncompaction. Can J Cardiol. 2014Oct;30(10):1249.e1-3. doi: 10.1016/j.cjca.2014.05.021. Epub 2014 Jun 12. PubMedPMID: 25262865.
  3. Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, ElGhissassi F, Bouvard V, Guha N, Mattock H, Straif K and IARC Collaborators (Sergi C). Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone. Lancet Oncol. 2014 Aug;15(9):924-5.
  4. Bahitham W, Liao X, Peng F, Bamforth F, Chan A, Mason A, Stone B, Stothard P, Sergi C. Mitochondriome and cholangiocellular carcinoma. PLoS One. 2014 Aug19;9(8):e104694. doi: 10.1371/journal.pone.0104694. eCollection 2014. PubMedPMID: 25137133; PubMed Central PMCID: PMC4138114.
  5. Valtuille L, Paterson I, Kim DH, Mullen J, Sergi C, Oudit GY. A case of lamin A/C mutation cardiomyopathy with overlap features of ARVC: a critical role ofgenetic testing. Int J Cardiol. 2013 Oct 9;168(4):4325-7. doi:10.1016/j.ijcard.2013.04.177. Epub 2013 May 16. PubMed PMID: 23684604.
  6. Pelletier JS, LaBossiere J, Dicken B, Gill RS, Sergi C, Tahbaz N, Bigam D,Cheung PY. Low-dose vasopressin improves cardiac function in newborn piglets withacute hypoxia-reoxygenation. Shock. 2013 Oct;40(4):320-6. doi:10.1097/SHK.0b013e3182a4284e. PubMed PMID: 23856923.
  7. Cave D, Ross DB, Bahitham W, Chan A, Sergi C, Adatia I. Mitochondrial DNAdepletion syndrome-an unusual reason for interstage attrition after the modified stage 1 Norwood operation. Congenit Heart Dis. 2013 Jan-Feb;8(1):E20-3. doi:10.1111/j.1747-0803.2011.00569.x. Epub 2011 Oct 20. PubMed PMID: 22011012.
  8. Chassaing N, Sorrentino S, Davis EE, Martin-Coignard D, Iacovelli A, Paznekas W, Webb BD, Faye-Petersen O, Encha-Razavi F, Lequeux L, Vigouroux A, Yesilyurt A,Boyadjiev SA, Kayserili H, Loget P, Carles D, Sergi C, Puvabanditsin S, Chen CP, Etchevers HC, Katsanis N, Mercer CL, Calvas P, Jabs EW. OTX2 mutations contributeto the otocephaly-dysgnathia complex. J Med Genet. 2012 Jun;49(6):373-9. doi:10.1136/jmedgenet-2012-100892. Epub 2012 May 10. PubMed PMID: 22577225.
  9. Mohammed S, Bahitham W, Chan A, Chiu B, Bamforth F, Sergi C. Mitochondrial DNArelated cardiomyopathies. Front Biosci (Elite Ed). 2012 Jan 1;4:1706-16. Review. PubMed PMID: 22201986.
  10. Yu TW, Mochida GH, Tischfield DJ, Sgaier SK, Flores-Sarnat L, Sergi CM, TopçuM, McDonald MT, Barry BJ, Felie JM, Sunu C, Dobyns WB, Folkerth RD, Barkovich AJ,Walsh CA. Mutations in WDR62, encoding a centrosome-associated protein, causemicrocephaly with simplified gyri and abnormal cortical architecture. Nat Genet. 2010 Nov;42(11):1015-20. doi: 10.1038/ng.683. Epub 2010 Oct 3. PubMed PMID:20890278; PubMed Central PMCID: PMC2969850.
  11. Stambader JD, Dorn L, Mikuz G, Sergi C. Genetic polymorphisms in dilatedcardiomyopathy. Front Biosci (Schol Ed). 2010 Jan 1;2:653-76. Review. PubMedPMID: 20036975.
  12. Chiu B, Sergi C. Dilated cardiomyopathy: etio-morphologic investigation.Front Biosci (Schol Ed). 2010 Jan 1;2:112-6. Review. PubMed PMID: 20036933.
  13. Nathan BM, Sockalosky J, Nelson L, Lai S, Sergi C, Petryk A. The use ofhormonal therapy in pediatric heart disease. Front Biosci (Schol Ed). 2009 Jun1;1:358-75. Review. PubMed PMID: 19482707.
  14. Ardizzone N, Cappello F, Di Felice V, Rappa F, Minervini F, Marasà S, Marasà L, Rabl W, Zummo G, Sergi C. Atrial natriuretic peptide and CD34 overexpressionin human idiopathic dilated cardiomyopathies. APMIS. 2007 Nov;115(11):1227-33.PubMed PMID: 18092954.
  15. Sergi C, Daum E, Pedal I, Hauröder B, Schnitzler P. Fatal circumstances ofhuman herpesvirus 6 infection: transcriptosome data analysis suggests caution in implicating HHV-6 in the cause of death. J Clin Pathol. 2007 Oct;60(10):1173-7.Epub 2007 Jun 1. PubMed PMID: 17545558; PubMed Central PMCID: PMC2014822.
  16. Johnson CA, Gissen P, Sergi C. Molecular pathology and genetics of congenitalhepatorenal fibrocystic syndromes. J Med Genet. 2003 May;40(5):311-9. Review.PubMed PMID: 12746391; PubMed Central PMCID: PMC1735460.
  17. Sergi C, Penzel R, Uhl J, Zoubaa S, Dietrich H, Decker N, Rieger P, Kopitz J,Otto HF, Kiessling M, Cantz M. Prenatal diagnosis and fetal pathology in aTurkish family harboring a novel nonsense mutation in the lysosomalalpha-N-acetyl-neuraminidase (sialidase) gene. Hum Genet. 2001 Oct;109(4):421-8. PubMed PMID: 11702224.
  18. Sergi C, Himbert U, Weinhardt F, Heilmann W, Meyer P, Beedgen B, Zilow E,Hofmann WJ, Linderkamp O, Otto HF. Hepatic failure with neonatal tissue siderosisof hemochromatotic type in an infant presenting with meconium ileus. Case report and differential diagnosis of the perinatal iron storage disorders. Pathol ResPract. 2001;197(10):699-709; discussion 711-3. PubMed PMID: 11700892.
  19. Sergi C, Kahl P, Otto HF. Contribution of apoptosis and apoptosis-relatedproteins to the malformation of the primitive intrahepatic biliary system inMeckel syndrome. Am J Pathol. 2000 May;156(5):1589-98. PubMed PMID: 10793071;PubMed Central PMCID: PMC1876920.
  20. Sergi C, Serpi M, Müller-Navia J, Schnabel PA, Hagl S, Otto HF, Ulmer HE.CATCH 22 syndrome: report of 7 infants with follow-up data and review of therecent advancements in the genetic knowledge of the locus 22q11. Pathologica.1999 Jun;91(3):166-72. Review. PubMed PMID: 10536461.
  21. Sergi C, Weitz J, Hofmann WJ, Sinn P, Eckart A, Otto G, Schnabel PA, Otto HF.Aspergillus endocarditis, myocarditis and pericarditis complicating necrotizingfasciitis. Case report and subject review. Virchows Arch. 1996Oct;429(2-3):177-80. Review. PubMed PMID: 8917720.

 

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